<?xml version="1.0" encoding="utf-8"?>
<export-example>
  <doc>
    <id>25890</id>
    <completedYear/>
    <publishedYear>2019</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>759</pageFirst>
    <pageLast>768</pageLast>
    <pageNumber/>
    <edition/>
    <issue>9</issue>
    <volume>139</volume>
    <type>articlenr</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Gentamicin vestibulotoxicity with modern systemic dosing regimens : a prospective study using videooculography</title>
    <abstract language="eng">Objectives: To determine the incidence of gentamicin vestibulotoxicity with current dosing regimens, and to evaluate the feasibility of routine video-oculography on all patients given gentamicin. Materials and methods: In this prospective incidence study serial horizontal vestibulo-ocular reflex (HVOR) gain measurements were recorded using video-oculography on adult inpatients receiving intravenous gentamicin. The primary outcome was the proportion of patients developing impairment of their HVOR gain. Results: After exclusions, 42 patients were included in the analysis. Three patients (7.1%) developed asymptomatic vestibulotoxicity, exact 95% confidence interval 1.5-19.5%. In two of these patients the deficit resolved within several hours. No patients developed symptomatic vestibulotoxicity. There was no evidence for a generalised reduction in group HVOR gain with time. HVOR gain was not associated with total gentamicin dose, dynamic visual acuity or subjective imbalance. Conclusions and significance: Gentamicin may cause reversible, asymptomatic vestibulotoxicity. Video-oculography may be useful to monitor for vestibulotoxicity in patients treated with gentamcin; however, testing all patients routinely may be challenging.</abstract>
    <parentTitle language="eng">Acta Oto-Laryngologica</parentTitle>
    <identifier type="doi">10.1080/00016489.2019.1637935</identifier>
    <enrichment key="BTU">an der BTU erstellt / created at BTU</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">false</enrichment>
    <author>
      <firstName>Duncan</firstName>
      <lastName>Smyth</lastName>
    </author>
    <submitter>
      <firstName>Cortina</firstName>
      <lastName>Geike</lastName>
    </submitter>
    <author>
      <firstName>Stuart</firstName>
      <lastName>Mossman</lastName>
    </author>
    <author>
      <firstName>Mark</firstName>
      <lastName>Weatherall</lastName>
    </author>
    <author>
      <firstName>Evan</firstName>
      <lastName>Jolliffe</lastName>
    </author>
    <author>
      <firstName>Purwa</firstName>
      <lastName>Joshi</lastName>
    </author>
    <author>
      <firstName>Jennifer</firstName>
      <lastName>Taylor</lastName>
    </author>
    <author>
      <firstName>Katie</firstName>
      <lastName>Thorne</lastName>
    </author>
    <author>
      <firstName>Eloise</firstName>
      <lastName>Watson</lastName>
    </author>
    <author>
      <firstName>Ruth</firstName>
      <lastName>Leadbetter</lastName>
    </author>
    <author>
      <firstName>Benjamin</firstName>
      <lastName>Mossman</lastName>
    </author>
    <author>
      <firstName>Tawhai</firstName>
      <lastName>Moss</lastName>
    </author>
    <author>
      <firstName>Nicholas Sean</firstName>
      <lastName>Todd</lastName>
    </author>
    <author>
      <firstName>Erich</firstName>
      <lastName>Schneider</lastName>
    </author>
    <collection role="institutes" number="1400">Institut für Medizintechnologie</collection>
  </doc>
</export-example>
