TY - GEN A1 - Döding, Rebekka A1 - Braun, Tobias A1 - Ehrenbrusthoff, Katja A1 - Elsner, Bernhard A1 - Kopkow, Christian A1 - Lange, Toni A1 - Lüdtke, Kerstin A1 - Jung, Andres A1 - Miller, Clint A1 - Owen, Patrick J A1 - Saueressig, Tobias A1 - Schäfer, Axel A1 - Schäfer, Robin A1 - Schleimer, Tim A1 - Shala, Rilind A1 - Szikszay, Tibor A1 - Zebisch, Jochen A1 - Belavý, Daniel L T1 - Evidence gaps in conservative non-pharmacological interventions and guideline implementation for high-burden non-communicable diseases: protocol for an overview of reviews T2 - BMJ Open Sport & Exercise Medicine N2 - Non-communicable diseases (NCDs) represent a high burden for the society and affected individuals. Conservative non-pharmacological interventions play a first-line role in the treatment and management of most NCDs. Systematic reviews (SRs) provide the highest level of evidence and significantly influence clinical decision-making. The primary aim of this study is to provide an overview of the evidence on the effectiveness of recommended conservative non-pharmacological interventions for highly burdensome NCDs. The secondary aim is to provide an overview of the evidence for guideline implementation. A literature search was performed in Medline (PubMed), EMBASE and Cochrane CENTRAL. Six reviewers will, in duplicate, independently screen and select studies following eligibility criteria. The population will include individuals with NCDs from disease categories chosen based on WHO burden of disease data and the importance of conservative rehabilitation for their management. Eligible interventions will encompass conservative non-pharmacological approaches recommended by clinical practice guidelines (ie, physical, psychological and education/advice). Eligible comparator will include no or minimal intervention and other competitive interventions. Outcomes will comprise proposed core outcomes for the respective diseases, including patient-reported (eg, pain) and performance-based (eg, physical functioning) outcomes. SRs published in the last 5 years as peer-reviewed journal article in the English language will be eligible. The overview will be reported in accordance with the Preferred Reporting Items for Overviews of reviews. Y1 - 2024 U6 - https://doi.org/10.1136/bmjsem-2024-002032 SN - 2055-7647 VL - 10 IS - 4 PB - BMJ ER - TY - BOOK A1 - Zundel, Stefan A1 - Blättel-Mink, Birgit A1 - Brohmann, Bettina A1 - Defila, Rico A1 - Di Giulio, Antonietta A1 - Fischer, Daniel A1 - Fuchs, Doris A1 - Gölz, Sebastian A1 - Götz, Konrad A1 - Homburg, Andreas A1 - Kaufmann-Hayoz, Ruth A1 - Matthies, Ellen A1 - Michelsen, Gerd A1 - Schäfer, Martina A1 - Tews, Kerstin A1 - Wassermann, Sandra T1 - Konsum-Botschaften : was Forschende für die gesellschaftliche Gestaltung nachhaltigen Konsums empfehlen Y1 - 2013 SN - 978-3-7776-2371-9 PB - Hirzel Verlag CY - Stuttgart ET - 1. Auflage ER - TY - GEN A1 - Homfeldt, Felix A1 - Rese, Alexandra A1 - Brenner, Hanno A1 - Baier, Daniel A1 - Schäfer, Fabio T1 - Identification and Generation of Innovative Ideas in the Procurement of the Automotive Industry: The Case of AUDI AG T2 - International Journal of Innovation Management Y1 - 2017 U6 - https://doi.org/10.1142/S1363919617500530 SN - 1363-9196 SN - 1757-5877 N1 - Artikel-Nr. 1750053 VL - 21 IS - 7 ER - TY - GEN A1 - Werder, Dina von A1 - Regnath, Franziska A1 - Schäfer, Daniel A1 - Jörres, Rudolf A1 - Lehnen, Nadine A1 - Glasauer, Stefan T1 - Post-COVID breathlessness: a mathematical model of respiratory processing in the brain T2 - European Archives of Psychiatry and Clinical Neuroscience N2 - Breathlessness is among the most common post-COVID symptoms. In a considerable number of patients, severe breathlessness cannot be explained by peripheral organ impairment. Recent concepts have described how such persistent breathlessness could arise from dysfunctional processing of respiratory information in the brain. In this paper, we present a first quantitative and testable mathematical model of how processing of respiratory-related signals could lead to breathlessness perception. The model is based on recent theories that the brain holds an adaptive and dynamic internal representation of a respiratory state that is based on previous experiences and comprises gas exchange between environment, lung and tissue cells. Perceived breathlessness reflects the brain’s estimate of this respiratory state signaling a potentially hazardous disequilibrium in gas exchange. The internal respiratory state evolves from the respiratory state of the last breath, is updated by a sensory measurement of CO2 concentration, and is dependent on the current activity context. To evaluate our model and thus test the assumed mechanism, we used data from an ongoing rebreathing experiment investigating breathlessness in patients with post-COVID without peripheral organ dysfunction (N = 5) and healthy control participants without complaints after COVID-19 (N = 5). Although the observed breathlessness patterns varied extensively between individual participants in the rebreathing experiment, our model shows good performance in replicating these individual, heterogeneous time courses. The model assumes the same underlying processes in the central nervous system in all individuals, i.e., also between patients and healthy control participants, and we hypothesize that differences in breathlessness are explained by different weighting and thus influence of these processes on the final percept. Our model could thus be applied in future studies to provide insight into where in the processing cascade of respiratory signals a deficit is located that leads to (post-COVID) breathlessness. A potential clinical application could be, e.g., the monitoring of effects of pulmonary rehabilitation on respiratory processing in the brain to improve the therapeutic strategies. KW - Pharmacology (medical) KW - Biological Psychiatry KW - Psychiatry and Mental health KW - General Medicine Y1 - 2024 U6 - https://doi.org/10.1007/s00406-023-01739-y SN - 0940-1334 ER - TY - GEN A1 - von Werder, Dina A1 - Aubele, Maria A1 - Regnath, Franziska A1 - Tebbe, Elisabeth A1 - Mladenov, Dejan A1 - von Rheinbaben, Victoria A1 - Hahn, Elisabeth A1 - Schäfer, Daniel A1 - Biersack, Katharina A1 - Adorjan, Kristina A1 - Stubbe, Hans C. A1 - Bogaerts, Katleen A1 - Jörres, Rudolf A. A1 - Nowak, Dennis A1 - Van den Bergh, Omer A1 - Glasauer, Stefan A1 - Lehnen, Nadine T1 - Increased breathlessness in post-COVID syndrome despite normal breathing patterns in a rebreathing challenge T2 - Scientific reports N2 - Severe symptoms in the absence of measurable body pathology are a frequent hallmark of post-COVID syndrome. From a Bayesian Brain perspective, such symptoms can be explained by incorrect internal models that the brain uses to interpret sensory signals. In this pre-registered study, we investigate whether induced breathlessness perception during a controlled CO2rebreathing challenge is reflected by altered respiratory measures (physiology and breathing patterns), and propose different computational mechanisms that could explain our findings in a Bayesian Brain framework. We analysed data from 40 patients with post-COVID syndrome and 40 healthy participants. Results from lung function, neurological and neurocognitive examination of all participants were within normal limits on the day of the experiment. Using a Bayesian repeated-measures ANOVA, we found that patients’ breathlessness was strongly increased (BF10,baseline =8.029, BF10,rebreathing =11636, BF10,recovery =43662) compared to controls. When excluding patients who hyperventilated (N = 8, 20%) during the experiment from the analysis, differences in breathlessness remained (BF10,baseline =1.283, BF10,rebreathing =126.812, BF10,recovery =751.282). For physiology and breathing patterns, all evidence pointed towards no difference between the two groups (0.307  BF10 < 0.704). In summary, we found intact breathing patterns and physiology but increased symptom perception in patients with post-COVID syndrome. Y1 - 2025 U6 - https://doi.org/10.1038/s41598-025-11728-x SN - 2045-2322 VL - 15 IS - 1 SP - 1 EP - 15 PB - Springer Nature CY - [London] ER -