TY - GEN A1 - Neubert, Tilmann J. A1 - Hielscher, Maximilian M. A1 - Walter, Keven A1 - Schröter, Carolin M. A1 - Stage, Marion A1 - Rosencrantz, Ruben R. A1 - Panis, Felix A1 - Rompel, Annette A1 - Balasubramanian, Kannan A1 - Waldvogel, Siegfried R. A1 - Börner, Hans G. T1 - Electrosynthesis of mussel‐inspired adhesive polymers as a novel class of transient enzyme stabilizers T2 - Angewandte Chemie : a journal of the Gesellschaft Deutscher Chemiker. International edition N2 - Multifunctional ortho‐quinones are required for the formation of thiol‐catechol‐connectivities (TCC) but can be delicate to handle. We present the electrochemical oxidation of the dipeptide DiDOPA, achieving up to 92 % conversion efficiency of the catechols to ortho‐quinones. Graphite and stainless steel could be employed as cost‐efficient electrodes. The electrochemical activation yields quinone‐solutions, which are free of undesired reactive compounds and eliminates the challenging step of isolating the reactive quinones. The DiDOPA quinones were employed in polyaddition reactions with multi‐thiols, forming oligomers that functioned as transient enzyme stabilizers (TES). These TCC‐TES‐additives improved the thermal stability and the activity of tyrosinase in heat stress assays. KW - Electrosynthesis KW - Protein engineering KW - PEGylation KW - Green chemistry KW - Peptide adhesive Y1 - 2025 U6 - https://doi.org/10.1002/anie.202419684 SN - 1433-7851 SN - 1521-3773 VL - 64 IS - 6 SP - 1 EP - 8 PB - Wiley-VCH CY - Weinheim ER -