<?xml version="1.0" encoding="utf-8"?>
<export-example>
  <doc>
    <id>18716</id>
    <completedYear/>
    <publishedYear>2011</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>320</pageFirst>
    <pageLast>325</pageLast>
    <pageNumber/>
    <edition/>
    <issue>2</issue>
    <volume>32</volume>
    <type>articler</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2017-02-20</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Comparison of 10-mg doses of 4-aminopyridine and 3,4-diaminopyridine for the treatment of downbeat nystagmus</title>
    <parentTitle language="eng">Journal of neuro-ophthalmology</parentTitle>
    <identifier type="doi">10.1097/WNO.0b013e3182258086</identifier>
    <identifier type="issn">1536-5166</identifier>
    <identifier type="issn">1070-8022</identifier>
    <enrichment key="BTU">nicht an der BTU erstellt / not created at BTU</enrichment>
    <author>
      <firstName>Roger</firstName>
      <lastName>Kalla</lastName>
    </author>
    <submitter>
      <firstName>Erich</firstName>
      <lastName>Schneider</lastName>
    </submitter>
    <author>
      <firstName>Rainer</firstName>
      <lastName>Spiegel</lastName>
    </author>
    <author>
      <firstName>Jens</firstName>
      <lastName>Claassen</lastName>
    </author>
    <author>
      <firstName>Stanislav</firstName>
      <lastName>Bardins</lastName>
    </author>
    <author>
      <firstName>Ales</firstName>
      <lastName>Hahn</lastName>
    </author>
    <author>
      <firstName>Erich</firstName>
      <lastName>Schneider</lastName>
    </author>
    <author>
      <firstName>Nicole</firstName>
      <lastName>Lehrer</lastName>
    </author>
    <author>
      <firstName>Stefan</firstName>
      <lastName>Glasauer</lastName>
    </author>
    <author>
      <firstName>Thomas</firstName>
      <lastName>Brandt</lastName>
    </author>
    <author>
      <firstName>Michael</firstName>
      <lastName>Strupp</lastName>
    </author>
    <collection role="institutes" number="1402">FG Medizinische Informationssysteme</collection>
  </doc>
  <doc>
    <id>18704</id>
    <completedYear/>
    <publishedYear>2012</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>190</pageFirst>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue>2</issue>
    <volume>32</volume>
    <type>articler</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2017-02-20</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Aminopyridine treatment in a patient with bilateral vestibular failure and cryptogenic downbeat nystagmus</title>
    <parentTitle language="eng">Journal of Neuro-Ophthalmology</parentTitle>
    <identifier type="issn">1536-5166</identifier>
    <identifier type="issn">1070-8022</identifier>
    <enrichment key="BTU">nicht an der BTU erstellt / not created at BTU</enrichment>
    <author>
      <firstName>Rainer</firstName>
      <lastName>Spiegel</lastName>
    </author>
    <submitter>
      <firstName>Erich</firstName>
      <lastName>Schneider</lastName>
    </submitter>
    <author>
      <firstName>Roger</firstName>
      <lastName>Kalla</lastName>
    </author>
    <author>
      <firstName>Jens</firstName>
      <lastName>Claassen</lastName>
    </author>
    <author>
      <firstName>Stanislav</firstName>
      <lastName>Bardins</lastName>
    </author>
    <author>
      <firstName>Fábio</firstName>
      <lastName>Anciães da Silva</lastName>
    </author>
    <author>
      <firstName>Parvis</firstName>
      <lastName>Farahmand</lastName>
    </author>
    <author>
      <firstName>Ales</firstName>
      <lastName>Hahn</lastName>
    </author>
    <author>
      <firstName>Erich</firstName>
      <lastName>Schneider</lastName>
    </author>
    <collection role="institutes" number="1402">FG Medizinische Informationssysteme</collection>
  </doc>
  <doc>
    <id>18686</id>
    <completedYear/>
    <publishedYear>2013</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>1152</pageFirst>
    <pageLast>1158</pageLast>
    <pageNumber/>
    <edition/>
    <issue>13</issue>
    <volume>81</volume>
    <type>articler</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2017-02-17</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Effect of chlorzoxazone in patients with downbeat nystagmus: a pilot trial</title>
    <parentTitle language="eng">Neurology</parentTitle>
    <identifier type="doi">10.1212/WNL.0b013e3182a55f6d</identifier>
    <identifier type="issn">0028-3878</identifier>
    <identifier type="issn">1526-632X</identifier>
    <enrichment key="BTU">nicht an der BTU erstellt / not created at BTU</enrichment>
    <author>
      <firstName>Katharina</firstName>
      <lastName>Feil</lastName>
    </author>
    <submitter>
      <firstName>Erich</firstName>
      <lastName>Schneider</lastName>
    </submitter>
    <author>
      <firstName>Jens</firstName>
      <lastName>Claassen</lastName>
    </author>
    <author>
      <firstName>Stanislavs</firstName>
      <lastName>Brandins</lastName>
    </author>
    <author>
      <firstName>Julian</firstName>
      <lastName>Teufel</lastName>
    </author>
    <author>
      <firstName>Siegbert</firstName>
      <lastName>Krafczyk</lastName>
    </author>
    <author>
      <firstName>Erich</firstName>
      <lastName>Schneider</lastName>
    </author>
    <collection role="institutes" number="1402">FG Medizinische Informationssysteme</collection>
  </doc>
  <doc>
    <id>18687</id>
    <completedYear/>
    <publishedYear>2013</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>1392</pageFirst>
    <pageLast>1399</pageLast>
    <pageNumber/>
    <edition/>
    <issue>12</issue>
    <volume>84</volume>
    <type>articler</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2017-02-17</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">A randomised double-blind, cross-over trial of 4-aminopyridine for downbeat nystagmus–effects on slowphase eye velocity, postural stability, locomotion and symptoms</title>
    <parentTitle language="eng">Journal of neurology, neurosurgery, and psychiatry</parentTitle>
    <identifier type="doi">10.1136/jnnp-2012-304736</identifier>
    <identifier type="issn">0022-3050</identifier>
    <identifier type="issn">1468-330X</identifier>
    <enrichment key="BTU">nicht an der BTU erstellt / not created at BTU</enrichment>
    <author>
      <firstName>Jens</firstName>
      <lastName>Claassen</lastName>
    </author>
    <submitter>
      <firstName>Erich</firstName>
      <lastName>Schneider</lastName>
    </submitter>
    <author>
      <firstName>Rainer</firstName>
      <lastName>Spiegel</lastName>
    </author>
    <author>
      <firstName>Roger</firstName>
      <lastName>Kalla</lastName>
    </author>
    <author>
      <firstName>Mary</firstName>
      <lastName>Faldon</lastName>
    </author>
    <author>
      <firstName>Christopher</firstName>
      <lastName>Kennard</lastName>
    </author>
    <author>
      <firstName>Erich</firstName>
      <lastName>Schneider</lastName>
    </author>
    <collection role="institutes" number="1402">FG Medizinische Informationssysteme</collection>
  </doc>
  <doc>
    <id>18688</id>
    <completedYear/>
    <publishedYear>2013</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>1992</pageFirst>
    <pageLast>1996</pageLast>
    <pageNumber/>
    <edition/>
    <issue>8</issue>
    <volume>260</volume>
    <type>articler</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2017-02-17</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Dalfampridine in patients with downbeat nystagmus–an observational study</title>
    <parentTitle language="eng">Journal of Neurology</parentTitle>
    <identifier type="doi">10.1007/s00415-013-6911-5</identifier>
    <identifier type="issn">0340-5354</identifier>
    <identifier type="issn">1432-1459</identifier>
    <enrichment key="BTU">nicht an der BTU erstellt / not created at BTU</enrichment>
    <author>
      <firstName>Jens</firstName>
      <lastName>Claassen</lastName>
    </author>
    <submitter>
      <firstName>Erich</firstName>
      <lastName>Schneider</lastName>
    </submitter>
    <author>
      <firstName>Katharina</firstName>
      <lastName>Feil</lastName>
    </author>
    <author>
      <firstName>Stanislav</firstName>
      <lastName>Bardins</lastName>
    </author>
    <author>
      <firstName>Julian</firstName>
      <lastName>Teufel</lastName>
    </author>
    <author>
      <firstName>Rainer</firstName>
      <lastName>Spiegel</lastName>
    </author>
    <author>
      <firstName>Roger</firstName>
      <lastName>Kalla</lastName>
    </author>
    <author>
      <firstName>Erich</firstName>
      <lastName>Schneider</lastName>
    </author>
    <collection role="institutes" number="1402">FG Medizinische Informationssysteme</collection>
  </doc>
  <doc>
    <id>31126</id>
    <completedYear/>
    <publishedYear>2016</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>66</pageFirst>
    <pageLast>73</pageLast>
    <pageNumber/>
    <edition/>
    <issue>1</issue>
    <volume>1375</volume>
    <type>articler</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2023-06-27</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Resting in darkness improves downbeat nystagmus: evidence from an observational study</title>
    <abstract language="eng">Resting in an upright position during daytime decreases downbeat nystagmus (DBN). When measured in brightness only, that is, without intermitting exposure to darkness, it does not make a significant difference whether patients have previously rested in brightness or in darkness. In real-world scenarios, people are often exposed to brightness and darkness intermittently. The aim of this study was to analyze whether resting in brightness or resting in darkness was associated with a lower post-resting DBN after intermitting exposures to brightness and darkness. Eight patients were recorded with three-dimensional video-oculography in brightness and darkness conditions, each following two 2-h resting intervals under either brightness or darkness resting conditions. The dependent variable was DBN intensity, measured in mean slow phase velocity. A repeated measures ANOVA with the factors measurement condition (brightness vs. darkness), resting condition (brightness vs. darkness), and time (after first vs. second resting interval) showed a significant effect for the factor resting condition, where previous resting in darkness was associated with a significantly lower DBN relative to previous resting in brightness (P &lt; 0.01). The clinical relevance is to advise patients with DBN to rest in darkness.</abstract>
    <parentTitle language="eng">Annals of the New York Academy of Sciences</parentTitle>
    <identifier type="doi">10.1111/nyas.13172</identifier>
    <identifier type="issn">1749-6632</identifier>
    <identifier type="issn">0077-8923</identifier>
    <enrichment key="BTU">an der BTU erstellt / created at BTU</enrichment>
    <enrichment key="Publikationsweg">Open Access</enrichment>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">false</enrichment>
    <submitter>
      <firstName>Anja</firstName>
      <lastName>Standfuß</lastName>
    </submitter>
    <author>
      <firstName>Rainer</firstName>
      <lastName>Spiegel</lastName>
    </author>
    <author>
      <firstName>Jens</firstName>
      <lastName>Claassen</lastName>
    </author>
    <author>
      <firstName>Julian</firstName>
      <lastName>Teufel</lastName>
    </author>
    <author>
      <firstName>Stanislav</firstName>
      <lastName>Bardins</lastName>
    </author>
    <author>
      <firstName>Erich</firstName>
      <lastName>Schneider</lastName>
    </author>
    <author>
      <firstName>Nicole</firstName>
      <lastName>Lehrer</lastName>
    </author>
    <author>
      <firstName>Klaus</firstName>
      <lastName>Jahn</lastName>
    </author>
    <author>
      <firstName>Fábio</firstName>
      <lastName>Anciaes da Silva</lastName>
    </author>
    <author>
      <firstName>Ales</firstName>
      <lastName>Hahn</lastName>
    </author>
    <author>
      <firstName>Parvis</firstName>
      <lastName>Farahmand</lastName>
    </author>
    <author>
      <firstName>Thomas</firstName>
      <lastName>Brandt</lastName>
    </author>
    <author>
      <firstName>Michael</firstName>
      <lastName>Strupp</lastName>
    </author>
    <author>
      <firstName>Roger</firstName>
      <lastName>Kalla</lastName>
    </author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>downbeat nystagmus</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>symptom relief</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>resting</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>oscillopsia</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>video-oculographic measurement (VOG)</value>
    </subject>
    <collection role="institutes" number="1400">Institut für Medizintechnologie</collection>
  </doc>
  <doc>
    <id>31078</id>
    <completedYear/>
    <publishedYear>2022</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>2518</pageFirst>
    <pageLast>2530</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume>270</volume>
    <type>articler</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2023-06-20</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Smartphone video nystagmography using convolutional neural networks: ConVNG</title>
    <abstract language="eng">Eye movement abnormalities are commonplace in neurological disorders. However, unaided eye movement assessments lack granularity. Although videooculography (VOG) improves diagnostic accuracy, resource intensiveness precludes its broad use. To bridge this care gap, we here validate a framework for smartphone video-based nystagmography capitalizing on recent computer vision advances.&#13;
Methods&#13;
&#13;
A convolutional neural network was fine-tuned for pupil tracking using &gt; 550 annotated frames: ConVNG. In a cross-sectional approach, slow-phase velocity of optokinetic nystagmus was calculated in 10 subjects using ConVNG and VOG. Equivalence of accuracy and precision was assessed using the “two one-sample t-test” (TOST) and Bayesian interval-null approaches. ConVNG was systematically compared to OpenFace and MediaPipe as computer vision (CV) benchmarks for gaze estimation.&#13;
Results&#13;
&#13;
ConVNG tracking accuracy reached 9–15% of an average pupil diameter. In a fully independent clinical video dataset, ConVNG robustly detected pupil keypoints (median prediction confidence 0.85). SPV measurement accuracy was equivalent to VOG (TOST p &lt; 0.017; Bayes factors (BF) &gt; 24). ConVNG, but not MediaPipe, achieved equivalence to VOG in all SPV calculations. Median precision was 0.30°/s for ConVNG, 0.7°/s for MediaPipe and 0.12°/s for VOG. ConVNG precision was significantly higher than MediaPipe in vertical planes, but both algorithms’ precision was inferior to VOG.&#13;
Conclusions&#13;
&#13;
ConVNG enables offline smartphone video nystagmography with an accuracy comparable to VOG and significantly higher precision than MediaPipe, a benchmark computer vision application for gaze estimation. This serves as a blueprint for highly accessible tools with potential to accelerate progress toward precise and personalized Medicine.</abstract>
    <parentTitle language="eng">Journal of Neurology</parentTitle>
    <identifier type="doi">10.1007/s00415-022-11493-1</identifier>
    <identifier type="issn">1432-1459</identifier>
    <enrichment key="BTU">an der BTU erstellt / created at BTU</enrichment>
    <enrichment key="Publikationsweg">Open Access</enrichment>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="Fprofil">2 Gesundheit und Lifes Sciences / Health and Life Sciences</enrichment>
    <submitter>
      <firstName>Anja</firstName>
      <lastName>Standfuß</lastName>
    </submitter>
    <author>
      <firstName>Maximilian U.</firstName>
      <lastName>Friedrich</lastName>
    </author>
    <author>
      <firstName>Erich</firstName>
      <lastName>Schneider</lastName>
    </author>
    <author>
      <firstName>Miriam</firstName>
      <lastName>Buerklein</lastName>
    </author>
    <author>
      <firstName>Johannes</firstName>
      <lastName>Taeger</lastName>
    </author>
    <author>
      <firstName>Johannes</firstName>
      <lastName>Hartig</lastName>
    </author>
    <author>
      <firstName>Jens</firstName>
      <lastName>Volkmann</lastName>
    </author>
    <author>
      <firstName>Robert</firstName>
      <lastName>Peach</lastName>
    </author>
    <author>
      <firstName>Daniel</firstName>
      <lastName>Zeller</lastName>
    </author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Digital medicine</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Nystagmus</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Eye movement disorders</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Videooculography</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Computer vision</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Telemedicine</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Precision medicine</value>
    </subject>
    <collection role="institutes" number="1400">Institut für Medizintechnologie</collection>
  </doc>
</export-example>
