TY - GEN A1 - Schulz, Christian M. A1 - Skrzypczak, M. A1 - Schneider, Erich A1 - Hapfelmeier, Alexander A1 - Martin, J. A1 - Kochs, Eberhard F. A1 - Schneider, G. T1 - Assessment of subjective workload in an anaesthesia simulator environment: reliability and validity T2 - European Journal of Anaesthesiology Y1 - 2011 SN - 0265-0215 VL - 28 IS - 7 SP - 502 EP - 505 ER - TY - CHAP A1 - Kohlbecher, Stefan A1 - Bartl, Klaus A1 - Schneider, Erich A1 - Blume, Jürgen A1 - Bannat, Alexander A1 - Sosnowski, Stefan A1 - Kühnlenz, Kolja A1 - Rigoll, Gerhard A1 - Wallhoff, Frank ED - Liu, Yunhui ED - Sun, Dong T1 - Test environment for studying the human-likeness of robotic eye movements T2 - Biologically Inspired Robotics Y1 - 2012 SN - 1-4398-5488-2 SP - 309 PB - CRC Press CY - Boca Raton, Fl ER - TY - GEN A1 - Schulz, Christian M. A1 - Schneider, Erich A1 - Kohlbecher, Stefan A1 - Hapfelmeier, Alexander A1 - Heuser, Fabian T1 - The influence of anaesthetists’ experience on workload, performance and visual attention during simulated critical incidents T2 - Journal of Clinical Monitoring and Computing Y1 - 2014 U6 - https://doi.org/10.1007/s10877-013-9443-8 SN - 1387-1307 SN - 1573-2614 VL - 28 IS - 5 SP - 475 EP - 480 ER - TY - GEN A1 - Ramaioli, Cecilia A1 - Colagiorgio, Paolo A1 - Sağlam, Murat A1 - Heuser, Fabian A1 - Schneider, Erich T1 - The effect of vestibulo-ocular reflex deficits and covert saccades on dynamic vision in opioid-induced vestibular T2 - PLoS One Y1 - 2014 U6 - https://doi.org/10.1371/journal.pone.0110322 SN - 1932-6203 VL - 9 IS - 10 SP - e110322 ER - TY - GEN A1 - Lehnen, Nadine A1 - Heuser, Fabian A1 - Sağlam, Murat A1 - Schulz, Christian M. A1 - Wagner, Klaus J. A1 - Taki, Masakatsu A1 - Kochs, Eberhard F. A1 - Jahn, Klaus A1 - Schneider, Erich T1 - Opioid-induced nausea involves a vestibular problem preventable by head-rest T2 - PLoS one Y1 - 2015 U6 - https://doi.org/10.1371/journal.pone.0135263 SN - 1932-6203 VL - 10 IS - 8 SP - e0135263 ER - TY - GEN A1 - Kugler, Günter A1 - Hart, Bernhard Marius 't A1 - Kohlbecher, Stefan A1 - Einhäuser, Wolfgang A1 - Schneider, Erich T1 - Gaze in visual search is guided more efficiently by positive cues than by negative cues T2 - PLoS one Y1 - 2015 U6 - https://doi.org/10.1371/journal.pone.0145910 SN - 1932-6203 VL - 10 IS - 12 SP - e0145910 ER - TY - GEN A1 - Kugler, Günter A1 - Hart, Bernhard Marius 't A1 - Kohlbecher, Stefan A1 - Bartl, Klaus A1 - Schumann, Frank A1 - Einhäuser, Wolfgang A1 - Schneider, Erich T1 - Visual search in the real world: Color vision deficiency affects peripheral guidance, but leaves foveal verification largely unaffected T2 - Frontiers in human neuroscience Y1 - 2015 U6 - https://doi.org/10.3389/fnhum.2015.00680 SN - 1662-5161 VL - 9 SP - 680 ER - TY - GEN A1 - Luis, Leonel A1 - Zhu, Hong A1 - Costa, João A1 - Valls-Solé, Josep A1 - Brandt, Thomas A1 - Zhou, Wu A1 - Schneider, Erich T1 - Reply to the commentary on luis et al. "spontaneous plugging of the horizontal semicircular canal with reversible canal dysfunction and recovery of vestibular evoked myogenic potentials T2 - Otology & Neurotology Y1 - 2014 SN - 1531-7129 VL - 35 IS - 2 SP - 379 EP - 383 ER - TY - GEN A1 - Kugler, Günter A1 - Huppert, Doreen A1 - Schneider, Erich A1 - Brandt, Thomas T1 - Fear of heights freezes gaze to the horizon T2 - Journal of Vestibular Research Y1 - 2014 U6 - https://doi.org/10.3233/VES-140529 SN - 0957-4271 SN - 1878-6464 VL - 24 IS - 5-6 SP - 433 EP - 441 ER - TY - GEN A1 - Kugler, Günter A1 - Huppert, Doreen A1 - Eckl, Maria A1 - Schneider, Erich A1 - Brandt, Thomas T1 - Visual exploration during locomotion limited by fear of heights T2 - PLoS One Y1 - 2014 U6 - https://doi.org/10.1371/journal.pone.0105906 SN - 1932-6203 VL - 9 IS - 8 SP - e105906 ER - TY - GEN A1 - Jerin, Claudia A1 - Bartl, Klaus A1 - Schneider, Erich A1 - Gürkov, Robert T1 - Enhancing the reproducibility of ocular vestibular evoked myogenic potentials by use of a visual target originating from a head-mounted laser T2 - European Archives of Oto-Rhino-Laryngology Y1 - 2014 U6 - https://doi.org/10.1007/s00405-014-3271-4 SN - 0937-4477 SN - 1434-4726 VL - 272 IS - 10 SP - 2737 EP - 2740 ER - TY - GEN A1 - Heuberger, Maria A1 - Sağlam, Murat A1 - Todd, Nicholas Sean A1 - Jahn, Klaus A1 - Schneider, Erich A1 - Lehnen, Nadine T1 - Covert anti-compensatory quick eye movements during head impulses T2 - PLoS One Y1 - 2014 U6 - https://doi.org/10.1371/journal.pone.0093086 SN - 1932-6203 VL - 9 IS - 4 SP - e93086 ER - TY - GEN A1 - Helmchen, Christoph A1 - Machner, Björn A1 - Lehnen, Nadine A1 - Jahn, Klaus A1 - Schneider, Erich T1 - Current state of diagnostic management of acute vertigo: a survey of neurologists in Germany T2 - Journal of Neurology Y1 - 2014 U6 - https://doi.org/10.1007/s00415-014-7405-9 SN - 0340-5354 SN - 1432-1459 VL - 261 IS - 8 SP - 1638 EP - 1640 ER - TY - GEN A1 - Agrawal, Yuri A1 - Schubert, Michael C. A1 - Migliaccio, Americo A. A1 - Zee, David S. A1 - Schneider, Erich A1 - Lehnen, Nadine T1 - Evaluation of quantitative head impulse testing using search coils versus video-oculography in older individuals T2 - Otology & neurotology Y1 - 2014 U6 - https://doi.org/10.1097/MAO.0b013e318287f343 SN - 1537-4505 VL - 35 IS - 2 SP - 283 EP - 288 ER - TY - GEN A1 - Srulijes, Karin A1 - Mack, David J. A1 - Klenk, Jochen A1 - Ihlen, Espen A. F. A1 - Schwenk, Michael A1 - Lindemann, Ulrich A1 - Schneider, Erich T1 - Association between vestibulo-ocular reflex suppression, balance, gait, and fall risk in ageing and neurodegenerative disease: protocol of a one-year prospective follow-up study. T2 - BMC Neurol Y1 - 2015 U6 - https://doi.org/10.1186/s12883-015-0447-5 SN - 1471-2377 VL - 15 SP - 192 ER - TY - GEN A1 - Schneider, Erich A1 - Villgrattner, Thomas A1 - Vockeroth, Johannes A1 - Bartl, Klaus A1 - Kohlbecher, Stefan A1 - Bardins, Stanislav A1 - Ulbrich, Heinz A1 - Brandt, Thomas T1 - Eyeseecam: an eye movement-driven head camera for the examination of natural visual exploration T2 - Annals of the New York Academy of Sciences Y1 - 2009 U6 - https://doi.org/10.1111/j.1749-6632.2009.03858.x SN - 1749-6632 VL - 1164 SP - 461 EP - 467 ER - TY - GEN A1 - Schneider, Erich A1 - Bartl, Klaus A1 - Glasauer, Stefan T1 - Galvanic vestibular stimulation combines with earth-horizontal rotation in roll to induce the illusion of translation. T2 - Annals of the New York Academy of Sciences Y1 - 2009 U6 - https://doi.org/10.1111/j.1749-6632.2008.03732.x SN - 1749-6632 VL - 1164 SP - 116 EP - 118 ER - TY - GEN A1 - Hart, Bernhard Marius 't A1 - Vockeroth, Johannes A1 - Schumann, Frank A1 - Bartl, Klaus A1 - Schneider, Erich A1 - König, Peter A1 - Einhäuser, Wolfgang T1 - Gaze allocation in natural stimuli: Comparing free exploration to head-fixed viewing conditions. T2 - Visual Cognition Y1 - 2009 U6 - https://doi.org/10.1080/13506280902812304 SN - 1350-6285 SN - 1464-0716 VL - 17 IS - 6-7 SP - 1132 EP - 1158 ER - TY - GEN A1 - Spiegel, Rainer A1 - Kalla, Roger A1 - Claassen, Jens A1 - Bardins, Stanislav A1 - Anciães da Silva, Fábio A1 - Farahmand, Parvis A1 - Hahn, Ales A1 - Schneider, Erich T1 - Aminopyridine treatment in a patient with bilateral vestibular failure and cryptogenic downbeat nystagmus T2 - Journal of Neuro-Ophthalmology Y1 - 2012 SN - 1536-5166 SN - 1070-8022 VL - 32 IS - 2 SP - 190 ER - TY - GEN A1 - Villgrattner, Thomas A1 - Schneider, Erich A1 - Andersch, Philipp A1 - Ulbrich, Heinz T1 - Compact high dynamic 3 DoF camera orientation system: Development and control T2 - Journal of System Design and Dynamics Y1 - 2011 U6 - https://doi.org/10.1299/jsdd.5.819 SN - 1881-3046 VL - 5 IS - 5 SP - 819 EP - 828 ER - TY - GEN A1 - Kohlbecher, Stefan A1 - Schneider, Erich T1 - On-line classification and prediction of eye movements by multiplemodel kalman filtering T2 - Annals of the New York Academy of Sciences Y1 - 2009 U6 - https://doi.org/10.1111/j.1749-6632.2009.03776.x SN - 1749-6632 VL - 1164 SP - 400 EP - 402 ER - TY - GEN A1 - Einhäuser, Wolfgang A1 - Moeller, Gudrun U. A1 - Schumann, Frank A1 - Conradt, Jörg A1 - Vockeroth, Johannes A1 - Bartl, Klaus A1 - Schneider, Erich A1 - König, Peter T1 - Eye-head coordination during free exploration in human and cat. T2 - Annals of the New York Academy of Sciences Y1 - 2009 U6 - https://doi.org/10.1111/j.1749-6632.2008.03709.x SN - 1749-6632 VL - 1164 SP - 353 EP - 366 ER - TY - GEN A1 - Bartl, Klaus A1 - Lehnen, Nadine A1 - Kohlbecher, Stefan A1 - Schneider, Erich T1 - Head impulse testing using video-oculography T2 - Annals of the New York Academy of Sciences Y1 - 2009 U6 - https://doi.org/10.1111/j.1749-6632.2009.03850.x SN - 1749-6632 SN - 0077-8923 VL - 1164 SP - 331 EP - 333 ER - TY - GEN A1 - Schneider, Erich A1 - Jahn, Klaus A1 - Dieterich, Marianne A1 - Brandt, Thomas A1 - Strupp, Michael T1 - Gait deviations induced by visual stimulation in roll T2 - Experimental Brain Research Y1 - 2008 U6 - https://doi.org/10.1007/s00221-007-1134-6 SN - 0014-4819 SN - 1432-1106 VL - 185 IS - 1 SP - 21 EP - 26 ER - TY - GEN A1 - Schumann, Frank A1 - Einhäuser, Wolfgang A1 - Vockeroth, Johannes A1 - Bartl, Klaus A1 - Schneider, Erich A1 - König, Peter T1 - Salient features in gaze-aligned recordings of human visual input during free exploration of natural environments T2 - Journal of Vision Y1 - 2008 U6 - https://doi.org/10.1167/8.14.12 SN - 1534-7362 VL - 8 IS - 14 SP - 1210 EP - 1217 ER - TY - GEN A1 - Luis, Leonel A1 - Costa, João A1 - Vaz Garcia, Fernando A1 - Valls-Solé, Josep A1 - Brandt, Thomas A1 - Schneider, Erich T1 - Spontaneous plugging of the horizontal semicircular canal with reversible canal dysfunction and recovery of vestibular evoked myogenic potentials T2 - Otology & neurotology Y1 - 2013 SN - 1537-4505 SN - 0192-9763 VL - 34 IS - 4 SP - 743 EP - 747 ER - TY - GEN A1 - Claassen, Jens A1 - Spiegel, Rainer A1 - Kalla, Roger A1 - Faldon, Mary A1 - Kennard, Christopher A1 - Schneider, Erich T1 - A randomised double-blind, cross-over trial of 4-aminopyridine for downbeat nystagmus–effects on slowphase eye velocity, postural stability, locomotion and symptoms T2 - Journal of neurology, neurosurgery, and psychiatry Y1 - 2013 U6 - https://doi.org/10.1136/jnnp-2012-304736 SN - 0022-3050 SN - 1468-330X VL - 84 IS - 12 SP - 1392 EP - 1399 ER - TY - GEN A1 - Claassen, Jens A1 - Feil, Katharina A1 - Bardins, Stanislav A1 - Teufel, Julian A1 - Spiegel, Rainer A1 - Kalla, Roger A1 - Schneider, Erich T1 - Dalfampridine in patients with downbeat nystagmus–an observational study T2 - Journal of Neurology Y1 - 2013 U6 - https://doi.org/10.1007/s00415-013-6911-5 SN - 0340-5354 SN - 1432-1459 VL - 260 IS - 8 SP - 1992 EP - 1996 ER - TY - GEN A1 - Brandt, Thomas A1 - Glasauer, Stefan A1 - Schneider, Erich T1 - A third eye for the surgeon T2 - Journal of neurology, neurosurgery, and psychiatry Y1 - 2006 U6 - https://doi.org/10.1136/jnnp.2005.073734 SN - 0022-3050 SN - 1468-330X VL - 77 IS - 2 SP - 278 ER - TY - GEN A1 - Jahn, Klaus A1 - Naeßl, Andrea A1 - Schneider, Erich A1 - Strupp, Michael A1 - Brandt, Thomas A1 - Dieterich, Marianne T1 - Inverse u-shaped curve for age dependency of torsional eye movement responses to galvanic vestibular stimulation T2 - Brain Y1 - 2003 U6 - https://doi.org/10.1093/brain/awg163 SN - 1460-2156 SN - 0006-8950 VL - 126 IS - 7 SP - 1579 EP - 1589 ER - TY - GEN A1 - Jahn, Klaus A1 - Naeßl, Andrea A1 - Strupp, Michael A1 - Schneider, Erich A1 - Brandt, Thomas A1 - Dieterich, Marianne T1 - Torsional eye movement responses to monaural and binaural galvanic vestibular stimulation: side-to-side asymmetries. T2 - Annals of the New York Academy of Sciences Y1 - 2003 U6 - https://doi.org/10.1111/j.1749-6632.2003.tb00265.x SN - 0077-8923 SN - 1749-6632 VL - 1004 SP - 485 EP - 489 ER - TY - GEN A1 - Jahn, Klaus A1 - Strupp, Michael A1 - Schneider, Erich A1 - Dieterich, Marianne A1 - Brandt, Thomas T1 - Visually induced gait deviations during different locomotion speeds T2 - Experimental Brain Research Y1 - 2001 U6 - https://doi.org/10.1007/s002210100884 SN - 0014-4819 SN - 1432-1106 VL - 141 IS - 3 SP - 370 EP - 374 ER - TY - GEN A1 - Schneider, Erich A1 - Glasauer, Stefan A1 - Dieterich, Marianne T1 - Central processing of human ocular torsion analyzed by galvanic vestibular stimulation T2 - Neuroreport Y1 - 2000 SN - 0959-4965 SN - 1473-558X VL - 11 IS - 7 SP - 1559 EP - 1563 ER - TY - GEN A1 - Jahn, Klaus A1 - Strupp, Michael A1 - Schneider, Erich A1 - Dieterich, Marianne A1 - Brandt, Thomas T1 - Differential effects of vestibular stimulation on walking and running T2 - Neuroreport Y1 - 2000 SN - 1473-558X SN - 0959-4965 VL - 11 IS - 8 SP - 1745 EP - 1748 ER - TY - GEN A1 - Stephan, Thomas A1 - Deutschländer, Angela A1 - Nolte, Annina A1 - Schneider, Erich A1 - Wiesmann, Martin A1 - Brandt, Thomas A1 - Dieterich, Marianne T1 - Functional mri of galvanic vestibular stimulation with alternating currents at different frequencies T2 - Neuroimage Y1 - 2005 U6 - https://doi.org/10.1016/j.neuroimage.2005.02.049 SN - 1053-8119 VL - 26 IS - 3 SP - 721 EP - 732 ER - TY - GEN A1 - Glasauer, Stefan A1 - Schneider, Erich A1 - Jahn, Klaus A1 - Strupp, Michael T1 - How the eyes move the body T2 - Neurology Y1 - 2005 U6 - https://doi.org/10.1212/01.wnl.0000175132.01370.fc SN - 0028-3878 SN - 1526-632X VL - 65 IS - 8 SP - 1291 EP - 1293 ER - TY - GEN A1 - Bartl, Klaus A1 - Schneider, Erich A1 - Glasauer, Stefan T1 - Dependence of the torsional vestibulo-ocular reflex on the direction of gravity T2 - Annals of the New York Academy of Sciences Y1 - 2005 U6 - https://doi.org/10.1196/annals.1325.043 SN - 1749-6632 VL - 1039 SP - 455 EP - 458 ER - TY - CHAP A1 - Stoll, Josef A1 - Kohlbecher, Stefan A1 - Marx, Svenja A1 - Schneider, Erich A1 - Einhäuser, Wolfgang ED - Westwood, James D. T1 - Mobile three dimensional gaze tracking T2 - Medicine meets virtual reality 18 Y1 - 2011 SN - 978-1-60750-705-5 SN - 978-1-60750-706-2 SP - 616 EP - 622 PB - IOS Press CY - Amsterdam ER - TY - CHAP A1 - Kohlbecher, Stefan A1 - Bartl, Klaus A1 - Bardins, Stanislav A1 - Schneider, Erich T1 - Low-latency combined eye and head tracking system for teleoperating a robotic head in real-time T2 - Proceedings of the 2010 Symposium on EyeTracking Research & Applications T2 - ETRA '10, Proceedings of the 2010 Symposium on Eye-Tracking Research & Applications, Austin, Texas — March 22 - 24 Y1 - 2010 SN - 978-1-60558-994-7 U6 - https://doi.org/10.1145/1743666.1743695 SP - 117 EP - 120 PB - ACM Press CY - New York ER - TY - CHAP A1 - Vockeroth, Johannes A1 - Bartl, Klaus A1 - Pfanzelt, Sandra A1 - Schneider, Erich ED - Westwood, James D. T1 - Medical documentation using a gaze-driven camera T2 - Medicine meets virtual reality 17 Y1 - 2009 SN - 978-160-750-402-3 SN - 978-144-160-558-0 SP - 413 EP - 416 PB - IOS Press CY - Amsterdam ER - TY - CHAP A1 - Schneider, Erich A1 - Kohlbecher, Stefan A1 - Bartl, Klaus A1 - Wallhoff, Frank A1 - Brandt, Thomas T1 - Experimental platform for wizard-of-oz evaluations of biomimetic active vision in robots T2 - IEEE International Conference on Robotics and Biomimetics (ROBIO), 2009, 19 - 23 Dec. 2009, Guilin, China Y1 - 2009 SN - 978-1-4244-4774-9 SN - 978-1-4244-4775-6 SP - 1484 EP - 1489 PB - IEEE CY - Piscataway, NJ ER - TY - GEN A1 - Schneider, Erich A1 - Glasauer, Stefan A1 - Brandt, Thomas A1 - Dieterich, Marianne T1 - Nonlinear nystagmus processing causes torsional vor nonlinearity T2 - Annals of the New York Academy of Sciences Y1 - 2003 SN - 1749-6632 VL - 1004 SP - 500 EP - 505 ER - TY - GEN A1 - Strupp, Michael A1 - Glasauer, Stefan A1 - Jahn, Klaus A1 - Schneider, Erich A1 - Krafczyk, Siegbert A1 - Brandt, Thomas T1 - Eye movements and balance T2 - Annals of the New York Academy of Sciences Y1 - 2003 SN - 1749-6632 VL - 1004 SP - 352 EP - 358 ER - TY - GEN A1 - Strupp, Michael A1 - Glasauer, Stefan A1 - Schneider, Erich A1 - Eggert, Thomas A1 - Glaser, Miriam T1 - Anterior canal failure: ocular torsion without perceptual tilt due to preserved otolith function T2 - Journal of Neurology Neurosurgery & Psychiatry Y1 - 2003 U6 - https://doi.org/10.1136/jnnp.74.9.1336 SN - 1468-330X SN - 0022-3050 VL - 74 IS - 9 SP - 1336 EP - 1338 ER - TY - GEN A1 - Heuser, Fabian A1 - Schulz, Christian A1 - Sağlam, Murat A1 - Ramaioli, Cecilia A1 - Heuberger, Maria A1 - Wagner, Klaus J. A1 - Jahn, Klaus A1 - Schneider, Erich A1 - Brandt, Thomas A1 - Glasauer, Stefan A1 - Lehnen, Nadine T1 - Preventing opioid-induced nausea and vomiting: Rest your head and close your eyes? T2 - PloS one Y1 - 2017 U6 - https://doi.org/10.1371/journal.pone.0173925 SN - 1932-6203 VL - 12 IS - 3 SP - e0173925 ER - TY - GEN A1 - Lehnen, Nadine A1 - Kellerer, Silvy A1 - Knorr, Alexander G. A1 - Schlick, Cornelia A1 - Jahn, Klaus A1 - Schneider, Erich A1 - Heuberger, Maria A1 - Ramaioli, Cecilia T1 - Head-Movement-Emphasized Rehabilitation in Bilateral Vestibulopathy T2 - Frontiers in Neurology Y1 - 2018 U6 - https://doi.org/10.3389/fneur.2018.00562 SN - 1664-2295 VL - 9 ER - TY - GEN A1 - Heuberger, Maria A1 - Grill, Eva A1 - Saglam, Murat A1 - Ramaioli, Cecilia A1 - Müller, Martin A1 - Strobl, Ralf A1 - Holle, Rolf A1 - Peters, Annette A1 - Schneider, Erich A1 - Lehnen, Nadine T1 - Usability of the Video Head Impulse Test: Lessons from the Population-Based Prospective KORA Study T2 - Frontiers in Neurology Y1 - 2018 U6 - https://doi.org/10.3389/fneur.2018.00659 SN - 1664-2295 VL - 9 ER - TY - GEN A1 - Schöberl, Florian A1 - Irving, Stephanie A1 - Pradhan, Cauchy A1 - Bardins, Stanislav A1 - Trapp, Christoph A1 - Schneider, Erich A1 - Kugler, Günter A1 - Bartenstein, Peter A1 - Dietrich, Marianne A1 - Brandt, Thomas A1 - Zwergal, Andreas T1 - Prolonged allocentric navigation deficits indicate hippocampal damage in TGA T2 - Neurology : official journal of the American Academy of Neurology N2 - Objective To investigate long-term recovery of allocentric and egocentric spatial orientation as a sensitive marker for hippocampal and extrahippocampal network function in transient global amnesia (TGA). Methods A group of 18 patients with TGA performed an established real-space navigation paradigm, requiring allo- and egocentric spatial orientation abilities, 3 days (postacute stage) and 3 months (follow-up) after symptom onset. Visual exploration behavior and navigation strategy were documented by a gaze-controlled, head-fixed camera. Allo- and egocentric spatial orientation performance was compared to that of 12 age-matched healthy controls. Navigation-induced brain activations were measured using [18F]-fluorodeoxyglucose-PET in a subgroup of 8 patients in the postacute stage and compared to those of the controls. Results In the postacute stage, the patients navigated worse and had higher error rates than controls in allocentric (p = 0.002), but not in egocentric, route planning (p = 0.30), despite complete recovery of verbal (p = 0.58) and figural memory (p = 0.11). Until follow-up, allocentric navigation deficits improved, but higher error rates and reduced use of shortcuts persisted (p < 0.0001). Patients still exhibited relatively more fixations of unique landmarks during follow-up (p = 0.05). PET measurements during the postacute stage showed increased navigation-induced brain activations in the right hippocampus, bilateral retrosplenial, parietal, and mesiofrontal cortices, and cerebellar dentate nucleus in patients compared to controls (p < 0.005). Conclusions Patients with TGA show selective and prolonged deficits of allocentric spatial orientation. Activations in right hippocampal and extrahippocampal hubs of the cerebral navigation network functionally substitute for the deficit in creating and updating the internal cognitive map in TGA. Y1 - 2019 UR - https://n.neurology.org/content/92/3/e234/tab-article-info U6 - https://doi.org/10.1212/WNL.0000000000006779 SN - 0028-3878 SN - 1526-632X VL - 92 IS - 3 SP - e234 EP - e243 ER - TY - GEN A1 - Grill, Eva A1 - Heuberger, Maria A1 - Strobl, Ralf A1 - Saglam, Murat A1 - Holle, Rolf A1 - Linkohr, Birgit A1 - Ladwig, Karl-Heinz A1 - Peters, Annette A1 - Schneider, Erich A1 - Jahn, Klaus A1 - Lehnen, Nadine T1 - Prevalence, determinants, and consequences of vestibular hypofunction. results from the kora-ff4 survey T2 - Frontiers in Neurology N2 - Objective: Uni- or bilateral vestibular hypofunction (VH) impairs balance and mobility, and may specifically lead to injury from falls and to disability. The extent of this problem in the general population is still unknown and most likely to be underestimated. Objective of this study was to determine the prevalence, determinants, and consequences of VH in the general population. Methods: Data originates from the cross-sectional second follow-up (FF4) in 2013/14 of the KORA (Cooperative Health Research in the Region of Augsburg)-S4 study (1999–2001) from Southern Germany. This was a random sample of the target population consisting of all residents of the region aged 25–74 years in 1999. We included all participants who reported moderate or severe vertigo or dizziness during the last 12 months and a random sub-sample of participants representative for the general population without vertigo or dizziness during the last 12 months were tested. VH was assessed with the Video-Head Impulse Test (vHIT). Trained examiners applied high-acceleration, small-amplitude passive head rotations (“head impulses”) to the left and right in the plane of the horizontal semicircular canals while participants fixated a target straight ahead. During head impulses, head movements were measured with inertial sensors, eye movements with video-oculography (EyeSeeCam vHIT). Results: A total of 2,279 participants were included (mean age 60.8 years, 51.6% female), 570 (25.0%) with moderate or severe vertigo or dizziness during the last 12 months. Of these, 450 were assessed with vHIT where 26 (5.8%) had unilateral VH, and 16 (3.6%) had bilateral VH. Likewise, 190 asymptomatic participants were tested. Of these 5 (2.6%) had unilateral VH, and 2 (1.1%) had bilateral VH. Prevalence of uni- or bilateral VH among tested symptomatic participants was 2.4% in those < 48 years, and 32.1% in individuals aged 79 and over. Age-adjusted prevalence was 6.7% (95% CI 4.8%; 8.6%). VH was associated with worse health, falls, hearing loss, hearing impairment, and ear pressure. Conclusion: VH may affect between 53 and 95 million adults in Europe and the US. While not all affected persons will experience the full spectrum of symptoms and consequences, adequate diagnostic and therapeutic measures should become standard of care to decrease the burden of disease. Y1 - 2018 U6 - https://doi.org/10.3389/fneur.2018.01076 SN - 1664-2295 VL - 9 ER - TY - GEN A1 - Donald, Aimee A1 - Tan, Chong Y. A1 - Chakrapani, Anupam A1 - Hughes, Derralyn A. A1 - Sharma, Reena A1 - Cole, Duncan A1 - Bardins, Stanislav A1 - Gorges, Martin A1 - Jones, Simon A. A1 - Schneider, Erich T1 - Eye movement biomarkers allow for the definition of phenotypes in Gaucher Disease T2 - Orphanet journal of rare diseases : OJRD N2 - Background: Neurological forms of Gaucher disease, the inherited disorder of β-Glucosylceramidase caused by bi-allelic variants in GBA1, is a progressive disorder which lacks a disease-modifying therapy. Systemic manifestations of disease are effectively treated with enzyme replacement therapy, however, molecules which cross the blood-brain barrier are still under investigation. Clinical trials of such therapeutics require robust, reproducible clinical endpoints to demonstrate efficacy and clear phenotypic definitions to identify suitable patients for inclusion in trials. The single consistent clinical feature in all patients with neuronopathic disease is the presence of a supranuclear saccadic gaze palsy, in the presence of Gaucher disease this finding serves as diagnostic of 'type 3' Gaucher disease. Y1 - 2020 UR - https://ojrd.biomedcentral.com/articles/10.1186/s13023-020-01637-9 U6 - https://doi.org/10.1186/s13023-020-01637-9 SN - 1750-1172 VL - 15 ER -