@inproceedings{VillgrattnerSchneiderAnderschetal., author = {Villgrattner, Thomas and Schneider, Erich and Andersch, Philipp and Ulbrich, Heinz}, title = {Compact high dynamic 3 dof camera orientation system, development and control}, series = {The 10th International Conference on Motion and Vibration Control MOVIC, proceedings, 17 - 20 August 2010, Tokyo, Japan}, booktitle = {The 10th International Conference on Motion and Vibration Control MOVIC, proceedings, 17 - 20 August 2010, Tokyo, Japan}, editor = {Suda, Yoshihiro}, publisher = {Institute of Industrial Science, the University of Tokyo}, address = {Tokyo}, pages = {10}, language = {en} } @inproceedings{WrightSchneider, author = {Wright, W. Geoffrey and Schneider, Erich}, title = {Manual motor control during "virtual" self-motion: Implications for vr rehabilitation}, series = {2009 Virtual Rehabilitation International Conference, Haifa, Israel, 29 June - 2 July 2009}, booktitle = {2009 Virtual Rehabilitation International Conference, Haifa, Israel, 29 June - 2 July 2009}, publisher = {IEEE}, address = {Piscataway, NJ}, isbn = {978-1-4244-4188-4}, pages = {166 -- 172}, language = {en} } @misc{AubeleGrillEggertetal., author = {Aubele, Maria and Grill, Eva and Eggert, Thomas and Schneider, Erich and Strobl, Ralf and Jahn, Klaus and M{\"u}ller, Martin and Holle, Rolf and Linkohr, Birgit and Heier, Margit and Ladwig, Karl-Heinz and Lehnen, Nadine}, title = {Symptoms in unilatral vestibular hypofunction are associated with number of catch-up saccades and retinal errors: results from the population-based KORA FF4study}, series = {Frontiers in Neurology}, volume = {2023}, journal = {Frontiers in Neurology}, number = {14}, issn = {1664-2295}, pages = {8}, abstract = {Objective: The presence and intensity of symptoms vary in patients with unilateral vestibular hypofunction. We aimed to determine which saccadic and vestibulo-ocular reflex parameters best predict the presence of symptoms in unilateral vestibular hypofunction in order to better understand vestibular compensation and its implications for rehabilitation therapy. Methods: Video head impulse test data were analyzed from a subpopulation of 23 symptomatic and 10 currently symptom-free participants with unilateral vestibular hypofunction, embedded in the KORA (Cooperative Health Research in the Region of Augsburg) FF4 study, the second follow-up of the KORA S4 population-based health survey (2,279 participants). Results: A higher number of catch-up saccades, a higher percentage of covert saccades, and a larger retinal error at 200 ms after the onset of the head impulse were associated with relevant symptoms in participants with unilateral vestibular hypofunction (p = 0.028, p = 0.046, and p = 0.038, respectively). After stepwise selection, the number of catch-up saccades and retinal error at 200 ms remained in the final logistic regression model, which was significantly better than a null model (p = 0.014). Age, gender, saccade amplitude, saccade latency, and VOR gain were not predictive of the presence of symptoms. Conclusion: The accuracy of saccadic compensation seems to be crucial for the presence of symptoms in unilateral vestibular hypofunction, highlighting the role of specific gaze stabilization exercises in rehabilitation. Early saccades, mainly triggered by the vestibular system, do not seem to compensate accurately enough, resulting in a relevant retinal error and the need for more as well as more accurate catch-up saccades, probably triggered by the visual system.}, language = {en} } @misc{MichailidouKordaWyssetal., author = {Michailidou, Efterpi and Korda, Athanasia and Wyss, Thomas and Bardins, Stanislav and Schneider, Erich and Morrison, Miranda and Wagner, Franca and Caversaccio, Marco and Mantokoudis, Georgios}, title = {The value of saccade metrics and VOR gain in detecting a vestibular stroke}, series = {Journal of Vestibular Research}, volume = {34}, journal = {Journal of Vestibular Research}, number = {1}, issn = {1878-6464}, doi = {10.3233/VES-230083}, pages = {49 -- 61}, abstract = {Objective: A normal video Head Impulse Test is the gold standard in the emergency department to rule-in patients with an acute vestibular syndrome and a stroke. We aimed to compare the diagnostic accuracy of vHIT metrics regarding the vestibulo-ocular reflex gain and the corrective saccades in detecting vestibular strokes. Methods: Prospective cross-sectional study (convenience sample) of patients presenting with acute vestibular syndrome in the emergency department of a tertiary referral centre between February 2015 and May 2020. We screened 1677 patients and enrolled 76 patients fulfilling the inclusion criteria of acute vestibular syndrome. All patients underwent video head impulse test with automated and manual data analysis. A delayed MRI served as a gold standard for vestibular stroke confirmation. Results: Out of 76 patients, 52 were diagnosed with acute unilateral vestibulopathy and 24 with vestibular strokes. The overall accuracy of detecting stroke with an automated vestibulo-ocular reflex gain was 86.8\%, compared to 77.6\% for cumulative saccade amplitude and automatic saccade mean peak velocity measured by an expert and 71\% for cumulative saccade amplitude and saccade mean peak velocity measured automatically. Gain misclassified 13.1\% of the patients as false positive or false negative, manual cumulative saccade amplitude and saccade mean peak velocity 22.3\%, and automated cumulative saccade amplitude and saccade mean peak velocity 28.9\% respectively. Conclusions: We found a better accuracy of video head impulse test for the diagnosis of vestibular strokes when using the vestibulo-ocular reflex gain than using saccade metrics. Nevertheless, saccades provide an additional and important information for video head impulse test evaluation. The automated saccade detection algorithm is not yet perfect compared to expert analysis, but it may become a valuable tool for future non-expert video head impulse test evaluations.}, language = {en} } @misc{LehnenRamaioliToddetal., author = {Lehnen, Nadine and Ramaioli, Cecilia and Todd, Nicholas Sean and Bartl, Klaus and Kohlbecher, Stefan and Jahn, Klaus and Schneider, Erich}, title = {Clinical and video head impulses: a simple bedside test in children}, series = {Journal of Neurology}, volume = {264}, journal = {Journal of Neurology}, number = {5}, issn = {1432-1459}, doi = {10.1007/s00415-017-8450-y}, pages = {1002 -- 1004}, language = {en} } @misc{NanningBrauneUttneretal., author = {Nanning, Felix and Braune, Katharina and Uttner, Ingo and Ludolph, Albert Christian and Gorges, Martin and Lul{\´e}, Doroth{\´e}e}, title = {Altered Gaze Control During Emotional Face Exploration in Patients With Amyotrophic Lateral Sclerosis}, series = {Neurology}, volume = {101}, journal = {Neurology}, number = {6}, issn = {0028-3878}, doi = {10.1212/WNL.0000000000207214}, pages = {264 -- 269}, abstract = {Objectives Up to 50\% of patients with amyotrophic lateral sclerosis (ALS) present with cognitive problems and behavioral dysfunctions including recognition of human faces presenting different emotions. We investigated whether impaired processing of emotional faces is associated with abnormal scan paths during visual exploration. Methods Cognitively unimpaired patients with ALS (n = 45) and matched healthy controls (n = 37) underwent neuropsychological assessment and video-based eye tracking. Eye movements were recorded while participants visually explored faces expressing different emotions (neutral, disgusted, happy, fearful, and sad) and houses mimicking faces. Results Compared with controls, patients with ALS fixated significantly longer to regions which are not relevant for emotional information when faces expressed fear (p = 0.007) and disgust (p = 0.006), whereas the eyes received less attention in faces expressing disgust (p = 0.041). Fixation duration in any area of interest was not significantly associated with the cognitive state or clinical symptoms of disease severity. Discussion In cognitively unimpaired patients with ALS, altered gaze patterns while visually exploring faces expressing different emotions might derive from impaired top-down attentional control with possible involvement of subliminal frontotemporal areas. This may account for indistinctness in emotion recognition reported in previous studies because nonsalient features retrieve more attention compared with salient areas. Current findings may indicate distinct emotion processing dysfunction of ALS pathology, which may be different from, for example, executive dysfunction.}, language = {en} } @misc{LehnenSchneiderJahn, author = {Lehnen, Nadine and Schneider, Erich and Jahn, Klaus}, title = {Do neurologists need the head impulse test?}, series = {Nervenarzt}, volume = {84}, journal = {Nervenarzt}, number = {8}, issn = {0028-2804}, doi = {10.1007/s00115-013-3822-8}, pages = {973 -- 974}, language = {de} } @misc{BrandtGlasauerSchneider, author = {Brandt, Thomas and Glasauer, Stefan and Schneider, Erich}, title = {Aufnahmevorrichtung f{\"u}r die kopfgest{\"u}tzte Bilderfassung und Verfahren zur Steuerung der Aufnahmevorrichtung}, language = {de} } @misc{JahnSchneider, author = {Jahn, Klaus and Schneider, Erich}, title = {Untersuchung der vestibul{\"a}ren Funktion bei Schwindelpatienten}, series = {Nervenheilkunde}, volume = {31}, journal = {Nervenheilkunde}, number = {5}, issn = {0722-1541}, pages = {370 -- 377}, language = {de} } @misc{FeilClaassenBrandinsetal., author = {Feil, Katharina and Claassen, Jens and Brandins, Stanislavs and Teufel, Julian and Krafczyk, Siegbert and Schneider, Erich}, title = {Effect of chlorzoxazone in patients with downbeat nystagmus: a pilot trial}, series = {Neurology}, volume = {81}, journal = {Neurology}, number = {13}, issn = {0028-3878}, doi = {10.1212/WNL.0b013e3182a55f6d}, pages = {1152 -- 1158}, language = {en} } @misc{KallaSpiegelClaassenetal., author = {Kalla, Roger and Spiegel, Rainer and Claassen, Jens and Bardins, Stanislav and Hahn, Ales and Schneider, Erich and Lehrer, Nicole and Glasauer, Stefan and Brandt, Thomas and Strupp, Michael}, title = {Comparison of 10-mg doses of 4-aminopyridine and 3,4-diaminopyridine for the treatment of downbeat nystagmus}, series = {Journal of neuro-ophthalmology}, volume = {32}, journal = {Journal of neuro-ophthalmology}, number = {2}, issn = {1536-5166}, doi = {10.1097/WNO.0b013e3182258086}, pages = {320 -- 325}, language = {en} } @misc{SchulzSchneiderFritzetal., author = {Schulz, Christian M. and Schneider, Erich and Fritz, L. and Vockeroth, Johannes and Hapfelmeier, Alexander and Wasmaier, M.}, title = {Eye tracking for assessment of workload: a pilot study in an anaesthesia simulator environment}, series = {British journal of anaesthesia}, volume = {106}, journal = {British journal of anaesthesia}, number = {1}, issn = {1471-6771}, doi = {10.1093/bja/aeq307}, pages = {44 -- 50}, language = {en} } @misc{SchulzSchneiderFritzetal., author = {Schulz, Christian M. and Schneider, Erich and Fritz, L. and Vockeroth, Johannes and Hapfelmeier, Alexander and Brandt, Thomas}, title = {Visual attention of anaesthetists during simulated critical incidents}, series = {British Journal of Anaesthesia}, volume = {106}, journal = {British Journal of Anaesthesia}, number = {6}, issn = {1471-6771}, doi = {10.1093/bja/aer087}, pages = {807 -- 813}, language = {en} } @misc{MorrisonKerkeniKordaetal., author = {Morrison, Miranda and Kerkeni, Hassen and Korda, Athanasia and R{\"a}ss, Simone and Caversaccio, Marco Domenico and Abegg, Mathias and Schneider, Erich and Mantokoudis, Georgios}, title = {Automated alternate cover test for 'HINTS' assessment: a validation study}, series = {European archives of oto-rhino-laryngology and head \& neck}, journal = {European archives of oto-rhino-laryngology and head \& neck}, issn = {1434-4726}, doi = {10.1007/s00405-021-06998-w}, pages = {2873 -- 2879}, abstract = {Objective The alternate cover test (ACT) in patients with acute vestibular syndrome is part of the 'HINTS' battery test. Although quantitative, the ACT is highly dependent on the examiner's experience and could theoretically vary greatly between examiners. In this study, we sought to validate an automated video-oculography (VOG) system based on eye tracking and dedicated glasses. Methods We artificially induced a vertical strabismus to simulate a skew deviation on ten healthy subjects, aged from 26 to 66, using different press-on Fresnel prisms on one eye while recording eye position with VOG of the contralateral eye. We then compared the system's performance to that of a blinded trained orthoptist using conventional, semi-quantitative method of skew measurement known as the alternate prism cover test (APCT) as a gold standard. Results We found a significant correlation between the reference APCT and the Skew VOG (Pearson's R2 = 0.606, p < 0.05). There was a good agreement between the two tests (intraclass correlation coefficient 0.852, 95 CI 0.728-0.917, p < 0.001). The overall accuracy of the VOG was estimated at 80.53\% with an error rate of 19.46\%. There was no significant difference in VOG skew estimations compared with the gold standard except for very small skews. Conclusions VOG offers an objective and quantitative skew measurement and proved to be accurate in measuring vertical eye misalignment compared to the ACT with prisms. Precision was moderate, which mandates a sufficient number of tests per subject.}, language = {en} } @misc{KuglerHuppertSchneideretal., author = {Kugler, G{\"u}nter and Huppert, Doreen and Schneider, Erich and Brandt, Thomas}, title = {Wie H{\"o}henschwindel die visuelle Exploration und den Gang beeintr{\"a}chtigt}, series = {Nervenarzt}, volume = {84}, journal = {Nervenarzt}, number = {10}, issn = {0028-2804}, doi = {10.1007/s00115-013-3905-6}, pages = {1233 -- 1237}, language = {de} } @misc{LehnenSchneiderJahn, author = {Lehnen, Nadine and Schneider, Erich and Jahn, Klaus}, title = {Klinische Untersuchungen bei Schwindel: Kopfimpulstest und dynamische Sehsch{\"a}rfe}, series = {Neurotransmitter}, volume = {24}, journal = {Neurotransmitter}, number = {4}, issn = {2196-6397}, pages = {39 -- 43}, language = {de} } @misc{TeufelBardinsSpiegeletal., author = {Teufel, Julian and Bardins, Stanislav and Spiegel, Rainer and Kremmyda, O. and Schneider, Erich and Strupp, Michael and Kalla, R.}, title = {Real time computerbased visual feedback improves visual acuity in downbeat nystagmus, a pilot study}, series = {Journal of NeuroEngineering and Rehabilitation}, volume = {13}, journal = {Journal of NeuroEngineering and Rehabilitation}, number = {1}, issn = {1743-0003}, language = {de} } @misc{GuinandVandeBergCavuscensetal., author = {Guinand, Nils and Van de Berg, Raymond and Cavuscens, Samuel and Ranieri, Maurizio and Schneider, Erich and Lucieer, Floor and Kingma, Hermann and Guyot, Jean-Philippe and Perez Fornos, Angelica}, title = {The Video Head Impulse Test to Assess the Efficacy of Vestibular Implants in Humans}, series = {Frontiers in neurology}, volume = {8}, journal = {Frontiers in neurology}, issn = {1664-2295}, doi = {10.3389/fneur.2017.00600}, pages = {13}, language = {en} } @misc{LuisCostaMunozetal., author = {Luis, L. and Costa, Jo{\~a}o and Mu{\~n}oz, E. and Carvalho, M. de and Carmona, S. and Schneider, Erich}, title = {Vestibulo-ocular reflex dynamics with head-impulses discriminates spinocerebellar ataxias types 1, 2 and 3 and Friedreich ataxia.}, series = {Journal of Vestibular Research}, volume = {26}, journal = {Journal of Vestibular Research}, number = {3}, issn = {0957-4271}, doi = {10.3233/VES-160579}, pages = {327 -- 334}, language = {en} } @misc{KellerGorgesAhoOezhanetal., author = {Keller, J{\"u}rgen and Gorges, Martin and Aho-{\"O}zhan, Helena Eira Anneli and Carmona, S. and Schneider, Erich}, title = {Eye-tracking control to assess cognitive functions in patients with amyotrophic lateral sclerosis}, series = {JoVE}, volume = {116}, journal = {JoVE}, issn = {1940-087X}, doi = {10.3791/54634}, pages = {e54634}, language = {en} } @misc{LuisLehnenMunozetal., author = {Luis, L. and Lehnen, Nadine and Mu{\~n}oz, E. and Carvalho, M. de and Schneider, Erich}, title = {Anticompensatory quick eye movements after head impulses: A peripheral vestibular sign in spontaneous nystagmus}, series = {Journal of Vestibular Research}, volume = {25}, journal = {Journal of Vestibular Research}, number = {5-6}, issn = {0957-4271}, doi = {10.3233/VES-160566}, pages = {267 -- 271}, language = {en} } @misc{MossmanMossmanPurdieetal., author = {Mossman, Benjamin and Mossman, Stuart and Purdie, Gordon and Schneider, Erich}, title = {Age dependent normal horizontal vor gain of head impulse test as measured with video-oculography}, series = {Journal of Otolaryngology - Head \& Neck Surgery}, volume = {44}, journal = {Journal of Otolaryngology - Head \& Neck Surgery}, issn = {1916-0216}, doi = {10.1186/s40463-015-0081-7}, pages = {29}, language = {en} } @misc{SpiegelKallaRettingeretal., author = {Spiegel, Rainer and Kalla, R. and Rettinger, N. and Schneider, Erich and Straumann, D. and Marti, S. and Glasauer, Stefan}, title = {Head position during resting modifies spontaneous daytime decrease of downbeat nystagmus}, series = {Neurology}, volume = {75}, journal = {Neurology}, number = {21}, issn = {0028-3878}, doi = {10.1212/WNL.0b013e3181feb22f}, pages = {1928 -- 1932}, language = {en} } @misc{WrightSchneiderGlasauer, author = {Wright, W. Geoffrey and Schneider, Erich and Glasauer, Stefan}, title = {Compensatory manual motor responses while object wielding during combined linear visual and physical roll tilt stimulation}, series = {Experimental Brain Research}, volume = {192}, journal = {Experimental Brain Research}, number = {4}, issn = {0014-4819}, doi = {10.1007/s00221-008-1581-8}, pages = {683 -- 694}, language = {en} } @misc{GuentherBartlNaudereretal., author = {Guenther, Anna L. and Bartl, Klaus and Nauderer, Josef and Schneider, Erich and Huesmann, Alexander and Brandt, Thomas and Glasauer, Stefan}, title = {Modalitydependent indication of the subjective vertical during combined linear and rotational movements}, series = {Annals of the New York Academy of Sciences}, volume = {1164}, journal = {Annals of the New York Academy of Sciences}, issn = {1749-6632}, doi = {10.1111/j.1749-6632.2009.03849.x}, pages = {376 -- 379}, language = {en} } @misc{EinhaeuserSchumannVockerothetal., author = {Einh{\"a}user, Wolfgang and Schumann, Frank and Vockeroth, Johannes and Bartl, Klaus and Cerf, Moran and Harel, Jonathan and Schneider, Erich and K{\"o}nig, Peter}, title = {Distinct roles for eye and head movements in selecting salient image parts during natural exploration}, series = {Annals of the New York Academy of Sciences}, volume = {1164}, journal = {Annals of the New York Academy of Sciences}, issn = {1749-6632}, doi = {10.1111/j.1749-6632.2008.03714.x}, pages = {188 -- 193}, language = {en} } @misc{GlasauerSchneiderGrassoetal., author = {Glasauer, Stefan and Schneider, Erich and Grasso, Renato and Ivanenko, Yuri P.}, title = {Space-time relativity in self-motion reproduction}, series = {Journal of Neurophysiology}, volume = {97}, journal = {Journal of Neurophysiology}, number = {1}, issn = {0022-3077}, doi = {10.1152/jn.01243.2005}, pages = {451 -- 461}, language = {en} } @misc{EinhaeuserSchumannBardinsetal., author = {Einh{\"a}user, Wolfgang and Schumann, Frank and Bardins, Stanislav and Bartl, Klaus and B{\"o}ning, Guido and Schneider, Erich and K{\"o}nig, Peter}, title = {Human eyehead co-ordination in natural exploration}, series = {Network}, volume = {18}, journal = {Network}, number = {3}, issn = {0954-898X}, doi = {10.1080/09548980701671094}, pages = {267 -- 297}, language = {en} } @misc{ZinglerKryvosheySchneideretal., author = {Zingler, Vera C. and Kryvoshey, Dmytro and Schneider, Erich and Glasauer, Stefan and Brandt, Thomas and Strupp, Michael}, title = {A clinical test of otolith function: static ocular counterroll with passive head tilt.}, series = {Neuroreport}, volume = {17}, journal = {Neuroreport}, number = {6}, issn = {0959-4965}, pages = {611 -- 615}, language = {en} } @misc{NowakHermsdoerferSchneideretal., author = {Nowak, Dennis A. and Hermsd{\"o}rfer, Joachim and Schneider, Erich and Glasauer, Stefan}, title = {Moving objects in a rotating environment rapid prediction of coriolis and centrifugal force perturbations}, series = {Experimental Brain Research}, volume = {157}, journal = {Experimental Brain Research}, number = {2}, issn = {0014-4819}, doi = {10.1007/s00221-004-1839-8}, pages = {241 -- 254}, language = {en} } @misc{SchneiderGlasauerDieterichetal., author = {Schneider, Erich and Glasauer, Stefan and Dieterich, Marianne and Kalla, Roger and Brandt, Thomas}, title = {Diagnosis of vestibular imbalance in the blink of an eye}, series = {Neurology}, volume = {63}, journal = {Neurology}, number = {7}, issn = {0028-3878}, pages = {1209 -- 1216}, language = {en} } @misc{HayashiKanzakiEthoetal., author = {Hayashi, Yujiro and Kanzaki, Jin and Etho, Norihito and Higashino, Kazutaka and Goto, Fumiyuki and Schneider, Erich and Kunihiro, Takanobu}, title = {Three-dimensional analysis of nystagmus in benign paroxysmal positional vertigo. new insights into its pathophysiology}, series = {Journal of Neurology}, volume = {249}, journal = {Journal of Neurology}, number = {12}, issn = {0340-5354}, doi = {10.1007/s00415-002-0905-z}, pages = {1683 -- 1688}, language = {en} } @misc{SchneiderGlasauerDieterich, author = {Schneider, Erich and Glasauer, Stefan and Dieterich, Marianne}, title = {Comparison of human ocular torsion patterns during natural and galvanic vestibular stimulation}, series = {Journal of Neurophysiology}, volume = {87}, journal = {Journal of Neurophysiology}, number = {4}, issn = {0022-3077}, doi = {10.1152/jn.00558.2001}, pages = {2064 -- 2073}, language = {en} } @misc{RamaioliSteinmetzerBrietzkeetal., author = {Ramaioli, Cecilia and Steinmetzer, Tobias and Brietzke, Adrian and Meyer, Paul and Pham Xuan, Rebecca and Schneider, Erich and Gorges, Martin}, title = {Assessment of vestibulo-ocular reflex and its adaptation during stop-and-go car rides in motion sickness susceptible passengers}, series = {Experimental Brain Research}, volume = {241}, journal = {Experimental Brain Research}, number = {6}, issn = {1432-1106}, doi = {10.1007/s00221-023-06619-4}, pages = {1523 -- 1531}, abstract = {Motion sickness is a physiological condition that negatively impacts a person's comfort and will be an emerging condition in autonomous vehicles without proper countermeasures. The vestibular system plays a key role in the origin of motion sickness. Understanding the susceptibility and (mal) adaptive mechanisms of the highly integrated vestibular system is a prerequisite for the development of countermeasures. We hypothesize a differential association between motion sickness and vestibular function in healthy individuals with and without susceptibility for motion sickness. We quantified vestibular function by measuring the high-frequency vestibulo-ocular reflex (VOR) using video head impulse testing (vHIT) in 17 healthy volunteers before and after a 11 min motion sickness-inducing naturalistic stop-and-go car ride on a test track (Dekra Test Oval, Klettwitz, Germany). The cohort was classified as motion sickness susceptible (n = 11) and non-susceptible (n = 6). Six (out of 11) susceptible participants developed nausea symptoms, while a total of nine participants were free of these symptoms. The VOR gain (1) did not differ significantly between participant groups with (n = 8) and without motion sickness symptoms (n = 9), (2) did not differ significantly in the factor time before and after the car ride, and showed no interaction between symptom groups and time, as indicated by a repeated measures ANOVA (F(1,15) = 2.19, p = 0.16. Bayesian inference confirmed that there was "anecdotal evidence" for equality of gain rather than difference across groups and time (BF10 < 0.77). Our results suggest that individual differences in VOR measures or adaptation to motion sickness provocative stimuli during naturalistic stop-and-go driving cannot predict motion sickness susceptibility or the likelihood of developing motion sickness.}, language = {en} } @misc{CharisseErusPomponioetal., author = {Chariss{\´e}, Daniel and Erus, Guray and Pomponio, Raymond and Gorges, Martin and Schmidt, Nele and Schneider, Christine and Liepelt-Scarfone, Inga and Riedel, Oliver and Reetz, Kathrin and Schulz, J{\"o}rg B. and Berg, Daniela and Storch, Alexander and Witt, Karsten and Dodel, Richard and Kalbe, Elke and Kassubek, Jan and Hilker-Roggendorf, R{\"u}diger and Baudrexel, Simon}, title = {Brain age and Alzheimer's-like atrophy are domain-specific predictors of cognitive impairment in Parkinson's disease}, series = {Neurobiology of Aging}, volume = {109}, journal = {Neurobiology of Aging}, issn = {0197-4580}, doi = {10.1016/j.neurobiolaging.2021.08.020}, pages = {31 -- 42}, abstract = {Recently, it was shown that patients with Parkinson's disease (PD) who exhibit an "Alzheimer's disease (AD)-like" pattern of brain atrophy are at greater risk for future cognitive decline. This study aimed to investigate whether this association is domain-specific and whether atrophy associated with brain aging also relates to cognitive impairment in PD. SPARE-AD, an MRI index capturing AD-like atrophy, and atrophy-based estimates of brain age were computed from longitudinal structural imaging data of 178 PD patients and 84 healthy subjects from the LANDSCAPE cohort. All patients underwent an extensive neuropsychological test battery. Patients diagnosed with mild cognitive impairment or dementia were found to have higher SPARE-AD scores as compared to patients with normal cognition and healthy controls. All patient groups showed increased brain age. SPARE-AD predicted impairment in memory, language and executive functions, whereas advanced brain age was associated with deficits in attention and working memory. Data suggest that SPARE-AD and brain age are differentially related to domain-specific cognitive decline in PD. The underlying pathomechanisms remain to be determined.}, language = {en} }