TY - GEN A1 - Jenihhin, Maksim A1 - Hamdioui, Said A1 - Sonza-Reorda, Matteo A1 - Krstic, Milos A1 - Langendörfer, Peter A1 - Sauer, Christian A1 - Klotz, Anton A1 - Hübner, Michael A1 - Nolte, Jörg A1 - Vierhaus, Heinrich Theodor A1 - Selimis, Georgions A1 - Alexandrescu, Dan A1 - Taouil, Mottaqiallah A1 - Schrijen, Geert-Jan A1 - Sterpone, Luca A1 - Squillero, Giovanni A1 - Dyka, Zoya A1 - Raik, Jaan T1 - RESCUE: Interdependent Challenges of Reliability, Security and Quality in Nanoelectronic Systems T2 - ArXiv.org Y1 - 2019 UR - https://arxiv.org/abs/1912.01561 ER - TY - GEN A1 - Mahmood, Safdar A1 - Scharoba, Stefan A1 - Schorlemer, Jonas A1 - Schulz, Christian A1 - Hübner, Michael A1 - Reichenbach, Marc  T1 - Detecting Improvised Land-mines using Deep Neural Networks on GPR Image Dataset targeting FPGAs  T2 - IEEE Nordic Circuits and Systems Conference (NORCAS), 25-26 October 2022, Oslo, Norway Y1 - 2022 SN - 979-8-3503-4550-6 SN - 979-8-3503-4551-3 U6 - https://doi.org/10.1109/norcas57515.2022.9934735 SP - 1 EP - 7 PB - IEEE CY - Piscataway, NJ ER - TY - GEN A1 - Schurig, Mona A1 - Umeh, Obinna A1 - Henze, Henriette A1 - Jung, Marie Juliane A1 - Gresing, Lennart A1 - Blanchard, Veronique A1 - Maltzahn, Julia von A1 - Hübner, Christian A1 - Franzka, Patricia T1 - Consequences of GMPPB deficiency for neuromuscular development and maintenance T2 - Frontiers in Molecular Neuroscience N2 - Guanosine diphosphate-mannose pyrophosphorylase B (GMPPB) catalyzes the conversion of mannose-1-phosphate and GTP to GDP-mannose, which is required as a mannose donor for the biosynthesis of glycan structures necessary for proper cellular functions. Mutations in GMPPB have been associated with variable neuromuscular disorders such as muscular dystrophy and myasthenic syndromes. Here, we report that GMPPB protein abundance increases during brain and skeletal muscle development, which is accompanied by an increase in overall protein mannosylation. To model the human disorder in mice, we generated heterozygous GMPPB KO mice using CRISPR/Cas9. While we were able to obtain homozygous KO mice from heterozygous matings at the blastocyst stage, homozygous KO embryos were absent beyond embryonic day E8.5, suggesting that the homozygous loss of GMPPB results in early embryonic lethality. Since patients with GMPPB loss-of-function manifest with neuromuscular disorders, we investigated the role of GMPPB in vitro. Thereby, we found that the siRNA-mediated knockdown of Gmppb in either primary myoblasts or the myoblast cell line C2C12 impaired myoblast differentiation and resulted in myotube degeneration. siRNA-mediated knockdown of Gmppb also impaired the neuron-like differentiation of N2A cells. Taken together, our data highlight the essential role of GMPPB during development and differentiation, especially in myogenic and neuronal cell types. Y1 - 2024 U6 - https://doi.org/10.3389/fnmol.2024.1356326 SN - 1662-5099 VL - 17 ER - TY - CHAP A1 - Tsonkova, Penka A1 - Böhm, Christian A1 - Hübner, Rico ED - Ferreiro-Domínguez, Nuria ED - Mosquera-Losada, María Rosa T1 - The biomass potential of existing linear woody-features in the agricultural landscape T2 - Proceedings of the 4th European Agroforestry Conference Agroforestry as Sustainable Land Use 28-30 May 2018, Nijmegen, The Netherlands N2 - Linear woody-features, such as hedgerows, windbreaks, and riparian buffer strips, composed of trees and/or shrubs are anthropogenic features, established in the past for different purposes, such as provision of field boundaries, protection from wind and supply of fuelwood. Today, they are primarily valued for their ecological benefit, while their production function has received rather little attention. This study assessed the biomass potential of existing linear woodyfeatures in a study area in southern Brandenburg, Germany. The merchantable tree volume of the measured woody-features ranged between 240 m3 ha-1 and 710 m3 ha-1, depending on the relative proportion of trees and shrubs. The results suggest that the biomass potential of linear woody-features with predominant tree proportion per hectare can be higher than this of forests. A strategy for utilising the production function of these woody-features should take into account the provision of benefits such as wind protection, habitat provision and landscape aesthetics. Y1 - 2018 UR - https://www.repository.utl.pt/bitstream/10400.5/15589/1/REP-CEF-EURAF-conference_book.pdf SN - 978-84-09-02384-4 SP - 527 EP - 531 CY - Santiago de Compostela ER - TY - CHAP A1 - Tsonkova, Penka A1 - Böhm, Christian A1 - Hübner, Rico A1 - Ehritt, Julia ED - Mosquera-Losada, María Rosa ED - Prabhu, Ravi T1 - Managing hedgerows to optimise ecosystem services in agroforestry systems T2 - Agroforestry for sustainable agriculture Y1 - 2019 SN - 978-1-78676-220-7 U6 - https://doi.org/10.19103/AS.2018.0041.03 SP - 39 EP - 88 PB - Burleigh Dodds Science Publishing CY - Cambridge ER - TY - GEN A1 - Tsonkova, Penka A1 - Böhm, Christian A1 - Ehritt, Julia A1 - Hübner, Rico ED - Dupraz, Christian ED - Gosme, Marie ED - Lawson, Gerry T1 - Assessing multiple ecosystem functions of linear woody-features in the agricultural landscape T2 - Book of Abstracts, 4th World Congress on Agroforestry. Agroforestry: strengthening links between science, society and policy Y1 - 2019 UR - https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=2&ved=2ahUKEwjkiYbdwK3nAhWOblAKHeeoAccQFjABegQIARAB&url=https%3A%2F%2Fwww.alphavisa.com%2Fagroforestry%2F2019%2Fdocuments%2FAgroforestry2019-Book-of-Abstract-v1.pdf&usg=AOvVaw1jKNMB1dbiho_8KJtwaynl SP - 544 PB - CIRAD, INRA, World Agroforestry CY - Montpellier ER -