@misc{KuenzelHoffmannWeberetal., author = {K{\"u}nzel, Stephan R. and Hoffmann, Maximilian and Weber, Silvio and K{\"u}nzel, Karolina and K{\"a}mmerer, Susanne and G{\"u}nscht, Mario and Klapproth, Erik and Rausch, Johanna S. E. and Sadek, Mirna S. and Kolanowski, Tomasz and Meyer-Roxlau, Stefanie and Piorkowski, Christopher and Tugtekin, Sems M. and Rose-John, Stefan and Yin, Xiaoke and Mayr, Manuel and Kuhlmann, Jan Dominik and Wimberger, Pauline and Gr{\"u}tzmann, Konrad and Herzog, Natalie and K{\"u}pper, Jan-Heiner and O'Reilly, Molly and Kabir, S. Nashitha and Sommerfeld, Laura C. and Guan, Kaomei and Wielockx, Ben and Fabritz, Larissa and Nattel, Stanley and Ravens, Ursula and Dobrev, Dobromir and Wagner, Michael and El-Armouche, Ali}, title = {Diminished PLK2 Induces Cardiac Fibrosis and Promotes Atrial Fibrillation}, series = {Circulation Research}, volume = {129}, journal = {Circulation Research}, number = {8}, issn = {1524-4571}, doi = {10.1161/CIRCRESAHA.121.319425}, pages = {804 -- 820}, abstract = {Rationale: Fibrosis promotes the maintenance of atrial fibrillation (AF), making it resistant to therapy. Improved understanding of the molecular mechanisms leading to atrial fibrosis will open new pathways toward effective antifibrotic therapies. Objective: This study aims to decipher the mechanistic interplay between PLK2 (polo-like kinase 2) and the profibrotic cytokine OPN (osteopontin) in the pathogenesis of atrial fibrosis and AF. Methods and Results: Atrial PLK2 mRNA expression was 10-fold higher in human fibroblasts than in cardiomyocytes. Compared with sinus rhythm, right atrial appendages and isolated right atrial fibroblasts from patients with AF showed downregulation of PLK2 mRNA and protein, along with increased PLK2 promotor methylation. Genetic deletion as well as pharmacological inhibition of PLK2 induced profibrotic phenotype conversion in cardiac fibroblasts and led to a striking de novo secretion of OPN. Accordingly, PLK2-deficient (PLK2 knockout) mice showed cardiac fibrosis and were prone to experimentally induced AF. In line with these findings, OPN plasma levels were significantly higher only in patients with AF with atrial low-voltage zones (surrogates of fibrosis) compared with sinus rhythm controls. Mechanistically, we identified ERK1/2 as the relevant downstream mediator of PLK2 leading to increased OPN expression. Finally, oral treatment with the clinically available drug mesalazine, known to inhibit ERK1/2, prevented cardiac OPN overexpression and reversed the pathological PLK2 knockout phenotype in PLK2 knockout mice. Conclusions: Abnormal PLK2/ERK1/2/OPN axis function critically contributes to AF-related atrial fibrosis, suggesting reinforcing PLK2 activity and/or OPN inhibition as innovative targets to prevent fibrosis progression in AF. Mesalazine derivatives may be used as lead compounds for the development of novel anti-AF agents targeting fibrosis.}, language = {en} } @techreport{MuellerDieterBauhusetal., author = {M{\"u}ller, J{\"o}rg and Dieter, M. and Bauhus, J. and Spellmann, H. and M{\"o}hring, B. and Wagner, S. and Wolf, Heino and Niekisch, M. and Weiger, H. and Feindt, Peter H. and Hamm, Ulrich and W{\"a}tzold, Frank and Wolters, Volkmar and Engels, Eve-Marie and Schraml, U. and Lang, F. and Pr{\"o}bstl-Haider, U. and Richter, K.}, title = {Wege zu einem effizienten Waldnaturschutz in Deutschland. Stellungnahme}, publisher = {Wissenschaftlicher Beirat Waldpolitik und Wissenschaftlicher Beirat Biodiversit{\"a}t und Genetische Ressourcen beim BMEL}, pages = {62}, language = {de} } @incollection{HenkelSchwiertzWagneretal., author = {Henkel, Karsten and Schwiertz, Carola and Wagner, S. and Valdeig, A. and List, M. and Schmeißer, Dieter}, title = {Partikel- und Tropfendetektion im Mikrometerbereich mittels Schwingquarzen}, publisher = {w.e.b.-Univ.-Verl.}, address = {Dresden}, isbn = {3-935712-92-8}, pages = {291 -- 294}, language = {de} } @inproceedings{WagnerOstendorfGrahmannetal., author = {Wagner, J. and Ostendorf, Ralf and Grahmann, Jan and Merten, A. and Hugger, S. and Jarvis, J.-P. and Fuchs, F. and Boscovic, D. and Schenk, Harald}, title = {Widely tunable quantum cascade lasers for spectroscopic sensing}, series = {Quantum sensing and nanophotonic devices XII, 8 - 12 February 2015, San Francisco, California, United States}, booktitle = {Quantum sensing and nanophotonic devices XII, 8 - 12 February 2015, San Francisco, California, United States}, editor = {Razeghi, Manijeh}, publisher = {SPIE}, address = {Bellingham, Wash.}, isbn = {978-1-62841-460-8}, pages = {937012-1 -- 937012-6}, language = {en} } @inproceedings{RodionovBensTrimbornetal., author = {Rodionov, Andrei and Bens, Oliver and Trimborn, Manfred and Wagner, S. and Schneider, Bernd Uwe and Raab, Thomas and H{\"u}ttl, Reinhard F.}, title = {Use of commercial soil amendments in initial soils (I) - Impact on yield and basic soil characteristics}, series = {EGU General Assembly 2009, Vienna, Austria, 19 - 24 April 2009}, booktitle = {EGU General Assembly 2009, Vienna, Austria, 19 - 24 April 2009}, publisher = {European Geophysical Society}, address = {Katlenburg-Lindau}, language = {en} } @misc{SteuerLiedkeButterlingetal., author = {Steuer, O. and Liedke, Maciej O. and Butterling, M. and Schwarz, D. and Schulze, J. and Li, Z. and Wagner, A. and Fischer, Inga Anita and H{\"u}bner, R. and Zhou, S.}, title = {Evolution of point defects in pulsed-laser-melted Ge1-xSnx probed by positron annihilation lifetime spectroscopy}, series = {Journal of Physics: Condensed Matter}, volume = {36}, journal = {Journal of Physics: Condensed Matter}, number = {8}, issn = {0953-8984}, doi = {10.1088/1361-648X/ad0a10}, pages = {1 -- 11}, abstract = {Direct-band-gap Germanium-Tin alloys (Ge1-xSnx) with high carrier mobilities are promising materials for nano- and optoelectronics. The concentration of open volume defects in the alloy, such as Sn and Ge vacancies, influences the final device performance. In this article, we present an evaluation of the point defects in molecular-beam-epitaxy grown Ge1-xSnx films treated by post-growth nanosecond-range pulsed laser melting (PLM). Doppler broadening - variable energy positron annihilation spectroscopy and variable energy positron annihilation lifetime spectroscopy are used to investigate the defect nanostructure in the Ge1-xSnx films exposed to increasing laser energy density. The experimental results, supported with ATomic SUPerposition calculations, evidence that after PLM, the average size of the open volume defects increases, which represents a raise in concentration of vacancy agglomerations, but the overall defect density is reduced as a function of the PLM fluence. At the same time, the positron annihilation spectroscopy analysis provides information about dislocations and Ge vacancies decorated by Sn atoms. Moreover, it is shown that the PLM reduces the strain in the layer, while dislocations are responsible for trapping of Sn and formation of small Sn-rich-clusters.}, language = {en} }