@misc{KorolovLeimkuehlerBoekeetal., author = {Korolov, Ihor and Leimk{\"u}hler, Marc and Boeke, Marc and Donk{\´o}, Zoltan and Schulz-von der Gathen, Volker and Bischoff, Lena and H{\"u}bner, Gerrit and Hartmann, Peter and Gans, Timo and Liu, Yue and Mussenbrock, Thomas and Schulze, Julian}, title = {Helium metastable species generation in atmospheric pressure RF plasma jets driven by tailored voltage waveforms in mixtures of He and N 2}, series = {Journal of Physics D: Applied Physics}, volume = {53}, journal = {Journal of Physics D: Applied Physics}, issn = {1361-6463}, doi = {10.1088/1361-6463/ab6d97}, pages = {18}, language = {en} } @misc{WilczekSchulzeBrinkmannetal., author = {Wilczek, Sebastian and Schulze, Julian and Brinkmann, Ralf Peter and Donk{\´o}, Zoltan and Trieschmann, Jan and Mussenbrock, Thomas}, title = {Electron dynamics in low pressure capacitively coupled radio frequency discharges}, series = {Journal of Applied Physics}, volume = {127}, journal = {Journal of Applied Physics}, number = {18}, doi = {10.1063/5.0003114.1}, language = {en} } @misc{SchoeberlPradhanIrvingetal., author = {Sch{\"o}berl, Florian and Pradhan, Cauchy and Irving, Stephanie and Buerger, Katharina and Xiong, Guoming and Kugler, G{\"u}nter and Kohlbecher, Stefan and Engmann, Julia and Werner, Philipp and Brendel, Matthias and Schneider, Erich and Perneczky, Robert and Jahn, Klaus and Foug{\`e}re, Christian la and Bartenstein, Peter and Brandt, Thomas and Dietrich, Marianne and Zwergal, Andreas}, title = {Real-space navigation testing differentiates between amyloid-positive and -negative aMCI}, series = {Neurology : official journal of the American Academy of Neurology}, volume = {94}, journal = {Neurology : official journal of the American Academy of Neurology}, number = {8}, issn = {1526-632X}, doi = {10.1212/WNL.0000000000008758}, pages = {e861 -- e873}, language = {en} } @misc{SchoeberlIrvingPradhanetal., author = {Sch{\"o}berl, Florian and Irving, Stephanie and Pradhan, Cauchy and Bardins, Stanislav and Trapp, Christoph and Schneider, Erich and Kugler, G{\"u}nter and Bartenstein, Peter and Dietrich, Marianne and Brandt, Thomas and Zwergal, Andreas}, title = {Prolonged allocentric navigation deficits indicate hippocampal damage in TGA}, series = {Neurology : official journal of the American Academy of Neurology}, volume = {92}, journal = {Neurology : official journal of the American Academy of Neurology}, number = {3}, issn = {0028-3878}, doi = {10.1212/WNL.0000000000006779}, pages = {e234 -- e243}, abstract = {Objective To investigate long-term recovery of allocentric and egocentric spatial orientation as a sensitive marker for hippocampal and extrahippocampal network function in transient global amnesia (TGA). Methods A group of 18 patients with TGA performed an established real-space navigation paradigm, requiring allo- and egocentric spatial orientation abilities, 3 days (postacute stage) and 3 months (follow-up) after symptom onset. Visual exploration behavior and navigation strategy were documented by a gaze-controlled, head-fixed camera. Allo- and egocentric spatial orientation performance was compared to that of 12 age-matched healthy controls. Navigation-induced brain activations were measured using [18F]-fluorodeoxyglucose-PET in a subgroup of 8 patients in the postacute stage and compared to those of the controls. Results In the postacute stage, the patients navigated worse and had higher error rates than controls in allocentric (p = 0.002), but not in egocentric, route planning (p = 0.30), despite complete recovery of verbal (p = 0.58) and figural memory (p = 0.11). Until follow-up, allocentric navigation deficits improved, but higher error rates and reduced use of shortcuts persisted (p < 0.0001). Patients still exhibited relatively more fixations of unique landmarks during follow-up (p = 0.05). PET measurements during the postacute stage showed increased navigation-induced brain activations in the right hippocampus, bilateral retrosplenial, parietal, and mesiofrontal cortices, and cerebellar dentate nucleus in patients compared to controls (p < 0.005). Conclusions Patients with TGA show selective and prolonged deficits of allocentric spatial orientation. Activations in right hippocampal and extrahippocampal hubs of the cerebral navigation network functionally substitute for the deficit in creating and updating the internal cognitive map in TGA.}, language = {en} } @misc{JurischkaDinterEfimovaetal., author = {Jurischka, Christoph and Dinter, Franziska and Efimova, Anastasia and Weiss, Romano and Schiebel, Juliane and Schulz, Christian and Fayziev, Bekzodjon and Schierack, Peter and Fischer, Thomas and R{\"o}diger, Stefan}, title = {An explorative study of polymers for 3D printing of bioanalytical test systems}, series = {Clinical Hemorheology and Microcirculation}, volume = {75}, journal = {Clinical Hemorheology and Microcirculation}, number = {1}, issn = {1875-8622}, doi = {10.3233/CH-190713}, pages = {57 -- 84}, abstract = {Background: The 3D printing is relevant as a manufacturing technology of functional models for forensic, pharmaceutical and bioanalytical applications such as drug delivery systems, sample preparation and point-of-care tests. Objective: Melting behavior and autofluorescence of materials are decisive for optimal printing and applicability of the product which are influenced by varying unknown additives. Methods: We have produced devices for bioanalytical applications from commercially available thermoplastic polymers using a melt-layer process. We characterized them by differential scanning calorimetry, fluorescence spectroscopy and functional assays (DNA capture assay, model for cell adhesion, bacterial adhesion and biofilm formation test). Results: From 14 tested colored, transparent and black materials we found only deep black acrylonitrile-butadiene-styrene (ABS) and some black polylactic acid (PLA) useable for fluorescence-based assays, with low autofluorescence only in the short-wave range of 300-400 nm. PLA was suitable for standard bioanalytical purposes due to a glass transition temperature of approximately 60°C, resistance to common laboratory chemicals and easy print processing. For temperature-critical methods, such as hybridization reactions up to 90°C, ABS was better suited. Conclusions: Autofluorescence was not a disadvantage per se but can also be used as a reference signal in assays. The rapid development of individual protocols for sample processing and analysis required the availability of a material with consistent quality over time. For fluorescence-based assays, the use of commercial standard materials did not seem to meet this requirement.}, language = {en} } @misc{KlichWilczekJanssenetal., author = {Klich, Maximilian and Wilczek, Sebastian and Janssen, Jesper Frederikus Jacobus and Brinkmann, Ralf Peter and Mussenbrock, Thomas and Trieschmann, Jan}, title = {Ion dynamics in capacitively coupled argon-xenon discharges}, series = {Plasma Sources Science and Technology}, volume = {30}, journal = {Plasma Sources Science and Technology}, number = {6}, issn = {1361-6595}, doi = {10.1088/1361-6595/ac02b0}, language = {en} } @misc{SchroederWerderRamaiolietal., author = {Schr{\"o}der, Lena and Werder, Dina von and Ramaioli, Cecilia and Wachtler, Thomas and Henningsen, Peter and Glasauer, Stefan and Lehnen, Nadine}, title = {Unstable Gaze in Functional Dizziness: A Contribution to Understanding the Pathophysiology of Functional Disorders}, series = {Frontiers in Neuroscience}, volume = {15}, journal = {Frontiers in Neuroscience}, issn = {1662-453X}, doi = {10.3389/fnins.2021.685590}, abstract = {Objective: We are still lacking a pathophysiological mechanism for functional disorders explaining the emergence and manifestation of characteristic, severely impairing bodily symptoms like chest pain or dizziness. A recent hypothesis based on the predictive coding theory of brain function suggests that in functional disorders, internal expectations do not match the actual sensory body states, leading to perceptual dysregulation and symptom perception. To test this hypothesis, we investigated the account of internal expectations and sensory input on gaze stabilization, a physiologically relevant parameter of gaze shifts, in functional dizziness. Methods: We assessed gaze stabilization in eight functional dizziness patients and 11 healthy controls during two distinct epochs of large gaze shifts: during a counter- rotation epoch (CR epoch), where the brain can use internal models, motor planning, and resulting internal expectations to achieve internally driven gaze stabilization; and during an oscillation epoch (OSC epoch), where, due to terminated motor planning, no movement expectations are present, and gaze is stabilized by sensory input alone. Results: Gaze stabilization differed between functional patients and healthy controls only when internal movement expectations were involved [F(1,17) = 14.63, p = 0.001, and partial η2 = 0.463]: functional dizziness patients showed reduced gaze stabilization during the CR (p = 0.036) but not OSC epoch (p = 0.26). Conclusion: While sensory-driven gaze stabilization is intact, there are marked, well- measurable deficits in internally-driven gaze stabilization in functional dizziness pointing at internal expectations that do not match actual body states. This experimental evidence supports the perceptual dysregulation hypothesis of functional disorders and is an important step toward understanding the underlying pathophysiology.}, language = {en} } @misc{SchmidtBorcherdingThieleetal., author = {Schmidt, Carsten and Borcherding, Heike and Thiele, Thomas and Schedler, Uwe and Werner, Franziska and R{\"o}diger, Stefan and Roggenbuck, Dirk and Schierack, Peter}, title = {Fluorescence-encoded poly (methyl metharcylate) nanoparticles for a lateral flow assay detecting IgM autoantibodies in rheumatoid arthritis}, series = {Analytical biochemistry}, volume = {Vol. 633}, journal = {Analytical biochemistry}, issn = {1096-0309}, doi = {10.1016/journal.ppat.1010118}, language = {en} } @misc{EmmeneggerKumarEmmeneggeretal., author = {Emmenegger, Marc and Kumar, Sreedhar Saseendran and Emmenegger, Vishalini and Malinauskas, Tomas and B{\"u}ttner, Thomas and Rose, Laura and Schierack, Peter and Sprinzl, Martin F. and Sommer, Clemens J. and Lackner, Karl J. and Aguzzi, Adriano and Roggenbuck, Dirk and Frauenknecht, Katrin B. M.}, title = {Anti-prothrombin autoantibodies enriched after infection with SARS-CoV-2 and influenced by strength of antibody response against SARS-CoV-2 proteins}, series = {PLoS pathogens}, volume = {17}, journal = {PLoS pathogens}, number = {12}, issn = {1553-7374}, doi = {10.1371/journal.ppat.1010118}, language = {en} } @misc{UchinoRaabBonhageetal., author = {Uchino, Kazuki and Raab, Alexandra and Bonhage, Alexander and Schneider, Anna and Raab, Thomas and Wechler, Klaus-Peter and Bauriegel, Albrecht}, title = {Spatial heterogeneity of buried and recent soils in a drift sand area in North-Eastern Germany}, series = {EGU General Assembly 2022, Vienna, Austria, 23-27 May 2022}, journal = {EGU General Assembly 2022, Vienna, Austria, 23-27 May 2022}, doi = {10.5194/egusphere-egu22-2354}, abstract = {In the North European Lowland, on the sandy deposits of the Weichselian glaciation, soils developed during periods of landscape stability are often conserved under windblown sand. However, small-scale changes of sediments and other soil forming factors can result in high spatial variation of soil properties in these landscapes; and relocation of soil material by geomorphic processes further increases the spatial heterogeneity of the soil landscape. These spatial variations in soil properties and conservation need to be considered in order to correctly decipher and interpret the buried soils as records of past environmental conditions. In the forefield of the open-cast mine Cottbus-Nord, archaeological excavations in a dune and drift sand area revealed widespread buried soils of different characteristics. The densely spaced excavation trenches give exceptionally good insights into the pedosphere, allow for reconstructing the distribution of fossil and recent soils in a high spatial resolution, and offer good opportunities to improve the understanding of spatial and temporal patterns of soil formation. Remains of postpleistocene hunter-gatherer campsites were documented in archaeological excavations and found to be associated with a buried soil horizon. We recorded the stratigraphy of soil profiles along more than 15 trenches within an area of about 20 ha, and additionally described the position of buried soils from GPR surveys and microdrone photogrammetry. In a recently opened, 455 m long trench, all characteristic soils and sediments of the study region could be observed and stratigraphically connected. Within this trench, four profiles were identified for further research. Each profile was classified and described according to WRB and German Guidelines for Soil Mapping; and was sampled and investigated through laboratory analyses including determination of organic matter, total carbon and nitrogen contents, soil colour identification, texture analysis, magnetic susceptibility measurement, metal content analysis using X-ray fluorescence analyzer and pH measurement. The compaction and cementation of soil horizons was assessed in situ with a pocket penetrometer. Results show a small-scale mosaic of soils developed on fluvio-aeolian, limnic and aeolian sediments, high spatial variations in pedogenesis due to varying groundwater influence and intensity of horizontal and vertical leachate transport, and high variations in the erosion or conservation of fossil soils. The soil and sediment stratigraphy reflects several phases of landscape development: i) the formation of a Late Pleistocene soil on fluvio-aeolian deposits, ii) a fossilization by aeolian sands, iii) a stability phase with intensive podsolization and peat formation, and iv) a land use-induced aeolian remobilization of the sands.}, language = {en} }