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  <doc>
    <id>32270</id>
    <completedYear/>
    <publishedYear>2023</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>181</pageFirst>
    <pageLast>193</pageLast>
    <pageNumber/>
    <edition/>
    <issue>2</issue>
    <volume>83</volume>
    <type>articler</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2024-01-04</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Current aspects of multimodal ultrasound liver diagnostics using contrast-enhanced ultrasonography (CEUS), fat evaluation, fibrosis assessment, and perfusion analysis – An update</title>
    <abstract language="eng">Current ultrasound multifrequency probes allow both improved detail resolution and depth of penetration when examining the liver. Also, new developments in vascular diagnostics, elastography with fibrosis assessment, evaluation of possible steatosis, and parametric and time intensity curve (TIC) analysis of dynamic microvascularization of the liver with contrast-enhanced ultrasound sonography (CEUS) complement ultrasound-guided diagnostics. State-of-the-art high-resolution technology includes a high frame rate (HiFR) mode for CEUS, fast shear wave measurements with the sound touch quantify (STQ) mode, artifact-free flow detection using HR flow and glazing flow in combination with a special flow-adapted imaging (Ultra Micro Angiography, UMA) and additionally different assessments of possible fatty liver (UltraSound ATtenuation Imaging Technology, USAT). In 50 cases with focal liver lesions, a multimodal liver diagnosis was performed with a still new high-performance ultrasound system as part of the clarification of questions from the university liver consultation and tumor outpatient clinic.</abstract>
    <parentTitle language="eng">Clinical Hemorheology and Microcirculation</parentTitle>
    <identifier type="url">https://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch239100</identifier>
    <identifier type="doi">10.3233/CH-239100</identifier>
    <identifier type="issn">1386-0291</identifier>
    <enrichment key="BTU">an der BTU erstellt / created at BTU</enrichment>
    <enrichment key="Publikationsweg">Open Access</enrichment>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="Fprofil">2 Gesundheit und Lifes Sciences / Health and Life Sciences</enrichment>
    <enrichment key="Fprofil">3 Globaler Wandel und Transformationsprozesse / Global Change and Transformation Processes</enrichment>
    <author>
      <firstName>Ernst Michael</firstName>
      <lastName>Jung</lastName>
    </author>
    <submitter>
      <firstName>Christian</firstName>
      <lastName>Schulz</lastName>
    </submitter>
    <author>
      <firstName>Yi</firstName>
      <lastName>Dong</lastName>
    </author>
    <author>
      <firstName>Friedrich</firstName>
      <lastName>Jung</lastName>
    </author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Contrast enhanced ultrasonography (CEUS)</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>fibrosis</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>perfusion analysis</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>liver cancer</value>
    </subject>
    <collection role="institutes" number="2110">FG Molekulare Zellbiologie</collection>
  </doc>
  <doc>
    <id>32273</id>
    <completedYear/>
    <publishedYear>2023</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>227</pageFirst>
    <pageLast>236</pageLast>
    <pageNumber/>
    <edition/>
    <issue>2</issue>
    <volume>84</volume>
    <type>articler</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2024-01-04</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Advanced multimodal imaging of solid thyroid lesions with artificial intelligence-optimized B-mode, elastography, and contrast-enhanced ultrasonography parametric and with perfusion imaging: Initial results</title>
    <abstract language="eng">Goal of the study was the assessment of AI-assisted diagnosis of solid thyroid foci with multimodal modern ultrasound imaging. 50 patients (26–81 years, 54.7±13.1 years) were included in the study. Multimodal ultrasound imaging by means of B-mode with linear probe (4–12 MHz) with option of automated documentation of findings by means of AI, with supplementary Ultra MicroAngiography (UMA) was used. Macrovascularisation was assessed by dynamic contrast ultrasonography (CEUS) with parametric evaluation and perfusion analysis, and microvascularization was assessed by combined strain and shear wave elastography on a novel high-performance ultrasound system (Resona R9/Mindray) by an experienced examiner with independent reading. The evaluation was performed according to TI-RADS III-V.&#13;
&#13;
The volume of the thyroid lobes on both sides averaged 39 ml±5 ml (27 to 69 ml). The 13 cases of histologically confirmed thyroid carcinomas (8 papillary, 2 medullary, 2 microfollicular, 1 anaplastic CA) with a mean size of 15 mm±6 mm (9–21 mm) were correctly evaluated by TI-RADS V on the basis of irregular shape, induration &gt; 2.5 m/s or &gt; 30kPA and striking wash-out kinetics. Tumor lymph nodes could only be correctly detected preoperatively in one case of medullary carcinoma according to the surgical findings, based on irregular vascularization with UMA in roundish shape with cortex &gt; 4 mm, transverse diameter up to 11 mm. In 25 cases of inhomogeneous nodular goiter an evaluation with TI-RADS III was performed in 31 cases, in 4 cases with incomplete marginal contour, partial marginal vascularization with UMA and partial wash out with indurations up to 2.5 m/s 30 kPA an evaluation with TI-RADS IV and surgical excision for nodular goiter. In 12 cases regressive nodular changes without relevant malignancy criteria resulted in nodular goiter, with focal changes up to 1.5 cm in diameter, classified as requiring control with TI-RADS III. There were no relevant changes in findings in the controls after 6 months. From the AI tool, the 20/25 goiter nodes were assessed as TI-RADS III, 7/12 adenomas, 5 goiter nodes, and 5 adenomas as TI-RADS IV, 5/13 carcinomas as TI-RADS IV, and 8/13 carcinomas as TI-RADS V.&#13;
&#13;
Multimodal ultrasound diagnostics supported by AI has a high diagnostic potential for the evaluation of solid thyroid lesions and standardizes the reporting with digital representative image documentation. CEUS perfusion and modern elastography techniques allow targeted follow-up of TI-RADS III findings.</abstract>
    <parentTitle language="eng">Clinical Hemorheology and Microcirculation</parentTitle>
    <identifier type="url">https://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch239102</identifier>
    <identifier type="doi">10.3233/CH-239102</identifier>
    <identifier type="issn">1386-0291</identifier>
    <enrichment key="BTU">an der BTU erstellt / created at BTU</enrichment>
    <enrichment key="Publikationsweg">Open Access</enrichment>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">false</enrichment>
    <enrichment key="Fprofil">2 Gesundheit und Lifes Sciences / Health and Life Sciences</enrichment>
    <enrichment key="Fprofil">3 Globaler Wandel und Transformationsprozesse / Global Change and Transformation Processes</enrichment>
    <author>
      <firstName>Ernst Michael</firstName>
      <lastName>Jung</lastName>
    </author>
    <submitter>
      <firstName>Christian</firstName>
      <lastName>Schulz</lastName>
    </submitter>
    <author>
      <firstName>Christian</firstName>
      <lastName>Stroszczynski</lastName>
    </author>
    <author>
      <firstName>Friedrich</firstName>
      <lastName>Jung</lastName>
    </author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Thyroid lesions</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>multimodal ultrasound</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>artificial intelligence (AI)</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>UMA-elastography</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>contrast enhanced ultrasonography (CEUS)</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>parametric-perfusion analysis</value>
    </subject>
    <collection role="institutes" number="2110">FG Molekulare Zellbiologie</collection>
  </doc>
  <doc>
    <id>32274</id>
    <completedYear/>
    <publishedYear>2024</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>89</pageFirst>
    <pageLast>97</pageLast>
    <pageNumber/>
    <edition/>
    <issue>1-2</issue>
    <volume>86</volume>
    <type>articler</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2024-01-04</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Initial description of the novel handheld wireless ultrasound device TE Air with Doppler and Color Duplex imaging</title>
    <abstract language="eng">OBJECTIVE:&#13;
To test and initially describe a new handheld wireless ultrasound technique (TE Air) for clinical use.&#13;
&#13;
METHODS:&#13;
In this pilot study, the new ultrasound device TE Air from Mindray was used to examine the hepatic and renal vessels of healthy volunteers for first impressions. The probe has a sector transducer with a frequency range of 1.8–4.5 MHz. The B-mode and color-coded doppler sonography (CCDS) scanning methods were used. A high-end device from the same company (Resona 9, Mindray) was used as a reference. The results were evaluated using an image rating scale ranging from 0 to 5, with 0 indicating not assessable and 5 indicating without limitations.&#13;
&#13;
RESULTS:&#13;
Altogether, 61 participants (n = 34 female [55.7%], n = 27 male [44.3%]), age range 18–83 years, mean age 37.9±16.5 years) could be adequately studied using TE AIR and the high-end device. With one exception, the image quality score for TE Air never fell below 3 and had a mean/median scored of 4.97/5.00 for the B-mode, 4.92/5.00 for the color flow (CF) mode, and 4.89/5.00 for the pulse wave (PW) mode of the hepatic vein, 4.90/5.00 for the portal vein, 4.11/4.00 for the hepatic artery, and 4.57/5.00 for the renal segmental artery. A significant difference in the assessment of flow measurement of the hepatic artery and renal segmental arteries was found between TE AIR and the high-end device.&#13;
&#13;
CONCLUSIONS:&#13;
TE Air represents a new dimension in point-of-care ultrasound via wireless handheld devices. Especially, its flow measurement ability offers a relevant advantage over other available handheld models. TE Air provides a formally sufficient image quality in terms of diagnostic significance.</abstract>
    <parentTitle language="eng">Clinical Hemorheology and Microcirculation</parentTitle>
    <identifier type="url">https://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch238100</identifier>
    <identifier type="doi">10.3233/CH-238100</identifier>
    <identifier type="issn">1386-0291</identifier>
    <enrichment key="BTU">an der BTU erstellt / created at BTU</enrichment>
    <enrichment key="Publikationsweg">Open Access</enrichment>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="Fprofil">2 Gesundheit und Lifes Sciences / Health and Life Sciences</enrichment>
    <enrichment key="Fprofil">3 Globaler Wandel und Transformationsprozesse / Global Change and Transformation Processes</enrichment>
    <author>
      <firstName>Ernst Michael</firstName>
      <lastName>Jung</lastName>
    </author>
    <submitter>
      <firstName>Christian</firstName>
      <lastName>Schulz</lastName>
    </submitter>
    <author>
      <firstName>Friedrich</firstName>
      <lastName>Jung</lastName>
    </author>
    <author>
      <firstName>Yi</firstName>
      <lastName>Dong</lastName>
    </author>
    <author>
      <firstName>Ulrich</firstName>
      <lastName>Kaiser</lastName>
    </author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Mindray</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>handheld ultrasound</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>TE Air</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>ultrasound</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>point-of-care ultrasound</value>
    </subject>
    <collection role="institutes" number="2110">FG Molekulare Zellbiologie</collection>
  </doc>
  <doc>
    <id>32275</id>
    <completedYear/>
    <publishedYear>2024</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>133</pageFirst>
    <pageLast>142</pageLast>
    <pageNumber/>
    <edition/>
    <issue>1-2</issue>
    <volume>86</volume>
    <type>articler</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2024-01-04</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">First assessment of flow phenomena of acute and chronic thrombosis in the jugular veins using new ultrasound vector-flow imaging</title>
    <abstract language="eng">AIM:&#13;
First assessment of flow changes in the jugular veins using high resolution ultrasound vector flow.&#13;
&#13;
MATERIAL UND METHODS:&#13;
15 patients (8 males, 7 females) with an age range of 35 to 82 years (mean age 58.53±12.26 years) were examined by an experienced examiner using high power ultrasound equipment (Resona R9, Mindray) with probe technology (Mindray L9-3U Linear Array transducer, 2.5 to 9.0 MHz). This group was compared with five healthy subjects (mean age 35.4±13.79 years) as a reference. To assess flow changes, the color-coded duplex sonography and the novel vector flow technique were used. The evaluation was performed of vector morphology changes, turbulence, and wall resistance measurements.&#13;
&#13;
RESULTS:&#13;
There were changes after acute and chronic thrombosis in 9 cases, and venous compression in 7 cases. Turbulence was measurable from 0.01 % to 64.44 %, the average turbulence was 19.73±22.06 % . Wall resistance measurement showed values from 0.01 Pa to 3.14 Pa, depending on the age of the thrombosis or compression. The reference veins showed turbulence of 0.94±1.5 % and a mean wall resistance of 0.05±0.05 Pa. There are statistically significant differences between normal and thrombotic or compressed veins in terms of maximum wall stress (p = 0.006) and mean degree of turbulence (p = 0.012), while the difference in mean wall stress is not statistically significant (p = 0.058).&#13;
&#13;
CONCLUSION:&#13;
Despite still existing technical limitations, the combination of V-flow and wall stress measurements in jugular vein changes suggests a high diagnostic potential.</abstract>
    <parentTitle language="eng">Clinical Hemorheology and Microcirculation</parentTitle>
    <identifier type="url">https://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch238117</identifier>
    <identifier type="doi">10.3233/CH-238117</identifier>
    <identifier type="issn">1386-0291</identifier>
    <enrichment key="BTU">an der BTU erstellt / created at BTU</enrichment>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="Fprofil">2 Gesundheit und Lifes Sciences / Health and Life Sciences</enrichment>
    <enrichment key="Fprofil">3 Globaler Wandel und Transformationsprozesse / Global Change and Transformation Processes</enrichment>
    <author>
      <firstName>V.</firstName>
      <lastName>Luderer</lastName>
    </author>
    <submitter>
      <firstName>Christian</firstName>
      <lastName>Schulz</lastName>
    </submitter>
    <author>
      <firstName>Friedrich</firstName>
      <lastName>Jung</lastName>
    </author>
    <author>
      <firstName>M.</firstName>
      <lastName>Brandenstein</lastName>
    </author>
    <author>
      <firstName>Christian</firstName>
      <lastName>Stroszczynski</lastName>
    </author>
    <author>
      <firstName>Ernst Michael</firstName>
      <lastName>Jung</lastName>
    </author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Thrombosis</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>vector-flow-imaging</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>high resolution ultrasound</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>color-coded duplex sonography</value>
    </subject>
    <collection role="institutes" number="2110">FG Molekulare Zellbiologie</collection>
  </doc>
  <doc>
    <id>32278</id>
    <completedYear/>
    <publishedYear>2023</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>479</pageFirst>
    <pageLast>487</pageLast>
    <pageNumber/>
    <edition/>
    <issue>4</issue>
    <volume>32</volume>
    <type>articler</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2024-01-04</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Color mapping using ultrasound system-integrated perfusion software for evaluation of focal liver lesions: a possible first step for more independent reading</title>
    <abstract language="eng">Aims&#13;
To assess the value of using integrated parametric ultrasound software for contrast-enhanced ultrasonography (CEUS) of liver tumors.&#13;
Methods&#13;
107 patients with liver tumors were studied. CEUS were performed to detect focal lesions. Parametric images were based on continuous CINE LOOPs, from the early-arterial phase (15 s) to the portal-venous phase (1 min) generated by perfusion software. The evaluations of the parametric images and their dignity for liver lesions were performed independently by an experienced and a less-experienced investigator. Computed tomography, magnetic resonance imaging scans or histological analysis were used as references.&#13;
Results&#13;
High parametric image quality were obtained in all patients. Among the patients, 44% lesions were benign, 56% were malignant. The experienced investigator correctly classified 46 of 47 (98%) as benign, and 60 of 60 (100%) as malignant tumors based on the parametric images. The less-experienced investigator correctly classified 39 of 47 (83%) as benign, and 49 of 60 (82%) malignant tumors, acheaving a high statistical accuracy of 98% with this type of diagnostic.&#13;
Conclusion&#13;
Parametric imaging for grading the malignant degree of tumor may be a good complement to existing ultrasound techniques and was particularly helpful for improving the assessments of the less-experienced examiner.</abstract>
    <parentTitle language="eng">Journal of Gastrointestinal and Liver Diseases</parentTitle>
    <identifier type="url">https://europepmc.org/article/med/38147619</identifier>
    <identifier type="doi">10.15403/jgld-4997</identifier>
    <identifier type="issn">1842-1121</identifier>
    <enrichment key="BTU">an der BTU erstellt / created at BTU</enrichment>
    <enrichment key="Publikationsweg">Open Access</enrichment>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">false</enrichment>
    <enrichment key="Fprofil">2 Gesundheit und Lifes Sciences / Health and Life Sciences</enrichment>
    <enrichment key="Fprofil">3 Globaler Wandel und Transformationsprozesse / Global Change and Transformation Processes</enrichment>
    <author>
      <firstName>Ivor</firstName>
      <lastName>Dropco</lastName>
    </author>
    <submitter>
      <firstName>Christian</firstName>
      <lastName>Schulz</lastName>
    </submitter>
    <author>
      <firstName>Ulrich</firstName>
      <lastName>Kaiser</lastName>
    </author>
    <author>
      <firstName>Lola</firstName>
      <lastName>Wagner</lastName>
    </author>
    <author>
      <firstName>Stefan M.</firstName>
      <lastName>Brunner</lastName>
    </author>
    <author>
      <firstName>Hans Jürgen</firstName>
      <lastName>Schlitt</lastName>
    </author>
    <author>
      <firstName>Christian</firstName>
      <lastName>Stroszczynski</lastName>
    </author>
    <author>
      <firstName>Friedrich</firstName>
      <lastName>Jung</lastName>
    </author>
    <author>
      <firstName>Dong</firstName>
      <lastName>Yi</lastName>
    </author>
    <author>
      <firstName>Wolfgang</firstName>
      <lastName>Herr</lastName>
    </author>
    <author>
      <firstName>Ernst Michael</firstName>
      <lastName>Jung</lastName>
    </author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>CEUS</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>parametric imaging</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>dynamic vascularization</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>liver malignancies</value>
    </subject>
    <collection role="institutes" number="2110">FG Molekulare Zellbiologie</collection>
  </doc>
  <doc>
    <id>36344</id>
    <completedYear/>
    <publishedYear>2025</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>1</pageFirst>
    <pageLast>16</pageLast>
    <pageNumber>16</pageNumber>
    <edition/>
    <issue>7</issue>
    <volume>15</volume>
    <type>articler</type>
    <publisherName>MDPI</publisherName>
    <publisherPlace>Basel</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2025-06-20</completedDate>
    <publishedDate>2025-06-20</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Super-resolution contrast-enhanced ultrasound examination down to the microvasculature enables quantitative analysis of liver lesions : first results</title>
    <abstract language="eng">This article investigates the first use of dynamic microvascularization of liver lesions in clinical evaluation using real-time super-resolution contrast-enhanced ultrasound (SR CEUS). A retrospective analysis of SR CEUS examinations of liver lesions was performed. All examinations were conducted using an SC7-1U convex probe after the bolus injection of the ultrasound contrast agent. Digital cine loops were stored for independent evaluation. The evaluation was performed with respect to parallel measuring lines (the diameter corresponded to the capillary density) in the area of the reference lesion, liver tissue, and liver capsule using statistical analysis. In total, 65 patients (female n = 28; male n = 37; average age 57.8 ± 17.2 years) were evaluated. The examined liver lesions were mostly benign masses ( n = 46). Mild liver fibrosis (stage F1) was present in most cases ( n = 35). The lesions examined were located at an average tissue depth of 6.07 ± 2.47 cm. The highest number of lesion measurements was observed in the malignant lesion group. Significant differences in the measurements were found when comparing benign lesions with the capillary region ( p &lt; 0.001) and normal liver tissue ( p &lt; 0.01). The use of SR CEUS opens up new possibilities for the quantification of neovascularization, assessment of microvascular changes, and evaluation of the follow-up of intrahepatic interventions.</abstract>
    <parentTitle language="eng">Life</parentTitle>
    <identifier type="issn">2075-1729</identifier>
    <identifier type="doi">10.3390/life15070991</identifier>
    <enrichment key="opus.import.date">2025-07-29T11:45:35+00:00</enrichment>
    <enrichment key="opus.source">sword</enrichment>
    <enrichment key="opus.import.user">deepgreen</enrichment>
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    <enrichment key="BTU">an der BTU erstellt / created at BTU</enrichment>
    <enrichment key="Publikationsweg">Open Access</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">false</enrichment>
    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>
      <firstName>Ulrich</firstName>
      <lastName>Kaiser</lastName>
    </author>
    <author>
      <firstName>Ursula</firstName>
      <lastName>Vehling-Kaiser</lastName>
    </author>
    <author>
      <firstName>Fabian</firstName>
      <lastName>Kück</lastName>
    </author>
    <author>
      <firstName>Mia</firstName>
      <lastName>Gilanschah</lastName>
    </author>
    <author>
      <firstName>Friedrich</firstName>
      <lastName>Jung</lastName>
    </author>
    <author>
      <firstName>Ernst Michael</firstName>
      <lastName>Jung</lastName>
    </author>
    <subject>
      <language>eng</language>
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    <issue>10</issue>
    <volume>15</volume>
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    <title language="eng">High-resolution contrast-enhanced ultrasound with SRCEUS for assessing the intrahepatic microvasculature and shunts in patients with hereditary haemorrhagic teleangiectasia (Osler’s disease)</title>
    <abstract language="eng">The aim of this retrospective clinical pilot study is to evaluate multiparametric ultrasound liver parenchyma assessments in the diagnosis of Osler’s disease, and to detect micro-shunts using SRCEUS with quantifications at the capillary level. Material/Method: All examinations were performed by an experienced examiner with a multi-frequency probe on a high-resolution matrix ultrasound device (SC 7-1U), convex probe (Mindray A 20), and were stored digitally in the PACS system. Vascular ultrasound was performed using colour-coded Doppler ultrasound (CCDS) and ultrasound microangiography (UMA). The recent M-Ref tool was utilised for the purpose of liver tissue characterisation, encompassing the domains of shear wave elastography, fat evaluation, and viscosity. Dynamic CEUS, HiFR CEUS, and SR CEUS were performed after the intravenous bolus injection of 1–2.4 mL of ultrasound contrast agent (SonoVue®). Measurements of SR CEUS capillary changes were performed independently by PACS-stored digital cine loops up to 5 s. Results: In the context of angiomas or haemangiomas, the initial contrast enhancement of echogenic or almost echogenic foci within 25 s without late wash-out was observed in 5/10 cases. In the evaluation of microvasculature, the presence of capsule-proximal shunts in Osler’s disease was observed, resulting in the identification of increased numbers of dilated capillaries within both peripheral and central shunts. In the control group, general liver tissue changes (20 cases) were observed in instances of inflammation (3/20 cases), peripherally in 4/20 cases with micro-shunts in altered parenchyma. In the context of multiparametric ultrasound, 16 out of 30 cases exhibited elevated fibrosis values, with a maximum recorded as high as 1.7 m/s, and in 13 out of 30 cases, there was an increase in fat values up to 0.65 dB/cm/MHz, indicative of moderate steatosis. Additionally, in seven cases, there was an increase in viscosity values up to 2.7 Pa·s, suggesting reactive changes. Conclusions: Recent advancements in medical imaging technology, specifically SR CEUS contrast ultrasound imaging, have led to the development of novel diagnostic tools that facilitate the evaluation of tissue and haemodynamic changes, in addition to capillary alterations, associated with Osler’s disease.</abstract>
    <parentTitle language="eng">Life</parentTitle>
    <identifier type="doi">10.3390/life15101631</identifier>
    <identifier type="issn">2075-1729</identifier>
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Material\/Method: All examinations were performed by an experienced examiner with a multi-frequency probe on a high-resolution matrix ultrasound device (SC 7-1U), convex probe (Mindray A 20), and were stored digitally in the PACS system. Vascular ultrasound was performed using colour-coded Doppler ultrasound (CCDS) and ultrasound microangiography (UMA). The recent M-Ref tool was utilised for the purpose of liver tissue characterisation, encompassing the domains of shear wave elastography, fat evaluation, and viscosity. Dynamic CEUS, HiFR CEUS, and SR CEUS were performed after the intravenous bolus injection of 1\u20132.4 mL of ultrasound contrast agent (SonoVue\u00ae). Measurements of SR CEUS capillary changes were performed independently by PACS-stored digital cine loops up to 5 s. Results: In the context of angiomas or haemangiomas, the initial contrast enhancement of echogenic or almost echogenic foci within 25 s without late wash-out was observed in 5\/10 cases. In the evaluation of microvasculature, the presence of capsule-proximal shunts in Osler\u2019s disease was observed, resulting in the identification of increased numbers of dilated capillaries within both peripheral and central shunts. In the control group, general liver tissue changes (20 cases) were observed in instances of inflammation (3\/20 cases), peripherally in 4\/20 cases with micro-shunts in altered parenchyma. In the context of multiparametric ultrasound, 16 out of 30 cases exhibited elevated fibrosis values, with a maximum recorded as high as 1.7 m\/s, and in 13 out of 30 cases, there was an increase in fat values up to 0.65 dB\/cm\/MHz, indicative of moderate steatosis. Additionally, in seven cases, there was an increase in viscosity values up to 2.7 Pa\u00b7s, suggesting reactive changes. Conclusions: Recent advancements in medical imaging technology, specifically SR CEUS contrast ultrasound imaging, have led to the development of novel diagnostic tools that facilitate the evaluation of tissue and haemodynamic changes, in addition to capillary alterations, associated with Osler\u2019s disease.&lt;\/jats:p&gt;","DOI":"10.3390\/life15101631","type":"journal-article","created":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:23:34Z","timestamp":1760952214000},"page":"1631","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["High-Resolution Contrast-Enhanced Ultrasound with SRCEUS for Assessing the Intrahepatic Microvasculature and Shunts in Patients with Hereditary Haemorrhagic Teleangiectasia (Osler\u2019s Disease)"],"prefix":"10.3390","volume":"15","author":[{"given":"Irmgard Maria","family":"Sieber","sequence":"first","affiliation":[{"name":"Interdisciplinary Ultrasound Department and Institute for Radiology, University Hospital Regensburg, 93053 Regensburg, Germany"}]},{"given":"Friedrich","family":"Jung","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology, Molecular Cell Biology, Brandenburg University of Technology, 01968 Senftenberg, Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7171-9774","authenticated-orcid":false,"given":"Ernst Michael","family":"Jung","sequence":"additional","affiliation":[{"name":"Interdisciplinary Ultrasound Department and Institute for Radiology, University Hospital Regensburg, 93053 Regensburg, Germany"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3233\/CH-239100","article-title":"Current aspects of multimodal ultrasound liver diagnostics using contrast-enhanced ultrasonography (CEUS), fat evaluation, fibrosis assessment, and perfusion analysis\u2014An update","volume":"83","author":"Jung","year":"2023","journal-title":"Clin. 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Identification of two distinct hereditary hemorrhagic telangiectasia patient subsets with different hepatic perfusion properties by combination of contrast-enhanced ultrasound (CEUS) with perfusion imaging quantification. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0215178"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3233\/CH-221646","article-title":"Application of contrast-enhanced ultrasound in hemothorax of hereditary hemorrhagic telangiectasia: A case report and literature review","volume":"83","author":"Chen","year":"2023","journal-title":"Clin. Hemorheol. Microcirc."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"486","DOI":"10.3748\/wjg.v23.i3.486","article-title":"Macro- and microcirculation patterns of intrahepatic blood flow changes in patients with hereditary hemorrhagic telangiectasia","volume":"23","author":"Schelker","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"ref_30","first-page":"285","article-title":"Carotid ultrasound for pulmonary arteriovenous malformation screening","volume":"10","author":"Schneider","year":"2015","journal-title":"Open Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1007\/s00431-018-3197-8","article-title":"Diagnosis of congenital and acquired focal lesions in the neck, abdomen, and pelvis with contrast-enhanced ultrasound: A pictorial essay","volume":"177","author":"Thimm","year":"2018","journal-title":"Eur. J. Pediatr."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s11547-008-0261-x","article-title":"Pulmonary arteriovenous malformations: Percutaneous treatment preserving parenchyma in high-flow fistulae","volume":"113","author":"Grosso","year":"2008","journal-title":"Radiol. 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    <author>
      <firstName>Irmgard Maria</firstName>
      <lastName>Sieber</lastName>
    </author>
    <submitter>
      <firstName>Sarah</firstName>
      <lastName>Kammerer</lastName>
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    <author>
      <firstName>Friedrich</firstName>
      <lastName>Jung</lastName>
    </author>
    <author>
      <firstName>Ernst Michael</firstName>
      <lastName>Jung</lastName>
    </author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Osler’s disease</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Shunts; Superresolution CEUS (SR-CEUS)</value>
    </subject>
    <subject>
      <language>eng</language>
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      <value>Multiparametric tissue imaging (M-Ref)</value>
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    <title language="eng">Intraoperative contrast-enhanced ultrasound (CEUS) with time intensity curve (TIC) analysis for better assessment of liver tumor margins</title>
    <title language="deu">Intraoperative Kontrastmittelsonografie (CEUS) mit Time Intensitiy Curve (TIC)-Analyse zur Beurteilung von Lebertumorgrenzen</title>
    <abstract language="eng">AbstractThe purpose of this study was to conduct an intraoperative evaluation of focal liver lesions using time intensity curve (TIC) analysis of contrast-enhanced ultrasound (CEUS) to better assess liver tumor margins.This study included 28 patients (21 men 75%, 7 women 25%) with malignant liver lesions (cholangiocellular carcinoma (CCC), n = 9; hepatocellular carcinoma (HCC), n = 6; hepatic metastases (HepMET), n = 13). A B-mode scan, color-coded Doppler sonography, and CEUS were performed intraoperatively to analyze the focal lesions. The generated parametric images were based on continuous cine loops, acquired with a multifrequency T-probe (6–9 MHz), from the early arterial phase (0–15 seconds) to the portal venous phase (1 minute), generated by integrated perfusion software. Analyses of the CEUS loops were performed using TICs with respect to time-to-peak (TTP) and area under the curve (AUC). Perfusion analysis was performed in the center and periphery of the tumor as well as in healthy liver tissue. All tumor lesions were evaluated histopathologically to verify the diagnosis.Sufficient image quality was achieved in all cases using CEUS for TIC analysis. A comparison of all groups showed a clear difference compared with the center, margin, and healthy liver tissue in the measured parameters of TTP and AUC (p = 0.035 and p = 0.045, respectively). In detail, differences were observed in the CCC group (TTP: p = 0.025) and in the HepMET group (TTP: p = 0.009), particularly in the peripheral areas (strong arterial flooding with a rapid increase in the flooding curve), with equally clear tumor edge representation compared with healthy liver tissue, as shown by the AUC analysis (CCC AUC: p = 0.032 and HepMET AUC: p = 0.029). In patients with HCC, the perfusion pattern (starting from the center) showed the center to be more clearly distinguishable from the edge with significant TTP and AUC (p = 0.035 and p = 0.038).Intraoperative TIC analysis of malignant liver tumors is an important diagnostic tool for better highlighting liver tumor margins during surgery.</abstract>
    <parentTitle language="eng">RöFo : Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren</parentTitle>
    <identifier type="doi">10.1055/a-2600-7229</identifier>
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A B-mode scan, color-coded Doppler sonography, and CEUS were performed intraoperatively to analyze the focal lesions. The generated parametric images were based on continuous cine loops, acquired with a multifrequency T-probe (6\u20139 MHz), from the early arterial phase (0\u201315 seconds) to the portal venous phase (1 minute), generated by integrated perfusion software. Analyses of the CEUS loops were performed using TICs with respect to time-to-peak (TTP) and area under the curve (AUC). Perfusion analysis was performed in the center and periphery of the tumor as well as in healthy liver tissue. All tumor lesions were evaluated histopathologically to verify the diagnosis.&lt;\/jats:p&gt;&lt;jats:p&gt;Sufficient image quality was achieved in all cases using CEUS for TIC analysis. A comparison of all groups showed a clear difference compared with the center, margin, and healthy liver tissue in the measured parameters of TTP and AUC (p = 0.035 and p = 0.045, respectively). In detail, differences were observed in the CCC group (TTP: p = 0.025) and in the HepMET group (TTP: p = 0.009), particularly in the peripheral areas (strong arterial flooding with a rapid increase in the flooding curve), with equally clear tumor edge representation compared with healthy liver tissue, as shown by the AUC analysis (CCC AUC: p = 0.032 and HepMET AUC: p = 0.029). In patients with HCC, the perfusion pattern (starting from the center) showed the center to be more clearly distinguishable from the edge with significant TTP and AUC (p = 0.035 and p = 0.038).&lt;\/jats:p&gt;&lt;jats:p&gt;Intraoperative TIC analysis of malignant liver tumors is an important diagnostic tool for better highlighting liver tumor margins during surgery.&lt;\/jats:p&gt;","DOI":"10.1055\/a-2600-7229","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T23:15:21Z","timestamp":1748301321000},"source":"Crossref","is-referenced-by-count":1,"title":["Intraoperative contrast-enhanced ultrasound (CEUS) with time intensity curve (TIC) analysis for better assessment of liver tumor margins"],"prefix":"10.1055","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4180-4964","authenticated-orcid":false,"given":"Ivor","family":"Dropco","sequence":"additional","affiliation":[{"name":"Department for Surgery, University Hospital Regensburg Department for 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Regensburg, Germany"}]},{"given":"Wolfgang","family":"Herr","sequence":"additional","affiliation":[{"name":"Department for Internal Medicine III, University Hospital Regensburg Department for Internal Medicine III, Regensburg, Germany"}]},{"given":"Stefan M","family":"Brunner","sequence":"additional","affiliation":[{"name":"Department for Surgery, University Hospital Regensburg Department for Surgery, Regensburg, Germany"}]},{"given":"Ernst Michael","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital Regensburg Department for Radiotherapy, Regensburg, Germany"}]}],"member":"194","published-online":{"date-parts":[[2025,5,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3233\/CH-221449","article-title":"Modified contrast-enhanced ultrasonography with the new high-resolution examination technique of high frame rate contrast-enhanced ultrasound (HiFR-CEUS) for characterization of liver 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    <author>
      <firstName>Ivor</firstName>
      <lastName>Dropco</lastName>
    </author>
    <submitter>
      <firstName>Sarah</firstName>
      <lastName>Kammerer</lastName>
    </submitter>
    <author>
      <firstName>Ulrich</firstName>
      <lastName>Kaiser</lastName>
    </author>
    <author>
      <firstName>Friedrich</firstName>
      <lastName>Jung</lastName>
    </author>
    <author>
      <firstName>Ľudivít</firstName>
      <lastName>Danihel</lastName>
    </author>
    <author>
      <firstName>Hans J</firstName>
      <lastName>Schlitt</lastName>
    </author>
    <author>
      <firstName>Christian</firstName>
      <lastName>Stroszczynski</lastName>
    </author>
    <author>
      <firstName>Wolfgang</firstName>
      <lastName>Herr</lastName>
    </author>
    <author>
      <firstName>Stefan M</firstName>
      <lastName>Brunner</lastName>
    </author>
    <author>
      <firstName>Ernst Michael</firstName>
      <lastName>Jung</lastName>
    </author>
    <collection role="institutes" number="2110">FG Molekulare Zellbiologie</collection>
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  <doc>
    <id>37383</id>
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    <publishedYear>2026</publishedYear>
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    <language>eng</language>
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    <pageNumber>10</pageNumber>
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    <issue>2</issue>
    <volume>90</volume>
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    <publisherName>Georg Thieme Verlag KG</publisherName>
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    <completedDate>2026-01-19</completedDate>
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    <title language="eng">Super-resolution contrast-enhanced ultrasound (SR-CEUS) in solid organs</title>
    <title language="deu">Superhochauflösender kontrastverstärkter Ultraschall (SR-CEUS) in festen Organen</title>
    <abstract language="eng">It is becoming increasingly common for multimodal radiological imaging to use contrast-enhanced ultrasound (CEUS) because of its high-resolution ultrasound techniques. CEUS has several advantages. It can be used repeatedly without affecting renal function or the thyroid gland. It is also considered to be highly accurate with regard to the diagnosis and detection of small solid liver lesions. In addition, it can be used to characterize solid lesions in other abdominal organs. With additional perfusion imaging and its (semi)quantitative analysis using wash-in and wash-out kinetics, therapies can be monitored. It is also frequently used in the assessment of solid tumors in the near field, such as thyroid tumors and lymph nodes. Super-resolution CEUS (SR-CEUS) is a novel imaging method with dynamic evaluation of microflow changes to the level of capillary structures. SR-CEUS could also open up new possibilities regarding the dynamic assessment of the micro-vascularization of solid abdominal organs and interventional procedures.</abstract>
    <parentTitle language="eng">RöFo : Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren</parentTitle>
    <identifier type="doi">10.1055/a-2754-0219</identifier>
    <identifier type="issn">1438-9029</identifier>
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In addition, it can be used to characterize\n                        solid lesions in other abdominal organs. With additional perfusion imaging\n                        and its (semi)quantitative analysis using wash-in and wash-out kinetics,\n                        therapies can be monitored. It is also frequently used in the assessment of\n                        solid tumors in the near field, such as thyroid tumors and lymph nodes.\n                        Super-resolution CEUS (SR-CEUS) is a novel imaging method with dynamic\n                        evaluation of microflow changes to the level of capillary structures.\n                        SR-CEUS could also open up new possibilities regarding the dynamic\n                        assessment of the micro-vascularization of solid abdominal organs and\n                        interventional procedures.\n               Citation Format\n               \u25aa Jung EM, Weber M, Jung F. Super-resolution contrast-enhanced\n                                ultrasound (SR-CEUS) in solid organs. Rofo 2025; DOI\n                                10.1055\/a-2754-0219&lt;\/jats:p&gt;","DOI":"10.1055\/a-2754-0219","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T15:29:12Z","timestamp":1768231752000},"source":"Crossref","is-referenced-by-count":0,"title":["Super-resolution contrast-enhanced ultrasound (SR-CEUS) in solid\n                    organs"],"prefix":"10.1055","author":[{"given":"Ernst Michael","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Radiology and Interdisciplinary Ultrasound\n                    Department, University Hospital Regensburg, Regensburg, Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3918-8066","authenticated-orcid":false,"given":"Marc-Andr\u00e9","family":"Weber","sequence":"additional","affiliation":[{"name":"University Medical Center Rostock, Institute of Diagnostic and\n                    Interventional Radiology, Pediatric Radiology and Neuroradiology, Rostock,\n              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