<?xml version="1.0" encoding="utf-8"?>
<export-example>
  <doc>
    <id>26338</id>
    <completedYear/>
    <publishedYear>2020</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>1210</pageFirst>
    <pageLast>1218</pageLast>
    <pageNumber/>
    <edition/>
    <issue>7</issue>
    <volume>10</volume>
    <type>articler</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2020-11-13</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Modeling atrial fibrosis in vitro - Generation and characterization of a novel human atrial fibroblast cell line</title>
    <abstract language="eng">Atrial fibrillation (AF) is regularly accompanied by cardiac fibrosis and concomitant heart failure. Due to the heterogeneous nature and complexity of fibrosis, the knowledge about the underlying mechanisms is limited, which prevents effective pharmacotherapy. A deeper understanding of cardiac fibroblasts is essential to meet this need. We previously described phenotypic and functional differences between atrial fibroblasts from patients in sinus rhythm and with AF. Herein, we established and characterized a novel human atrial fibroblast line, which displays typical fibroblast morphology and function comparable to primary cells but with improved proliferation capacity and low spontaneous myofibroblast differentiation. These traits make our model suitable for the study of fibrosis mechanisms and for drug screening aimed at developing effective antifibrotic pharmacotherapy.</abstract>
    <parentTitle language="eng">FEBS Open Bio</parentTitle>
    <identifier type="doi">10.1002/2211-5463.12896</identifier>
    <identifier type="issn">2211-5463</identifier>
    <enrichment key="BTU">an der BTU erstellt / created at BTU</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">false</enrichment>
    <enrichment key="Fprofil">2 Gesundheit und Lifes Sciences / Health and Life Sciences</enrichment>
    <enrichment key="Fprofil">3 Globaler Wandel und Transformationsprozesse / Global Change and Transformation Processes</enrichment>
    <author>
      <firstName>Stephan R.</firstName>
      <lastName>Künzel</lastName>
    </author>
    <submitter>
      <firstName>Christian</firstName>
      <lastName>Schulz</lastName>
    </submitter>
    <author>
      <firstName>Johanna S. E.</firstName>
      <lastName>Rausch</lastName>
    </author>
    <author>
      <firstName>Charlotte</firstName>
      <lastName>Schäffer</lastName>
    </author>
    <author>
      <firstName>Maximilian</firstName>
      <lastName>Hoffmann</lastName>
    </author>
    <author>
      <firstName>Karolina</firstName>
      <lastName>Künzel</lastName>
    </author>
    <author>
      <firstName>Erik</firstName>
      <lastName>Klapproth</lastName>
    </author>
    <author>
      <firstName>Theresa</firstName>
      <lastName>Kant</lastName>
    </author>
    <author>
      <firstName>Natalie</firstName>
      <lastName>Herzog</lastName>
    </author>
    <author>
      <firstName>Jan-Heiner</firstName>
      <lastName>Küpper</lastName>
    </author>
    <author>
      <firstName>Kristina</firstName>
      <lastName>Lorenz</lastName>
    </author>
    <author>
      <firstName>Svenja</firstName>
      <lastName>Dudek</lastName>
    </author>
    <author>
      <firstName>Ramona</firstName>
      <lastName>Emig</lastName>
    </author>
    <author>
      <firstName>Ursula</firstName>
      <lastName>Ravens</lastName>
    </author>
    <author>
      <firstName>Eva A.</firstName>
      <lastName>Rog‐Zielinska</lastName>
    </author>
    <author>
      <firstName>Rémi</firstName>
      <lastName>Peyronnet</lastName>
    </author>
    <author>
      <firstName>Ali</firstName>
      <lastName>El-Armouche</lastName>
    </author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>cardiovascular disease</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>cell culture</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>cell lines</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>fibroblasts</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>fibrosis</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>heart</value>
    </subject>
    <collection role="institutes" number="2110">FG Molekulare Zellbiologie</collection>
  </doc>
</export-example>
