<?xml version="1.0" encoding="utf-8"?>
<export-example>
  <doc>
    <id>26311</id>
    <completedYear/>
    <publishedYear>2020</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>353</pageFirst>
    <pageLast>361</pageLast>
    <pageNumber/>
    <edition/>
    <issue>4</issue>
    <volume>74</volume>
    <type>articler</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2020-11-12</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Contrast enhanced ultrasonography (CEUS) to detect abdominal microcirculatory disorders in severe cases of COVID-19 infection: First experience</title>
    <abstract language="eng">In the hands of experienced examiners, the contrast enhanced sonography (CEUS) offers the possibility to analyze dynamic microcirculatory disturbances in real time dynamically without any risk for kidneys and thyroid gland even in severe progressing disease bedside. Based on severe COVID-19 infections, first experiences with abdominal CEUS examinations are presented. In the stage of an imminent organ failure with significantly reduced kidney and liver function, CEUS can be used to show a narrowing of the organ-supplying arteries, as well as a delayed capillary filling of vessels near the capsule, a regional reduced parenchymal perfusion or an inflammatory hyperemia with capillary hypercirculation. It is possible to quickly rule out organ infarction and to dynamically record the mesenteric arterial and venous blood flow.</abstract>
    <parentTitle language="eng">Clinical Hemorheology and Microcirculation</parentTitle>
    <identifier type="doi">10.3233/CH-209003</identifier>
    <identifier type="url">https://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch209003</identifier>
    <identifier type="issn">1875-8622</identifier>
    <identifier type="issn">1386-0291</identifier>
    <enrichment key="BTU">an der BTU erstellt / created at BTU</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">false</enrichment>
    <enrichment key="Fprofil">2 Gesundheit und Lifes Sciences / Health and Life Sciences</enrichment>
    <enrichment key="Fprofil">3 Globaler Wandel und Transformationsprozesse / Global Change and Transformation Processes</enrichment>
    <author>
      <firstName>Ernst Michael</firstName>
      <lastName>Jung</lastName>
    </author>
    <submitter>
      <firstName>Christian</firstName>
      <lastName>Schulz</lastName>
    </submitter>
    <author>
      <firstName>Christian</firstName>
      <lastName>Stroszczynski</lastName>
    </author>
    <author>
      <firstName>Friedrich</firstName>
      <lastName>Jung</lastName>
    </author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Corona virus</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>contrast enhanced ultrasound sonography (CEUS)</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>COVID-19</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>liver</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>kidney</value>
    </subject>
    <collection role="institutes" number="2110">FG Molekulare Zellbiologie</collection>
  </doc>
  <doc>
    <id>26312</id>
    <completedYear/>
    <publishedYear>2020</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>19</pageFirst>
    <pageLast>26</pageLast>
    <pageNumber/>
    <edition/>
    <issue>1</issue>
    <volume>75</volume>
    <type>articler</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2020-11-12</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Contrast enhanced ultrasound (CEUS) to assess pleural pulmonal changes in severe Covid 19 infection: First results</title>
    <abstract language="eng">AIM:&#13;
&#13;
Use of contrast enhanced ultrasound (CEUS) in severe cases of COVID-19 infection to assess pulmonary changes near the pleura.&#13;
MATERIAL AND METHODS:&#13;
&#13;
Bedside examinations by an experienced intensive care unit examiner using a multi-frequency probe (C1-6 MHz) with B-mode and CEUS to assess pleural-near changes in severe cases of COVID-19 infection with respiratory failure. CEUS with bolus delivery via a central venous catheter of 2.4 ml Sulphur hexafluoride microbubbles from the arterial phase (10–15 s) to the late phase of 5 min. Digital storage of cine sequences of the lung sound with abdomen for independent assessment with the subsequently performed contrast-enhanced dual-source CT.&#13;
RESULTS:&#13;
&#13;
In 11 intubated and ventilated patients (arithmetic mean 62 years, 48 to 78 years, 3 women) with confirmed severe COVID-19 infections, a peripherally accentuated consolidation with irregular hyperemia was found in the CEUS and also in the CT examination. Of the 5 cases with pulmonary arterial embolisms, signs of right ventricular failure were found. In all cases, using CEUS low perfused areas of the pleura with adjacent hyperemia could be detected, while, with CT segmental contrast medium, gaps with subpleural compressions were found. Interstitial changes near the pleura led to B-lines and to ground glass opacities in the CT. Near the diaphragm a delayed arterial contrast of the liver was observed. In addition, in 2 cases partial atelectasis, in 3 cases marginal pleural effusions were found.&#13;
CONCLUSION:&#13;
&#13;
CEUS opens up new possibilities for bedside monitoring of pleural reactive inflammatory or peripheral thrombus embolism in severe cases of COVID-19 infection.</abstract>
    <parentTitle language="eng">Clinical Hemorheology and Microcirculation</parentTitle>
    <identifier type="doi">10.3233/CH-209005</identifier>
    <identifier type="url">https://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch209005</identifier>
    <identifier type="issn">1875-8622</identifier>
    <identifier type="issn">1386-0291</identifier>
    <enrichment key="BTU">an der BTU erstellt / created at BTU</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">false</enrichment>
    <enrichment key="Fprofil">2 Gesundheit und Lifes Sciences / Health and Life Sciences</enrichment>
    <enrichment key="Fprofil">3 Globaler Wandel und Transformationsprozesse / Global Change and Transformation Processes</enrichment>
    <author>
      <firstName>Ernst Michael</firstName>
      <lastName>Jung</lastName>
    </author>
    <submitter>
      <firstName>Christian</firstName>
      <lastName>Schulz</lastName>
    </submitter>
    <author>
      <firstName>Christian</firstName>
      <lastName>Stroszczynski</lastName>
    </author>
    <author>
      <firstName>Friedrich</firstName>
      <lastName>Jung</lastName>
    </author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>COVID-19 infection</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>lung- Contrast-enhanced ultrasound (CEUS)</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>pleural affection</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>peripheral embolic consolidation</value>
    </subject>
    <collection role="institutes" number="2110">FG Molekulare Zellbiologie</collection>
  </doc>
  <doc>
    <id>26318</id>
    <completedYear/>
    <publishedYear>2020</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>221</pageFirst>
    <pageLast>231</pageLast>
    <pageNumber/>
    <edition/>
    <issue>2</issue>
    <volume>76</volume>
    <type>articler</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2020-11-12</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Imaging of breast implant and implant-associated complications: Capsular contracture and intraor extracapsular rupture</title>
    <abstract language="eng">BACKGROUND:&#13;
&#13;
In recent years, follow-up after breast reconstruction with silicone implants and the detection of complications have been relieved by the possibility of improved diagnostic methods.&#13;
METHODS:&#13;
&#13;
Between January 2015 and December 2019 a total of 40 patients (29–84 years) with silicone implants were included in this retrospective study. The implants were examined clinically and with modern imaging: general ultrasound imaging (US), magnetic resonance imaging (MRI), high resolution computed tomography (CT) and positron emission tomography –computed tomography (PET-CT). If necessary, a histological/cytological sample was taken. The breast implants were assessed by three radiologists specialized in breast imaging. The grade of capsular contracture was classified according to the Baker classification.&#13;
RESULTS:&#13;
&#13;
All 40 women obtained a clinical examination and an US diagnostic to identify early and more common complications such as implant folding and capsular fibrosis. Depending on the clinical examination and ultrasound findings additional MRI (n = 10), CT (n = 9) and/or PET-CT (n = 2) were performed. 16 patients had implants folding proven with US (n = 16), MRI (n = 6) and CT (n = 1). The grade of capsular fibrosis was determined according to the Baker classification. The following results were obtained in our study: 25 breast implants with Baker grade I and eleven breast implants with Baker grade II, both proven with US; one breast implants with Baker grade III and one breast implant with Baker grade IV, proven with US (n = 2), MRI (n = 1) and CT (n = 1). One patient had intracapsular rupture and one patient had extracapsular rupture, both detected on CT and surgically proven. No patient had a silicone accumulation in the lymph nodes. One patient had pathologically enlarged axillary lymph nodes, which were evaluated as inflammatory changes in PET-CT. Long-term complications such as the development of malignant breast tumors could not be observed.&#13;
CONCLUSION:&#13;
&#13;
To detect early complications after breast implant surgery, a regular clinical examination is indispensable. Imaging methods complement each other and if they are used multimodal, it is easier to identify early complications. Modern diagnostic modalities like ultrasound and magnetic resonance imaging expand the spectrum and improve diagnostic safety.</abstract>
    <parentTitle language="eng">Clinical Hemorheology and Microcirculation</parentTitle>
    <identifier type="doi">10.3233/CH-209218</identifier>
    <identifier type="url">https://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch209218</identifier>
    <identifier type="issn">1875-8622</identifier>
    <identifier type="issn">1386-0291</identifier>
    <enrichment key="BTU">an der BTU erstellt / created at BTU</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">false</enrichment>
    <enrichment key="Fprofil">2 Gesundheit und Lifes Sciences / Health and Life Sciences</enrichment>
    <enrichment key="Fprofil">3 Globaler Wandel und Transformationsprozesse / Global Change and Transformation Processes</enrichment>
    <author>
      <firstName>Georgieva</firstName>
      <lastName>Martina</lastName>
    </author>
    <submitter>
      <firstName>Christian</firstName>
      <lastName>Schulz</lastName>
    </submitter>
    <author>
      <firstName>Sarah</firstName>
      <lastName>Kammerer</lastName>
    </author>
    <author>
      <firstName>Lukas</firstName>
      <lastName>Prantl</lastName>
    </author>
    <author>
      <firstName>Friedrich</firstName>
      <lastName>Jung</lastName>
    </author>
    <author>
      <firstName>Christian</firstName>
      <lastName>Stroszczynski</lastName>
    </author>
    <author>
      <firstName>Ernst Michael</firstName>
      <lastName>Jung</lastName>
    </author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Breast implant</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>ultrasound</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>magnetic resonance imaging</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>capsular contracture</value>
    </subject>
    <collection role="institutes" number="2110">FG Molekulare Zellbiologie</collection>
  </doc>
  <doc>
    <id>26319</id>
    <completedYear/>
    <publishedYear>2020</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>143</pageFirst>
    <pageLast>153</pageLast>
    <pageNumber/>
    <edition/>
    <issue>2</issue>
    <volume>76</volume>
    <type>articler</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2020-11-12</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Contrast enhanced ultrasound (CEUS) with parametric imaging and time intensity curve analysis (TIC) for evaluation of the success of prostate arterial embolization (PAE) in cases of prostate hyperplasia</title>
    <abstract language="eng">AIM:&#13;
&#13;
To evaluate the use of dynamic contrast enhanced ultrasound (CEUS) with parametric color-coded imaging and time intensity curve analysis (TIC) for planning and follow-up after prostate arterial embolization (PAE).&#13;
MATERIAL/METHOD:&#13;
&#13;
Before and after selective iliacal embolization by PAE with a follow up of 6 months 18 male patients (43–78 years, mean 63±3.5 years) with histopathological proven benign prostate hyperplasia were examined by one experienced examiner. A multifrequency high resolution probe (1–6 MHz) was used for transabdominal ultrasound and CEUS with bolus injections of 2.4 ml sulphur-hexafluoride microbubbles. Independent evaluation of color-coded parametric imaging before and after PAE by in PACS stored DICOM loops from arterial phase (10–15 s) up to 1min were performed. Criteria for successful treatment were reduction of early arterial enhancement by changes of time to peak (TTP) and area under the curve (AUC) by measurements in 8 regions of interest (ROI) of 5 mm in diameter at the margin and in the center and changes from hyperenhancement in parametric imaging (perfusion evaluation of arterial enhancement over 15 s) from red and yellow to blue and green by partial infarctions. Reference imaging method was the contrast high resolution 3 tesla magnetic resonance tomography (MRI) using 3D vibe sequences before and after PAE and for the follow up after 3 and 6 months.&#13;
RESULTS:&#13;
&#13;
PAE was technically and clinically successful in all 18 patients with less clinical symptoms and reduction of the gland volume. In all cases color-coded CEUS parametric imaging was able to evaluate partial infarction after embolization with changes from red and yellow to green and blue colors in the embolization areas. Relevant changes could be evaluated for TIC-analysis of CEUS with reduced arterial enhancement in the arterial phase and prolonged enhancement of up to 1 min with significant changes (p = 0.0024). The area under the curve (AUC) decreased from 676±255.04 rU (160 rU–1049 rU) before PAE to 370.43±255.19 rU (45 rU–858 rU) after PAE. Time to peak (TTP) did not change significantly (p = 0.6877); TTP before PAE was 25.82±9.04 s (12.3 s–42.5 s) and after PAE 24.43±9.10 s (12–39 s). Prostate volume decreased significantly (p = 0.0045) from 86.93±34.98 ml (30–139 ml) before PAE to 50.57±26.26 ml (19–117 ml) after PAE. There were no major complications and, in most cases (14/18) a volume reduction of the benign prostate hyperplasia occurred.&#13;
CONCLUSION:&#13;
&#13;
Performed by an experienced examiner CEUS with parametric imaging and TIC-analysis is highly useful to further establish prostatic artery embolization (PAE) as a successful minimal invasive treatment of benign prostatic hyperplasia.</abstract>
    <parentTitle language="eng">Clinical Hemorheology and Microcirculation</parentTitle>
    <identifier type="doi">10.3233/CH-209202</identifier>
    <identifier type="url">https://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch209202</identifier>
    <identifier type="issn">1875-8622</identifier>
    <identifier type="issn">1386-0291</identifier>
    <enrichment key="BTU">an der BTU erstellt / created at BTU</enrichment>
    <enrichment key="Fprofil">2 Gesundheit und Lifes Sciences / Health and Life Sciences</enrichment>
    <enrichment key="Fprofil">3 Globaler Wandel und Transformationsprozesse / Global Change and Transformation Processes</enrichment>
    <author>
      <firstName>Ernst Michael</firstName>
      <lastName>Jung</lastName>
    </author>
    <submitter>
      <firstName>Christian</firstName>
      <lastName>Schulz</lastName>
    </submitter>
    <author>
      <firstName>T.</firstName>
      <lastName>Wertheimer</lastName>
    </author>
    <author>
      <firstName>F. J.</firstName>
      <lastName>Putz</lastName>
    </author>
    <author>
      <firstName>Friedrich</firstName>
      <lastName>Jung</lastName>
    </author>
    <author>
      <firstName>Sarah</firstName>
      <lastName>Kammerer</lastName>
    </author>
    <author>
      <firstName>B.</firstName>
      <lastName>Pregler</lastName>
    </author>
    <author>
      <firstName>L.</firstName>
      <lastName>Luerken</lastName>
    </author>
    <author>
      <firstName>Christian</firstName>
      <lastName>Stroszczynski</lastName>
    </author>
    <author>
      <firstName>L.</firstName>
      <lastName>Beyer</lastName>
    </author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Contrast enhanced ultrasound (CEUS)</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>parametric imaging</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>time intensity curve analysis (TIC)</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>prostate arterial embolization (PAE)</value>
    </subject>
    <collection role="institutes" number="2110">FG Molekulare Zellbiologie</collection>
  </doc>
  <doc>
    <id>27983</id>
    <completedYear/>
    <publishedYear>2021</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>3</pageFirst>
    <pageLast>17</pageLast>
    <pageNumber/>
    <edition/>
    <issue>1</issue>
    <volume>79</volume>
    <type>articler</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2021-11-23</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">High resolution flow (HR Flow) and Glazing Flow in cases of hepatic flow changes: Comparison to color-coded doppler sonography (CCDS)</title>
    <abstract language="eng">AIM:&#13;
To evaluate the possibilities of flow detection using high resolution flow (HR Flow) and Glazing Flow technique in patients with liver parenchymal changes and flow changes in comparison to color-coded Doppler sonography (CCDS).&#13;
&#13;
MATERIAL AND METHODS:&#13;
All examinations were performed using a multi frequency matrix convex probe with high resolution technique (SC6-1U/Resona7, Mindray, Shenzhen, China) by one experienced examiner to evaluate the venous, portal venous and arterial liver flow with digital documentation of the dynamic flow parameters like peak systolic flow, end-diastolic flow and resistance index. For liver parenchymal stiffness changes shear wave elastography was performed with at least 10 measurements. By two independent readers an elevation was performed to evaluate the image quality and the degree of flow artefacts, from 0 = not available to 5 points with excellent image quality without flow artefacts.&#13;
&#13;
RESULTS:&#13;
All 40 patients (24 men, 16 women, age 27–83 years, mean 56±5 years) showed morphology changes from B-Mode of the liver parenchyma to inhomogeneous tissue with higher stiffness evaluated by the shear wave elastography (1.45 m/s up to 2.79 m/s±1.79 m/s, considering F1 up to F4 fibrosis) and in 15 cases histopathologically proven liver cirrhosis. In 9 cases after non-acute thrombosis flow reduction of the portal vein was the reason for the diameter less than 5 mm. Flow parameters for the venous flow were between 8 cm/s up to 29 cm/s, mean 14±4 cm/s, for the hepatic portal vein 5 cm/s up to 57 cm/s, mean 17±5 cm/s, for the hepatic artery systolic flow between 50 cm/s up to 127±33 cm/s, end-diastolic flow from 22 cm/s up to 47±8 cm/s. Resistance index for the hepatic artery was between 0.41 up to 0.73, mean 0.67±0.25. The image quality for CCDS over all cases was evaluated for CCDS between 1 up to 4. The mean quality was 2.5±0.5, for HR Flow in combination with Glazing Flow 3±0.5, with significant differences for the 2 readers (P &lt; 0.01).&#13;
&#13;
CONCLUSION:&#13;
Combination of HR Flow with Glazing Flow could be helpful to evaluate morphological und hemodynamic changes of liver arterial flow, portal venous and venous flow. Reduction of flow artefacts in combination with a higher image quality could be helpful for optimizing the digital measurements also for follow up examinations.</abstract>
    <parentTitle language="eng">Clinical Hemorheology and Microcirculation</parentTitle>
    <identifier type="url">https://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch219102</identifier>
    <identifier type="doi">10.3233/CH-219102</identifier>
    <identifier type="issn">1875-8622</identifier>
    <identifier type="issn">1386-0291</identifier>
    <enrichment key="BTU">an der BTU erstellt / created at BTU</enrichment>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">false</enrichment>
    <enrichment key="Fprofil">2 Gesundheit und Lifes Sciences / Health and Life Sciences</enrichment>
    <enrichment key="Fprofil">3 Globaler Wandel und Transformationsprozesse / Global Change and Transformation Processes</enrichment>
    <author>
      <firstName>Ernst Michael</firstName>
      <lastName>Jung</lastName>
    </author>
    <submitter>
      <firstName>Christian</firstName>
      <lastName>Schulz</lastName>
    </submitter>
    <author>
      <firstName>Sarah</firstName>
      <lastName>Kammerer</lastName>
    </author>
    <author>
      <firstName>M.</firstName>
      <lastName>Brandenstein</lastName>
    </author>
    <author>
      <firstName>F. J.</firstName>
      <lastName>Putz</lastName>
    </author>
    <author>
      <firstName>Christian</firstName>
      <lastName>Stroszczynski</lastName>
    </author>
    <author>
      <firstName>Friedrich</firstName>
      <lastName>Jung</lastName>
    </author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Liver vascular imaging</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>high resolution flow (HR)</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Glazing Flow</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>imaging quality</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>artefact reduction</value>
    </subject>
    <collection role="institutes" number="2110">FG Molekulare Zellbiologie</collection>
  </doc>
  <doc>
    <id>27985</id>
    <completedYear/>
    <publishedYear>2021</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume>11</volume>
    <type>articler</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2021-11-23</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Quantification of dynamic contrast-enhanced ultrasound (CEUS) in non-cystic breast lesions using external perfusion software</title>
    <abstract language="eng">The aim of this present clinical pilot study is the display of typical perfusion results in patients with solid, non-cystic breast lesions. The lesions were characterized using contrast enhanced ultrasound (CEUS) with (i) time intensity curve analyses (TIC) and (ii) parametric color maps. The 24 asymptomatic patients included were genetically tested for having an elevated risk for breast cancer. At a center of early detection of familial ovary and breast cancer, those patients received annual MRI and grey-scale ultrasound. If lesions remained unclear or appeared even suspicious, those patients also received CEUS. CEUS was performed after intravenous application of sulfur hexafluoride microbubbles. Digital DICOM cine loops were continuously stored for one minute in PACS (picture archiving and communication system). Perfusion images and TIC analyses were calculated off-line with external perfusion software (VueBox). The lesion diameter ranged between 7 and 15 mm (mean 11 ± 3 mm). Five hypoechoic irregular lesions were scars, 6 lesions were benign and 12 lesions were highly suspicious for breast cancer with irregular enhancement at the margins and a partial wash out. In those 12 cases, histopathology confirmed breast cancer. All the suspicious lesions were correctly identified visually. For the perfusion analysis only Peak Enhancement (PE) and Area Under the Curve (AUC) added more information for correctly identifying the lesions. Typical for benign lesions is a prolonged contrast agent enhancement with lower PE and prolonged wash out, while scars are characterized typically by a reduced enhancement in the center. No differences (p = 0.428) were found in PE in the center of benign lesions (64.2 ± 28.9 dB), malignant lesions (88.1 ± 93.6 dB) and a scar (40.0 ± 17.0 dB). No significant differences (p = 0.174) were found for PE values at the margin of benign lesions (96.4 ± 144.9 dB), malignant lesions (54.3 ± 86.2 dB) or scar tissue (203.8 ± 218.9 dB). Significant differences (p &lt; 0.001) were found in PE of the surrounding tissue when comparing benign lesions (33.6 ± 25.2 dB) to malignant lesions (15.7 ± 36.3 dB) and scars (277.2 ± 199.9 dB). No differences (p = 0.821) were found in AUC in the center of benign lesions (391.3 ± 213.7), malignant lesions (314.7 ± 643.9) and a scar (213.1 ± 124.5). No differences (p = 0.601) were found in AUC values of the margin of benign lesions (313.3 ± 372.8), malignant lesions (272.6 ± 566.4) or scar tissue (695.0 ± 360.6). Significant differences (p &lt; 0.01) were found in AUC of the surrounding tissue for benign lesions (151.7 ± 127.8), malignant lesions (177.9 ± 1345.6) and scars (1091 ± 693.3). There were no differences in perfusion evaluation for mean transit time (mTT), rise time (RT) and time to peak (TTP) when comparing the center to the margins and the surrounding tissue. The CEUS perfusion parameters PE and AUC allow a very good assessment of the risk of malignant breast lesions and thus a downgrading of BI-RADS 4 lesions. The use of the external perfusion software (VueBox, Bracco, Milan, Italy) did not lead to any further improvement in the diagnosis of suspicious breast lesions and does appears not to have any additional diagnostic value in breast lesions.</abstract>
    <parentTitle language="eng">Scientific Reports</parentTitle>
    <identifier type="url">https://www.nature.com/articles/s41598-021-96137-6</identifier>
    <identifier type="doi">10.1038/s41598-021-96137-6</identifier>
    <identifier type="issn">2045-2322</identifier>
    <enrichment key="BTU">an der BTU erstellt / created at BTU</enrichment>
    <enrichment key="Artikelnummer">17677</enrichment>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="Fprofil">2 Gesundheit und Lifes Sciences / Health and Life Sciences</enrichment>
    <enrichment key="Fprofil">3 Globaler Wandel und Transformationsprozesse / Global Change and Transformation Processes</enrichment>
    <author>
      <firstName>Ernst Michael</firstName>
      <lastName>Jung</lastName>
    </author>
    <submitter>
      <firstName>Christian</firstName>
      <lastName>Schulz</lastName>
    </submitter>
    <author>
      <firstName>Friedrich</firstName>
      <lastName>Jung</lastName>
    </author>
    <author>
      <firstName>Christian</firstName>
      <lastName>Stroszczynski</lastName>
    </author>
    <author>
      <firstName>Isabel</firstName>
      <lastName>Wiesinger</lastName>
    </author>
    <collection role="institutes" number="2110">FG Molekulare Zellbiologie</collection>
  </doc>
  <doc>
    <id>27981</id>
    <completedYear/>
    <publishedYear>2021</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>463</pageFirst>
    <pageLast>474</pageLast>
    <pageNumber/>
    <edition/>
    <issue>3</issue>
    <volume>79</volume>
    <type>articler</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2021-11-23</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Wireless point-of-care ultrasound: First experiences with a new generation handheld device</title>
    <abstract language="eng">AIM:&#13;
To evaluate the diagnostic reliability of a new generation wireless point-of care ultrasound device for abdominal and thoracic findings.&#13;
&#13;
MATERIAL AND METHODS:&#13;
40 patients (16 females, 24 males 19 –80 years, on average 56.1 years) were scanned by an experienced examiner using the new wireless Vscan Air device for abdominal and thoracic findings. The probe frequencies were 2–5 MHz (convex probe) and 3–12 MHz for the linear probe. As a reference standard, all patients were also examined using high-end ultrasound (LOGIQ E9/10). Results were interpreted independently by two examiners in consensus, also with regard to the image quality (0–4, from not assessable = 0, to excellent 4).&#13;
&#13;
RESULTS:&#13;
In all 40 patients (100%) examination with conventional high-end ultrasound and the Vscan Air ultrasound device was feasible. Sensitivity, specificity, positive and negative predictive value for the diagnosis of abdominal and thoracic findings were 63.3%, 100%, 100%, and 40%, respectively. Most main diagnostic findings were detected using the mobile device compared to the high-end ultrasound. Limitations were found regarding characterization and classification of hepatic and renal tumorous lesions.&#13;
&#13;
Image quality revealed mostly minor diagnostic limitations for the mobile device, mean 2.9 (SD –0.300) and was excellent or with only minor diagnostic limitations for conventional high-end ultrasound, mean 3.25 (SD –0.438).&#13;
&#13;
CONCLUSION:&#13;
Due to its easy application and its high diagnostic reliability, point-of-care ultrasound systems of the latest generation represent a valuable imaging method for the primary assessment of abdominal and thoracic findings, especially in patients on intensive care units or in emergency situations.</abstract>
    <parentTitle language="eng">Clinical Hemorheology and Microcirculation</parentTitle>
    <identifier type="url">https://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch211197</identifier>
    <identifier type="doi">10.3233/CH-211197</identifier>
    <identifier type="issn">1875-8622</identifier>
    <identifier type="issn">1386-0291</identifier>
    <enrichment key="BTU">an der BTU erstellt / created at BTU</enrichment>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="Fprofil">2 Gesundheit und Lifes Sciences / Health and Life Sciences</enrichment>
    <enrichment key="Fprofil">3 Globaler Wandel und Transformationsprozesse / Global Change and Transformation Processes</enrichment>
    <author>
      <firstName>Ernst Michael</firstName>
      <lastName>Jung</lastName>
    </author>
    <submitter>
      <firstName>Christian</firstName>
      <lastName>Schulz</lastName>
    </submitter>
    <author>
      <firstName>J.</firstName>
      <lastName>Dinkel</lastName>
    </author>
    <author>
      <firstName>Niklas</firstName>
      <lastName>Verloh</lastName>
    </author>
    <author>
      <firstName>M.</firstName>
      <lastName>Brandenstein</lastName>
    </author>
    <author>
      <firstName>Christian</firstName>
      <lastName>Stroszczynski</lastName>
    </author>
    <author>
      <firstName>Friedrich</firstName>
      <lastName>Jung</lastName>
    </author>
    <author>
      <firstName>J.</firstName>
      <lastName>Rennert</lastName>
    </author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Point-of-care ultrasound</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Vscan Air</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>high-end ultrasound</value>
    </subject>
    <collection role="institutes" number="2110">FG Molekulare Zellbiologie</collection>
  </doc>
  <doc>
    <id>27982</id>
    <completedYear/>
    <publishedYear>2021</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>27</pageFirst>
    <pageLast>38</pageLast>
    <pageNumber/>
    <edition/>
    <issue>1</issue>
    <volume>79</volume>
    <type>articler</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2021-11-23</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">High-performance sonographical multimodal imaging of non cystic thyroid lesions: Chances of the preoperative diagnostics in relation to histopathology</title>
    <abstract language="eng">AIM:&#13;
To improve preoperative diagnostics of solid non-cystic thyroid lesions by using new high-performance ultrasound techniques: optimized B-mode morphology, elastography, Color-Coded Doppler-Sonography (CCDS) and contrast enhanced ultrasound (CEUS)&#13;
&#13;
MATERIALS AND METHODS:&#13;
In 33 cases solid, non-cystic thyroid lesions were rated as TIRADS 3 and up from conventional B-mode examinations. Additional high resolution Power Doppler including HR- and Glazing-Flow as optimized macrovascularization techniques, shear wave elastography and CEUS were performed on these patients by one experienced examiner. For CEUS a bolus of 1–2.4 ml Sulfurhexafluorid microbubbles (SonoVue®, Bracco, Milan, Italy) was injected into a cubital vein and then the distribution kinetics of the contrast agent were documented from the early arterial phase (10 to 15 seconds after injection) to the late venous phase (5 minutes after injection). Postoperative histopathology was the diagnostic gold standard as it provides the most reliable proof.&#13;
&#13;
RESULTS:&#13;
33 patients (13 males, 20 females; age 29 –77 years; mean 55 years; SD 13 years) were included in this study. 28 of them had benign regressive thyroid nodules, 3 had adenomas and 4 were diagnosed with carcinomas (3 were histologically identified as papillary thyroid carcinomas, one as a medullary thyroid carcinoma). The volume of the thyroid gland ranged from 6.6 to 401.3 cm2 (mean 72.6±92.0 cm2).&#13;
&#13;
The adenoma diameters ranged from 9 to 40 mm (mean 22±16 mm) and the carcinoma diameters ranged from 19 to 33 mm (mean 26±6 mm). The 3 adenomas had different echogenicities: One was completely echofree, one was hypoechoic and one isoechoic. The 4 carcinomas however were equally characterized as hypoechoic and echofree. Two of three adenomas and all of the carcinomas showed an incomplete or diffuse margin. Micro-calcifications were found in one adenoma and in every carcinoma. However, no micro-calcifications were observed in cases of benign regressive nodules.&#13;
&#13;
Performing shear-wave elastography the adenomas showed lower values than the carcinomas: The tissue velocity of the adenomas ranged from 2.86 m/s to 3.85 m/s (mean 3.32±0.5 m/s) and in carcinomas from 3.89 m/s to 5.66 m/s (mean 4.18±0.3 m/s).&#13;
&#13;
Marginal hypervascularization was detected in two adenomas after applying CCDS. One adenoma was hypovascularized. The four carcinomas showed an irregular extreme hypervascularization along their margins as well as an irregular central normo- or hypervascularization in CCDS. The additional HR-Flow helped reducing artefacts.&#13;
&#13;
In CEUS the dynamic capillary microvascularization of all carcinomas was very irregular with early enhancement and followed by partial or complete wash-out. In CEUS two adenomas had no wash-out and the other one showed a partial wash-out.&#13;
&#13;
CONCLUSION:&#13;
Using modern multimodal imaging offers new possibilities for the differentiation between benign and malignant thyroid lesions. It is a very important diagnostic tool in addition to the B-Mode TIRADS classification and eases the decision between TIRADS 3, 4 and 5. However, additional multicenter studies are required for more detailed evaluations.</abstract>
    <parentTitle language="eng">Clinical Hemorheology and Microcirculation</parentTitle>
    <identifier type="url">https://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch219101</identifier>
    <identifier type="doi">10.3233/CH-219101</identifier>
    <identifier type="issn">1875-8622</identifier>
    <identifier type="issn">1386-0291</identifier>
    <enrichment key="BTU">an der BTU erstellt / created at BTU</enrichment>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">false</enrichment>
    <enrichment key="Fprofil">2 Gesundheit und Lifes Sciences / Health and Life Sciences</enrichment>
    <enrichment key="Fprofil">3 Globaler Wandel und Transformationsprozesse / Global Change and Transformation Processes</enrichment>
    <author>
      <firstName>M.</firstName>
      <lastName>Brandenstein</lastName>
    </author>
    <submitter>
      <firstName>Christian</firstName>
      <lastName>Schulz</lastName>
    </submitter>
    <author>
      <firstName>Isabel</firstName>
      <lastName>Wiesinger</lastName>
    </author>
    <author>
      <firstName>Friedrich</firstName>
      <lastName>Jung</lastName>
    </author>
    <author>
      <firstName>Christian</firstName>
      <lastName>Stroszczynski</lastName>
    </author>
    <author>
      <firstName>Ernst Michael</firstName>
      <lastName>Jung</lastName>
    </author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Solid thyroid lesions</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>high-resolution ultrasound</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>HR-flow</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>elastography</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>CEUS</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>histopathology</value>
    </subject>
    <collection role="institutes" number="2110">FG Molekulare Zellbiologie</collection>
  </doc>
  <doc>
    <id>29869</id>
    <completedYear/>
    <publishedYear>2022</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>49</pageFirst>
    <pageLast>59</pageLast>
    <pageNumber/>
    <edition/>
    <issue>2</issue>
    <volume>80</volume>
    <type>articler</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2023-01-04</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Dynamic endoluminal contrast enhanced ultrasound (CEUS) for display of drainages in inflammatory abdominal fluid collections</title>
    <parentTitle language="eng">Clinical Hemorheology and Microcirculation</parentTitle>
    <identifier type="doi">10.3233/CH-211370</identifier>
    <identifier type="issn">1875-8622</identifier>
    <identifier type="issn">1386-0291</identifier>
    <enrichment key="BTU">an der BTU erstellt / created at BTU</enrichment>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">false</enrichment>
    <enrichment key="Fprofil">2 Gesundheit und Lifes Sciences / Health and Life Sciences</enrichment>
    <enrichment key="Fprofil">3 Globaler Wandel und Transformationsprozesse / Global Change and Transformation Processes</enrichment>
    <author>
      <firstName>Ernst Michael</firstName>
      <lastName>Jung</lastName>
    </author>
    <submitter>
      <firstName>Sarah</firstName>
      <lastName>Kammerer</lastName>
    </submitter>
    <author>
      <firstName>Friedrich</firstName>
      <lastName>Jung</lastName>
    </author>
    <author>
      <firstName>Christian</firstName>
      <lastName>Stroszczynski</lastName>
    </author>
    <author>
      <firstName>Isabel</firstName>
      <lastName>Wiesinger</lastName>
    </author>
    <collection role="institutes" number="2110">FG Molekulare Zellbiologie</collection>
  </doc>
  <doc>
    <id>29873</id>
    <completedYear/>
    <publishedYear>2022</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>1</pageFirst>
    <pageLast>16</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>articler</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2023-01-04</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Modified contrast-enhanced ultrasonography with the new high-resolution examination technique of high frame rate contrast-enhanced ultrasound (HiFR-CEUS) for characterization of liver lesions: First results</title>
    <parentTitle language="eng">Clinical Hemorheology and Microcirculation</parentTitle>
    <identifier type="doi">10.3233/CH-221449</identifier>
    <identifier type="issn">1875-8622</identifier>
    <enrichment key="BTU">an der BTU erstellt / created at BTU</enrichment>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="Fprofil">2 Gesundheit und Lifes Sciences / Health and Life Sciences</enrichment>
    <enrichment key="Fprofil">3 Globaler Wandel und Transformationsprozesse / Global Change and Transformation Processes</enrichment>
    <author>
      <firstName>Ernst Michael</firstName>
      <lastName>Jung</lastName>
    </author>
    <submitter>
      <firstName>Sarah</firstName>
      <lastName>Kammerer</lastName>
    </submitter>
    <author>
      <firstName>Valentina Ocañaa</firstName>
      <lastName>Moran</lastName>
    </author>
    <author>
      <firstName>Martin</firstName>
      <lastName>Engel</lastName>
    </author>
    <author>
      <firstName>Anne</firstName>
      <lastName>Krüger-Genge</lastName>
    </author>
    <author>
      <firstName>Christian</firstName>
      <lastName>Stroszczynski</lastName>
    </author>
    <author>
      <firstName>Friedrich</firstName>
      <lastName>Jung</lastName>
    </author>
    <collection role="institutes" number="2110">FG Molekulare Zellbiologie</collection>
  </doc>
  <doc>
    <id>29875</id>
    <completedYear/>
    <publishedYear>2022</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>231</pageFirst>
    <pageLast>238</pageLast>
    <pageNumber/>
    <edition/>
    <issue>3</issue>
    <volume>82</volume>
    <type>articler</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2023-01-04</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">High resolution flow with glazing flow for optimized flow detection in transjugular intrahepatic portosystemic stent shunt (TIPS): First results</title>
    <parentTitle language="eng">Clinical hemorheology and microcirculation</parentTitle>
    <identifier type="doi">10.3233/CH-221427</identifier>
    <identifier type="issn">1875-8622</identifier>
    <identifier type="issn">1386-0291</identifier>
    <enrichment key="BTU">an der BTU erstellt / created at BTU</enrichment>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">false</enrichment>
    <enrichment key="Fprofil">2 Gesundheit und Lifes Sciences / Health and Life Sciences</enrichment>
    <enrichment key="Fprofil">3 Globaler Wandel und Transformationsprozesse / Global Change and Transformation Processes</enrichment>
    <author>
      <firstName>Ernst Michael</firstName>
      <lastName>Jung</lastName>
    </author>
    <submitter>
      <firstName>Sarah</firstName>
      <lastName>Kammerer</lastName>
    </submitter>
    <author>
      <firstName>Friedrich</firstName>
      <lastName>Jung</lastName>
    </author>
    <author>
      <firstName>Niklas</firstName>
      <lastName>Verloh</lastName>
    </author>
    <author>
      <firstName>Michael</firstName>
      <lastName>Haimerl</lastName>
    </author>
    <author>
      <firstName>Lukas</firstName>
      <lastName>Lürken</lastName>
    </author>
    <author>
      <firstName>Simon</firstName>
      <lastName>Jage</lastName>
    </author>
    <author>
      <firstName>Christian</firstName>
      <lastName>Stroszczynski</lastName>
    </author>
    <author>
      <firstName>Gregor</firstName>
      <lastName>Scharf</lastName>
    </author>
    <collection role="institutes" number="2110">FG Molekulare Zellbiologie</collection>
  </doc>
  <doc>
    <id>34167</id>
    <completedYear/>
    <publishedYear/>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>10</pageNumber>
    <edition/>
    <issue>9</issue>
    <volume>14</volume>
    <type>articlenr</type>
    <publisherName>MDPI</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>2024-09-22</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Contrast-enhanced intraoperative ultrasound shows excellent performance in improving intraoperative decision-making</title>
    <abstract language="eng">Background: The aim of this study was to evaluate the performance and the impact of contrast-enhanced intraoperative ultrasound (CE-IOUS) on intraoperative decision-making, as there is still no standardized protocol for its use. Therefore, we retrospectively analyzed multiple CE-IOUS performed in hepato-pancreatic-biliary surgery with respect to pre- and postoperative imaging and histopathological findings. Methods: Data of 50 patients who underwent hepato-pancreatic-biliary surgery between 03/2022 and 03/2024 were retrospectively collected. CE-IOUS was performed with a linear 6–9 MHz multifrequency probe connected to a high-resolution device. The ultrasound contrast agent used was a stabilized aqueous suspension of sulphur hexafluoride microbubbles. Results: In total, all 50 lesions indicated for surgery were correctly identified. In 30 cases, CE-IOUS was used to localize the primary lesion and to define the resection margins. In the remaining 20 cases, CE-IOUS identified an additional lesion. Fifteen of these findings were identified as malignant. In eight of these cases, the additional malignant lesion was subsequently resected. In the remaining seven cases, CE-IOUS again revealed an inoperable situation. In summary, CE-IOUS diagnostics resulted in a high correct classification rate of 95.7%, with positive and negative predictive values of 95.2% and 100.0%, respectively. Conclusions: CE-IOUS shows excellent performance in describing intraoperative findings in hepato-pancreatic-biliary surgery, leading to a substantial impact on intraoperative decision-making.</abstract>
    <parentTitle language="eng">Life</parentTitle>
    <identifier type="issn">2075-1729</identifier>
    <identifier type="doi">10.3390/life14091199</identifier>
    <enrichment key="opus.import.date">2024-10-07T10:55:41+00:00</enrichment>
    <enrichment key="opus.source">sword</enrichment>
    <enrichment key="opus.import.user">deepgreen</enrichment>
    <enrichment key="opus.import.file">attachment; filename=deposit.zip</enrichment>
    <enrichment key="opus.import.checksum">8b714f8c06580424910295c41c9905c5</enrichment>
    <enrichment key="Publikationsweg">Open Access</enrichment>
    <enrichment key="BTU">an der BTU erstellt / created at BTU</enrichment>
    <author>
      <firstName>Laura S.</firstName>
      <lastName>Kupke</lastName>
    </author>
    <editor>
      <firstName>Roberto</firstName>
      <lastName>Miraglia</lastName>
    </editor>
    <author>
      <firstName>Ivor</firstName>
      <lastName>Dropco</lastName>
    </author>
    <author>
      <firstName>Markus</firstName>
      <lastName>Götz</lastName>
    </author>
    <author>
      <firstName>Paul</firstName>
      <lastName>Kupke</lastName>
    </author>
    <author>
      <firstName>Friedrich</firstName>
      <lastName>Jung</lastName>
    </author>
    <author>
      <firstName>Christian</firstName>
      <lastName>Stroszczynski</lastName>
    </author>
    <author>
      <firstName>Ernst Michael</firstName>
      <lastName>Jung</lastName>
    </author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>ultrasound</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>contrast-enhanced ultrasound</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>CEUS</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>micro-vascularization</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>intraoperative ultrasound</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>IOUS</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>intraoperative decision-making</value>
    </subject>
    <collection role="institutes" number="2110">FG Molekulare Zellbiologie</collection>
    <collection role="Import" number="import">Import</collection>
  </doc>
  <doc>
    <id>32273</id>
    <completedYear/>
    <publishedYear>2023</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>227</pageFirst>
    <pageLast>236</pageLast>
    <pageNumber/>
    <edition/>
    <issue>2</issue>
    <volume>84</volume>
    <type>articler</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2024-01-04</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Advanced multimodal imaging of solid thyroid lesions with artificial intelligence-optimized B-mode, elastography, and contrast-enhanced ultrasonography parametric and with perfusion imaging: Initial results</title>
    <abstract language="eng">Goal of the study was the assessment of AI-assisted diagnosis of solid thyroid foci with multimodal modern ultrasound imaging. 50 patients (26–81 years, 54.7±13.1 years) were included in the study. Multimodal ultrasound imaging by means of B-mode with linear probe (4–12 MHz) with option of automated documentation of findings by means of AI, with supplementary Ultra MicroAngiography (UMA) was used. Macrovascularisation was assessed by dynamic contrast ultrasonography (CEUS) with parametric evaluation and perfusion analysis, and microvascularization was assessed by combined strain and shear wave elastography on a novel high-performance ultrasound system (Resona R9/Mindray) by an experienced examiner with independent reading. The evaluation was performed according to TI-RADS III-V.&#13;
&#13;
The volume of the thyroid lobes on both sides averaged 39 ml±5 ml (27 to 69 ml). The 13 cases of histologically confirmed thyroid carcinomas (8 papillary, 2 medullary, 2 microfollicular, 1 anaplastic CA) with a mean size of 15 mm±6 mm (9–21 mm) were correctly evaluated by TI-RADS V on the basis of irregular shape, induration &gt; 2.5 m/s or &gt; 30kPA and striking wash-out kinetics. Tumor lymph nodes could only be correctly detected preoperatively in one case of medullary carcinoma according to the surgical findings, based on irregular vascularization with UMA in roundish shape with cortex &gt; 4 mm, transverse diameter up to 11 mm. In 25 cases of inhomogeneous nodular goiter an evaluation with TI-RADS III was performed in 31 cases, in 4 cases with incomplete marginal contour, partial marginal vascularization with UMA and partial wash out with indurations up to 2.5 m/s 30 kPA an evaluation with TI-RADS IV and surgical excision for nodular goiter. In 12 cases regressive nodular changes without relevant malignancy criteria resulted in nodular goiter, with focal changes up to 1.5 cm in diameter, classified as requiring control with TI-RADS III. There were no relevant changes in findings in the controls after 6 months. From the AI tool, the 20/25 goiter nodes were assessed as TI-RADS III, 7/12 adenomas, 5 goiter nodes, and 5 adenomas as TI-RADS IV, 5/13 carcinomas as TI-RADS IV, and 8/13 carcinomas as TI-RADS V.&#13;
&#13;
Multimodal ultrasound diagnostics supported by AI has a high diagnostic potential for the evaluation of solid thyroid lesions and standardizes the reporting with digital representative image documentation. CEUS perfusion and modern elastography techniques allow targeted follow-up of TI-RADS III findings.</abstract>
    <parentTitle language="eng">Clinical Hemorheology and Microcirculation</parentTitle>
    <identifier type="url">https://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch239102</identifier>
    <identifier type="doi">10.3233/CH-239102</identifier>
    <identifier type="issn">1386-0291</identifier>
    <enrichment key="BTU">an der BTU erstellt / created at BTU</enrichment>
    <enrichment key="Publikationsweg">Open Access</enrichment>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">false</enrichment>
    <enrichment key="Fprofil">2 Gesundheit und Lifes Sciences / Health and Life Sciences</enrichment>
    <enrichment key="Fprofil">3 Globaler Wandel und Transformationsprozesse / Global Change and Transformation Processes</enrichment>
    <author>
      <firstName>Ernst Michael</firstName>
      <lastName>Jung</lastName>
    </author>
    <submitter>
      <firstName>Christian</firstName>
      <lastName>Schulz</lastName>
    </submitter>
    <author>
      <firstName>Christian</firstName>
      <lastName>Stroszczynski</lastName>
    </author>
    <author>
      <firstName>Friedrich</firstName>
      <lastName>Jung</lastName>
    </author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Thyroid lesions</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>multimodal ultrasound</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>artificial intelligence (AI)</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>UMA-elastography</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>contrast enhanced ultrasonography (CEUS)</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>parametric-perfusion analysis</value>
    </subject>
    <collection role="institutes" number="2110">FG Molekulare Zellbiologie</collection>
  </doc>
  <doc>
    <id>32275</id>
    <completedYear/>
    <publishedYear>2024</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>133</pageFirst>
    <pageLast>142</pageLast>
    <pageNumber/>
    <edition/>
    <issue>1-2</issue>
    <volume>86</volume>
    <type>articler</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2024-01-04</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">First assessment of flow phenomena of acute and chronic thrombosis in the jugular veins using new ultrasound vector-flow imaging</title>
    <abstract language="eng">AIM:&#13;
First assessment of flow changes in the jugular veins using high resolution ultrasound vector flow.&#13;
&#13;
MATERIAL UND METHODS:&#13;
15 patients (8 males, 7 females) with an age range of 35 to 82 years (mean age 58.53±12.26 years) were examined by an experienced examiner using high power ultrasound equipment (Resona R9, Mindray) with probe technology (Mindray L9-3U Linear Array transducer, 2.5 to 9.0 MHz). This group was compared with five healthy subjects (mean age 35.4±13.79 years) as a reference. To assess flow changes, the color-coded duplex sonography and the novel vector flow technique were used. The evaluation was performed of vector morphology changes, turbulence, and wall resistance measurements.&#13;
&#13;
RESULTS:&#13;
There were changes after acute and chronic thrombosis in 9 cases, and venous compression in 7 cases. Turbulence was measurable from 0.01 % to 64.44 %, the average turbulence was 19.73±22.06 % . Wall resistance measurement showed values from 0.01 Pa to 3.14 Pa, depending on the age of the thrombosis or compression. The reference veins showed turbulence of 0.94±1.5 % and a mean wall resistance of 0.05±0.05 Pa. There are statistically significant differences between normal and thrombotic or compressed veins in terms of maximum wall stress (p = 0.006) and mean degree of turbulence (p = 0.012), while the difference in mean wall stress is not statistically significant (p = 0.058).&#13;
&#13;
CONCLUSION:&#13;
Despite still existing technical limitations, the combination of V-flow and wall stress measurements in jugular vein changes suggests a high diagnostic potential.</abstract>
    <parentTitle language="eng">Clinical Hemorheology and Microcirculation</parentTitle>
    <identifier type="url">https://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch238117</identifier>
    <identifier type="doi">10.3233/CH-238117</identifier>
    <identifier type="issn">1386-0291</identifier>
    <enrichment key="BTU">an der BTU erstellt / created at BTU</enrichment>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="Fprofil">2 Gesundheit und Lifes Sciences / Health and Life Sciences</enrichment>
    <enrichment key="Fprofil">3 Globaler Wandel und Transformationsprozesse / Global Change and Transformation Processes</enrichment>
    <author>
      <firstName>V.</firstName>
      <lastName>Luderer</lastName>
    </author>
    <submitter>
      <firstName>Christian</firstName>
      <lastName>Schulz</lastName>
    </submitter>
    <author>
      <firstName>Friedrich</firstName>
      <lastName>Jung</lastName>
    </author>
    <author>
      <firstName>M.</firstName>
      <lastName>Brandenstein</lastName>
    </author>
    <author>
      <firstName>Christian</firstName>
      <lastName>Stroszczynski</lastName>
    </author>
    <author>
      <firstName>Ernst Michael</firstName>
      <lastName>Jung</lastName>
    </author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Thrombosis</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>vector-flow-imaging</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>high resolution ultrasound</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>color-coded duplex sonography</value>
    </subject>
    <collection role="institutes" number="2110">FG Molekulare Zellbiologie</collection>
  </doc>
  <doc>
    <id>32278</id>
    <completedYear/>
    <publishedYear>2023</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>479</pageFirst>
    <pageLast>487</pageLast>
    <pageNumber/>
    <edition/>
    <issue>4</issue>
    <volume>32</volume>
    <type>articler</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2024-01-04</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Color mapping using ultrasound system-integrated perfusion software for evaluation of focal liver lesions: a possible first step for more independent reading</title>
    <abstract language="eng">Aims&#13;
To assess the value of using integrated parametric ultrasound software for contrast-enhanced ultrasonography (CEUS) of liver tumors.&#13;
Methods&#13;
107 patients with liver tumors were studied. CEUS were performed to detect focal lesions. Parametric images were based on continuous CINE LOOPs, from the early-arterial phase (15 s) to the portal-venous phase (1 min) generated by perfusion software. The evaluations of the parametric images and their dignity for liver lesions were performed independently by an experienced and a less-experienced investigator. Computed tomography, magnetic resonance imaging scans or histological analysis were used as references.&#13;
Results&#13;
High parametric image quality were obtained in all patients. Among the patients, 44% lesions were benign, 56% were malignant. The experienced investigator correctly classified 46 of 47 (98%) as benign, and 60 of 60 (100%) as malignant tumors based on the parametric images. The less-experienced investigator correctly classified 39 of 47 (83%) as benign, and 49 of 60 (82%) malignant tumors, acheaving a high statistical accuracy of 98% with this type of diagnostic.&#13;
Conclusion&#13;
Parametric imaging for grading the malignant degree of tumor may be a good complement to existing ultrasound techniques and was particularly helpful for improving the assessments of the less-experienced examiner.</abstract>
    <parentTitle language="eng">Journal of Gastrointestinal and Liver Diseases</parentTitle>
    <identifier type="url">https://europepmc.org/article/med/38147619</identifier>
    <identifier type="doi">10.15403/jgld-4997</identifier>
    <identifier type="issn">1842-1121</identifier>
    <enrichment key="BTU">an der BTU erstellt / created at BTU</enrichment>
    <enrichment key="Publikationsweg">Open Access</enrichment>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">false</enrichment>
    <enrichment key="Fprofil">2 Gesundheit und Lifes Sciences / Health and Life Sciences</enrichment>
    <enrichment key="Fprofil">3 Globaler Wandel und Transformationsprozesse / Global Change and Transformation Processes</enrichment>
    <author>
      <firstName>Ivor</firstName>
      <lastName>Dropco</lastName>
    </author>
    <submitter>
      <firstName>Christian</firstName>
      <lastName>Schulz</lastName>
    </submitter>
    <author>
      <firstName>Ulrich</firstName>
      <lastName>Kaiser</lastName>
    </author>
    <author>
      <firstName>Lola</firstName>
      <lastName>Wagner</lastName>
    </author>
    <author>
      <firstName>Stefan M.</firstName>
      <lastName>Brunner</lastName>
    </author>
    <author>
      <firstName>Hans Jürgen</firstName>
      <lastName>Schlitt</lastName>
    </author>
    <author>
      <firstName>Christian</firstName>
      <lastName>Stroszczynski</lastName>
    </author>
    <author>
      <firstName>Friedrich</firstName>
      <lastName>Jung</lastName>
    </author>
    <author>
      <firstName>Dong</firstName>
      <lastName>Yi</lastName>
    </author>
    <author>
      <firstName>Wolfgang</firstName>
      <lastName>Herr</lastName>
    </author>
    <author>
      <firstName>Ernst Michael</firstName>
      <lastName>Jung</lastName>
    </author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>CEUS</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>parametric imaging</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>dynamic vascularization</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>liver malignancies</value>
    </subject>
    <collection role="institutes" number="2110">FG Molekulare Zellbiologie</collection>
  </doc>
  <doc>
    <id>37379</id>
    <completedYear/>
    <publishedYear>2025</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>430</pageFirst>
    <pageLast>446</pageLast>
    <pageNumber>17</pageNumber>
    <edition/>
    <issue>2</issue>
    <volume>6</volume>
    <type>articler</type>
    <publisherName>Georg Thieme Verlag KG</publisherName>
    <publisherPlace>Stuttgart</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2026-01-19</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Intraoperative contrast-enhanced ultrasound (CEUS) with time intensity curve (TIC) analysis for better assessment of liver tumor margins</title>
    <title language="deu">Intraoperative Kontrastmittelsonografie (CEUS) mit Time Intensitiy Curve (TIC)-Analyse zur Beurteilung von Lebertumorgrenzen</title>
    <abstract language="eng">AbstractThe purpose of this study was to conduct an intraoperative evaluation of focal liver lesions using time intensity curve (TIC) analysis of contrast-enhanced ultrasound (CEUS) to better assess liver tumor margins.This study included 28 patients (21 men 75%, 7 women 25%) with malignant liver lesions (cholangiocellular carcinoma (CCC), n = 9; hepatocellular carcinoma (HCC), n = 6; hepatic metastases (HepMET), n = 13). A B-mode scan, color-coded Doppler sonography, and CEUS were performed intraoperatively to analyze the focal lesions. The generated parametric images were based on continuous cine loops, acquired with a multifrequency T-probe (6–9 MHz), from the early arterial phase (0–15 seconds) to the portal venous phase (1 minute), generated by integrated perfusion software. Analyses of the CEUS loops were performed using TICs with respect to time-to-peak (TTP) and area under the curve (AUC). Perfusion analysis was performed in the center and periphery of the tumor as well as in healthy liver tissue. All tumor lesions were evaluated histopathologically to verify the diagnosis.Sufficient image quality was achieved in all cases using CEUS for TIC analysis. A comparison of all groups showed a clear difference compared with the center, margin, and healthy liver tissue in the measured parameters of TTP and AUC (p = 0.035 and p = 0.045, respectively). In detail, differences were observed in the CCC group (TTP: p = 0.025) and in the HepMET group (TTP: p = 0.009), particularly in the peripheral areas (strong arterial flooding with a rapid increase in the flooding curve), with equally clear tumor edge representation compared with healthy liver tissue, as shown by the AUC analysis (CCC AUC: p = 0.032 and HepMET AUC: p = 0.029). In patients with HCC, the perfusion pattern (starting from the center) showed the center to be more clearly distinguishable from the edge with significant TTP and AUC (p = 0.035 and p = 0.038).Intraoperative TIC analysis of malignant liver tumors is an important diagnostic tool for better highlighting liver tumor margins during surgery.</abstract>
    <parentTitle language="eng">RöFo : Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren</parentTitle>
    <identifier type="doi">10.1055/a-2600-7229</identifier>
    <identifier type="issn">1438-9029</identifier>
    <enrichment key="opus_doi_flag">true</enrichment>
    <enrichment key="opus_import_data">{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T08:08:43Z","timestamp":1761898123723,"version":"3.41.0"},"reference-count":33,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rofo"],"abstract":"&lt;jats:title&gt;Abstract&lt;\/jats:title&gt;&lt;jats:p&gt;The purpose of this study was to conduct an intraoperative evaluation of focal liver lesions using time intensity curve (TIC) analysis of contrast-enhanced ultrasound (CEUS) to better assess liver tumor margins.&lt;\/jats:p&gt;&lt;jats:p&gt;This study included 28 patients (21 men 75%, 7 women 25%) with malignant liver lesions (cholangiocellular carcinoma (CCC), n = 9; hepatocellular carcinoma (HCC), n = 6; hepatic metastases (HepMET), n = 13). A B-mode scan, color-coded Doppler sonography, and CEUS were performed intraoperatively to analyze the focal lesions. The generated parametric images were based on continuous cine loops, acquired with a multifrequency T-probe (6\u20139 MHz), from the early arterial phase (0\u201315 seconds) to the portal venous phase (1 minute), generated by integrated perfusion software. Analyses of the CEUS loops were performed using TICs with respect to time-to-peak (TTP) and area under the curve (AUC). Perfusion analysis was performed in the center and periphery of the tumor as well as in healthy liver tissue. All tumor lesions were evaluated histopathologically to verify the diagnosis.&lt;\/jats:p&gt;&lt;jats:p&gt;Sufficient image quality was achieved in all cases using CEUS for TIC analysis. A comparison of all groups showed a clear difference compared with the center, margin, and healthy liver tissue in the measured parameters of TTP and AUC (p = 0.035 and p = 0.045, respectively). In detail, differences were observed in the CCC group (TTP: p = 0.025) and in the HepMET group (TTP: p = 0.009), particularly in the peripheral areas (strong arterial flooding with a rapid increase in the flooding curve), with equally clear tumor edge representation compared with healthy liver tissue, as shown by the AUC analysis (CCC AUC: p = 0.032 and HepMET AUC: p = 0.029). In patients with HCC, the perfusion pattern (starting from the center) showed the center to be more clearly distinguishable from the edge with significant TTP and AUC (p = 0.035 and p = 0.038).&lt;\/jats:p&gt;&lt;jats:p&gt;Intraoperative TIC analysis of malignant liver tumors is an important diagnostic tool for better highlighting liver tumor margins during surgery.&lt;\/jats:p&gt;","DOI":"10.1055\/a-2600-7229","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T23:15:21Z","timestamp":1748301321000},"source":"Crossref","is-referenced-by-count":1,"title":["Intraoperative contrast-enhanced ultrasound (CEUS) with time intensity curve (TIC) analysis for better assessment of liver tumor margins"],"prefix":"10.1055","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4180-4964","authenticated-orcid":false,"given":"Ivor","family":"Dropco","sequence":"additional","affiliation":[{"name":"Department for Surgery, University Hospital Regensburg Department for Surgery, Regensburg, Germany"}]},{"given":"Ulrich","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Department for Internal Medicine III, University Hospital Regensburg Department for Internal Medicine III, Regensburg, Germany"}]},{"given":"Friedrich","family":"Jung","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology, Brandenburg University of Technology Cottbus-Senftenberg, Cottbus, Germany"}]},{"given":"\u013dudiv\u00edt","family":"Danihel","sequence":"additional","affiliation":[{"name":"Department of 3rd surgical clinic, Comenius University in Bratislava, Bratislava, Slovakia"}]},{"given":"Hans J","family":"Schlitt","sequence":"additional","affiliation":[{"name":"Department for Surgery, University Hospital Regensburg Department for Surgery, Regensburg, Germany"}]},{"given":"Christian","family":"Stroszczynski","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital Regensburg Department for Radiotherapy, Regensburg, Germany"}]},{"given":"Wolfgang","family":"Herr","sequence":"additional","affiliation":[{"name":"Department for Internal Medicine III, University Hospital Regensburg Department for Internal Medicine III, Regensburg, Germany"}]},{"given":"Stefan M","family":"Brunner","sequence":"additional","affiliation":[{"name":"Department for Surgery, University Hospital Regensburg Department for Surgery, Regensburg, Germany"}]},{"given":"Ernst Michael","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital Regensburg Department for Radiotherapy, Regensburg, Germany"}]}],"member":"194","published-online":{"date-parts":[[2025,5,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3233\/CH-221449","article-title":"Modified contrast-enhanced ultrasonography with the new high-resolution examination technique of high frame rate contrast-enhanced ultrasound (HiFR-CEUS) for characterization of liver lesions: First results","volume":"83","author":"EM Jung","year":"2023","journal-title":"Clin Hemorheol Microcirc"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/s0033-8389(05)70288-8","article-title":"Ultrasound contrast agents: a promising future","volume":"39","author":"ML Robbin","year":"2001","journal-title":"Radiol Clin North Am"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1055\/a-2157-2587","article-title":"EFSUMB Technical Review \u2013 Update 2023: Dynamic Contrast-Enhanced Ultrasound (DCE-CEUS) for the Quantification of Tumor Perfusion","volume":"45","author":"CF Dietrich","year":"2024","journal-title":"Ultraschall Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1055\/a-1177-0530","article-title":"Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) in the Liver \u2013 Update 2020 \u2013 WFUMB in Cooperation with EFSUMB, AFSUMB, AIUM, and FLAUS","volume":"41","author":"CF Dietrich","year":"2020","journal-title":"Ultraschall Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s00117-021-00891-7","article-title":"Contrast-enhanced ultrasound perfusion imaging of organs","volume":"61","author":"EM Jung","year":"2021","journal-title":"Radiologe"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"e7058","DOI":"10.1590\/1414-431x20177058","article-title":"Repeatability of the \u201cflash-replenishment\u201d method in contrast-enhanced ultrasound for the quantitative assessment of hepatic microvascular perfusion","volume":"51","author":"F Xie","year":"2018","journal-title":"Braz J Med Biol Res"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"95","DOI":"10.3233\/CH-199221","article-title":"Quantitative perfusion analysis of hepatocellular carcinoma using dynamic contrast enhanced ultrasound (CEUS) to determine tumor microvascularization","volume":"73","author":"J Schaible","year":"2019","journal-title":"Clin Hemorheol Microcirc"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1055\/a-2203-2733","article-title":"Comparison of Microwave and Radiofrequency Ablation for the Treatment of Small- and Medium-Sized Hepatocellular Carcinomas in a Prospective Randomized Trial","volume":"196","author":"TJ Vogl","year":"2024","journal-title":"Rofo"},{"key":"ref9","first-page":"1199","article-title":"Contrast-Enhanced Intraoperative Ultrasound Shows Excellent Performance in Improving Intraoperative Decision-Making","volume":"14","author":"LS Kupke","year":"2024","journal-title":"Life (Basel)"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.3390\/diagnostics11071244","article-title":"Quantitative Analysis of the Time-Intensity Curve of Contrast-Enhanced Ultrasound of the Liver: Differentiation of Benign and Malignant Liver Lesions","volume":"11","author":"S Schwarz","year":"2021","journal-title":"Diagnostics (Basel)"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1055\/s-0031-1271114","article-title":"Diagnostic accuracy of CEUS in the differential diagnosis of small (\u2264\u200a20 \u200amm) and subcentimetric (\u2264\u200a10\u200a mm) focal liver lesions in comparison with histology. Results of the DEGUM multicenter trial","volume":"32","author":"D Strobel","year":"2011","journal-title":"Ultraschall Med"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.3390\/cells10051092","article-title":"Parametric Imaging of Contrast-Enhanced Ultrasound (CEUS) for the Evaluation of Acute Gastrointestinal Graft-Versus-Host Disease","volume":"10","author":"AM Pausch","year":"2021","journal-title":"Cells"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1055\/s-2008-1027806","article-title":"Contrast-enhanced ultrasound for the characterization of focal liver lesions--diagnostic accuracy in clinical practice (DEGUM multicenter trial)","volume":"29","author":"D Strobel","year":"2008","journal-title":"Ultraschall Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e20","DOI":"10.1055\/a-1220-8561","article-title":"Contrast-Enhanced Ultrasound Algorithms (CEUS-LIRADS\/ESCULAP) for the Noninvasive Diagnosis of Hepatocellular Carcinoma \u2013 A Prospective Multicenter DEGUM Study","volume":"42","author":"B Schellhaas","year":"2021","journal-title":"Ultraschall Med"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"435","DOI":"10.3233\/CH-168112","article-title":"Chronic liver disease: Quantitative MRI vs\u00a0CEUS-based microperfusion","volume":"64","author":"M Haimerl","year":"2016","journal-title":"Clin Hemorheol Microcirc"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"499","DOI":"10.15403\/jgld.2014.1121.254.tai","article-title":"Contrast-Enhanced Ultrasound and Computed Tomography Assessment of Hepatocellular Carcinoma after Transcatheter Arterial Chemo-Embolization: A Systematic Review","volume":"25","author":"CJ Tai","year":"2016","journal-title":"J Gastrointestin Liver Dis"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.1007\/s00247-020-04867-y","article-title":"Contrast-enhanced ultrasound of transplant organs \u2013 liver and kidney \u2013 in children","volume":"51","author":"D Franke","year":"2021","journal-title":"Pediatr Radiol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1055\/a-2275-2972","article-title":"Contrast-enhanced ultrasound of the liver: Vascular pathologies and interventions","volume":"196","author":"E Safai Zadeh","year":"2024","journal-title":"Rofo"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"429","DOI":"10.3233\/CH-211164","article-title":"Diagnostic performance of intravascular perfusion based contrast-enhanced ultrasound LI-RADS in the evaluation of hepatocellular carcinoma","volume":"78","author":"D Zuo","year":"2021","journal-title":"Clin Hemorheol Microcirc"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"479","DOI":"10.15403\/jgld-4997","article-title":"Color Mapping using Ultrasound System-integrated Perfusion Software for Evaluation of Focal Liver Lesions: A Possible First Step for More Independent Reading","volume":"32","author":"I Dropco","year":"2023","journal-title":"J Gastrointestin Liver Dis"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1002\/jum.15545","article-title":"Intraoperative Characterization of Pancreatic Tumors Using Contrast-Enhanced Ultrasound and Shear Wave Elastography for Optimization of Surgical Strategies","volume":"40","author":"N Platz Batista da Silva","year":"2021","journal-title":"J Ultrasound Med"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1186\/s12882-017-0681-8","article-title":"Diagnostic accuracy of contrast-enhanced ultrasound for characterization of kidney lesions in patients with and without chronic kidney disease","volume":"18","author":"EH Chang","year":"2017","journal-title":"BMC Nephrol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3233\/CH-152003","article-title":"Evaluation of the diagnostic accuracy of CEUS in children with benign and malignant liver lesions and portal vein anomalies","volume":"61","author":"K Pschierer","year":"2015","journal-title":"Clin Hemorheol Microcirc"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"181","DOI":"10.3233\/CH-239100","article-title":"Current aspects of multimodal ultrasound liver diagnostics using contrast-enhanced ultrasonography (CEUS), fat evaluation, fibrosis assessment, and perfusion analysis \u2013 An update","volume":"83","author":"EM Jung","year":"2023","journal-title":"Clin Hemorheol Microcirc"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.3390\/cancers3021763","article-title":"Contrast-Enhanced Ultrasound (CEUS) for Echographic Detection of Hepato Cellular Carcinoma in Cirrhotic Patients Previously Treated with Multiple Techniques: Comparison of Conventional US, Spiral CT and 3-Dimensional CEUS with Navigator Technique (3DNav CEUS)","volume":"3","author":"F Giangregorio","year":"2011","journal-title":"Cancers (Basel)"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"E2","DOI":"10.1055\/s-0043-123931","article-title":"How to perform Contrast-Enhanced Ultrasound (CEUS)","volume":"4","author":"CF Dietrich","year":"2018","journal-title":"Ultrasound Int Open"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"250","DOI":"10.26574\/maedica.2020.15.2.250","article-title":"Routine Intraoperative Ultrasound for the Detection of Liver Metastases during Resection of Primary Colorectal Cancer \u2013 A Systematic Review","volume":"15","author":"D Coco","year":"2020","journal-title":"Maedica (Bucur)"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1111\/bju.15353","article-title":"Cost-effectiveness analysis of multiple imaging modalities in diagnosis and follow-up of intermediate complex cystic renal lesions","volume":"128","author":"P Spiesecke","year":"2021","journal-title":"BJU Int"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"3997","DOI":"10.3390\/cancers14163997","article-title":"Current Imaging Diagnosis of Hepatocellular Carcinoma","volume":"14","author":"E Chartampilas","year":"2022","journal-title":"Cancers (Basel)"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.dld.2024.09.009","article-title":"Contrast-enhanced intraoperative ultrasound improved hepatic recurrence-free survival in initially unresectable colorectal cancer liver metastases","volume":"57","author":"H Li","year":"2025","journal-title":"Dig Liver Dis"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"E6","DOI":"10.3171\/2015.11.FOCUS15570","article-title":"Versatile utilization of real-time intraoperative contrast-enhanced ultrasound in cranial neurosurgery: technical note and retrospective case series","volume":"40","author":"I Lekht","year":"2016","journal-title":"Neurosurg Focus"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"435","DOI":"10.3233\/CH-168112","article-title":"Chronic liver disease: Quantitative MRI vs\u00a0CEUS-based microperfusion","volume":"64","author":"M Haimerl","year":"2016","journal-title":"Clin Hemorheol Microcirc"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1055\/a-2249-6791","article-title":"Intraoperative contrast-enhanced ultrasound has an outcome-relevant impact on surgery of primary and metastatic liver lesions","author":"F Bitterer","year":"2024","journal-title":"Ultraschall Med"}],"container-title":["R\u00f6Fo - Fortschritte auf dem Gebiet der R\u00f6ntgenstrahlen und der bildgebenden Verfahren"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2600-7229.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T23:15:23Z","timestamp":1748301323000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2600-7229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,26]]},"references-count":33,"URL":"https:\/\/doi.org\/10.1055\/a-2600-7229","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1438-9029","1438-9010"],"issn-type":[{"value":"1438-9029","type":"print"},{"value":"1438-9010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,26]]}}}</enrichment>
    <enrichment key="opus_crossrefDocumentType">journal-article</enrichment>
    <enrichment key="local_import_origin">crossref</enrichment>
    <enrichment key="local_doiImportPopulated">PersonAuthorFirstName_1,PersonAuthorLastName_1,PersonAuthorIdentifierOrcid_1,PersonAuthorFirstName_2,PersonAuthorLastName_2,PersonAuthorFirstName_3,PersonAuthorLastName_3,PersonAuthorFirstName_4,PersonAuthorLastName_4,PersonAuthorFirstName_5,PersonAuthorLastName_5,PersonAuthorFirstName_6,PersonAuthorLastName_6,PersonAuthorFirstName_7,PersonAuthorLastName_7,PersonAuthorFirstName_8,PersonAuthorLastName_8,PersonAuthorFirstName_9,PersonAuthorLastName_9,PublisherName,TitleMain_1,Language,TitleAbstract_1,TitleParent_1,PublishedYear,IdentifierIssn</enrichment>
    <enrichment key="BTU">an der BTU erstellt / created at BTU</enrichment>
    <enrichment key="Referiert">Beitrag ist referiert / Article peer-reviewed</enrichment>
    <enrichment key="opus.source">doi-import</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">false</enrichment>
    <author>
      <firstName>Ivor</firstName>
      <lastName>Dropco</lastName>
    </author>
    <submitter>
      <firstName>Sarah</firstName>
      <lastName>Kammerer</lastName>
    </submitter>
    <author>
      <firstName>Ulrich</firstName>
      <lastName>Kaiser</lastName>
    </author>
    <author>
      <firstName>Friedrich</firstName>
      <lastName>Jung</lastName>
    </author>
    <author>
      <firstName>Ľudivít</firstName>
      <lastName>Danihel</lastName>
    </author>
    <author>
      <firstName>Hans J</firstName>
      <lastName>Schlitt</lastName>
    </author>
    <author>
      <firstName>Christian</firstName>
      <lastName>Stroszczynski</lastName>
    </author>
    <author>
      <firstName>Wolfgang</firstName>
      <lastName>Herr</lastName>
    </author>
    <author>
      <firstName>Stefan M</firstName>
      <lastName>Brunner</lastName>
    </author>
    <author>
      <firstName>Ernst Michael</firstName>
      <lastName>Jung</lastName>
    </author>
    <collection role="institutes" number="2110">FG Molekulare Zellbiologie</collection>
  </doc>
  <doc>
    <id>37383</id>
    <completedYear/>
    <publishedYear>2026</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>10</pageNumber>
    <edition/>
    <issue>2</issue>
    <volume>90</volume>
    <type>articler</type>
    <publisherName>Georg Thieme Verlag KG</publisherName>
    <publisherPlace>Stuttgart</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2026-01-19</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Super-resolution contrast-enhanced ultrasound (SR-CEUS) in solid organs</title>
    <title language="deu">Superhochauflösender kontrastverstärkter Ultraschall (SR-CEUS) in festen Organen</title>
    <abstract language="eng">It is becoming increasingly common for multimodal radiological imaging to use contrast-enhanced ultrasound (CEUS) because of its high-resolution ultrasound techniques. CEUS has several advantages. It can be used repeatedly without affecting renal function or the thyroid gland. It is also considered to be highly accurate with regard to the diagnosis and detection of small solid liver lesions. In addition, it can be used to characterize solid lesions in other abdominal organs. With additional perfusion imaging and its (semi)quantitative analysis using wash-in and wash-out kinetics, therapies can be monitored. It is also frequently used in the assessment of solid tumors in the near field, such as thyroid tumors and lymph nodes. Super-resolution CEUS (SR-CEUS) is a novel imaging method with dynamic evaluation of microflow changes to the level of capillary structures. SR-CEUS could also open up new possibilities regarding the dynamic assessment of the micro-vascularization of solid abdominal organs and interventional procedures.</abstract>
    <parentTitle language="eng">RöFo : Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren</parentTitle>
    <identifier type="doi">10.1055/a-2754-0219</identifier>
    <identifier type="issn">1438-9029</identifier>
    <enrichment key="opus_doi_flag">true</enrichment>
    <enrichment key="opus_import_data">{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T07:29:32Z","timestamp":1768289372972,"version":"3.49.0"},"reference-count":39,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rofo"],"abstract":"&lt;jats:title&gt;Abstract&lt;\/jats:title&gt;\n                  &lt;jats:p&gt;It is becoming increasingly common for multimodal radiological imaging to use\n                        contrast-enhanced ultrasound (CEUS) because of its high-resolution\n                        ultrasound techniques. CEUS has several advantages. It can be used\n                        repeatedly without affecting renal function or the thyroid gland. It is also\n                        considered to be highly accurate with regard to the diagnosis and detection\n                        of small solid liver lesions. In addition, it can be used to characterize\n                        solid lesions in other abdominal organs. With additional perfusion imaging\n                        and its (semi)quantitative analysis using wash-in and wash-out kinetics,\n                        therapies can be monitored. It is also frequently used in the assessment of\n                        solid tumors in the near field, such as thyroid tumors and lymph nodes.\n                        Super-resolution CEUS (SR-CEUS) is a novel imaging method with dynamic\n                        evaluation of microflow changes to the level of capillary structures.\n                        SR-CEUS could also open up new possibilities regarding the dynamic\n                        assessment of the micro-vascularization of solid abdominal organs and\n                        interventional procedures.\n               Citation Format\n               \u25aa Jung EM, Weber M, Jung F. Super-resolution contrast-enhanced\n                                ultrasound (SR-CEUS) in solid organs. Rofo 2025; DOI\n                                10.1055\/a-2754-0219&lt;\/jats:p&gt;","DOI":"10.1055\/a-2754-0219","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T15:29:12Z","timestamp":1768231752000},"source":"Crossref","is-referenced-by-count":0,"title":["Super-resolution contrast-enhanced ultrasound (SR-CEUS) in solid\n                    organs"],"prefix":"10.1055","author":[{"given":"Ernst Michael","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Radiology and Interdisciplinary Ultrasound\n                    Department, University Hospital Regensburg, Regensburg, Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3918-8066","authenticated-orcid":false,"given":"Marc-Andr\u00e9","family":"Weber","sequence":"additional","affiliation":[{"name":"University Medical Center Rostock, Institute of Diagnostic and\n                    Interventional Radiology, Pediatric Radiology and Neuroradiology, Rostock,\n                    Germany"}]},{"given":"Friedrich","family":"Jung","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology, Brandenburg University of\n                    Technology Cottbus-Senftenberg, Senftenberg, Germany"}]},{"given":"Christian","family":"Stroszczynski","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital Regensburg,\n                    Regensburg, Germany"}]}],"member":"194","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"issue":"S 01","key":"ref1","doi-asserted-by":"publisher","first-page":"113","DOI":"10.3233\/CH-248109","article-title":"Improved diagnostic confidence using Super Resolution CEUS imaging in testicular\n                    lesions","volume":"88","author":"M Apfelbeck","year":"2024","journal-title":"Clin Hemorheol Microcirc"},{"issue":"01","key":"ref2","doi-asserted-by":"publisher","first-page":"61","DOI":"10.3233\/CH-221484","article-title":"Contrast-enhanced ultrasound (CEUS) \u2013 A new tool for evaluating blood supply in\n                    primary peripheral lung cancer","volume":"83","author":"Q Li","year":"2023","journal-title":"Clin Hemorheol Microcirc"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1016\/j.ultrasmedbio.2020.04.030","article-title":"Guidelines and Good Clinical Practice Recommendations for Contrast-Enhanced\n                    Ultrasound (CEUS) in the Liver-Update 2020 WFUMB in Cooperation with EFSUMB,\n                    AFSUMB, AIUM, and FLAUS","volume":"46","author":"CF Dietrich","year":"2020","journal-title":"Ultrasound Med Biol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1055\/s-0044-101254","article-title":"The EFSUMB Guidelines and Recommendations for the Clinical Practice of\n                    Contrast-Enhanced Ultrasound (CEUS) in Non-Hepatic Applications: Update 2017\n                    (Short Version)","volume":"39","author":"PS Sidhu","year":"2018","journal-title":"Ultraschall Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1055\/s-0032-1313026","article-title":"An EFSUMB introduction into Dynamic Contrast-Enhanced Ultrasound (DCE-US) for\n                    quantification of tumour perfusion","volume":"33","author":"CF Dietrich","year":"2012","journal-title":"Ultraschall Med"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s11523-010-0136-7","article-title":"Dynamic contrast-enhanced ultrasonography (DCE-US): a new tool for the early\n                    evaluation of antiangiogenic treatment","volume":"5","author":"N Lassau","year":"2010","journal-title":"Target Oncol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3233\/ch-201040","article-title":"Contrast-enhanced ultrasound (CEUS) and perfusion imaging using VueBox","author":"I Wiesinger","year":"2021","journal-title":"Clin Hemorheol Microcirc"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1016\/j.ultrasmedbio.2006.05.031","article-title":"The safety of Sonovue in abdominal applications: retrospective analysis of 23188\n                    investigations","volume":"32","author":"F Piscaglia","year":"2006","journal-title":"Ultrasound Med Biol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"269","DOI":"10.2147\/TCRM.S235235","article-title":"Safety Profile of Musculoskeletal Contrast-Enhanced Ultrasound with Sulfur\n                    Hexafluoride Contrast Agent","volume":"16","author":"C Fischer","year":"2020","journal-title":"Ther Clin Risk Manag"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1055\/a-1198-4874","article-title":"Contrast-Enhanced Ultrasound Algorithms (CEUS-LIRADS\/ESCULAP) for the\n                    Noninvasive Diagnosis of Hepatocellular Carcinoma \u2013 A Prospective Multicenter\n                    DEGUM Study","author":"B Schellhaas","year":"2020","journal-title":"Ultraschall Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"559","DOI":"10.3233\/CH-200898","article-title":"In vivo detection of breast cancer liver metastases in humanized tumour mice\n                    using tumour specific contrast agent BR55","volume":"76","author":"F Bitterer","year":"2020","journal-title":"Clin Hemorheol Microcirc"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1177\/0300060520930151","article-title":"Diagnostic value of contrast-enhanced ultrasound versus computed tomography for\n                    hepatocellular carcinoma: a retrospective, single-center evaluation of 234\n                    patients","volume":"48","author":"V Schwarze","year":"2020","journal-title":"J Int Med Res"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"59","DOI":"10.3233\/CH-189131","article-title":"Evaluation of integrated color-coded perfusion analysis for contrast-enhanced\n                    ultrasound (CEUS) after percutaneous interventions for malignant liver lesions:\n                    First results","volume":"69","author":"I Wiesinger","year":"2018","journal-title":"Clin Hemorheol Microcirc"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1055\/s-0043-119353","article-title":"Percutaneous Treatment of Malignant Liver Lesions: Evaluation of Success Using\n                    Contrast- Enhanced Ultrasound (CEUS) and Perfusion Software","volume":"39","author":"I Wiesinger","year":"2018","journal-title":"Ultraschall Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s00117-018-0390-8","article-title":"CEUS-diagnosis of benign liver lesions","volume":"58","author":"K M\u00fcller-Peltzer","year":"2018","journal-title":"Radiologe"},{"key":"ref16","first-page":"545","article-title":"CEUS-diagnostic workup of cystic renal lesions","volume":"58","author":"J R\u00fcbenthaler","year":"2018","journal-title":"Radiologe"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1055\/a-1300-1727","article-title":"EFSUMB 2020 Proposal for a Contrast-Enhanced Ultrasound-Adapted Bosniak Cyst\n                    Categorization \u2013 Position Statement","author":"V Cantisani","year":"2020","journal-title":"Ultraschall Med"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"419","DOI":"10.3233\/CH-190764","article-title":"Contrast-enhanced ultrasound (CEUS) of cystic renal lesions in comparison to CT\n                    and MRI in a multicenter setting","volume":"75","author":"MH Lerchbaumer","year":"2020","journal-title":"Clin Hemorheol Microcirc"},{"key":"ref19","first-page":"887","article-title":"Reliable diagnosis of cystic renal lesions","volume":"58","author":"K M\u00fcller-Peltzer","year":"2018","journal-title":"Radiologe"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3390\/medicina56110624.","article-title":"Diagnostic Performance of Contrast-Enhanced Ultrasound (CEUS) in the Evaluation\n                    of Solid Renal Masses","volume":"56","author":"T Geyer","year":"2020","journal-title":"Medicina (Kaunas)"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3233\/ch-201000","article-title":"Contrast enhanced ultrasound (CEUS) with parametric imaging after irreversible\n                    electroporation (IRE) of the prostate to assess the success of prostate cancer\n                    treatment","author":"EM Jung","year":"2020","journal-title":"Clin Hemorheol Microcirc"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3233\/CH-209202","article-title":"Contrast enhanced ultrasound (CEUS) with parametric imaging and time intensity\n                    curve analysis (TIC) for evaluation of the success of prostate arterial\n                    embolization (PAE) in cases of prostate hyperplasia","volume":"76","author":"EM Jung","year":"2020","journal-title":"Clin Hemorheol Microcirc"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1007\/s00120-014-3533-1","article-title":"Sonographic imaging of the prostate","volume":"53","author":"B Schlenker","year":"2014","journal-title":"Urologe A"},{"key":"ref24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0231775","article-title":"Contrast-enhanced ultrasound for the differential diagnosis of thyroid nodules:\n                    An updated meta-analysis with comprehensive heterogeneity analysis","volume":"15","author":"J Zhang","year":"2020","journal-title":"PLoS One"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000014051","article-title":"Clinical diagnostic value of contrast-enhanced ultrasound and TI-RADS\n                    classification for benign and malignant thyroid tumors: One comparative cohort\n                    study","volume":"98","author":"Y Xu","year":"2019","journal-title":"Medicine (Baltimore)"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"747","DOI":"10.3233\/CH-168044","article-title":"Analysis of arterial dynamic micro-vascularization with contrast-enhanced\n                    ultrasound (CEUS) in thyroid lesions using external perfusion software: First\n                    results","volume":"64","author":"I Wiesinger","year":"2016","journal-title":"Clin Hemorheol Microcirc"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.ejrad.2008.07.037","article-title":"New potential and applications of contrast-enhanced ultrasound of the breast:\n                    Own investigations and review of the literature","volume":"69","author":"C Balleyguier","year":"2009","journal-title":"Eur J Radiol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"291","DOI":"10.3233\/CH-170368","article-title":"Application of contrast-enhanced ultrasound in the diagnosis of small breast\n                    lesions","volume":"70","author":"YR Du","year":"2018","journal-title":"Clin Hemorheol Microcirc"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"2259","DOI":"10.1002\/jum.14917","article-title":"Contrast-Enhanced Ultrasound Imaging of Breast Masses: Adjunct Tool to Decrease\n                    the Number of False-Positive Biopsy Results","volume":"38","author":"SC Lee","year":"2019","journal-title":"J Ultrasound Med"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/s11604-018-0792-6","article-title":"Perfusion contrast-enhanced ultrasound to predict early lymph-node metastasis in\n                    breast cancer","volume":"37","author":"N Mori","year":"2019","journal-title":"Jpn J Radiol"},{"issue":"01","key":"ref31","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1186\/s41747-024-00540-3","article-title":"Focal liver lesions: multiparametric microvasculature characterization via\n                    super-resolution ultrasound imaging","volume":"8","author":"QQ Zeng","year":"2024","journal-title":"Eur Radiol Exp"},{"issue":"03","key":"ref32","doi-asserted-by":"publisher","first-page":"263","DOI":"10.3233\/CH-249103","article-title":"Novel high-resolution contrast agent ultrasound techniques HiFR CEUS and SR CEUS\n                    in combination with shear wave elastography, fat assessment and viscosity of\n                    liver parenchymal changes and tumors","volume":"86","author":"EM Jung","year":"2024","journal-title":"Clin Hemorheol Microcirc"},{"issue":"01","key":"ref33","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1055\/a-2157-2587","article-title":"EFSUMB Technical Review \u2013 Update 2023: Dynamic Contrast-Enhanced Ultrasound\n                    (DCE-CEUS) for the Quantification of Tumor Perfusion","volume":"45","author":"CF Dietrich","year":"2024","journal-title":"Ultraschall Med"},{"issue":"01","key":"ref34","doi-asserted-by":"crossref","first-page":"50","DOI":"10.11152\/mu-4260","article-title":"Comments and illustrations of the WFUMB CEUS liver guidelines: Rare benign focal\n                    liver lesion, part I","volume":"26","author":"Y Dong","year":"2024","journal-title":"Med Ultrason"},{"issue":"02","key":"ref35","doi-asserted-by":"publisher","first-page":"181","DOI":"10.3233\/CH-239100","article-title":"Current aspects of multimodal ultrasound liver diagnostics using\n                    contrast-enhanced ultrasonography (CEUS), fat evaluation, fibrosis assessment,\n                    and perfusion analysis \u2013 An update","volume":"83","author":"EM Jung","year":"2023","journal-title":"Clin Hemorheol Microcirc"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"353","DOI":"10.3233\/CH-209003","article-title":"Contrast enhanced ultrasonography CEUS) to detect abdominal microcirculatory\n                    disorders in severe cases of COVID-19 infection: First experience","volume":"74","author":"EM Jung","year":"2020","journal-title":"Clin Hemorheol Microcirc"},{"issue":"03","key":"ref37","doi-asserted-by":"publisher","first-page":"239","DOI":"10.3233\/CH-221487","article-title":"Ultrasound features of abdominal thrombosis in COVID 19 patients","volume":"82","author":"Y Dong","year":"2022","journal-title":"Clin Hemorheol Microcirc"},{"issue":"02","key":"ref38","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3233\/CH-242296","article-title":"Renal medullary perfusion differs from that in renal cortex in patients with\n                    sepsis associated acute kidney injury and correlates with renal function\n                    prognosis: A prospective cohort study","volume":"88","author":"R Chen","year":"2024","journal-title":"Clin Hemorheol Microcirc"},{"issue":"02","key":"ref39","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3233\/CH-242296","article-title":"Renal medullary perfusion differs from that in renal cortex in patients with\n                    sepsis associated acute kidney injury and correlates with renal function\n                    prognosis: A prospective cohort study","volume":"88","author":"R Chen","year":"2024","journal-title":"Clin Hemorheol Microcirc"}],"container-title":["R\u00f6Fo - Fortschritte auf dem Gebiet der R\u00f6ntgenstrahlen und der bildgebenden Verfahren"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2754-0219.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T23:43:50Z","timestamp":1768261430000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2754-0219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,12]]},"references-count":39,"URL":"https:\/\/doi.org\/10.1055\/a-2754-0219","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1438-9029","1438-9010"],"issn-type":[{"value":"1438-9029","type":"print"},{"value":"1438-9010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,12]]}}}</enrichment>
    <enrichment key="opus_crossrefDocumentType">journal-article</enrichment>
    <enrichment key="local_import_origin">crossref</enrichment>
    <enrichment key="local_doiImportPopulated">PersonAuthorFirstName_1,PersonAuthorLastName_1,PersonAuthorFirstName_2,PersonAuthorLastName_2,PersonAuthorIdentifierOrcid_2,PersonAuthorFirstName_3,PersonAuthorLastName_3,PersonAuthorFirstName_4,PersonAuthorLastName_4,PublisherName,TitleMain_1,Language,TitleAbstract_1,TitleParent_1,PublishedYear,IdentifierIssn</enrichment>
    <enrichment key="BTU">an der BTU erstellt / created at BTU</enrichment>
    <enrichment key="Referiert">Beitrag ist referiert / Article peer-reviewed</enrichment>
    <enrichment key="opus.source">doi-import</enrichment>
    <author>
      <firstName>Ernst Michael</firstName>
      <lastName>Jung</lastName>
    </author>
    <submitter>
      <firstName>Sarah</firstName>
      <lastName>Kammerer</lastName>
    </submitter>
    <author>
      <firstName>Marc-André</firstName>
      <lastName>Weber</lastName>
    </author>
    <author>
      <firstName>Friedrich</firstName>
      <lastName>Jung</lastName>
    </author>
    <author>
      <firstName>Christian</firstName>
      <lastName>Stroszczynski</lastName>
    </author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>CEUS</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>SR-CEUS</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Microcirculation</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Solid internal organs</value>
    </subject>
    <collection role="institutes" number="2110">FG Molekulare Zellbiologie</collection>
  </doc>
</export-example>
