TY - GEN A1 - Jahn, Klaus A1 - Naeßl, Andrea A1 - Strupp, Michael A1 - Schneider, Erich A1 - Brandt, Thomas A1 - Dieterich, Marianne T1 - Torsional eye movement responses to monaural and binaural galvanic vestibular stimulation: side-to-side asymmetries. T2 - Annals of the New York Academy of Sciences Y1 - 2003 U6 - https://doi.org/10.1111/j.1749-6632.2003.tb00265.x SN - 0077-8923 SN - 1749-6632 VL - 1004 SP - 485 EP - 489 ER - TY - GEN A1 - Jahn, Klaus A1 - Strupp, Michael A1 - Schneider, Erich A1 - Dieterich, Marianne A1 - Brandt, Thomas T1 - Visually induced gait deviations during different locomotion speeds T2 - Experimental Brain Research Y1 - 2001 U6 - https://doi.org/10.1007/s002210100884 SN - 0014-4819 SN - 1432-1106 VL - 141 IS - 3 SP - 370 EP - 374 ER - TY - GEN A1 - Schneider, Erich A1 - Glasauer, Stefan A1 - Dieterich, Marianne T1 - Central processing of human ocular torsion analyzed by galvanic vestibular stimulation T2 - Neuroreport Y1 - 2000 SN - 0959-4965 SN - 1473-558X VL - 11 IS - 7 SP - 1559 EP - 1563 ER - TY - GEN A1 - Jahn, Klaus A1 - Strupp, Michael A1 - Schneider, Erich A1 - Dieterich, Marianne A1 - Brandt, Thomas T1 - Differential effects of vestibular stimulation on walking and running T2 - Neuroreport Y1 - 2000 SN - 1473-558X SN - 0959-4965 VL - 11 IS - 8 SP - 1745 EP - 1748 ER - TY - GEN A1 - Stephan, Thomas A1 - Deutschländer, Angela A1 - Nolte, Annina A1 - Schneider, Erich A1 - Wiesmann, Martin A1 - Brandt, Thomas A1 - Dieterich, Marianne T1 - Functional mri of galvanic vestibular stimulation with alternating currents at different frequencies T2 - Neuroimage Y1 - 2005 U6 - https://doi.org/10.1016/j.neuroimage.2005.02.049 SN - 1053-8119 VL - 26 IS - 3 SP - 721 EP - 732 ER - TY - GEN A1 - Glasauer, Stefan A1 - Schneider, Erich A1 - Jahn, Klaus A1 - Strupp, Michael T1 - How the eyes move the body T2 - Neurology Y1 - 2005 U6 - https://doi.org/10.1212/01.wnl.0000175132.01370.fc SN - 0028-3878 SN - 1526-632X VL - 65 IS - 8 SP - 1291 EP - 1293 ER - TY - GEN A1 - Bartl, Klaus A1 - Schneider, Erich A1 - Glasauer, Stefan T1 - Dependence of the torsional vestibulo-ocular reflex on the direction of gravity T2 - Annals of the New York Academy of Sciences Y1 - 2005 U6 - https://doi.org/10.1196/annals.1325.043 SN - 1749-6632 VL - 1039 SP - 455 EP - 458 ER - TY - CHAP A1 - Stoll, Josef A1 - Kohlbecher, Stefan A1 - Marx, Svenja A1 - Schneider, Erich A1 - Einhäuser, Wolfgang ED - Westwood, James D. T1 - Mobile three dimensional gaze tracking T2 - Medicine meets virtual reality 18 Y1 - 2011 SN - 978-1-60750-705-5 SN - 978-1-60750-706-2 SP - 616 EP - 622 PB - IOS Press CY - Amsterdam ER - TY - CHAP A1 - Kohlbecher, Stefan A1 - Bartl, Klaus A1 - Bardins, Stanislav A1 - Schneider, Erich T1 - Low-latency combined eye and head tracking system for teleoperating a robotic head in real-time T2 - Proceedings of the 2010 Symposium on EyeTracking Research & Applications T2 - ETRA '10, Proceedings of the 2010 Symposium on Eye-Tracking Research & Applications, Austin, Texas — March 22 - 24 Y1 - 2010 SN - 978-1-60558-994-7 U6 - https://doi.org/10.1145/1743666.1743695 SP - 117 EP - 120 PB - ACM Press CY - New York ER - TY - CHAP A1 - Vockeroth, Johannes A1 - Bartl, Klaus A1 - Pfanzelt, Sandra A1 - Schneider, Erich ED - Westwood, James D. T1 - Medical documentation using a gaze-driven camera T2 - Medicine meets virtual reality 17 Y1 - 2009 SN - 978-160-750-402-3 SN - 978-144-160-558-0 SP - 413 EP - 416 PB - IOS Press CY - Amsterdam ER - TY - CHAP A1 - Schneider, Erich A1 - Kohlbecher, Stefan A1 - Bartl, Klaus A1 - Wallhoff, Frank A1 - Brandt, Thomas T1 - Experimental platform for wizard-of-oz evaluations of biomimetic active vision in robots T2 - IEEE International Conference on Robotics and Biomimetics (ROBIO), 2009, 19 - 23 Dec. 2009, Guilin, China Y1 - 2009 SN - 978-1-4244-4774-9 SN - 978-1-4244-4775-6 SP - 1484 EP - 1489 PB - IEEE CY - Piscataway, NJ ER - TY - GEN A1 - Schneider, Erich A1 - Glasauer, Stefan A1 - Brandt, Thomas A1 - Dieterich, Marianne T1 - Nonlinear nystagmus processing causes torsional vor nonlinearity T2 - Annals of the New York Academy of Sciences Y1 - 2003 SN - 1749-6632 VL - 1004 SP - 500 EP - 505 ER - TY - GEN A1 - Strupp, Michael A1 - Glasauer, Stefan A1 - Jahn, Klaus A1 - Schneider, Erich A1 - Krafczyk, Siegbert A1 - Brandt, Thomas T1 - Eye movements and balance T2 - Annals of the New York Academy of Sciences Y1 - 2003 SN - 1749-6632 VL - 1004 SP - 352 EP - 358 ER - TY - GEN A1 - Strupp, Michael A1 - Glasauer, Stefan A1 - Schneider, Erich A1 - Eggert, Thomas A1 - Glaser, Miriam T1 - Anterior canal failure: ocular torsion without perceptual tilt due to preserved otolith function T2 - Journal of Neurology Neurosurgery & Psychiatry Y1 - 2003 U6 - https://doi.org/10.1136/jnnp.74.9.1336 SN - 1468-330X SN - 0022-3050 VL - 74 IS - 9 SP - 1336 EP - 1338 ER - TY - GEN A1 - Heuser, Fabian A1 - Schulz, Christian A1 - Sağlam, Murat A1 - Ramaioli, Cecilia A1 - Heuberger, Maria A1 - Wagner, Klaus J. A1 - Jahn, Klaus A1 - Schneider, Erich A1 - Brandt, Thomas A1 - Glasauer, Stefan A1 - Lehnen, Nadine T1 - Preventing opioid-induced nausea and vomiting: Rest your head and close your eyes? T2 - PloS one Y1 - 2017 U6 - https://doi.org/10.1371/journal.pone.0173925 SN - 1932-6203 VL - 12 IS - 3 SP - e0173925 ER - TY - GEN A1 - Lehnen, Nadine A1 - Kellerer, Silvy A1 - Knorr, Alexander G. A1 - Schlick, Cornelia A1 - Jahn, Klaus A1 - Schneider, Erich A1 - Heuberger, Maria A1 - Ramaioli, Cecilia T1 - Head-Movement-Emphasized Rehabilitation in Bilateral Vestibulopathy T2 - Frontiers in Neurology Y1 - 2018 U6 - https://doi.org/10.3389/fneur.2018.00562 SN - 1664-2295 VL - 9 ER - TY - GEN A1 - Heuberger, Maria A1 - Grill, Eva A1 - Saglam, Murat A1 - Ramaioli, Cecilia A1 - Müller, Martin A1 - Strobl, Ralf A1 - Holle, Rolf A1 - Peters, Annette A1 - Schneider, Erich A1 - Lehnen, Nadine T1 - Usability of the Video Head Impulse Test: Lessons from the Population-Based Prospective KORA Study T2 - Frontiers in Neurology Y1 - 2018 U6 - https://doi.org/10.3389/fneur.2018.00659 SN - 1664-2295 VL - 9 ER - TY - GEN A1 - Schöberl, Florian A1 - Irving, Stephanie A1 - Pradhan, Cauchy A1 - Bardins, Stanislav A1 - Trapp, Christoph A1 - Schneider, Erich A1 - Kugler, Günter A1 - Bartenstein, Peter A1 - Dietrich, Marianne A1 - Brandt, Thomas A1 - Zwergal, Andreas T1 - Prolonged allocentric navigation deficits indicate hippocampal damage in TGA T2 - Neurology : official journal of the American Academy of Neurology N2 - Objective To investigate long-term recovery of allocentric and egocentric spatial orientation as a sensitive marker for hippocampal and extrahippocampal network function in transient global amnesia (TGA). Methods A group of 18 patients with TGA performed an established real-space navigation paradigm, requiring allo- and egocentric spatial orientation abilities, 3 days (postacute stage) and 3 months (follow-up) after symptom onset. Visual exploration behavior and navigation strategy were documented by a gaze-controlled, head-fixed camera. Allo- and egocentric spatial orientation performance was compared to that of 12 age-matched healthy controls. Navigation-induced brain activations were measured using [18F]-fluorodeoxyglucose-PET in a subgroup of 8 patients in the postacute stage and compared to those of the controls. Results In the postacute stage, the patients navigated worse and had higher error rates than controls in allocentric (p = 0.002), but not in egocentric, route planning (p = 0.30), despite complete recovery of verbal (p = 0.58) and figural memory (p = 0.11). Until follow-up, allocentric navigation deficits improved, but higher error rates and reduced use of shortcuts persisted (p < 0.0001). Patients still exhibited relatively more fixations of unique landmarks during follow-up (p = 0.05). PET measurements during the postacute stage showed increased navigation-induced brain activations in the right hippocampus, bilateral retrosplenial, parietal, and mesiofrontal cortices, and cerebellar dentate nucleus in patients compared to controls (p < 0.005). Conclusions Patients with TGA show selective and prolonged deficits of allocentric spatial orientation. Activations in right hippocampal and extrahippocampal hubs of the cerebral navigation network functionally substitute for the deficit in creating and updating the internal cognitive map in TGA. Y1 - 2019 UR - https://n.neurology.org/content/92/3/e234/tab-article-info U6 - https://doi.org/10.1212/WNL.0000000000006779 SN - 0028-3878 SN - 1526-632X VL - 92 IS - 3 SP - e234 EP - e243 ER - TY - GEN A1 - Grill, Eva A1 - Heuberger, Maria A1 - Strobl, Ralf A1 - Saglam, Murat A1 - Holle, Rolf A1 - Linkohr, Birgit A1 - Ladwig, Karl-Heinz A1 - Peters, Annette A1 - Schneider, Erich A1 - Jahn, Klaus A1 - Lehnen, Nadine T1 - Prevalence, determinants, and consequences of vestibular hypofunction. results from the kora-ff4 survey T2 - Frontiers in Neurology N2 - Objective: Uni- or bilateral vestibular hypofunction (VH) impairs balance and mobility, and may specifically lead to injury from falls and to disability. The extent of this problem in the general population is still unknown and most likely to be underestimated. Objective of this study was to determine the prevalence, determinants, and consequences of VH in the general population. Methods: Data originates from the cross-sectional second follow-up (FF4) in 2013/14 of the KORA (Cooperative Health Research in the Region of Augsburg)-S4 study (1999–2001) from Southern Germany. This was a random sample of the target population consisting of all residents of the region aged 25–74 years in 1999. We included all participants who reported moderate or severe vertigo or dizziness during the last 12 months and a random sub-sample of participants representative for the general population without vertigo or dizziness during the last 12 months were tested. VH was assessed with the Video-Head Impulse Test (vHIT). Trained examiners applied high-acceleration, small-amplitude passive head rotations (“head impulses”) to the left and right in the plane of the horizontal semicircular canals while participants fixated a target straight ahead. During head impulses, head movements were measured with inertial sensors, eye movements with video-oculography (EyeSeeCam vHIT). Results: A total of 2,279 participants were included (mean age 60.8 years, 51.6% female), 570 (25.0%) with moderate or severe vertigo or dizziness during the last 12 months. Of these, 450 were assessed with vHIT where 26 (5.8%) had unilateral VH, and 16 (3.6%) had bilateral VH. Likewise, 190 asymptomatic participants were tested. Of these 5 (2.6%) had unilateral VH, and 2 (1.1%) had bilateral VH. Prevalence of uni- or bilateral VH among tested symptomatic participants was 2.4% in those < 48 years, and 32.1% in individuals aged 79 and over. Age-adjusted prevalence was 6.7% (95% CI 4.8%; 8.6%). VH was associated with worse health, falls, hearing loss, hearing impairment, and ear pressure. Conclusion: VH may affect between 53 and 95 million adults in Europe and the US. While not all affected persons will experience the full spectrum of symptoms and consequences, adequate diagnostic and therapeutic measures should become standard of care to decrease the burden of disease. Y1 - 2018 U6 - https://doi.org/10.3389/fneur.2018.01076 SN - 1664-2295 VL - 9 ER - TY - GEN A1 - Donald, Aimee A1 - Tan, Chong Y. A1 - Chakrapani, Anupam A1 - Hughes, Derralyn A. A1 - Sharma, Reena A1 - Cole, Duncan A1 - Bardins, Stanislav A1 - Gorges, Martin A1 - Jones, Simon A. A1 - Schneider, Erich T1 - Eye movement biomarkers allow for the definition of phenotypes in Gaucher Disease T2 - Orphanet journal of rare diseases : OJRD N2 - Background: Neurological forms of Gaucher disease, the inherited disorder of β-Glucosylceramidase caused by bi-allelic variants in GBA1, is a progressive disorder which lacks a disease-modifying therapy. Systemic manifestations of disease are effectively treated with enzyme replacement therapy, however, molecules which cross the blood-brain barrier are still under investigation. Clinical trials of such therapeutics require robust, reproducible clinical endpoints to demonstrate efficacy and clear phenotypic definitions to identify suitable patients for inclusion in trials. The single consistent clinical feature in all patients with neuronopathic disease is the presence of a supranuclear saccadic gaze palsy, in the presence of Gaucher disease this finding serves as diagnostic of 'type 3' Gaucher disease. Y1 - 2020 UR - https://ojrd.biomedcentral.com/articles/10.1186/s13023-020-01637-9 U6 - https://doi.org/10.1186/s13023-020-01637-9 SN - 1750-1172 VL - 15 ER - TY - GEN A1 - Belyakova-Bodina, Alexandra A1 - Ratanov, Mikhail A1 - Schneider, Erich A1 - Seliverstov, Yury A1 - Nuzhnyi, Evgenii A1 - Klyushnikov, Sergey A1 - Broutian, Amayak T1 - Uncovering bilateral vestibulopathy in patients with SANDO syndrome caused by mutations in POLG gene: a case series T2 - Journal of Neurology N2 - The triad of sensory ataxic neuropathy, dysarthria, and ophthalmoparesis (SANDO) comprise a distinct phenotype of rare mitochondrial disease. It is caused mainly by mitochondrial DNA depletion and deletions due to mutations in the nuclear genes, with POLG being one of the most common ones [1]. In SANDO syndrome, balance and gait disturbances have traditionally been attributed to sensory ataxic neuropathy and, in some patients, to cerebellar ataxia and/or limb weakness [2, 3]. However, there has been a report of bilateral vestibulopathy (BV) in a patient with SANDO caused by mutations in the POLG gene [4]. We present five patients with SANDO due to POLG gene mutations, whose vestibular and oculomotor function were assessed with video-oculography (VOG) Y1 - 2021 U6 - https://doi.org/10.1007/s00415-021-10650-2 SN - 1432-1459 SN - 0340-5354 VL - 268 IS - 10 SP - 3909 EP - 3912 ER - TY - GEN A1 - Korda, Athanasia A1 - Zamaro, Ewa A1 - Wagner, Franca A1 - Morrison, Miranda A1 - Schneider, Erich A1 - Caversaccio, Marco Domenico A1 - Sauter, Thomas C. A1 - Mantokoudis, Georgios T1 - Acute vestibular syndrome: is skew deviation a central sign? T2 - Journal of Neurology N2 - Objective Skew deviation results from a dysfunction of the graviceptive pathways in patients with an acute vestibular syndrome (AVS) leading to vertical diplopia due to vertical ocular misalignment. It is considered as a central sign, however, the prevalence of skew and the accuracy of its test is not well known . Methods We performed a prospective study from February 2015 until September 2020 of all patients presenting at our emergency department (ED) with signs of AVS. All patients underwent clinical HINTS and video test of skew (vTS) followed by a delayed MRI, which served as a gold standard for vestibular stroke confirmation. Results We assessed 58 healthy subjects, 53 acute unilateral vestibulopathy patients (AUVP) and 24 stroke patients. Skew deviation prevalence was 24% in AUVP and 29% in strokes. For a positive clinical test of skew, the cut-off of vertical misalignment was 3 deg with a very low sensitivity of 15% and specificity of 98.2%. The sensitivity of vTS was 29.2% with a specificity of 75.5%. Conclusions Contrary to prior knowledge, skew deviation proved to be more prevalent in patients with AVS and occurred in every forth patient with AUVP. Large skew deviations (> 3.3 deg), were pointing toward a central lesion. Clinical and video test of skew offered little additional diagnostic value compared to other diagnostic tests such as the head impulse test and nystagmus test. Video test of skew could aid to quantify skew in the ED setting in which neurotological expertise is not always readily available. KW - Acute stroke KW - Acute unilateral vestibulopathy KW - Test of skew KW - VOG KW - Vertigo KW - Video-oculography Y1 - 2021 U6 - https://doi.org/10.1007/s00415-021-10692-6 SN - 1432-1459 SN - 0340-5354 VL - 269 IS - 3 SP - 1396 EP - 1403 ER - TY - GEN A1 - Spiegel, Rainer A1 - Claassen, Jens A1 - Teufel, Julian A1 - Bardins, Stanislav A1 - Schneider, Erich A1 - Lehrer, Nicole A1 - Jahn, Klaus A1 - Anciaes da Silva, Fábio A1 - Hahn, Ales A1 - Farahmand, Parvis A1 - Brandt, Thomas A1 - Strupp, Michael A1 - Kalla, Roger T1 - Resting in darkness improves downbeat nystagmus: evidence from an observational study T2 - Annals of the New York Academy of Sciences N2 - Resting in an upright position during daytime decreases downbeat nystagmus (DBN). When measured in brightness only, that is, without intermitting exposure to darkness, it does not make a significant difference whether patients have previously rested in brightness or in darkness. In real-world scenarios, people are often exposed to brightness and darkness intermittently. The aim of this study was to analyze whether resting in brightness or resting in darkness was associated with a lower post-resting DBN after intermitting exposures to brightness and darkness. Eight patients were recorded with three-dimensional video-oculography in brightness and darkness conditions, each following two 2-h resting intervals under either brightness or darkness resting conditions. The dependent variable was DBN intensity, measured in mean slow phase velocity. A repeated measures ANOVA with the factors measurement condition (brightness vs. darkness), resting condition (brightness vs. darkness), and time (after first vs. second resting interval) showed a significant effect for the factor resting condition, where previous resting in darkness was associated with a significantly lower DBN relative to previous resting in brightness (P < 0.01). The clinical relevance is to advise patients with DBN to rest in darkness. KW - downbeat nystagmus KW - symptom relief KW - resting KW - oscillopsia KW - video-oculographic measurement (VOG) Y1 - 2016 U6 - https://doi.org/10.1111/nyas.13172 SN - 1749-6632 SN - 0077-8923 VL - 1375 IS - 1 SP - 66 EP - 73 ER - TY - CHAP A1 - Villgrattner, Thomas A1 - Schneider, Erich A1 - Andersch, Philipp A1 - Ulbrich, Heinz ED - Suda, Yoshihiro T1 - Compact high dynamic 3 dof camera orientation system, development and control T2 - The 10th International Conference on Motion and Vibration Control MOVIC, proceedings, 17 - 20 August 2010, Tokyo, Japan Y1 - 2010 PB - Institute of Industrial Science, the University of Tokyo CY - Tokyo ER - TY - CHAP A1 - Wright, W. Geoffrey A1 - Schneider, Erich T1 - Manual motor control during "virtual" self-motion: Implications for vr rehabilitation T2 - 2009 Virtual Rehabilitation International Conference, Haifa, Israel, 29 June - 2 July 2009 Y1 - 2009 UR - http://ieeexplore.ieee.org/stamp/stamp.jsp?arnumber=5174226 SN - 978-1-4244-4188-4 SN - 978-1-4244-4189-1 SP - 166 EP - 172 PB - IEEE CY - Piscataway, NJ ER - TY - GEN A1 - Aubele, Maria A1 - Grill, Eva A1 - Eggert, Thomas A1 - Schneider, Erich A1 - Strobl, Ralf A1 - Jahn, Klaus A1 - Müller, Martin A1 - Holle, Rolf A1 - Linkohr, Birgit A1 - Heier, Margit A1 - Ladwig, Karl-Heinz A1 - Lehnen, Nadine T1 - Symptoms in unilatral vestibular hypofunction are associated with number of catch-up saccades and retinal errors: results from the population-based KORA FF4study T2 - Frontiers in Neurology N2 - Objective: The presence and intensity of symptoms vary in patients with unilateral vestibular hypofunction. We aimed to determine which saccadic and vestibulo-ocular reflex parameters best predict the presence of symptoms in unilateral vestibular hypofunction in order to better understand vestibular compensation and its implications for rehabilitation therapy. Methods: Video head impulse test data were analyzed from a subpopulation of 23 symptomatic and 10 currently symptom-free participants with unilateral vestibular hypofunction, embedded in the KORA (Cooperative Health Research in the Region of Augsburg) FF4 study, the second follow-up of the KORA S4 population-based health survey (2,279 participants). Results: A higher number of catch-up saccades, a higher percentage of covert saccades, and a larger retinal error at 200 ms after the onset of the head impulse were associated with relevant symptoms in participants with unilateral vestibular hypofunction (p = 0.028, p = 0.046, and p = 0.038, respectively). After stepwise selection, the number of catch-up saccades and retinal error at 200 ms remained in the final logistic regression model, which was significantly better than a null model (p = 0.014). Age, gender, saccade amplitude, saccade latency, and VOR gain were not predictive of the presence of symptoms. Conclusion: The accuracy of saccadic compensation seems to be crucial for the presence of symptoms in unilateral vestibular hypofunction, highlighting the role of specific gaze stabilization exercises in rehabilitation. Early saccades, mainly triggered by the vestibular system, do not seem to compensate accurately enough, resulting in a relevant retinal error and the need for more as well as more accurate catch-up saccades, probably triggered by the visual system. KW - video head impulse test, vHIT, catch-up saccades, unilateral vestibular hypofunction, retinal error, vestibulo-ocular reflex, VOR, population-based survey Y1 - 2023 UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10715252/ SN - 1664-2295 VL - 2023 IS - 14 ER - TY - GEN A1 - Michailidou, Efterpi A1 - Korda, Athanasia A1 - Wyss, Thomas A1 - Bardins, Stanislav A1 - Schneider, Erich A1 - Morrison, Miranda A1 - Wagner, Franca A1 - Caversaccio, Marco A1 - Mantokoudis, Georgios T1 - The value of saccade metrics and VOR gain in detecting a vestibular stroke T2 - Journal of Vestibular Research N2 - Objective: A normal video Head Impulse Test is the gold standard in the emergency department to rule-in patients with an acute vestibular syndrome and a stroke. We aimed to compare the diagnostic accuracy of vHIT metrics regarding the vestibulo-ocular reflex gain and the corrective saccades in detecting vestibular strokes. Methods: Prospective cross-sectional study (convenience sample) of patients presenting with acute vestibular syndrome in the emergency department of a tertiary referral centre between February 2015 and May 2020. We screened 1677 patients and enrolled 76 patients fulfilling the inclusion criteria of acute vestibular syndrome. All patients underwent video head impulse test with automated and manual data analysis. A delayed MRI served as a gold standard for vestibular stroke confirmation. Results: Out of 76 patients, 52 were diagnosed with acute unilateral vestibulopathy and 24 with vestibular strokes. The overall accuracy of detecting stroke with an automated vestibulo-ocular reflex gain was 86.8%, compared to 77.6% for cumulative saccade amplitude and automatic saccade mean peak velocity measured by an expert and 71% for cumulative saccade amplitude and saccade mean peak velocity measured automatically. Gain misclassified 13.1% of the patients as false positive or false negative, manual cumulative saccade amplitude and saccade mean peak velocity 22.3%, and automated cumulative saccade amplitude and saccade mean peak velocity 28.9% respectively. Conclusions: We found a better accuracy of video head impulse test for the diagnosis of vestibular strokes when using the vestibulo-ocular reflex gain than using saccade metrics. Nevertheless, saccades provide an additional and important information for video head impulse test evaluation. The automated saccade detection algorithm is not yet perfect compared to expert analysis, but it may become a valuable tool for future non-expert video head impulse test evaluations. KW - Head impulse test saccades KW - vestibular stroke KW - saccades Y1 - 2024 U6 - https://doi.org/10.3233/VES-230083 SN - 1878-6464 VL - 34 IS - 1 SP - 49 EP - 61 ER - TY - GEN A1 - Lehnen, Nadine A1 - Ramaioli, Cecilia A1 - Todd, Nicholas Sean A1 - Bartl, Klaus A1 - Kohlbecher, Stefan A1 - Jahn, Klaus A1 - Schneider, Erich T1 - Clinical and video head impulses: a simple bedside test in children T2 - Journal of Neurology KW - Head Velocity KW - Head Impulse KW - Head Impulse Testing KW - Rotational Chair KW - Vestibular Function Test Y1 - 2017 U6 - https://doi.org/10.1007/s00415-017-8450-y SN - 1432-1459 VL - 264 IS - 5 SP - 1002 EP - 1004 ER - TY - GEN A1 - Friedrich, Maximilian U. A1 - Schneider, Erich A1 - Buerklein, Miriam A1 - Taeger, Johannes A1 - Hartig, Johannes A1 - Volkmann, Jens A1 - Peach, Robert A1 - Zeller, Daniel T1 - Smartphone video nystagmography using convolutional neural networks: ConVNG T2 - Journal of Neurology N2 - Eye movement abnormalities are commonplace in neurological disorders. However, unaided eye movement assessments lack granularity. Although videooculography (VOG) improves diagnostic accuracy, resource intensiveness precludes its broad use. To bridge this care gap, we here validate a framework for smartphone video-based nystagmography capitalizing on recent computer vision advances. Methods A convolutional neural network was fine-tuned for pupil tracking using > 550 annotated frames: ConVNG. In a cross-sectional approach, slow-phase velocity of optokinetic nystagmus was calculated in 10 subjects using ConVNG and VOG. Equivalence of accuracy and precision was assessed using the “two one-sample t-test” (TOST) and Bayesian interval-null approaches. ConVNG was systematically compared to OpenFace and MediaPipe as computer vision (CV) benchmarks for gaze estimation. Results ConVNG tracking accuracy reached 9–15% of an average pupil diameter. In a fully independent clinical video dataset, ConVNG robustly detected pupil keypoints (median prediction confidence 0.85). SPV measurement accuracy was equivalent to VOG (TOST p < 0.017; Bayes factors (BF) > 24). ConVNG, but not MediaPipe, achieved equivalence to VOG in all SPV calculations. Median precision was 0.30°/s for ConVNG, 0.7°/s for MediaPipe and 0.12°/s for VOG. ConVNG precision was significantly higher than MediaPipe in vertical planes, but both algorithms’ precision was inferior to VOG. Conclusions ConVNG enables offline smartphone video nystagmography with an accuracy comparable to VOG and significantly higher precision than MediaPipe, a benchmark computer vision application for gaze estimation. This serves as a blueprint for highly accessible tools with potential to accelerate progress toward precise and personalized Medicine. KW - Digital medicine KW - Nystagmus KW - Eye movement disorders KW - Videooculography KW - Computer vision KW - Telemedicine KW - Precision medicine Y1 - 2022 U6 - https://doi.org/10.1007/s00415-022-11493-1 SN - 1432-1459 VL - 270 SP - 2518 EP - 2530 ER - TY - GEN A1 - Dong-Han, Lee A1 - Schneider, Erich A1 - Sang-Yeon, Lee A1 - Kim, Ji-Soo A1 - Koo, Ja-Won T1 - Objective measurement of HINTS (Head Impulse, Nystagmus, Test of Skew) in peripheral vestibulopathy T2 - Auris Nasus Larynx N2 - ABSTRACT Objective To evaluate how often the positive sign of HINTS (Head-Impulse, Gaze Evoked Nystagmus, Test of Skew) appears in patients with acute peripheral vestibular lesion, HINTS findings were quantitatively measured and analyzed in patients with peripheral vestibulopathy accompanying spontaneous nystagmus. Methods HINTS was evaluated in 14 vertigo patients with spontaneous nystagmus. Horizontal vestibulo-ocular reflex (VOR) gain was measured using the video head impulse test (vHIT). To evaluate gaze-evoked nystagmus (GEN), slow-phase velocities at different points of lateral gaze were measured and plotted, then the slope and its inverse value, the neural integrator time constant, were calculated. Skew deviation was tested using anaglyph filters to simulate the alternate cover test, and the degree and latency of vertical eyeball deviation were measured. The ABCD2 score was calculated to evaluate the risk of stroke. Results Among 13 patients of peripheral vestibulopathy, 7 showed positive signs in HINTS (normal vHIT: 5, direction-changing GEN: 0, skew deviation: 3). One patient with a cerebellopontine angle tumor presented with both a peripheral and central pattern and showed positive HINTS findings (presence of direction-changing GEN). The mean VOR gain of patients with abnormal vHIT was 0.58±0.29 and 1.10±0.11 in the affected and contralateral side, respectively, while those in patients with normal vHIT were 1.04±0.21 and 1.13±0.12, respectively. The neural integrator time constant calculated from the mean slope of horizontal slow-phase velocity according to horizontal eye position was 42.9 s. The mean vertical eyeball deviation of patients with positive skew was 2.14±1.18° while uncovering the eye on the affected side, and -1.97±1.59° while uncovering the eye on the unaffected side. The median ABCD2 score of 14 patients was 2 (range, 1-3). Conclusions HINTS findings were objectively measured in vertigo patients with spontaneous nystagmus. Although positive findings of HINTS have been recognized as a central sign, 54% (7/13) of cases with peripheral vestibulopathy showed positive HINTS signs. HINTS results should be interpreted carefully considering that a substantial proportion of peripheral vestibulopathy shows a positive HINTS sign. KW - Dizziness KW - Vertigo KW - Head impulse test KW - Nystagmus KW - Skew deviation Y1 - 2022 U6 - https://doi.org/10.1016/j.anl.2022.03.003 SN - 1879-1476 SN - 0385-8146 VL - 49 IS - 6 SP - 938 EP - 949 ER - TY - GEN A1 - Lehnen, Nadine A1 - Schneider, Erich A1 - Jahn, Klaus T1 - Do neurologists need the head impulse test? T1 - Braucht der Neurologe den Kopfimpulstest? T2 - Nervenarzt Y1 - 2013 U6 - https://doi.org/10.1007/s00115-013-3822-8 SN - 0028-2804 SN - 1433-0407 VL - 84 IS - 8 SP - 973 EP - 974 ER - TY - PAT A1 - Brandt, Thomas A1 - Glasauer, Stefan A1 - Schneider, Erich T1 - Aufnahmevorrichtung für die kopfgestützte Bilderfassung und Verfahren zur Steuerung der Aufnahmevorrichtung Y1 - 2004 UR - http://google.com/patents/DE10251933A1?cl=no. ER - TY - GEN A1 - Jahn, Klaus A1 - Schneider, Erich T1 - Untersuchung der vestibulären Funktion bei Schwindelpatienten T2 - Nervenheilkunde Y1 - 2012 SN - 0722-1541 VL - 31 IS - 5 SP - 370 EP - 377 ER - TY - GEN A1 - Smyth, Duncan A1 - Mossman, Stuart A1 - Weatherall, Mark A1 - Jolliffe, Evan A1 - Joshi, Purwa A1 - Taylor, Jennifer A1 - Thorne, Katie A1 - Watson, Eloise A1 - Leadbetter, Ruth A1 - Mossman, Benjamin A1 - Moss, Tawhai A1 - Todd, Nicholas Sean A1 - Schneider, Erich T1 - Gentamicin vestibulotoxicity with modern systemic dosing regimens : a prospective study using videooculography T2 - Acta Oto-Laryngologica N2 - Objectives: To determine the incidence of gentamicin vestibulotoxicity with current dosing regimens, and to evaluate the feasibility of routine video-oculography on all patients given gentamicin. Materials and methods: In this prospective incidence study serial horizontal vestibulo-ocular reflex (HVOR) gain measurements were recorded using video-oculography on adult inpatients receiving intravenous gentamicin. The primary outcome was the proportion of patients developing impairment of their HVOR gain. Results: After exclusions, 42 patients were included in the analysis. Three patients (7.1%) developed asymptomatic vestibulotoxicity, exact 95% confidence interval 1.5-19.5%. In two of these patients the deficit resolved within several hours. No patients developed symptomatic vestibulotoxicity. There was no evidence for a generalised reduction in group HVOR gain with time. HVOR gain was not associated with total gentamicin dose, dynamic visual acuity or subjective imbalance. Conclusions and significance: Gentamicin may cause reversible, asymptomatic vestibulotoxicity. Video-oculography may be useful to monitor for vestibulotoxicity in patients treated with gentamcin; however, testing all patients routinely may be challenging. Y1 - 2019 U6 - https://doi.org/10.1080/00016489.2019.1637935 VL - 139 IS - 9 SP - 759 EP - 768 ER - TY - GEN A1 - Feil, Katharina A1 - Claassen, Jens A1 - Brandins, Stanislavs A1 - Teufel, Julian A1 - Krafczyk, Siegbert A1 - Schneider, Erich T1 - Effect of chlorzoxazone in patients with downbeat nystagmus: a pilot trial T2 - Neurology Y1 - 2013 U6 - https://doi.org/10.1212/WNL.0b013e3182a55f6d SN - 0028-3878 SN - 1526-632X VL - 81 IS - 13 SP - 1152 EP - 1158 ER - TY - GEN A1 - Schöberl, Florian A1 - Pradhan, Cauchy A1 - Irving, Stephanie A1 - Buerger, Katharina A1 - Xiong, Guoming A1 - Kugler, Günter A1 - Kohlbecher, Stefan A1 - Engmann, Julia A1 - Werner, Philipp A1 - Brendel, Matthias A1 - Schneider, Erich A1 - Perneczky, Robert A1 - Jahn, Klaus A1 - Fougère, Christian la A1 - Bartenstein, Peter A1 - Brandt, Thomas A1 - Dietrich, Marianne A1 - Zwergal, Andreas T1 - Real-space navigation testing differentiates between amyloid-positive and -negative aMCI T2 - Neurology : official journal of the American Academy of Neurology Y1 - 2020 UR - https://n.neurology.org/content/94/8/e861 U6 - https://doi.org/10.1212/WNL.0000000000008758 SN - 1526-632X VL - 94 IS - 8 SP - e861 EP - e873 ER - TY - GEN A1 - Kalla, Roger A1 - Spiegel, Rainer A1 - Claassen, Jens A1 - Bardins, Stanislav A1 - Hahn, Ales A1 - Schneider, Erich A1 - Lehrer, Nicole A1 - Glasauer, Stefan A1 - Brandt, Thomas A1 - Strupp, Michael T1 - Comparison of 10-mg doses of 4-aminopyridine and 3,4-diaminopyridine for the treatment of downbeat nystagmus T2 - Journal of neuro-ophthalmology Y1 - 2011 U6 - https://doi.org/10.1097/WNO.0b013e3182258086 SN - 1536-5166 SN - 1070-8022 VL - 32 IS - 2 SP - 320 EP - 325 ER - TY - GEN A1 - Schulz, Christian M. A1 - Schneider, Erich A1 - Fritz, L. A1 - Vockeroth, Johannes A1 - Hapfelmeier, Alexander A1 - Wasmaier, M. T1 - Eye tracking for assessment of workload: a pilot study in an anaesthesia simulator environment T2 - British journal of anaesthesia Y1 - 2011 U6 - https://doi.org/10.1093/bja/aeq307 SN - 1471-6771 SN - 0007-0912 VL - 106 IS - 1 SP - 44 EP - 50 ER - TY - GEN A1 - Schulz, Christian M. A1 - Schneider, Erich A1 - Fritz, L. A1 - Vockeroth, Johannes A1 - Hapfelmeier, Alexander A1 - Brandt, Thomas T1 - Visual attention of anaesthetists during simulated critical incidents T2 - British Journal of Anaesthesia Y1 - 2011 U6 - https://doi.org/10.1093/bja/aer087 SN - 1471-6771 SN - 0007-0912 VL - 106 IS - 6 SP - 807 EP - 813 ER - TY - GEN A1 - Morrison, Miranda A1 - Kerkeni, Hassen A1 - Korda, Athanasia A1 - Räss, Simone A1 - Caversaccio, Marco Domenico A1 - Abegg, Mathias A1 - Schneider, Erich A1 - Mantokoudis, Georgios T1 - Automated alternate cover test for 'HINTS' assessment: a validation study T2 - European archives of oto-rhino-laryngology and head & neck N2 - Objective The alternate cover test (ACT) in patients with acute vestibular syndrome is part of the ‘HINTS’ battery test. Although quantitative, the ACT is highly dependent on the examiner’s experience and could theoretically vary greatly between examiners. In this study, we sought to validate an automated video-oculography (VOG) system based on eye tracking and dedicated glasses. Methods We artificially induced a vertical strabismus to simulate a skew deviation on ten healthy subjects, aged from 26 to 66, using different press-on Fresnel prisms on one eye while recording eye position with VOG of the contralateral eye. We then compared the system’s performance to that of a blinded trained orthoptist using conventional, semi-quantitative method of skew measurement known as the alternate prism cover test (APCT) as a gold standard. Results We found a significant correlation between the reference APCT and the Skew VOG (Pearson’s R2 = 0.606, p < 0.05). There was a good agreement between the two tests (intraclass correlation coefficient 0.852, 95 CI 0.728–0.917, p < 0.001). The overall accuracy of the VOG was estimated at 80.53% with an error rate of 19.46%. There was no significant difference in VOG skew estimations compared with the gold standard except for very small skews. Conclusions VOG offers an objective and quantitative skew measurement and proved to be accurate in measuring vertical eye misalignment compared to the ACT with prisms. Precision was moderate, which mandates a sufficient number of tests per subject. KW - Skew deviation KW - Validation KW - Test of skew KW - Alternate cover test KW - Video-oculography Y1 - 2022 U6 - https://doi.org/10.1007/s00405-021-06998-w SN - 1434-4726 SP - 2873 EP - 2879 ER - TY - GEN A1 - Kugler, Günter A1 - Huppert, Doreen A1 - Schneider, Erich A1 - Brandt, Thomas T1 - Wie Höhenschwindel die visuelle Exploration und den Gang beeinträchtigt T1 - How acrophobia impairs visual exploration and gait T2 - Nervenarzt Y1 - 2013 U6 - https://doi.org/10.1007/s00115-013-3905-6 SN - 0028-2804 SN - 1433-0407 VL - 84 IS - 10 SP - 1233 EP - 1237 ER - TY - GEN A1 - Lehnen, Nadine A1 - Schneider, Erich A1 - Jahn, Klaus T1 - Klinische Untersuchungen bei Schwindel: Kopfimpulstest und dynamische Sehschärfe T2 - Neurotransmitter Y1 - 2013 SN - 2196-6397 SN - 1436-123X VL - 24 IS - 4 SP - 39 EP - 43 ER - TY - GEN A1 - Teufel, Julian A1 - Bardins, Stanislav A1 - Spiegel, Rainer A1 - Kremmyda, O. A1 - Schneider, Erich A1 - Strupp, Michael A1 - Kalla, R. T1 - Real time computerbased visual feedback improves visual acuity in downbeat nystagmus, a pilot study T2 - Journal of NeuroEngineering and Rehabilitation Y1 - 2016 SN - 1743-0003 VL - 13 IS - 1 ER - TY - GEN A1 - Guinand, Nils A1 - Van de Berg, Raymond A1 - Cavuscens, Samuel A1 - Ranieri, Maurizio A1 - Schneider, Erich A1 - Lucieer, Floor A1 - Kingma, Hermann A1 - Guyot, Jean-Philippe A1 - Perez Fornos, Angelica T1 - The Video Head Impulse Test to Assess the Efficacy of Vestibular Implants in Humans T2 - Frontiers in neurology Y1 - 2017 U6 - https://doi.org/10.3389/fneur.2017.00600 SN - 1664-2295 VL - 8 SP - 13 ER - TY - GEN A1 - Luis, L. A1 - Costa, João A1 - Muñoz, E. A1 - Carvalho, M. de A1 - Carmona, S. A1 - Schneider, Erich T1 - Vestibulo-ocular reflex dynamics with head-impulses discriminates spinocerebellar ataxias types 1, 2 and 3 and Friedreich ataxia. T2 - Journal of Vestibular Research Y1 - 2016 U6 - https://doi.org/10.3233/VES-160579 SN - 0957-4271 SN - 1878-6464 VL - 26 IS - 3 SP - 327 EP - 334 ER - TY - GEN A1 - Keller, Jürgen A1 - Gorges, Martin A1 - Aho-Özhan, Helena Eira Anneli A1 - Carmona, S. A1 - Schneider, Erich T1 - Eye-tracking control to assess cognitive functions in patients with amyotrophic lateral sclerosis T2 - JoVE Y1 - 2016 U6 - https://doi.org/10.3791/54634 SN - 1940-087X VL - 116 SP - e54634 ER - TY - GEN A1 - Luis, L. A1 - Lehnen, Nadine A1 - Muñoz, E. A1 - Carvalho, M. de A1 - Schneider, Erich T1 - Anticompensatory quick eye movements after head impulses: A peripheral vestibular sign in spontaneous nystagmus T2 - Journal of Vestibular Research Y1 - 2016 U6 - https://doi.org/10.3233/VES-160566 SN - 0957-4271 SN - 1878-6464 VL - 25 IS - 5-6 SP - 267 EP - 271 ER - TY - GEN A1 - Mossman, Benjamin A1 - Mossman, Stuart A1 - Purdie, Gordon A1 - Schneider, Erich T1 - Age dependent normal horizontal vor gain of head impulse test as measured with video-oculography T2 - Journal of Otolaryngology - Head & Neck Surgery Y1 - 2015 U6 - https://doi.org/10.1186/s40463-015-0081-7 SN - 1916-0216 VL - 44 SP - 29 ER - TY - GEN A1 - Spiegel, Rainer A1 - Kalla, R. A1 - Rettinger, N. A1 - Schneider, Erich A1 - Straumann, D. A1 - Marti, S. A1 - Glasauer, Stefan T1 - Head position during resting modifies spontaneous daytime decrease of downbeat nystagmus T2 - Neurology Y1 - 2010 U6 - https://doi.org/10.1212/WNL.0b013e3181feb22f SN - 0028-3878 SN - 1526-632X VL - 75 IS - 21 SP - 1928 EP - 1932 ER - TY - GEN A1 - Wright, W. Geoffrey A1 - Schneider, Erich A1 - Glasauer, Stefan T1 - Compensatory manual motor responses while object wielding during combined linear visual and physical roll tilt stimulation T2 - Experimental Brain Research Y1 - 2009 U6 - https://doi.org/10.1007/s00221-008-1581-8 SN - 0014-4819 SN - 1432-1106 VL - 192 IS - 4 SP - 683 EP - 694 ER -