TY - GEN A1 - Jenihhin, Maksim A1 - Hamdioui, Said A1 - Sonza-Reorda, Matteo A1 - Krstic, Milos A1 - Langendörfer, Peter A1 - Sauer, Christian A1 - Klotz, Anton A1 - Hübner, Michael A1 - Nolte, Jörg A1 - Vierhaus, Heinrich Theodor A1 - Selimis, Georgions A1 - Alexandrescu, Dan A1 - Taouil, Mottaqiallah A1 - Schrijen, Geert-Jan A1 - Sterpone, Luca A1 - Squillero, Giovanni A1 - Dyka, Zoya A1 - Raik, Jaan T1 - RESCUE: Interdependent Challenges of Reliability, Security and Quality in Nanoelectronic Systems T2 - ArXiv.org Y1 - 2019 UR - https://arxiv.org/abs/1912.01561 ER - TY - GEN A1 - Schurig, Mona A1 - Umeh, Obinna A1 - Henze, Henriette A1 - Jung, Marie Juliane A1 - Gresing, Lennart A1 - Blanchard, Veronique A1 - Maltzahn, Julia von A1 - Hübner, Christian A1 - Franzka, Patricia T1 - Consequences of GMPPB deficiency for neuromuscular development and maintenance T2 - Frontiers in Molecular Neuroscience N2 - Guanosine diphosphate-mannose pyrophosphorylase B (GMPPB) catalyzes the conversion of mannose-1-phosphate and GTP to GDP-mannose, which is required as a mannose donor for the biosynthesis of glycan structures necessary for proper cellular functions. Mutations in GMPPB have been associated with variable neuromuscular disorders such as muscular dystrophy and myasthenic syndromes. Here, we report that GMPPB protein abundance increases during brain and skeletal muscle development, which is accompanied by an increase in overall protein mannosylation. To model the human disorder in mice, we generated heterozygous GMPPB KO mice using CRISPR/Cas9. While we were able to obtain homozygous KO mice from heterozygous matings at the blastocyst stage, homozygous KO embryos were absent beyond embryonic day E8.5, suggesting that the homozygous loss of GMPPB results in early embryonic lethality. Since patients with GMPPB loss-of-function manifest with neuromuscular disorders, we investigated the role of GMPPB in vitro. Thereby, we found that the siRNA-mediated knockdown of Gmppb in either primary myoblasts or the myoblast cell line C2C12 impaired myoblast differentiation and resulted in myotube degeneration. siRNA-mediated knockdown of Gmppb also impaired the neuron-like differentiation of N2A cells. Taken together, our data highlight the essential role of GMPPB during development and differentiation, especially in myogenic and neuronal cell types. Y1 - 2024 U6 - https://doi.org/10.3389/fnmol.2024.1356326 SN - 1662-5099 VL - 17 ER - TY - GEN A1 - Mahmood, Safdar A1 - Scharoba, Stefan A1 - Schorlemer, Jonas A1 - Schulz, Christian A1 - Hübner, Michael A1 - Reichenbach, Marc T1 - Detecting Improvised Land-mines using Deep Neural Networks on GPR Image Dataset targeting FPGAs  T2 - IEEE Nordic Circuits and Systems Conference (NORCAS), 25-26 October 2022, Oslo, Norway Y1 - 2022 SN - 979-8-3503-4550-6 SN - 979-8-3503-4551-3 U6 - https://doi.org/10.1109/norcas57515.2022.9934735 SP - 1 EP - 7 PB - IEEE CY - Piscataway, NJ ER - TY - CHAP A1 - Tsonkova, Penka A1 - Böhm, Christian A1 - Hübner, Rico A1 - Ehritt, Julia ED - Mosquera-Losada, María Rosa ED - Prabhu, Ravi T1 - Managing hedgerows to optimise ecosystem services in agroforestry systems T2 - Agroforestry for sustainable agriculture Y1 - 2019 SN - 978-1-78676-220-7 U6 - https://doi.org/10.19103/AS.2018.0041.03 SP - 39 EP - 88 PB - Burleigh Dodds Science Publishing CY - Cambridge ER - TY - CHAP A1 - Tsonkova, Penka A1 - Böhm, Christian A1 - Hübner, Rico ED - Ferreiro-Domínguez, Nuria ED - Mosquera-Losada, María Rosa T1 - The biomass potential of existing linear woody-features in the agricultural landscape T2 - Proceedings of the 4th European Agroforestry Conference Agroforestry as Sustainable Land Use 28-30 May 2018, Nijmegen, The Netherlands N2 - Linear woody-features, such as hedgerows, windbreaks, and riparian buffer strips, composed of trees and/or shrubs are anthropogenic features, established in the past for different purposes, such as provision of field boundaries, protection from wind and supply of fuelwood. Today, they are primarily valued for their ecological benefit, while their production function has received rather little attention. This study assessed the biomass potential of existing linear woodyfeatures in a study area in southern Brandenburg, Germany. The merchantable tree volume of the measured woody-features ranged between 240 m3 ha-1 and 710 m3 ha-1, depending on the relative proportion of trees and shrubs. The results suggest that the biomass potential of linear woody-features with predominant tree proportion per hectare can be higher than this of forests. A strategy for utilising the production function of these woody-features should take into account the provision of benefits such as wind protection, habitat provision and landscape aesthetics. Y1 - 2018 UR - https://www.repository.utl.pt/bitstream/10400.5/15589/1/REP-CEF-EURAF-conference_book.pdf SN - 978-84-09-02384-4 SP - 527 EP - 531 CY - Santiago de Compostela ER - TY - GEN A1 - Tsonkova, Penka A1 - Böhm, Christian A1 - Ehritt, Julia A1 - Hübner, Rico ED - Dupraz, Christian ED - Gosme, Marie ED - Lawson, Gerry T1 - Assessing multiple ecosystem functions of linear woody-features in the agricultural landscape T2 - Book of Abstracts, 4th World Congress on Agroforestry. Agroforestry: strengthening links between science, society and policy Y1 - 2019 UR - https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=2&ved=2ahUKEwjkiYbdwK3nAhWOblAKHeeoAccQFjABegQIARAB&url=https%3A%2F%2Fwww.alphavisa.com%2Fagroforestry%2F2019%2Fdocuments%2FAgroforestry2019-Book-of-Abstract-v1.pdf&usg=AOvVaw1jKNMB1dbiho_8KJtwaynl SP - 544 PB - CIRAD, INRA, World Agroforestry CY - Montpellier ER - TY - GEN A1 - Shahin, Keyvan A1 - Hübner, Michael A1 - Herglotz, Christian T1 - A width-configurable hardware approach for accelerating fixed-point simulation T2 - IEEE Computer Society Annual Symposium on VLSI (ISVLSI) N2 - Fixed-point simulation is a critical step in the design flow of Digital Signal Processing (DSP) systems and consumes a significant portion of the overall development time. This work proposes a novel hardware-based approach to improve the performance of fixed-point simulation through a widthconfigurable architecture implemented on Field-Programmable Gate Arrays (FPGAs). To our knowledge, this is the first reported hardware-based solution for fixed-point simulation reported in the literature, which provides substantial speedup compared to traditional software-based approaches. The presented approach utilizes High-Level Synthesis (HLS) tools to create modular, reusable components that enhance the design reusability. This approach accelerates fixed-point simulation for various applications, requiring only minor modifications to the application code to utilize it. By incorporating simulation capabilities within reusable functions, this work improves the efficiency and adaptability of the fixed-point simulation process. Implementation results for two FIR filter applications show that the proposed methodology is superior to traditional software-based approaches in reducing simulation time by two orders of magnitude and thus has the potential to improve the productivity of the DSP system design flow. KW - Fixed-Point Simulation, Width-Configurable Hardware, Hardware-based Acceleration, High-Level Synthesis (HLS) Y1 - 2025 SN - 979-8-3315-3477-6 U6 - https://doi.org/10.1109/ISVLSI65124.2025.11130205 SN - 2159-3477 PB - IEEE CY - Piscataway, NJ ER - TY - GEN A1 - Muñoz-Hernandez, Hector Gerardo A1 - Ali, Muhammad A1 - Shahin, Keyvan A1 - Siyavashi, Alireza A1 - Göhringer, Diana A1 - Reichenbach, Marc A1 - Herglotz, Christian A1 - Hübner, Michael T1 - Towards complete open-source environments : FPGA-based GPU overlay controlled by RISC-V T2 - Architecture of computing systems : 38th International Conference, ARCS 2025 Kiel, Germany, April 22–24, 2025, proceedings N2 - Image and signal processing applications have been widely implemented in Field Programmable Gate Arrays (FPGAs) and Graphical Processing Units (GPUs) due to their energy efficiency and performance, respectively. GPUs provide high data processing parallelism and are usually chosen to accelerate applications where low energy consumption is not a high priority. On the other hand, FPGAs are more tailored to hardware solutions due to their reconfigurability, but they struggle to outperform GPUs in data throughput. Soft IP cores implemented on reconfigurable hardware, are an alternative offering advantages from both worlds. Some of these soft-core solutions offer an entire environment that includes scripts to automate their implementation, custom compilers, and other diverse tools. Unfortunately, some of these soft-cores are dependent on proprietary Intellectual Property (IP) or require hardware expertise to use properly. In this work, we propose an extended version of a popular open-source soft GPU, which can now run alongside a soft RISC-V core, and with High-Bandwidth memory (HBM2) compatibility. Previously, this soft GPU was only ready to be deployed in boards with a hard ARM core, but now it can be easily used in FPGAs without this requirement. We also provide an evaluation of how the soft GPU performs with respect to the pure RISC-V core, and a hard ARM core achieving geometric mean speed-ups of 114.60x and 19.72x respectively when performing some image and signal processing applications. Finally, we demonstrate how our soft GPU benefits from the HBM integration. KW - FPGA KW - Soft-core GPU KW - System-On-Chip KW - RISC-V KW - HBM Y1 - 2025 SN - 978-3-032-03280-5 U6 - https://doi.org/https://doi.org/10.1007/978-3-032-03281-2_7 SN - 0302-9743 SP - 94 EP - 108 PB - Springer CY - Berlin ER -