@misc{JahnkeCruysenPrilletal., author = {Jahnke, Sonja and Cruysen, Caren and Prill, Robert and Kittmann, Fabian and Pflug, Nicola and Albert, Justin Amadeus and Camargo, Tibor de and Arnrich, Bert and Krolikowska, Aleksandra and Kolcz, Anna and Reichert, Pawel and Oleksy, Lukasz and Michel, Sven and Kopf, Sebastian and Wagner, Michael and Scheffler, Sven and Becker, Roland}, title = {Protocol for a Randomized Crossover Trial to Evaluate the Effect of Soft Brace and Rigid Orthosis on Performance and Readiness to Return to Sport Six Months Post‑ACL‑Reconstruction}, series = {Healthcare}, volume = {11}, journal = {Healthcare}, number = {4}, issn = {2227-9032}, doi = {10.3390/healthcare11040513}, abstract = {A randomized crossover trial was designed to investigate the influence of muscle activation and strength on functional stability/control of the knee joint, to determine whether bilateral imbalances still occur six months after successful anterior cruciate ligament reconstruction (ACLR), and to analyze whether the use of orthotic devices changes the activity onset of these muscles. Furthermore, conclusions on the feedforward and feedback mechanisms are highlighted. Therefore, twenty‑eight patients will take part in a modified Back in Action (BIA) test battery at an average of six months after a primary unilateral ACLR, which used an autologous ipsilateral semitendinosus tendon graft. This includes double‑leg and single‑leg stability tests, double‑leg and single‑leg countermovement jumps, double‑leg and single‑leg drop jumps, a speedy jump test, and a quick feet test. During the tests, gluteus medius and semitendinosus muscle activity are analyzed using surface electromyography (sEMG). Motion analysis is conducted using Microsoft Azure DK and 3D force plates. The tests are performed while wearing knee rigid orthosis, soft brace, and with no aid, in random order. Additionally, the range of hip and knee motion and hip abductor muscle strength under isometric conditions are measured. Furthermore, patient‑rated outcomes will be assessed.}, language = {en} } @misc{WaelderFrischbierBredemeieretal., author = {W{\"a}lder, Konrad and Frischbier, Nico and Bredemeier, Michael and N{\"a}ther, Wolfgang and Wagner, Sven}, title = {Analysis of OF - layer humus mass variation in a mixed stand of European beech and Norway spruce: An application of structural equation modelling}, series = {Ecological Modelling}, volume = {213}, journal = {Ecological Modelling}, number = {3-4}, issn = {0304-3800}, pages = {319 -- 330}, language = {de} } @techreport{FeindtWoltersBackesetal., author = {Feindt, Peter H. and Wolters, Volkmar and Backes, Gunter and Bahrs, Enno and Dempfle, Leo and Engels, Eve-Marie and Engels, Johannes and Graner, Andreas and Hamm, Ulrich and Herdegen, Matthias and Isselstein, Johannes and Konnert, Monika and Schr{\"o}der, Stefan and Schulte-Coerne, Hermann and Wagner, Sven and W{\"a}tzold, Frank and Wedekind, Helmut}, title = {Gr{\"u}ndung der Deutschen Genbank landwirtschaftlicher Nutztiere : Kurzstellungnahme des Wissenschaftlichen Beirats f{\"u}r Biodiversit{\"a}t und Genetische Ressourcen beim Bundesministerium f{\"u}r Ern{\"a}hrung und Landwirtschaft}, publisher = {BMEL}, address = {Bonn}, pages = {10}, language = {de} } @techreport{WaetzoldBahrsFeindtetal., author = {W{\"a}tzold, Frank and Bahrs, Enno and Feindt, Peter H. and Hamm, Ulrich and Isselstein, Johannes and Schr{\"o}der, Stefan and Wolters, Volkmar and Backes, Gunter and Dempfle, Leo and Engels, Eve-Marie and Engels, Johannes and Graner, Andreas and Herdegen, Matthias and Konnert, Monika and Schulte-Coerne, Hermann and Wagner, Sven and Wedekind, Helmut}, title = {Perspektiven f{\"u}r das artenreiche Gr{\"u}nland - Alternativen zur Belohnung einer {\"U}berschussproduktion bei Milch}, address = {Bonn}, pages = {9}, language = {de} } @techreport{FeindtWoltersBackesetal., author = {Feindt, Peter H. and Wolters, Volkmar and Backes, Gunter and Bahrs, Enno and Brandt, Horst and Dempfle, Leo and Engels, Eve-Marie and Engels, Johannes and Graner, Andreas and Hamm, Ulrich and Herdegen, Matthias and Isselstein, Johannes and Konnert, Monika and Schr{\"o}der, Stefan and Wagner, Sven and W{\"a}tzold, Frank and Wedekind, Helmut}, title = {Verbraucher f{\"u}r die Erhaltung der biologischen Vielfalt in der Landwirtschaft aktivieren!}, publisher = {Bundesanstalt f{\"u}r Landwirtschaft und Ern{\"a}hrung (BLE) Informations- und Koordinationszentrum f{\"u}r Biologische Vielfalt (IBV)}, address = {Bonn}, pages = {12}, language = {de} } @techreport{FeindtWoltersBackesetal., author = {Feindt, Peter H. and Wolters, Volkmar and Backes, Gunter and Bahrs, Enno and Brandt, Horst and Engels, Eve-Marie and Engels, Johannes and Graner, Andreas and Hamm, Ulrich and Herdegen, Matthias and Isselstein, Johannes and Schr{\"o}der, Stefan and Tholen, Ernst and Wagner, Sven and W{\"a}tzold, Frank and Wolf, Heino}, title = {Schutz tiergenetischer Ressourcen im Tierseuchenfall - Vorschl{\"a}ge zum Schutz von Tierbest{\"a}nden in Nukleus- bzw. Basiszuchtbetrieben und Besamungsstationen bei Auftreten der Afrikanischen Schweinepest}, publisher = {Bundesanstalt f{\"u}r Landwirtschaft und Ern{\"a}hrung (BLE), Informations- und Koordinationszentrum f{\"u}r Biologische Vielfalt (IBV)}, address = {Bonn}, pages = {9}, language = {de} } @techreport{FeindtWoltersBackesetal., author = {Feindt, Peter H. and Wolters, Volkmar and Backes, Gunter and Bahrs, Enno and Brandt, Horst and Engels, Eve-Marie and Engels, Johannes and Graner, Andreas and Hamm, Ulrich and Herdegen, Matthias and Isselstein, Johannes and Schr{\"o}der, Stefan and Tholen, Ernst and Wagner, Sven and W{\"a}tzold, Frank and Wedekind, Helmut and Wolf, Heino}, title = {Wege zu einem effizienten Waldnaturschutz in Deutschland: Stellungnahme Januar 2020}, address = {Berlin}, pages = {69}, language = {de} } @misc{WaetzoldFeindtBahrsetal., author = {W{\"a}tzold, Frank and Feindt, Peter H. and Bahrs, Enno and Hamm, Ulrich and Isselstein, Johannes and Schr{\"o}der, Stefan and Wagner, Sven and Wedekind, Helmut and Wolters, Volkmar}, title = {Wie die Politik auf die Bedrohung der Biodiversit{\"a}t in Agrarlandschaften durch den Klimawandel reagieren kann. Stellungnahme des Wissenschaftlichen Beirats f{\"u}r Biodiversit{\"a}t und Genetische Ressourcen beim Bundesministerium f{\"u}r Ern{\"a}hrung und Landwirtschaft}, series = {Berichte {\"u}ber Landwirtschaft : Zeitschrift f{\"u}r Agrarpolitik und Landwirtschaft. Sonderheft}, journal = {Berichte {\"u}ber Landwirtschaft : Zeitschrift f{\"u}r Agrarpolitik und Landwirtschaft. Sonderheft}, number = {232}, issn = {2196-5099}, doi = {10.12767/buel.vi232.330}, pages = {30}, language = {de} } @article{RaulienFriedrichStrobeletal., author = {Raulien, Nora and Friedrich, Kathleen and Strobel, Sarah and Raps, Stefanie and Hecker, Friederike and Pierer, Matthias and Schilling, Erik and Lainka, Elke and Kallinich, Tilmann and Baumann, Sven and Fritz-Wallace, Katarina and Rolle-Kampczyk, Ulrike and Bergen, Martin von and Aigner, Achim and Ewe, Alexander and Schett, Georg and Cross, Michael and Rossol, Manuela and Wagner, Ulf}, title = {Glucose-oxygen deprivation constrains HMGCR function and Rac1 prenylation and activates the NLRP3 inflammasome in human monocytes}, series = {Science Signaling}, volume = {17}, journal = {Science Signaling}, number = {845}, publisher = {American Association for the Advancement of Science (AAAS)}, issn = {1945-0877}, doi = {10.1126/scisignal.add8913}, pages = {19}, abstract = {Hypoxia and low glucose abundance often occur simultaneously at sites of inflammation. In monocytes and macrophages, glucose-oxygen deprivation stimulates the assembly of the NLRP3 inflammasome to generate the proinflammatory cytokine IL-1β. We found that concomitant glucose deprivation and hypoxia activated the NLRP3 inflammasome by constraining the function of HMG-CoA reductase (HMGCR), the rate-limiting enzyme of the mevalonate kinase pathway. HMGCR is involved in the synthesis of geranylgeranyl pyrophosphate (GGPP), which is required for the prenylation and lipid membrane integration of proteins. Under glucose-oxygen deprivation, GGPP synthesis was decreased, leading to reduced prenylation of the small GTPase Rac1, increased binding of nonprenylated Rac1 to the scaffolding protein IQGAP1, and enhanced activation of the NLRP3 inflammasome. In response to restricted oxygen and glucose supply, patient monocytes with a compromised mevalonate pathway due to mevalonate kinase deficiency or Muckle-Wells syndrome released more IL-1β than did control monocytes. Thus, reduced GGPP synthesis due to inhibition of HMGCR under glucose-oxygen deprivation results in proinflammatory innate responses, which are normally kept in check by the prenylation of Rac1. We suggest that this mechanism is also active in inflammatory autoimmune conditions.}, language = {en} }