TY - GEN A1 - Kordi, N A1 - Saydi, A A1 - Azimi, M A1 - Mazdarani, F A1 - Gadruni, K A1 - Jung, F A1 - Karami, S T1 - Cuproptosis and physical training T2 - Clinical Hemorheology and Microcirculation N2 - Copper is an essential element in the human body, involved in many physiological and metabolic functions, including coagulation, oxidative metabolism, and hormone production. The maintenance of copper homeostasis within cells is a complex procedure that is intrinsically controlled by a multitude of intricate mechanisms. Disorders of copper homeostasis encompass a wide range of pathological conditions, including degenerative neurological diseases, metabolic disorders, cardio-cerebrovascular diseases, and tumors. Cuproptosis, a recently identified non-apoptotic mode of cell death mode, is characterized by copper dependence and the regulation of mitochondrial respiration. Cuproptosis represents a novel form of cell death distinct from the previously described modes, including apoptosis, necrosis, pyroptosis, and ferroptosis. Excess copper has been shown to induce cuproptosis by stimulating protein toxic stress responses via copper-dependent abnormal oligomerization of lipoylation proteins within the tricarboxyli KW - Copper KW - Exercise KW - Cell death KW - Physical activity KW - Cuproptosis Y1 - 2024 UR - https://journals.sagepub.com/doi/epub/10.3233/CH-242329 U6 - https://doi.org/10.3233/CH-242329 VL - 88 (2024) IS - 3 SP - 337 EP - 350 ER -