TY - GEN A1 - Ramaioli, Cecilia A1 - Colagiorgio, Paolo A1 - Sağlam, Murat A1 - Heuser, Fabian A1 - Schneider, Erich T1 - The effect of vestibulo-ocular reflex deficits and covert saccades on dynamic vision in opioid-induced vestibular T2 - PLoS One Y1 - 2014 U6 - https://doi.org/10.1371/journal.pone.0110322 SN - 1932-6203 VL - 9 IS - 10 SP - e110322 ER - TY - GEN A1 - Heuser, Fabian A1 - Schulz, Christian A1 - Sağlam, Murat A1 - Ramaioli, Cecilia A1 - Heuberger, Maria A1 - Wagner, Klaus J. A1 - Jahn, Klaus A1 - Schneider, Erich A1 - Brandt, Thomas A1 - Glasauer, Stefan A1 - Lehnen, Nadine T1 - Preventing opioid-induced nausea and vomiting: Rest your head and close your eyes? T2 - PloS one Y1 - 2017 U6 - https://doi.org/10.1371/journal.pone.0173925 SN - 1932-6203 VL - 12 IS - 3 SP - e0173925 ER - TY - GEN A1 - Lehnen, Nadine A1 - Ramaioli, Cecilia A1 - Henningsen, Peter A1 - Glasauer, Stefan T1 - An experimental litmus test of the emerging hypothesis that persistent physical symptoms can be explained as perceptual dysregulation T2 - Journal of Psychosomatic Research Y1 - 2018 U6 - https://doi.org/10.1016/j.jpsychores.2018.08.007 SN - 1879-1360 SN - 0022-3999 VL - 114 SP - 15 EP - 17 ER - TY - GEN A1 - Heuberger, Maria A1 - Grill, Eva A1 - Saglam, Murat A1 - Ramaioli, Cecilia A1 - Müller, Martin A1 - Strobl, Ralf A1 - Holle, Rolf A1 - Peters, Annette A1 - Schneider, Erich A1 - Lehnen, Nadine T1 - Usability of the Video Head Impulse Test: Lessons from the Population-Based Prospective KORA Study T2 - Frontiers in Neurology Y1 - 2018 U6 - https://doi.org/10.3389/fneur.2018.00659 SN - 1664-2295 VL - 9 ER - TY - GEN A1 - Lehnen, Nadine A1 - Kellerer, Silvy A1 - Knorr, Alexander G. A1 - Schlick, Cornelia A1 - Jahn, Klaus A1 - Schneider, Erich A1 - Heuberger, Maria A1 - Ramaioli, Cecilia T1 - Head-Movement-Emphasized Rehabilitation in Bilateral Vestibulopathy T2 - Frontiers in Neurology Y1 - 2018 U6 - https://doi.org/10.3389/fneur.2018.00562 SN - 1664-2295 VL - 9 ER - TY - GEN A1 - Lehnen, Nadine A1 - Schröder, Lena A1 - Henningsen, Peter A1 - Glasauer, Stefan A1 - Ramaioli, Cecilia T1 - Deficient head motor control in functional dizziness: Experimental evidence of central sensory-motor dysfunction in persistent physical symptoms T2 - Progress in Brain Research N2 - Understanding the mechanisms of symptoms that are insufficiently explained by organic dysfunction remains challenging. Recently, it has been proposed that such “functional symptoms” are based on erroneous sensory processing in the central nervous system (CNS), with internal expectations dominating sensory inputs. In a pilot study, we used a head motor control set-up to assess the interplay between sensory input and expectation on the example of patients with functional dizziness. Eight patients and 11 age-matched healthy controls performed large active eye-head gaze shifts towards visual targets in the natural situation and with the head moment of inertia 3.3-fold increased. The latter induces head oscillations and the expected sensory outcome of the movement, estimated in the CNS, does not match the actual sensory input. Head oscillations were assessed in patients and in healthy subjects and compared to prior results from patients with organic disease (vestibular loss and cerebellar ataxia). Head oscillations in patients with functional dizziness were different from those of healthy subjects (F(1,17) = 27.26, P < 0.001, partial η2 = 0.62), and similar to those of patients with cerebellar ataxia, and with vestibular loss (F(2,19) = 0.56, P = 0.58). Even in the natural, unweighted, condition, head oscillations were higher in functional dizziness patients than in healthy subjects (P = 0.001). Since an extensive work-up failed to demonstrate any explanatory peripheral vestibular, motor, or cerebellar organic dysfunction, these motor control deficits are a first indication of erroneous interplay between expectations and sensory input in the CNS that could account for persistent physical symptoms. Y1 - 2019 U6 - https://doi.org/10.1016/bs.pbr.2019.02.006 SN - 1875-7855 SN - 0079-6123 VL - 249 SP - 385 EP - 400 ER - TY - GEN A1 - Lehnen, Nadine A1 - Ramaioli, Cecilia A1 - Todd, Nicholas Sean A1 - Bartl, Klaus A1 - Kohlbecher, Stefan A1 - Jahn, Klaus A1 - Schneider, Erich T1 - Clinical and video head impulses: a simple bedside test in children T2 - Journal of Neurology KW - Head Velocity KW - Head Impulse KW - Head Impulse Testing KW - Rotational Chair KW - Vestibular Function Test Y1 - 2017 U6 - https://doi.org/10.1007/s00415-017-8450-y SN - 1432-1459 VL - 264 IS - 5 SP - 1002 EP - 1004 ER - TY - GEN A1 - Schröder, Lena A1 - Werder, Dina von A1 - Ramaioli, Cecilia A1 - Wachtler, Thomas A1 - Henningsen, Peter A1 - Glasauer, Stefan A1 - Lehnen, Nadine T1 - Unstable Gaze in Functional Dizziness: A Contribution to Understanding the Pathophysiology of Functional Disorders T2 - Frontiers in Neuroscience N2 - Objective: We are still lacking a pathophysiological mechanism for functional disorders explaining the emergence and manifestation of characteristic, severely impairing bodily symptoms like chest pain or dizziness. A recent hypothesis based on the predictive coding theory of brain function suggests that in functional disorders, internal expectations do not match the actual sensory body states, leading to perceptual dysregulation and symptom perception. To test this hypothesis, we investigated the account of internal expectations and sensory input on gaze stabilization, a physiologically relevant parameter of gaze shifts, in functional dizziness. Methods: We assessed gaze stabilization in eight functional dizziness patients and 11 healthy controls during two distinct epochs of large gaze shifts: during a counter- rotation epoch (CR epoch), where the brain can use internal models, motor planning, and resulting internal expectations to achieve internally driven gaze stabilization; and during an oscillation epoch (OSC epoch), where, due to terminated motor planning, no movement expectations are present, and gaze is stabilized by sensory input alone. Results: Gaze stabilization differed between functional patients and healthy controls only when internal movement expectations were involved [F(1,17) = 14.63, p = 0.001, and partial η2 = 0.463]: functional dizziness patients showed reduced gaze stabilization during the CR (p = 0.036) but not OSC epoch (p = 0.26). Conclusion: While sensory-driven gaze stabilization is intact, there are marked, well- measurable deficits in internally-driven gaze stabilization in functional dizziness pointing at internal expectations that do not match actual body states. This experimental evidence supports the perceptual dysregulation hypothesis of functional disorders and is an important step toward understanding the underlying pathophysiology. Y1 - 2021 U6 - https://doi.org/10.3389/fnins.2021.685590 SN - 1662-453X SN - 1662-4548 VL - 15 ER - TY - GEN A1 - Ramaioli, Cecilia A1 - Steinmetzer, Tobias A1 - Brietzke, Adrian A1 - Meyer, Paul A1 - Pham Xuan, Rebecca A1 - Schneider, Erich A1 - Gorges, Martin T1 - Assessment of vestibulo-ocular reflex and its adaptation during stop-and-go car rides in motion sickness susceptible passengers T2 - Experimental Brain Research N2 - Motion sickness is a physiological condition that negatively impacts a person's comfort and will be an emerging condition in autonomous vehicles without proper countermeasures. The vestibular system plays a key role in the origin of motion sickness. Understanding the susceptibility and (mal) adaptive mechanisms of the highly integrated vestibular system is a prerequisite for the development of countermeasures. We hypothesize a differential association between motion sickness and vestibular function in healthy individuals with and without susceptibility for motion sickness. We quantified vestibular function by measuring the high-frequency vestibulo-ocular reflex (VOR) using video head impulse testing (vHIT) in 17 healthy volunteers before and after a 11 min motion sickness-inducing naturalistic stop-and-go car ride on a test track (Dekra Test Oval, Klettwitz, Germany). The cohort was classified as motion sickness susceptible (n = 11) and non-susceptible (n = 6). Six (out of 11) susceptible participants developed nausea symptoms, while a total of nine participants were free of these symptoms. The VOR gain (1) did not differ significantly between participant groups with (n = 8) and without motion sickness symptoms (n = 9), (2) did not differ significantly in the factor time before and after the car ride, and showed no interaction between symptom groups and time, as indicated by a repeated measures ANOVA (F(1,15) = 2.19, p = 0.16. Bayesian inference confirmed that there was “anecdotal evidence” for equality of gain rather than difference across groups and time (BF10 < 0.77). Our results suggest that individual differences in VOR measures or adaptation to motion sickness provocative stimuli during naturalistic stop-and-go driving cannot predict motion sickness susceptibility or the likelihood of developing motion sickness. KW - Video head impulse test KW - Vestibulo-ocular reflex KW - Adaptation KW - Motion sickness KW - Stop-and-go car ride Y1 - 2023 U6 - https://doi.org/10.1007/s00221-023-06619-4 SN - 1432-1106 SN - 0014-4819 VL - 241 IS - 6 SP - 1523 EP - 1531 ER -