TY - GEN A1 - Chen, Siyi A1 - Glasauer, Stefan A1 - Müller, Hermann J. A1 - Conci, Markus T1 - Surface filling-in and contour interpolation contribute independently to Kanizsa figure formation T2 - Journal of Experimental Psychology Y1 - 2018 U6 - https://doi.org/10.1037/xhp0000540 SN - 1939-1277 SN - 0096-1523 VL - 44 IS - 9 SP - 1399 EP - 1413 ER - TY - CHAP A1 - Xue, Rui A1 - Sun, Lu A1 - Bestle, Dieter A1 - Wang, Guoping A1 - Chen, Dongyang A1 - Rui, Xiaoting T1 - Vortex-induced Vibration Analysis of a composite Riser System Based on the Transfer Matrix Method T2 - 14th International Conference on Multibody Systems, Nonlinear Dynamics, and Control - Quebec City, Quebec, Canada, August 26–29, 2018 Y1 - 2018 SN - 978-0-7918-5183-8 PB - ASME CY - New York ER - TY - GEN A1 - Zhao, Dapeng A1 - Chen, Yu-kai A1 - Chang, Keke A1 - Ebel, Thomas A1 - Luthringer, Bérengère A1 - Willumeit-Römer, Regine A1 - Pyczak, Florian T1 - Surface topography and cytocompatibility of metal injection molded Ti–22Nb alloy as biomaterial T2 - Transactions of Nonferrous Metals Society of China Y1 - 2018 U6 - https://doi.org/10.1016/S1003-6326(18)64772-7 SN - 1003-6326 VL - 28 IS - 7 SP - 1342 EP - 1350 ER - TY - GEN A1 - Chen, Lin A1 - Klinkel, Sven A1 - Dornisch, Wolfgang T1 - Hybrid collocation-Galerkin approach for the analysis of surface represented 3D-solids employing SB-FEM T2 - Computer Methods in Applied Mechanics and Engineering N2 - This paper presents a numerical method to solve the three-dimensional elasticity problem of surface represented solids. A surface oriented formulation is derived, in which the three-dimensional solid is described by its boundary surfaces and a radial scaling center. Scaling the boundary surfaces with respect to the scaling center yields a parameterization of the complete solid. The definition of the boundary surfaces is sufficient for the description of the solid. Thus, the formulation conforms ideally to the boundary representation modeling technique used in CAD. In the present approach, no tensor-product structure of three-dimensional objects is exploited to parameterize the physical domain. The weak form of the equation of motion and the weak form of the Neumann boundary conditions are enforced only at the boundary surfaces. It leads to a transformation of the governing partial differential equations of elasticity to an ordinary differential equation (ODE) of Euler type. Solving the ODE leads to the displacement in the radial scaling direction. In the present approach, the isogeometric Galerkin finite element method is employed to describe the geometry of the boundary surfaces and also to approximate the displacement response of the boundary surfaces. It exploits two-dimensional NURBS objects to parameterize the boundary surfaces. The final Euler type ODE is solved by the NURBS based collocation method. The displacement response in the radial scaling direction is approximated by the NURBS basis functions. Hence, the method can be extended to nonlinear problems. The accuracy of the method is validated against analytical solutions. In general, the proposed formulation is able to model solids bounded by an arbitrary number of surfaces. KW - Surface represented solid KW - NURBS basis functions KW - Scaled boundary finite element method KW - Hybrid collocation-Galerkin method Y1 - 2015 U6 - https://doi.org/10.1016/j.cma.2015.07.004 SN - 0045-7825 VL - 295 SP - 268 EP - 289 ER - TY - GEN A1 - Klinkel, Sven A1 - Chen, Lin A1 - Dornisch, Wolfgang T1 - A NURBS based hybrid collocation-Galerkin method for the analysis of boundary represented solids T2 - Computer Methods in Applied Mechanics and Engineering N2 - The paper is concerned with a new numerical method, NURBS based hybrid collocation–Galerkin method (NURBS-HCGM), to solve the in-plane motion problem of elastic solids. It combines the merits of the so-called scaled boundary finite-element method (SB-FEM) and the isogeometric collocation method. For the analysis, the boundary scaling technique of SB-FEM is adopted. It leads to a formulation, where only the boundary of a structure is discretized. Here, the NURBS basis functions are employed for the description of the geometry of the boundary as well as for the approximation of the displacements at the boundary. This is in accordance with the boundary representation modeling technique, which is commonly employed in computer aided design software. The inner domain is described by a radial scaling parameter. Applying the weak form only in circumferential direction the governing partial differential equations of elasticity are transformed to an ordinary differential equation (ODE) of Euler type, where the unknown displacements are a function of the radial scaling parameter. In the present work a NURBS based collocation scheme is introduced to solve this equation. NURBS basis functions are suggested for the approximation of the displacements in scaling direction. The higher continuity provided by NURBS allows to use collocation to solve the ODE directly instead of using the weak form in scaling direction. The proposed approach is validated by comparison with the eigenvalue solution of the ODE. It is remarked that the eigenvalue solution is restricted to linear problems, whereas the proposed method could be extended to nonlinear problems. In general, the presented formulation will allow to model patches bounded by an arbitrary number of contour boundaries. The accuracy of the proposed approach is analyzed and estimated with respect to analytical solutions. The computational cost is investigated with the help of numerical examples and is compared to isogeometric Galerkin approach. KW - Collocation method KW - NURBS basis functions KW - Scaled boundary finite element method KW - Hybrid collocation–Galerkin method Y1 - 2015 U6 - https://doi.org/10.1016/j.cma.2014.10.029 SN - 0045-7825 VL - 284 SP - 689 EP - 711 ER - TY - GEN A1 - Hofman, Jakub A1 - Sorf, Ales A1 - Vagiannis, Dimitrios A1 - Sucha, Simona A1 - Kammerer, Sarah A1 - Küpper, Jan-Heiner A1 - Chen, Si A1 - Guo, Lei A1 - Ceckova, Martina A1 - Staud, Frantisek T1 - Brivanib Exhibits Potential for Pharmacokinetic Drug-Drug Interactions and the Modulation of Multidrug Resistance through the Inhibition of Human ABCG2 Drug Efflux Transporter and CYP450 Biotransformation Enzymes T2 - Molecular Pharmaceutics Y1 - 2019 U6 - https://doi.org/10.1021/acs.molpharmaceut.9b00361 VL - 16 IS - 11 SP - 4436 EP - 4450 ER - TY - GEN A1 - Segabinazzi Ferreira, Raphael A1 - George, Nevin A1 - Chen, Junchao A1 - Hübner, Michael A1 - Krstic, Milos A1 - Nolte, Jörg A1 - Vierhaus, Heinrich Theodor T1 - Configurable Fault Tolerant Circuits and System Level Integration for Self-Awareness T2 - Proceedings of the Work in Progress Session held in connection with SEAA 2019, the 45th EUROMICRO Conference on Software Engineering and Advanced Applications and DSD 2019, the 22nd EUROMICRO Conference on Digital System Design N2 - Scaling minimum features of ICs down to the 10nm- area and below has allowed high integration rates in electronics. Scaling at supply voltages of 1V and below also implies a rising level of stress which drives aging effects that reduce switching speed and the expected life time. Additionally, vulnerability from particle radiation is increased. Hence, fault detection and on- line correction become a must for many applications. However, not only fault tolerance but self-awareness becomes also an advantage. Provided that by being aware of its own healthy state allow optimized configurations regarding system operation modes and configurable hardware mechanism. This paper shows a preliminary work in a configurable circuit and explores its configuration possibilities when integrated into a complete system. Y1 - 2019 SN - 978-3-902457-54-7 U6 - https://doi.org/10.26127/BTUOpen-5050 PB - SEA-Publications CY - Kallithea, Chalkidiki (Greece) ER - TY - GEN A1 - Harlander, Uwe A1 - Le Gal, Patrice A1 - Borcia, Ion-Dan A1 - Le Dizès, Stéphane A1 - Chen, Jun A1 - Favier, Benjamin T1 - The linear instability of the stratified plane Poiseuille flow T2 - 17th European Turbulence Conference, ETC 2019, September 3 - 6, 2019, Torino, Italy Y1 - 2019 UR - http://www.symposium.it/files/eventi/84/etc-2019-561.pdf CY - Turin ER - TY - GEN A1 - Chao, Chen-Xiang A1 - Bestle, Dieter A1 - Krüger, David T1 - Tooth Root Shape Optimization of Thin-Rimmed Planet Gears T2 - Proceedings of ASME 2019 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, Volume 10: 2019 International Power Transmission and Gearing Conference N2 - Planetary gearboxes in highly sophisticated applications such as turbofan engines are required to have a high power-to-weight ratio and excellent reliability. Hence, thin-rimmed gear units need to be designed as compact as possible which, however, is usually limited by the tooth root load capacity. In order to come up with the best design, a tooth root shape optimization process is developed for thin-rimmed planet gears. Y1 - 2019 SN - 978-0-7918-5930-8 U6 - https://doi.org/10.1115/DETC2019-97345 ER - TY - GEN A1 - Chao, Chen-Xiang A1 - Bestle, Dieter A1 - Krüger, David T1 - Isight Process for Optimizing Tooth Roots in a High-Performance Gearbox T2 - 3DExperience Conference Germany 2019At: Darmstadt, Germany Y1 - 2019 UR - https://events.3ds.com/sites/default/Files/3dexperience-conference-chao-tu-cottbus-senftenberg.pdf UR - https://www.researchgate.net/publication/341152054_Isight_Process_for_Optimizing_Tooth_Roots_in_a_High-Performance_Gearbox CY - Darmstadt ER - TY - GEN A1 - Chao, Chen-Xiang A1 - Bestle, Dieter A1 - Krüger, David A1 - Meissner, Bernd T1 - Zahnfußtragfähigkeitsoptimierung von Stirnrädern für den Einsatz in Hochleistungsgetrieben mithilfe von Isight T2 - Tagungsband Simulia Anwenderkonferenz, DASSAULT SYSTÈMES User Conference, Hanau, 4.-6. Dezember 2018 Y1 - 2018 UR - https://www.3ds.com/events/dassault-systemes-user-conferences/dassault-systemes-user-conference-germany-2018/download-archive/ UR - https://www.3ds.com/fileadmin/EVENTS/3DS-Events-img/3DS_USER_CONFERENCE_GER_2019/DownloadArchive/2018-DSUC-Chao-UNI-Senftenberg.pdf CY - Hanau ER - TY - GEN A1 - Andjelkovic, Marko A1 - Veleski, Mitko A1 - Chen, Junchao A1 - Simevski, Aleksandar A1 - Krstic, Milos T1 - A Particle Detector Based on Pulse Stretching Inverter Chain T2 - 26th IEEE International Conference on Electronics, Circuits and Systems (ICECS 2019), Genova Y1 - 2019 SN - 978-1-7281-0996-1 SN - 978-1-7281-0997-8 U6 - https://doi.org/10.1109/ICECS46596.2019.8964644 ER - TY - GEN A1 - Chen, Boxiong A1 - Oevermann, Michael T1 - An Eulerian stochastic field cavitation model coupled to a pressure based solver T2 - Computer and Fluids N2 - Probability density functions (PDF) and the relevant methods have been widely used to describe non-linear phenomena in the realm of turbulence modelling and CFD. In order to solve PDF transport equations, the main trend of previous studies rely on Monte Carlo method with Lagrangian particle tracking. However, as with any Lagrangian based approach, the scalability of the parallelized simulations of such method is less than satisfactory. An Eulerian stochastic field model has been presented recently by Dumond et al. [1] to simulate cavitating flows. Their model uses a fully compressible density based solver. Here we present an adapted version using an iso-thermal cavitation model adopting the homogeneous mixture assumption in a pressure based flow solver which is more relevant to engine simulations. A PDF method is used to represent a distribution of vapour volume fractions, based on which the Eulerian stochastic field (ESF) method is applied to perform a three-dimensional large eddy simulation (LES) of the cavitation phenomena inside an academic fuel injector configuration. The numerical model is based on a volume of fluids approach and coupled with a pressure based solver for the flow field, and is implemented in the framework of the open source C++ toolbox OpenFOAM. The result of the ESF simulation is compared against that from a typical single volume fraction solver for validation. Vortex structures and its correspondence to cavitation are shown, and the behaviour of the PDF at different probe locations at different times are acquired to demonstrate the potential of the ESF model in capturing both transient and stochastically steady cavitation. KW - Multiphase flow KW - Cavitation KW - Volume of fluid KW - Eulerian stochastic field method Y1 - 2018 U6 - https://doi.org/10.1016/j.compfluid.2017.12.002 SN - 0045-7930 VL - 162 SP - 1 EP - 10 ER - TY - GEN A1 - Andjelkovic, Marko A1 - Chen, Junchao A1 - Simevski, Aleksandar A1 - Stamenkovic, Zoran A1 - Krstic, Milos A1 - Kraemer, Rolf T1 - A Review of Particle Detectors for Space-Borne Self-Adaptive Fault Tolerant Systems T2 - 18th IEEE East-West Design and Test Symposium (EWDTS 2020), Varna, Bulgaria, 04 - 07 September 2020 Y1 - 2020 SN - 978-1-7281-9899-6 SN - 978-1-7281-9898-9 SN - 978-1-7281-9900-9 U6 - https://doi.org/10.1109/EWDTS50664.2020.9225138 SN - 2472-761X PB - IEEE ER - TY - GEN A1 - Vagiannis, Dimitrios A1 - Novotna, Eva A1 - Skarka, Adam A1 - Kammerer, Sarah A1 - Küpper, Jan-Heiner A1 - Chen, Si A1 - Guo, Lei A1 - Staud, Frantisek A1 - Hofman, Jakub T1 - Ensartinib (X-396) Effectively Modulates Pharmacokinetic Resistance Mediated by ABCB1 and ABCG2 Drug Efflux Transporters and CYP3A4 Biotransformation Enzyme T2 - Cancers N2 - Ensartinib (X-396) is a promising tyrosine kinase inhibitor currently undergoing advanced clinical evaluation for the treatment of non-small cell lung cancer. In this work, we investigate possible interactions of this promising drug candidate with ATP-binding cassette (ABC) drug efflux transporters and cytochrome P450 biotransformation enzymes (CYPs), which play major roles in multidrug resistance (MDR) and pharmacokinetic drug-drug interactions (DDIs). Accumulation studies showed that ensartinib is a potent inhibitor of ABCB1 and ABCG2 transporters. Additionally, incubation experiments with recombinant CYPs showed that ensartinib significantly inhibits CYP3A4 and CYP2C9. Subsequent molecular docking studies confirmed these findings. Drug combination experiments demonstrated that ensartinib synergistically potentiates the antiproliferative effects of daunorubicin, mitoxantrone, and docetaxel in ABCB1, ABCG2, and CYP3A4-overexpressing cellular models, respectively. Advantageously, ensartinib’s antitumor efficiency was not compromised by the presence of MDR-associated ABC transporters, although it acted as a substrate of ABCB1 in Madin-Darby Canine Kidney II (MDCKII) monolayer transport assays. Finally, we demonstrated that ensartinib had no significant effect on the mRNA-level expression of examined transporters and enzymes in physiological and lung tumor cellular models. In conclusion, ensartinib may perpetrate clinically relevant pharmacokinetic DDIs and modulate ABCB1-, ABCG2-, and CYP3A4-mediated MDR. The in vitro findings presented here will provide a valuable foundation for future in vivo investigations. KW - ensartinib KW - cancer KW - multidrug resistance KW - drug-drug interaction KW - ABC transporter KW - cytochrome P450 Y1 - 2020 UR - https://www.mdpi.com/2072-6694/12/4/813 U6 - https://doi.org/10.3390/cancers12040813 SN - 2072-6694 VL - 12 IS - 4 ER - TY - GEN A1 - Le Gal, Patrice A1 - Harlander, Uwe A1 - Borcia, Ion-Dan A1 - Le Dizès, Stéphane A1 - Chen, J. A1 - Favier, Benjamin T1 - Instability of vertically stratified horizontal plane Poiseuille flow T2 - Journal of Fluid Mechanics Y1 - 2021 U6 - https://doi.org/10.1017/jfm.2020.917 SN - 1469-7645 SN - 0022-1120 VL - 907 IS - R1 SP - 1 EP - 14 ER - TY - GEN A1 - Liu, Fei A1 - Assaf, George A1 - Chen, Ming A1 - Heiner, Monika T1 - A Petri nets-based framework for whole-cell modeling T2 - Biosystems N2 - Whole-cell modeling aims to incorporate all main genes and processes, and their interactions of a cell in one model. Whole-cell modeling has been regarded as the central aim of systems biology but also as a grand challenge, which plays essential roles in current and future systems biology. In this paper, we analyze whole-cell modeling challenges and requirements and classify them into three aspects (or dimensions): heterogeneous biochemical networks, uncertainties in components, and representation of cell structure. We then explore how to use different Petri net classes to address different aspects of whole-cell modeling requirements. Based on these analyses, we present a Petri nets-based framework for whole-cell modeling, which not only addresses many whole-cell modeling requirements, but also offers a graphical, modular, and hierarchical modeling tool. We think this framework can offer a feasible modeling approach for whole-cell model construction. KW - Whole-cell modeling KW - Systems biology KW - Petri nets KW - Modeling framework Y1 - 2021 UR - https://www.sciencedirect.com/science/article/abs/pii/S0303264721001738?via%3Dihub U6 - https://doi.org/10.1016/j.biosystems.2021.104533 SN - 0303-2647 SN - 1872-8324 VL - 210 ER - TY - THES A1 - Chao, Chen-Xiang T1 - Strategies for Optimizing the Tooth Root Load Capacity of High-Performance Gears N2 - Abstract Strategies for Optimizing the Tooth Root Load Capacity of High-Performance Gears Keywords: planet gears, high-performance gearbox, tooth root load capacity, tooth root optimization, multi-objective optimization In order to achieve greater efficiency, many modern applications such as geared turbofans require high-performance gearboxes with excellent reliability and low weight. The tooth root load capacity often is a limiting design criterion driving minimum face widths and hence the weight of gears. Consequently, strategies for optimizing the tooth root load capacity of gears are explored in this thesis. Two methods for tooth root load capacity analysis – a maximum tensile stress method derived from ISO 6336 and a local fatigue approach taking into account mean stress infl – are introduced and ompared to each other with respect to their applicability to optimization problems. A study with 2D fi element models of unidirectionally loaded sun gears reveals that the local fatigue analysis method should be preferred over the common approach of minimizing the maximum tooth root stress, since applying both methods as optimization targets results in diff nt tooth root shapes and a vast overestimation of safety gains when only tensile stresses are considered. Due to alternating loading, planet gears usually have a lower tooth root load capacity than other gears. Additionally, they are often designed with thin rims making the gear body lighter but also more elastic. Therefore, the tooth root shape of a thin-rimmed planet gear is optimized to explore possible interactions. The results show that overly thin rims negatively affect the maximization of tooth root safety. Hence, it is necessary to conduct multi-objectiveoptimizations of planet gears, which maximize tooth root safety and minimize mass simultaneously by optimizing tooth root shape, rim geometry and face width. The efficacy of this approach is demonstrated for 3D gear simulation models of spur as well as double helical planet gears. Pareto-optimal designs show significant improvements compared to the baseline design. Moreover, investigations demonstrate the opportunity to vastly decrease the computational cost of multi-objective optimizations by scalarizing them and using the result to approximate parts of the Pareto front. KW - planet gears, high-performance gearbox, tooth root load capacity, tooth root optimization, multi-objective optimization Y1 - 2022 SN - 978-3-8440-8453-5 PB - Shaker CY - Düren ER - TY - PAT A1 - Chao, Chen-Xiang A1 - Krüger, David A1 - Flassig, Peter Michael A1 - Meissner, Bernd T1 - Verfahren zur Herstellung einer Verzahnung und Verzahnung Y1 - 2018 UR - https://patents.google.com/patent/DE102018108753A1/de?inventor=Chen-Xiang+Chao ER - TY - PAT A1 - Chao, Chen-Xiang A1 - Krüger, David A1 - Flassig, Peter Michael A1 - Meissner, Bernd T1 - Method for manufacturing a toothing and toothing Y1 - 2019 UR - https://patents.google.com/patent/DE102018108753A1/en?inventor=Chen-Xiang+Chao ER -