@misc{KuenzelHoffmannWeberetal., author = {K{\"u}nzel, Stephan R. and Hoffmann, Maximilian and Weber, Silvio and K{\"u}nzel, Karolina and K{\"a}mmerer, Susanne and G{\"u}nscht, Mario and Klapproth, Erik and Rausch, Johanna S. E. and Sadek, Mirna S. and Kolanowski, Tomasz and Meyer-Roxlau, Stefanie and Piorkowski, Christopher and Tugtekin, Sems M. and Rose-John, Stefan and Yin, Xiaoke and Mayr, Manuel and Kuhlmann, Jan Dominik and Wimberger, Pauline and Gr{\"u}tzmann, Konrad and Herzog, Natalie and K{\"u}pper, Jan-Heiner and O'Reilly, Molly and Kabir, S. Nashitha and Sommerfeld, Laura C. and Guan, Kaomei and Wielockx, Ben and Fabritz, Larissa and Nattel, Stanley and Ravens, Ursula and Dobrev, Dobromir and Wagner, Michael and El-Armouche, Ali}, title = {Diminished PLK2 Induces Cardiac Fibrosis and Promotes Atrial Fibrillation}, series = {Circulation Research}, volume = {129}, journal = {Circulation Research}, number = {8}, issn = {1524-4571}, doi = {10.1161/CIRCRESAHA.121.319425}, pages = {804 -- 820}, abstract = {Rationale: Fibrosis promotes the maintenance of atrial fibrillation (AF), making it resistant to therapy. Improved understanding of the molecular mechanisms leading to atrial fibrosis will open new pathways toward effective antifibrotic therapies. Objective: This study aims to decipher the mechanistic interplay between PLK2 (polo-like kinase 2) and the profibrotic cytokine OPN (osteopontin) in the pathogenesis of atrial fibrosis and AF. Methods and Results: Atrial PLK2 mRNA expression was 10-fold higher in human fibroblasts than in cardiomyocytes. Compared with sinus rhythm, right atrial appendages and isolated right atrial fibroblasts from patients with AF showed downregulation of PLK2 mRNA and protein, along with increased PLK2 promotor methylation. Genetic deletion as well as pharmacological inhibition of PLK2 induced profibrotic phenotype conversion in cardiac fibroblasts and led to a striking de novo secretion of OPN. Accordingly, PLK2-deficient (PLK2 knockout) mice showed cardiac fibrosis and were prone to experimentally induced AF. In line with these findings, OPN plasma levels were significantly higher only in patients with AF with atrial low-voltage zones (surrogates of fibrosis) compared with sinus rhythm controls. Mechanistically, we identified ERK1/2 as the relevant downstream mediator of PLK2 leading to increased OPN expression. Finally, oral treatment with the clinically available drug mesalazine, known to inhibit ERK1/2, prevented cardiac OPN overexpression and reversed the pathological PLK2 knockout phenotype in PLK2 knockout mice. Conclusions: Abnormal PLK2/ERK1/2/OPN axis function critically contributes to AF-related atrial fibrosis, suggesting reinforcing PLK2 activity and/or OPN inhibition as innovative targets to prevent fibrosis progression in AF. Mesalazine derivatives may be used as lead compounds for the development of novel anti-AF agents targeting fibrosis.}, language = {en} } @misc{FischerMarchettiDeschmannAssisetal., author = {Fischer, Thomas and Marchetti-Deschmann, Martina and Assis, Ana Cristina and Elad, Michal Levin and Algarra, Manuel and Barac, Marko and Bogdanovic Radovic, Iva and Cicconi, Flavio and Claes, Britt and Frascione, Nunzianda and George, Sony and Guedes, Alexandra and Heaton, Cameron and Heeren, Ron and Lasic, Violeta and Lerma, Jos{\´e} Luis and Valle Martinez de Yuso Garcia, Maria del and Nosko, Martin and O'Hara, John and Oshina, Ilze and Palucci, Antonio and Pawlaczyk, Aleksandra and Posp{\´i}škov{\´a}, Krist{\´y}na and de Puit, Marcel and Radodic, Ksenija and Rēpele, Māra and Ristova, Mimoza and Romolo, Francesco Saverio and Šafař{\´i}k, Ivo and Siketic, Zdravko and Spigulis, Janis and Szynkowska-Jozwik, Malgorzata Iwona and Tsiatsiuyeu, Andrei and Vella, Joanna and Dawson, Lorna and R{\"o}diger, Stefan and Francese, Simona}, title = {Profiling and imaging of forensic evidence - A pan-European forensic round robin study part 1: Document forgery}, series = {Science \& Justice}, volume = {62}, journal = {Science \& Justice}, number = {4}, issn = {1876-4452}, doi = {10.1016/j.scijus.2022.06.001}, pages = {433 -- 447}, language = {en} } @misc{NeyretLeProvostBoesingetal., author = {Neyret, Margot and Le Provost, Ga{\"e}tane and Boesing, Andrea Larissa and Schneider, Florian D. and Baulechner, Dennis and Bergmann, Joana and Vries, Franciska T. de and Fiore-Donno, Anna Maria and Geisen, Stefan and Goldmann, Kezia and Merges, Anna and Saifutdinov, Ruslan A. and Simons, Nadja K. and Tobias, Joseph A. and Zaitsev, Andrey S. and Gossner, Martin M. and Jung, Kirsten and Kandeler, Ellen and Krauss, Jochen and Penone, Caterina and Schloter, Michael and Schulz, Stefanie and Staab, Michael and Wolters, Volkmar and Apostolakis, Antonios and Birkhofer, Klaus and Boch, Steffen and Boeddinghaus, Runa S. and Bolliger, Ralph and Bonkowski, Michael and Buscot, Fran{\c{c}}ois and Dumack, Kenneth and Fischer, Markus and Gan, Huei Ying and Heinze, Johannes and H{\"o}lzel, Norbert and John, Katharina and Klaus, Valentin H. and Kleinebecker, Till and Marhan, Sven and M{\"u}ller, J{\"o}rg and Renner, Swen C. and Rillig, Matthias C. and Schenk, No{\"e}lle V. and Sch{\"o}ning, Ingo and Schrumpf, Marion and Seibold, Sebastian and Socher, Stephanie A. and Solly, Emily F. and Teuscher, Miriam and Kleunen, Mark van and Wubet, Tesfaye and Manning, Peter}, title = {A slow-fast trait continuum at the whole community level in relation to land-use intensification}, series = {Nature Communications}, volume = {15}, journal = {Nature Communications}, number = {1}, issn = {2041-1723}, doi = {10.1038/s41467-024-45113-5}, abstract = {AbstractOrganismal functional strategies form a continuum from slow- to fast-growing organisms, in response to common drivers such as resource availability and disturbance. However, whether there is synchronisation of these strategies at the entire community level is unclear. Here, we combine trait data for 2800 above- and belowground taxa from 14 trophic guilds spanning a disturbance and resource availability gradient in German grasslands. The results indicate that most guilds consistently respond to these drivers through both direct and trophically mediated effects, resulting in a 'slow-fast' axis at the level of the entire community. Using 15 indicators of carbon and nutrient fluxes, biomass production and decomposition, we also show that fast trait communities are associated with faster rates of ecosystem functioning. These findings demonstrate that 'slow' and 'fast' strategies can be manifested at the level of whole communities, opening new avenues of ecosystem-level functional classification.}, language = {en} } @misc{JohnKosiolLambersetal., author = {John, Stefan and Kosiol, Jens and Lambers, Leen and Taentzer, Gabriele}, title = {A graph-based framework for model-driven optimization facilitating impact analysis of mutation operator properties}, series = {Software and Systems Modeling}, volume = {22}, journal = {Software and Systems Modeling}, issn = {1619-1374}, doi = {10.1007/s10270-022-01078-x}, pages = {1281 -- 1318}, abstract = {Optimization problems in software engineering typically deal with structures as they occur in the design and maintenance of software systems. In model-driven optimization (MDO), domain-specific models are used to represent these structures while evolutionary algorithms are often used to solve optimization problems. However, designing appropriate models and evolutionary algorithms to represent and evolve structures is not always straightforward. Domain experts often need deep knowledge of how to configure an evolutionary algorithm. This makes the use of model-driven meta-heuristic search difficult and expensive. We present a graph-based framework for MDO that identifies and clarifies core concepts and relies on mutation operators to specify evolutionary change. This framework is intended to help domain experts develop and study evolutionary algorithms based on domain-specific models and operators. In addition, it can help in clarifying the critical factors for conducting reproducible experiments in MDO. Based on the framework, we are able to take a first step toward identifying and studying important properties of evolutionary operators in the context of MDO. As a showcase, we investigate the impact of soundness and completeness at the level of mutation operator sets on the effectiveness and efficiency of evolutionary algorithms.}, language = {en} } @misc{BuchananLewisParisetal., author = {Buchanan, Erin M. and Lewis, Savannah C. and Paris, Bastien and Forscher, Patrick S. and Pavlacic, Jeffrey M. and Beshears, Julie E. and Drexler, Shira Meir and Gourdon-Kanhukamwe, Am{\´e}lie and Mallik, Peter R and Silan, Miguel Alejandro A. and Miller, Jeremy K. and IJzerman, Hans and Moshontz, Hannah and Beaudry, Jennifer L. and Suchow, Jordan W. and Chartier, Christopher R. and Coles, Nicholas A. and Sharifian, MohammadHasan and Todsen, Anna Louise and Levitan, Carmel A. and Azevedo, Fl{\´a}vio and Legate, Nicole and Heller, Blake and Rothman, Alexander J. and Dorison, Charles A. and Gill, Brian P. and Wang, Ke and Rees, Vaughan W. and Gibbs, Nancy and Goldenberg, Amit and Thi Nguyen, Thuy-vy and Gross, James J. and Kaminski, Gwena{\^e}l and von Bastian, Claudia C. and Paruzel-Czachura, Mariola and Mosannenzadeh, Farnaz and Azouaghe, Soufian and Bran, Alexandre and Ruiz-Fernandez, Susana and Santos, Anabela Caetano and Reggev, Niv and Zickfeld, Janis H. and Akkas, Handan and Pantazi, Myrto and Ropovik, Ivan and Korbmacher, Max and Arriaga, Patr{\´i}cia and Gjoneska, Biljana and Warmelink, Lara and Alves, Sara G. and de Holanda Coelho, Gabriel Lins and Stieger, Stefan and Schei, Vidar and Hanel, Paul H. P. and Szaszi, Barnabas and Fedotov, Maksim and Antfolk, Jan and Marcu, Gabriela-Mariana and Schr{\"o}tter, Jana and Kunst, Jonas R. and Geiger, Sandra J. and Adetula, Adeyemi and Kocalar, Halil Emre and Kielińska, Julita and Kačm{\´a}r, Pavol and Bokkour, Ahmed and Galindo-Caballero, Oscar J. and Djamai, Ikhlas and P{\"o}ntinen, Sara Johanna and AGESIN, Bamikole Emmanuel and Jerns{\"a}ther, Teodor and Urooj, Anum and Rachev, Nikolay R. and Koptjevskaja-Tamm, Maria and Kurfal{\i}, Murathan and Pit, Ilse L. and Li, Ranran and {\c{C}}oksan, Sami and Dubrov, Dmitrii and Paltrow, Tamar Elise and Ban{\´i}k, Gabriel and Korobova, Tatiana and Studzinska, Anna and Jiang, Xiaoming and Aruta, John Jamir Benzon R. and Vintr, J{\´a}chym and Chiu, Faith and Kaliska, Lada and Berkessel, Jana B. and T{\"u}mer, Murat and Morales-Izquierdo, Sara and Chuan-Peng, Hu and Vezirian, Kevin and Rosa, Anna Dalla and Bialobrzeska, Olga and Vasilev, Martin R. and Beitner, Julia and K{\´a}cha, Ondřej and Žuro, Barbara and Westerlund, Minja and Nedelcheva-Datsova, Mina and Findor, Andrej and Krupić, Dajana and Kowal, Marta and Askelund, Adrian Dahl and Pourafshari, Razieh and Đorđević, Jasna Milošević and Schmidt, Nadya-Daniela and Baklanova, Ekaterina and Szala, Anna and Zakharov, Ilya and Vranka, Marek A. and Ihaya, Keiko and Grano, Caterina and Cellini, Nicola and Białek, Michał and Anton-Boicuk, Lisa and Dalgar, Ilker and Ad{\i}g{\"u}zel, Arca and Verharen, Jeroen P. H. and Maturan, Princess Lovella G. and Kassianos, Angelos P. and Oliveira, Raquel and Čadek, Martin and Adoric, Vera Cubela and {\"O}zdoğru, Asil Ali and Sverdrup, Therese E. and Aczel, Balazs and Zambrano, Danilo and Ahmed, Afroja and Tamnes, Christian K. and Yamada, Yuki and Volz, Leonhard and Sunami, Naoyuki and Suter, Lilian and Vieira, Luc and Groyecka-Bernard, Agata and Kamburidis, Julia Arhondis and Reips, Ulf-Dietrich and Harutyunyan, Mikayel and Adetula, Gabriel Agboola and Allred, Tara Bulut and Barzykowski, Krystian and Antazo, Benedict G and Zsido, Andras N. and Šakan, Dušana Dušan and Cyrus-Lai, Wilson and Ahlgren, Lina Pernilla and Hruška, Matej and Vega, Diego and Manunta, Efisio and Mokady, Aviv and Capizzi, Mariagrazia and Martončik, Marcel and Say, Nicolas and Filip, Katarzyna and Vilar, Roosevelt and Staniaszek, Karolina and Vdovic, Milica and Adamkovic, Matus and Johannes, Niklas and Hajdu, Nandor and Cohen, Noga and Overkott, Clara and Krupić, Dino and Hubena, Barbora and Nilsonne, Gustav and Mioni, Giovanna and Solorzano, Claudio Singh and Ishii, Tatsunori and Chen, Zhang and Kushnir, Elizaveta and Karaarslan, Cemre and Ribeiro, Rafael R. and Khaoudi, Ahmed and Kossowska, Małgorzata and Bavolar, Jozef and Hoyer, Karlijn and Roczniewska, Marta and Karababa, Alper and Becker, Maja and Monteiro, Renan P. and Kunisato, Yoshihiko and Metin-Orta, Irem and Adamus, Sylwia and Kozma, Luca and Czarnek, Gabriela and Domurat, Artur and Štrukelj, Eva and Alvarez, Daniela Serrato and Parzuchowski, Michal and Massoni, S{\´e}bastien and Czamanski-Cohen, Johanna and Pronizius, Ekaterina and Muchembled, Fany and van Schie, Kevin and Sa{\c{c}}akl{\i}, Asl{\i} and Hristova, Evgeniya and Kuzminska, Anna O. and Charyate, Abdelilah and Bijlstra, Gijsbert and Afhami, Reza and Majeed, Nadyanna M. and Musser, Erica D. and Sirota, Miroslav and Ross, Robert M. and Yeung, Siu Kit and Papadatou-Pastou, Marietta and Foroni, Francesco and Almeida, In{\^e}s A. T. and Grigoryev, Dmitry and Lewis, David M. G. and Holford, Dawn L. and Janssen, Steve M. J. and Tatachari, Srinivasan and Batres, Carlota and Olofsson, Jonas K. and Daches, Shimrit and Belaus, Anabel and Pfuhl, Gerit and Corral-Frias, Nadia Sarai and Sousa, Daniela and R{\"o}er, Jan Philipp and Isager, Peder Mortvedt and Godbersen, Hendrik and Walczak, Radoslaw B. and Van Doren, Natalia and Ren, Dongning and Gill, Tripat and Voracek, Martin and DeBruine, Lisa M. and Anne, Michele and Očovaj, Sanja Batić and Thomas, Andrew G. and Arvanitis, Alexios and Ostermann, Thomas and Wolfe, Kelly and Arinze, Nwadiogo Chisom and Bundt, Carsten and Lamm, Claus and Calin-Jageman, Robert J and Davis, William E. and Karekla, Maria and Zorjan, Saša and Jaremka, Lisa M. and Uttley, Jim and Hricova, Monika and Koehn, Monica A and Kiselnikova, Natalia and Bai, Hui and Krafnick, Anthony J. and Balci, Busra Bahar and Ballantyne, Tonia and Lins, Samuel and Vally, Zahir and Esteban-Serna, Celia and Schmidt, Kathleen and Macapagal, Paulo Manuel L. and Szwed, Paulina and Zdybek, Przemysław Marcin and Moreau, David and Collins, W. Matthew and Joy-Gaba, Jennifer A. and Vilares, Iris and Tran, Ulrich S. and Boudesseul, Jordane and Albayrak-Aydemir, Nihan and Dixson, Barnaby James Wyld and Perillo, Jennifer T and Ferreira, Ana and Westgate, Erin C. and Aberson, Christopher L. and Arinze, Azuka Ikechukwu and Jaeger, Bastian and Butt, Muhammad Mussaffa and Silva, Jaime R. and Storage, Daniel Shafik and Janak, Allison P and Jim{\´e}nez-Leal, William and Soto, Jose A. and Sorokowska, Agnieszka and McCarthy, Randy and Tullett, Alexa M and Frias-Armenta, Martha and Ribeiro, Matheus Fernando Felix and Hartanto, Andree and Forbes, Paul A. G. and Willis, Megan L. and del Carmen Tejada R, Mar{\´i}a and Torres, Adriana Julieth Olaya and Stephen, Ian D and Vaidis, David C. and de la Rosa-G{\´o}mez, Anabel and Yu, Karen and Sutherland, Clare A. M. and Manavalan, Mathi and Behzadnia, Behzad and Urban, Jan and Baskin, Ernest and McFall, Joseph P. and Ogbonnaya, Chisom Esther and Fu, Cynthia H. Y. and Rahal, Rima-Maria and Ndukaihe, Izuchukwu L. G. and Hostler, Thomas J. and Kappes, Heather Barry and Sorokowski, Piotr and Khosla, Meetu and Lazarevic, Ljiljana B. and Eudave, Luis and Vilsmeier, Johannes K. and Luis, Elkin O. and Muda, Rafał and Agadullina, Elena and C{\´a}rcamo, Rodrigo A. and Reeck, Crystal and Anjum, Gulnaz and Venegas, M{\´o}nica Camila Toro and Misiak, Michal and Ryan, Richard M. and Nock, Nora L. and Travaglino, Giovanni A. and Mensink, Michael C. and Feldman, Gilad and Wichman, Aaron L. and Chou, Weilun and Ziano, Ignazio and Seehuus, Martin and Chopik, William J. and Kung, Franki Y. H. and Carpentier, Joelle and Vaughn, Leigh Ann and Du, Hongfei and Xiao, Qinyu and Lima, Tiago J. S. and Noone, Chris and Onie, Sandersan and Verbruggen, Frederick and Radtke, Theda and Primbs, Maximilian A.}, title = {The psychological science accelerator's COVID-19 rapid-response dataset}, series = {Scientific Data}, volume = {10}, journal = {Scientific Data}, number = {1}, publisher = {Springer Science and Business Media LLC}, issn = {2052-4463}, doi = {10.1038/s41597-022-01811-7}, pages = {1 -- 15}, language = {en} }