TY - GEN A1 - Wasmer, Kristina A1 - Köbe, Julia A1 - Andresen, Dietrich A1 - Zahn, Ralf A1 - Spitzer, Stefan G. A1 - Jehle, Joachim A1 - Brachmann, Johannes A1 - Stellbrink, Christoph A1 - Martens, Eimo A1 - Hochadel, Matthias A1 - Senges, Jochen A1 - Klein, Helmut A1 - Eckhardt, Lars T1 - Comparing outcome of patients with coronary artery disease and dilated cardiomyopathy in ICD and CRT recipients: data from the German DEVICE—registry T2 - Clinical Research in Cardiology Y1 - 2013 U6 - https://doi.org/10.1007/s00392-013-0559-0 SN - 1861-0684 SN - 1861-0692 VL - 102 IS - 7 SP - 513 EP - 521 ER - TY - GEN A1 - Schöberl, Florian A1 - Irving, Stephanie A1 - Pradhan, Cauchy A1 - Bardins, Stanislav A1 - Trapp, Christoph A1 - Schneider, Erich A1 - Kugler, Günter A1 - Bartenstein, Peter A1 - Dietrich, Marianne A1 - Brandt, Thomas A1 - Zwergal, Andreas T1 - Prolonged allocentric navigation deficits indicate hippocampal damage in TGA T2 - Neurology : official journal of the American Academy of Neurology N2 - Objective To investigate long-term recovery of allocentric and egocentric spatial orientation as a sensitive marker for hippocampal and extrahippocampal network function in transient global amnesia (TGA). Methods A group of 18 patients with TGA performed an established real-space navigation paradigm, requiring allo- and egocentric spatial orientation abilities, 3 days (postacute stage) and 3 months (follow-up) after symptom onset. Visual exploration behavior and navigation strategy were documented by a gaze-controlled, head-fixed camera. Allo- and egocentric spatial orientation performance was compared to that of 12 age-matched healthy controls. Navigation-induced brain activations were measured using [18F]-fluorodeoxyglucose-PET in a subgroup of 8 patients in the postacute stage and compared to those of the controls. Results In the postacute stage, the patients navigated worse and had higher error rates than controls in allocentric (p = 0.002), but not in egocentric, route planning (p = 0.30), despite complete recovery of verbal (p = 0.58) and figural memory (p = 0.11). Until follow-up, allocentric navigation deficits improved, but higher error rates and reduced use of shortcuts persisted (p < 0.0001). Patients still exhibited relatively more fixations of unique landmarks during follow-up (p = 0.05). PET measurements during the postacute stage showed increased navigation-induced brain activations in the right hippocampus, bilateral retrosplenial, parietal, and mesiofrontal cortices, and cerebellar dentate nucleus in patients compared to controls (p < 0.005). Conclusions Patients with TGA show selective and prolonged deficits of allocentric spatial orientation. Activations in right hippocampal and extrahippocampal hubs of the cerebral navigation network functionally substitute for the deficit in creating and updating the internal cognitive map in TGA. Y1 - 2019 UR - https://n.neurology.org/content/92/3/e234/tab-article-info U6 - https://doi.org/10.1212/WNL.0000000000006779 SN - 0028-3878 SN - 1526-632X VL - 92 IS - 3 SP - e234 EP - e243 ER - TY - GEN A1 - Birkhofer, Klaus A1 - Dietrich, Christoph A1 - John, Katharina A1 - Schorpp, Quentin A1 - Zaitsev, Andrey S. A1 - Wolters, Volkmar T1 - Regional conditions and land-use alter the contribution of soil arthropos to ecosystem services in grasslands. Frontiers in Agroecology and Land-Use Systems T2 - Frontiers in Ecology and Evolution Y1 - 2016 U6 - https://doi.org/10.3389/fevo.2015.00150 SN - 2296-701X VL - 3 SP - 150 ER -