TY - GEN A1 - Morrison, Miranda A1 - Kerkeni, Hassen A1 - Korda, Athanasia A1 - Räss, Simone A1 - Caversaccio, Marco Domenico A1 - Abegg, Mathias A1 - Schneider, Erich A1 - Mantokoudis, Georgios T1 - Automated alternate cover test for 'HINTS' assessment: a validation study T2 - European archives of oto-rhino-laryngology and head & neck N2 - Objective The alternate cover test (ACT) in patients with acute vestibular syndrome is part of the ‘HINTS’ battery test. Although quantitative, the ACT is highly dependent on the examiner’s experience and could theoretically vary greatly between examiners. In this study, we sought to validate an automated video-oculography (VOG) system based on eye tracking and dedicated glasses. Methods We artificially induced a vertical strabismus to simulate a skew deviation on ten healthy subjects, aged from 26 to 66, using different press-on Fresnel prisms on one eye while recording eye position with VOG of the contralateral eye. We then compared the system’s performance to that of a blinded trained orthoptist using conventional, semi-quantitative method of skew measurement known as the alternate prism cover test (APCT) as a gold standard. Results We found a significant correlation between the reference APCT and the Skew VOG (Pearson’s R2 = 0.606, p < 0.05). There was a good agreement between the two tests (intraclass correlation coefficient 0.852, 95 CI 0.728–0.917, p < 0.001). The overall accuracy of the VOG was estimated at 80.53% with an error rate of 19.46%. There was no significant difference in VOG skew estimations compared with the gold standard except for very small skews. Conclusions VOG offers an objective and quantitative skew measurement and proved to be accurate in measuring vertical eye misalignment compared to the ACT with prisms. Precision was moderate, which mandates a sufficient number of tests per subject. KW - Skew deviation KW - Validation KW - Test of skew KW - Alternate cover test KW - Video-oculography Y1 - 2022 U6 - https://doi.org/10.1007/s00405-021-06998-w SN - 1434-4726 SP - 2873 EP - 2879 ER -