TY - GEN A1 - Avitabile, Daniele A1 - Salchert, Katrin A1 - Werner, Carsten A1 - Capogrossi, Maurizio C. A1 - Pesce, Maurizio T1 - Growth induction and low-oxygen apoptosis inhibition of human CD34+ progenitors in collagen gels T2 - BioMed Research International N2 - Various reports have indicated low survival of injected progenitors into unfavorable environments such as the ischemic myocardium or lower limb tissues. This represents a major bottleneck in stem-cell-based cardiovascular regenerative medicine. Strategies to enhance survival of these cells in recipient tissues have been therefore sought to improve stem cell survival and ensure long-term engraftment. In the present contribution, we show that embedding human cord blood-derived CD34(+) cells into a collagen I-based hydrogel containing cytokines is a suitable strategy to promote stem cell proliferation and protect these cells from anoxia-induced apoptosis. Y1 - 2013 U6 - https://doi.org/10.1155/2013/542810 SN - 2314-6133 SN - 2314-6141 SP - 542810 ER -