@misc{HoxhaChevallierCiarchietal., author = {Hoxha, Isabelle and Chevallier, Sylvain and Ciarchi, Matteo and Glasauer, Stefan and Delorme, Arnaud and Amorim, Michel-Ange}, title = {Accounting for endogenous effects in decision-making with a non-linear diffusion decision model}, series = {Scientific Reports}, volume = {13}, journal = {Scientific Reports}, issn = {2045-2322}, doi = {10.1038/s41598-023-32841-9}, abstract = {The Drift-Diffusion Model (DDM) is widely accepted for two-alternative forced-choice decision paradigms thanks to its simple formalism and close fit to behavioral and neurophysiological data. However, this formalism presents strong limitations in capturing inter-trial dynamics at the single- trial level and endogenous influences. We propose a novel model, the non-linear Drift-Diffusion Model (nl-DDM), that addresses these issues by allowing the existence of several trajectories to the decision boundary. We show that the non-linear model performs better than the drift-diffusion model for an equivalent complexity. To give better intuition on the meaning of nl-DDM parameters, we compare the DDM and the nl-DDM through correlation analysis. This paper provides evidence of the functioning of our model as an extension of the DDM. Moreover, we show that the nl-DDM captures time effects better than the DDM. Our model paves the way toward more accurately analyzing across-trial variability for perceptual decisions and accounts for peri-stimulus influences.}, language = {en} } @misc{GlasauerStraka, author = {Glasauer, Stefan and Straka, Hans}, title = {Der Beginn der Warmbl{\"u}tigkeit}, series = {Spektrum der Wissenschaft}, journal = {Spektrum der Wissenschaft}, number = {2}, issn = {0170-2971}, pages = {30 -- 31}, language = {de} } @misc{Glasauer, author = {Glasauer, Stefan}, title = {Individual differences do matter}, series = {Behavioral and Brain Sciences}, volume = {47}, journal = {Behavioral and Brain Sciences}, issn = {0140-525X}, doi = {10.1017/S0140525X2300242X}, abstract = {The integrative experiment design proposal currently only relates to group results, but downplays individual differences between participants, which may nevertheless be substantial enough to constitute a relevant dimension in the design space. Excluding the individual participant in the integrative design will not solve all problems mentioned in the target article, because averaging results may obscure the underlying mechanisms.}, language = {en} } @misc{ShiGuGlasaueretal., author = {Shi, Zhuanghua and Gu, Bon-Mi and Glasauer, Stefan and Meck, Warren H.}, title = {Beyond Scalar Timing Theory: Integrating Neural Oscillators with Computational Accessibility in Memory}, series = {Timing \& Time Perception}, journal = {Timing \& Time Perception}, issn = {2213-4468}, doi = {10.1163/22134468-bja10059}, pages = {1 -- 22}, abstract = {One of the major challenges for computational models of timing and time perception is to identify a neurobiological plausible implementation that predicts various behavioral properties, including the scalar property and retrospective timing. The available timing models primarily focus on the scalar property and prospective timing, while virtually ignoring the computational accessibility. Here, we first selectively review timing models based on ramping activity, oscillatory pattern, and time cells, and discuss potential challenges for the existing models. We then propose a multifrequency oscilla- tory model that offers computational accessibility, which could account for a much broader range of timing features, including both retrospective and prospective timing.}, language = {en} } @misc{BrandtGlasauerSchneider, author = {Brandt, Thomas and Glasauer, Stefan and Schneider, Erich}, title = {Aufnahmevorrichtung f{\"u}r die kopfgest{\"u}tzte Bilderfassung und Verfahren zur Steuerung der Aufnahmevorrichtung}, language = {de} } @misc{ShirzhiyanGlasauer, author = {Shirzhiyan, Zahra and Glasauer, Stefan}, title = {Dual-task modulation of neural activity related to perception of time}, series = {Abstract NWG Meeting G{\"o}ttingen 2021}, volume = {2021}, journal = {Abstract NWG Meeting G{\"o}ttingen 2021}, address = {G{\"o}ttingen}, language = {en} } @misc{ChoiGlasauerZeeetal., author = {Choi, Jeong-Yoon and Glasauer, Stefan and Zee, David S. and Kim, Ji-Soo}, title = {Characteristics and Mechanism of Apogeotropic Central Positional Nystagmus}, series = {Brain}, volume = {141}, journal = {Brain}, number = {3}, issn = {1460-2156}, doi = {10.1093/brain/awx381}, pages = {762 -- 775}, language = {en} } @incollection{GlasauerMacNeilage, author = {Glasauer, Stefan and MacNeilage, Paul R.}, title = {Computational Rules for Integrating Vestibular and Multi-Modal Motion Signals in the Central Nervous System}, series = {The Senses: A Comprehensive Reference; Volume 6: Vestibular System and Balance}, booktitle = {The Senses: A Comprehensive Reference; Volume 6: Vestibular System and Balance}, editor = {Fritzsch, Bernd and Straka, Hans}, edition = {2. Edition}, publisher = {Elsevier}, address = {Amsterdam}, doi = {10.1016/B978-0-12-809324-5.24262-4}, pages = {445 -- 457}, abstract = {Integration of multi-sensory signals is normally required to infer the properties and states of the external world and of the own body. This applies also to vestibular signals, which, when activated are naturally accompanied by other sensory or self-generated signals. Here, we review computational schemes and normative principles that have been proposed to achieve meaningful signal fusion that allows perception and action in the face of uncertain information.}, language = {en} } @misc{SchroederWerderRamaiolietal., author = {Schr{\"o}der, Lena and Werder, Dina von and Ramaioli, Cecilia and Wachtler, Thomas and Henningsen, Peter and Glasauer, Stefan and Lehnen, Nadine}, title = {Unstable Gaze in Functional Dizziness: A Contribution to Understanding the Pathophysiology of Functional Disorders}, series = {Frontiers in Neuroscience}, volume = {15}, journal = {Frontiers in Neuroscience}, issn = {1662-453X}, doi = {10.3389/fnins.2021.685590}, abstract = {Objective: We are still lacking a pathophysiological mechanism for functional disorders explaining the emergence and manifestation of characteristic, severely impairing bodily symptoms like chest pain or dizziness. A recent hypothesis based on the predictive coding theory of brain function suggests that in functional disorders, internal expectations do not match the actual sensory body states, leading to perceptual dysregulation and symptom perception. To test this hypothesis, we investigated the account of internal expectations and sensory input on gaze stabilization, a physiologically relevant parameter of gaze shifts, in functional dizziness. Methods: We assessed gaze stabilization in eight functional dizziness patients and 11 healthy controls during two distinct epochs of large gaze shifts: during a counter- rotation epoch (CR epoch), where the brain can use internal models, motor planning, and resulting internal expectations to achieve internally driven gaze stabilization; and during an oscillation epoch (OSC epoch), where, due to terminated motor planning, no movement expectations are present, and gaze is stabilized by sensory input alone. Results: Gaze stabilization differed between functional patients and healthy controls only when internal movement expectations were involved [F(1,17) = 14.63, p = 0.001, and partial η2 = 0.463]: functional dizziness patients showed reduced gaze stabilization during the CR (p = 0.036) but not OSC epoch (p = 0.26). Conclusion: While sensory-driven gaze stabilization is intact, there are marked, well- measurable deficits in internally-driven gaze stabilization in functional dizziness pointing at internal expectations that do not match actual body states. This experimental evidence supports the perceptual dysregulation hypothesis of functional disorders and is an important step toward understanding the underlying pathophysiology.}, language = {en} } @misc{KnorrGravotGlasaueretal., author = {Knorr, Alexander G. and Gravot, C{\´e}line M. and Glasauer, Stefan and Straka, Hans}, title = {Image motion with color contrast suffices to elicit an optokinetic reflex in Xenopus laevis tadpoles}, series = {Scientific Reports}, volume = {11}, journal = {Scientific Reports}, issn = {2045-2322}, doi = {10.1038/s41598-021-87835-2}, abstract = {The optokinetic reflex is a closed-loop gaze-stabilizing ocular motor reaction that minimizes residual retinal image slip during vestibulo-ocular reflexes. In experimental isolation, the reflex is usually activated by motion of an achromatic large-field visual background with strong influence of radiance contrast on visual motion estimation and behavioral performance. The presence of color in natural environments, however, suggests that chromatic cues of visual scenes provide additional parameters for image motion detection. Here, we employed Xenopus laevis tadpoles to study the influence of color cues on the performance of the optokinetic reflex and multi-unit optic nerve discharge during motion of a large-field visual scene. Even though the amplitude of the optokinetic reflex decreases with smaller radiance contrast, considerable residual eye movements persist at the 'point of equiluminance' of the colored stimuli. Given the color motion preferences of individual optic nerve fibers, the underlying computation potentially originates in retinal circuits. Differential retinal ganglion cell projections and associated ocular motor signal transformation might further reinforce the color dependency in conceptual correspondence with head/body optomotor signaling. Optokinetic reflex performance under natural light conditions is accordingly influenced by radiance contrast as well as by the color composition of the moving visual scene.}, language = {en} } @misc{DietrichHeidgerSchnieppetal., author = {Dietrich, Haike and Heidger, F. and Schniepp, Roman and MacNeilage, Paul R. and Glasauer, Stefan and W{\"u}hr, Max}, title = {Head motion predictability explains phase-and speed-dependent suppression of vestibular balance control during walking}, series = {Elsevier}, volume = {131}, journal = {Elsevier}, number = {4}, edition = {1.}, publisher = {Elsevier}, doi = {10.1016/j.clinph.2019.12.083}, pages = {e219 -- e220}, abstract = {Methods: Body sway was analyzed by measuring the center of pressure (CoP) in 10 healthy participants on a pressure-sensitive treadmill during standing and walking at 0.4 or 0.8 m/s. Continuous SVS (0-25 Hz; peak amplitude at±4.5 mA) was delivered by a bipolar binaural electrode configuration over the mastoid processes to evoke postural responses in the roll plane. Time-dependent coherence between SVS and medio-lateral body sway was analyzed to examine the dynamic impact of vestibular cues during locomotion. HMP was estimated using a previously established model (MacNeilage and Glasauer, 2017). Results: SVS-CoP coherence decreased from standing to slow walking and further decreased with increasing locomotor speed (p< 0.001). Correspondingly, HMP increased with faster locomotion (p= 0.001). SVS-CoP coherence depended on the gait cycle phase with two distinct peaks occurring at 25 …}, language = {en} } @misc{ChenGlasauerMuelleretal., author = {Chen, Siyi and Glasauer, Stefan and M{\"u}ller, Hermann J. and Conci, Markus}, title = {Surface filling-in and contour interpolation contribute independently to Kanizsa figure formation}, series = {Journal of Experimental Psychology}, volume = {44}, journal = {Journal of Experimental Psychology}, number = {9}, issn = {1939-1277}, doi = {10.1037/xhp0000540}, pages = {1399 -- 1413}, language = {en} } @misc{KallaSpiegelClaassenetal., author = {Kalla, Roger and Spiegel, Rainer and Claassen, Jens and Bardins, Stanislav and Hahn, Ales and Schneider, Erich and Lehrer, Nicole and Glasauer, Stefan and Brandt, Thomas and Strupp, Michael}, title = {Comparison of 10-mg doses of 4-aminopyridine and 3,4-diaminopyridine for the treatment of downbeat nystagmus}, series = {Journal of neuro-ophthalmology}, volume = {32}, journal = {Journal of neuro-ophthalmology}, number = {2}, issn = {1536-5166}, doi = {10.1097/WNO.0b013e3182258086}, pages = {320 -- 325}, language = {en} } @misc{FlanaginKlinkowskiBrodtetal., author = {Flanagin, Virginia and Klinkowski, Svenja and Brodt, Svenja and Graetsch, Melanie and Roselli, Carolina and Glasauer, Stefan and Gais, Steffen}, title = {The precuneus as a central node in declarative memory retrieval}, series = {Cerebral Cortex}, volume = {33}, journal = {Cerebral Cortex}, number = {10}, issn = {1460-2199}, doi = {10.1093/cercor/bhac476}, pages = {5981 -- 5990}, abstract = {Both, the hippocampal formation and the neocortex are contributing to declarative memory, but their functional specialization remains unclear. We investigated the differential contribution of both memory systems during free recall of word lists. In total, 21 women and 17 men studied the same list but with the help of different encoding associations. Participants associated the words either sequentially with the previous word on the list, with spatial locations on a well-known path, or with unique autobiographical events. After intensive rehearsal, subjects recalled the words during functional magnetic resonance imaging (fMRI). Common activity to all three types of encoding associations was identified in the posterior parietal cortex, in particular in the precuneus. Additionally, when associating spatial or autobiographical material, retrosplenial cortex activity was elicited during word list recall, while hippocampal activity emerged only for autobiographically associated words. These findings support a general, critical function of the precuneus in episodic memory storage and retrieval. The encoding-retrieval repetitions during learning seem to have accelerated hippocampus-independence and lead to direct neocortical integration in the sequentially associated and spatially associated word list tasks. During recall of words associated with autobiographical memories, the hippocampus might add spatiotemporal information supporting detailed scenic and contextual memories.}, language = {en} } @incollection{GlasauerKnorr, author = {Glasauer, Stefan and Knorr, Alexander G.}, title = {Physical Nature of Vestibular Stimuli}, series = {The Senses: A Comprehensive Reference, Volume 6: Vestibular System and Balance}, booktitle = {The Senses: A Comprehensive Reference, Volume 6: Vestibular System and Balance}, editor = {Fritzsch, Bernd and Straka, Hans}, edition = {2. Edition}, publisher = {Elsevier}, address = {Amsterdam}, doi = {10.1016/B978-0-12-809324-5.23909-6}, pages = {6 -- 11}, abstract = {The vestibular sensors in the inner ear measure head movement with respect to an inertial frame of reference. The chapter describes the principles of measurement of the vestibular sensors, the physical stimuli that are measured, and specific issues that require central processing. An overview about so-called artificial vestibular stimuli that mimic the effect of natural head movement is provided.}, language = {en} } @misc{CostalagoMerueloFleurietBakstetal., author = {Costalago Meruelo, Alicia and Fleuriet, J{\´e}rome and Bakst, Leah and Mustari, Michael J. and Glasauer, Stefan}, title = {Modeling and Prediction of Sinusoidal Smooth Pursuit using Artificial Neural Networks}, series = {40th Annual International Conference of the IEEE, Engineering in Medicine and Biology Society, 2018}, journal = {40th Annual International Conference of the IEEE, Engineering in Medicine and Biology Society, 2018}, publisher = {IEEE EMBC Hawaii}, pages = {1}, language = {en} } @misc{GlasauerDieterichBrandt, author = {Glasauer, Stefan and Dieterich, Marianne and Brandt, Thomas}, title = {Neuronal network-based mathematical modeling of perceived verticality in acute unilateral vestibular lesions: from nerve to thalamus and cortex}, series = {Journal of Neurology}, volume = {265}, journal = {Journal of Neurology}, number = {Supplement 1}, issn = {1432-1459}, doi = {10.1007/s00415-018-8909-5}, pages = {112}, language = {en} } @misc{XiangSeemungalGlasauer, author = {Xiang, Min and Seemungal, Barry M. and Glasauer, Stefan}, title = {Quantitative postural models as biomarkers of balance in Parkinson's disease}, series = {Brain}, volume = {141}, journal = {Brain}, number = {10}, issn = {0006-8950}, doi = {10.1093/brain/awy250}, pages = {2824 -- 2827}, language = {en} } @misc{SalmasiGlasauerStemmler, author = {Salmasi, Mehrdad and Glasauer, Stefan and Stemmler, Martin}, title = {The optimal number of release sites in synapses with neurotransmitter spillover}, series = {Bernstein Conference 2019}, journal = {Bernstein Conference 2019}, doi = {10.12751/nncn.bc2019.0264}, language = {en} } @misc{GlasauerShi, author = {Glasauer, Stefan and Shi, Z.}, title = {Another dead salmon? The measurement flaw of serial dependence in human perception}, series = {Abstract for SfN Global Connectome}, journal = {Abstract for SfN Global Connectome}, pages = {1891 -- 11892}, language = {en} } @misc{YudiceBayerBockischetal., author = {Yudice, Joshua and Bayer, Johanna and Bockisch, Christopher and Glasauer, Stefan}, title = {Inter-subject variability of visual-vestibular sensory fusion during angular rotation}, series = {Bernstein Conference 2020}, journal = {Bernstein Conference 2020}, doi = {10.12751/nncn.bc2020.0250}, language = {en} } @misc{YudiceGlasauer, author = {Yudice, Joshua and Glasauer, Stefan}, title = {Navigational frame of reference during idiothetic path integration in humans}, series = {INAV 2020}, volume = {2020}, journal = {INAV 2020}, pages = {41}, language = {en} } @misc{SpiegelKallaRettingeretal., author = {Spiegel, Rainer and Kalla, R. and Rettinger, N. and Schneider, Erich and Straumann, D. and Marti, S. and Glasauer, Stefan}, title = {Head position during resting modifies spontaneous daytime decrease of downbeat nystagmus}, series = {Neurology}, volume = {75}, journal = {Neurology}, number = {21}, issn = {0028-3878}, doi = {10.1212/WNL.0b013e3181feb22f}, pages = {1928 -- 1932}, language = {en} } @misc{WrightSchneiderGlasauer, author = {Wright, W. Geoffrey and Schneider, Erich and Glasauer, Stefan}, title = {Compensatory manual motor responses while object wielding during combined linear visual and physical roll tilt stimulation}, series = {Experimental Brain Research}, volume = {192}, journal = {Experimental Brain Research}, number = {4}, issn = {0014-4819}, doi = {10.1007/s00221-008-1581-8}, pages = {683 -- 694}, language = {en} } @misc{GuentherBartlNaudereretal., author = {Guenther, Anna L. and Bartl, Klaus and Nauderer, Josef and Schneider, Erich and Huesmann, Alexander and Brandt, Thomas and Glasauer, Stefan}, title = {Modalitydependent indication of the subjective vertical during combined linear and rotational movements}, series = {Annals of the New York Academy of Sciences}, volume = {1164}, journal = {Annals of the New York Academy of Sciences}, issn = {1749-6632}, doi = {10.1111/j.1749-6632.2009.03849.x}, pages = {376 -- 379}, language = {en} } @misc{GlasauerSchneiderGrassoetal., author = {Glasauer, Stefan and Schneider, Erich and Grasso, Renato and Ivanenko, Yuri P.}, title = {Space-time relativity in self-motion reproduction}, series = {Journal of Neurophysiology}, volume = {97}, journal = {Journal of Neurophysiology}, number = {1}, issn = {0022-3077}, doi = {10.1152/jn.01243.2005}, pages = {451 -- 461}, language = {en} } @misc{ZinglerKryvosheySchneideretal., author = {Zingler, Vera C. and Kryvoshey, Dmytro and Schneider, Erich and Glasauer, Stefan and Brandt, Thomas and Strupp, Michael}, title = {A clinical test of otolith function: static ocular counterroll with passive head tilt.}, series = {Neuroreport}, volume = {17}, journal = {Neuroreport}, number = {6}, issn = {0959-4965}, pages = {611 -- 615}, language = {en} } @misc{NowakHermsdoerferSchneideretal., author = {Nowak, Dennis A. and Hermsd{\"o}rfer, Joachim and Schneider, Erich and Glasauer, Stefan}, title = {Moving objects in a rotating environment rapid prediction of coriolis and centrifugal force perturbations}, series = {Experimental Brain Research}, volume = {157}, journal = {Experimental Brain Research}, number = {2}, issn = {0014-4819}, doi = {10.1007/s00221-004-1839-8}, pages = {241 -- 254}, language = {en} } @misc{SchneiderGlasauerDieterichetal., author = {Schneider, Erich and Glasauer, Stefan and Dieterich, Marianne and Kalla, Roger and Brandt, Thomas}, title = {Diagnosis of vestibular imbalance in the blink of an eye}, series = {Neurology}, volume = {63}, journal = {Neurology}, number = {7}, issn = {0028-3878}, pages = {1209 -- 1216}, language = {en} } @misc{SchneiderGlasauerDieterich, author = {Schneider, Erich and Glasauer, Stefan and Dieterich, Marianne}, title = {Comparison of human ocular torsion patterns during natural and galvanic vestibular stimulation}, series = {Journal of Neurophysiology}, volume = {87}, journal = {Journal of Neurophysiology}, number = {4}, issn = {0022-3077}, doi = {10.1152/jn.00558.2001}, pages = {2064 -- 2073}, language = {en} } @misc{SchroederRegnathGlasaueretal., author = {Schr{\"o}der, Lena and Regnath, Franziska and Glasauer, Stefan and Hackenberg, Anna and Hente, Juliane and Weilenmann, Sonja and Pohl, Daniel and K{\"a}nel, Roland von and Lehnen, Nadine}, title = {Altered sensorimotor processing in irritable bowel syndrome: Evidence for a transdiagnostic pathomechanism in functional somatic disorders}, series = {Frontiers in Neuroscience}, volume = {16}, journal = {Frontiers in Neuroscience}, issn = {1662-453X}, doi = {10.3389/fnins.2022.1029126}, abstract = {Objective A recent hypothesis suggests that functional somatic symptoms are due to altered information processing in the brain, with rigid expectations biasing sensorimotor signal processing. First experimental results confirmed such altered processing within the affected symptom modality, e.g., deficient eye-head coordination in patients with functional dizziness. Studies in patients with functional somatic symptoms looking at general, trans-symptomatic processing deficits are sparse. Here, we investigate sensorimotor processing during eye-head gaze shifts in irritable bowel syndrome (IBS) to test whether processing deficits exist across symptom modalities. Methods Study participants were seven patients suffering from IBS and seven age- and gender-matched healthy controls who performed large gaze shifts toward visual targets. Participants performed combined eye-head gaze shifts in the natural condition and with experimentally increased head moment of inertia. Head oscillations as a marker for sensorimotor processing deficits were assessed. Bayes statistics was used to assess evidence for the presence or absence of processing differences between IBS patients and healthy controls. Results With the head moment of inertia increased, IBS patients displayed more pronounced head oscillations than healthy controls (Bayes Factor 10 = 56.4, corresponding to strong evidence). Conclusion Patients with IBS show sensorimotor processing deficits, reflected by increased head oscillations during large gaze shifts to visual targets. In particular, patients with IBS have difficulties to adapt to the context of altered head moment of inertia. Our results suggest general transdiagnostic processing deficits in functional somatic disorders.}, language = {en} } @misc{WerderRegnathSchaeferetal., author = {Werder, Dina von and Regnath, Franziska and Sch{\"a}fer, Daniel and J{\"o}rres, Rudolf and Lehnen, Nadine and Glasauer, Stefan}, title = {Post-COVID breathlessness: a mathematical model of respiratory processing in the brain}, series = {European Archives of Psychiatry and Clinical Neuroscience}, journal = {European Archives of Psychiatry and Clinical Neuroscience}, issn = {0940-1334}, doi = {10.1007/s00406-023-01739-y}, abstract = {Breathlessness is among the most common post-COVID symptoms. In a considerable number of patients, severe breathlessness cannot be explained by peripheral organ impairment. Recent concepts have described how such persistent breathlessness could arise from dysfunctional processing of respiratory information in the brain. In this paper, we present a first quantitative and testable mathematical model of how processing of respiratory-related signals could lead to breathlessness perception. The model is based on recent theories that the brain holds an adaptive and dynamic internal representation of a respiratory state that is based on previous experiences and comprises gas exchange between environment, lung and tissue cells. Perceived breathlessness reflects the brain's estimate of this respiratory state signaling a potentially hazardous disequilibrium in gas exchange. The internal respiratory state evolves from the respiratory state of the last breath, is updated by a sensory measurement of CO2 concentration, and is dependent on the current activity context. To evaluate our model and thus test the assumed mechanism, we used data from an ongoing rebreathing experiment investigating breathlessness in patients with post-COVID without peripheral organ dysfunction (N = 5) and healthy control participants without complaints after COVID-19 (N = 5). Although the observed breathlessness patterns varied extensively between individual participants in the rebreathing experiment, our model shows good performance in replicating these individual, heterogeneous time courses. The model assumes the same underlying processes in the central nervous system in all individuals, i.e., also between patients and healthy control participants, and we hypothesize that differences in breathlessness are explained by different weighting and thus influence of these processes on the final percept. Our model could thus be applied in future studies to provide insight into where in the processing cascade of respiratory signals a deficit is located that leads to (post-COVID) breathlessness. A potential clinical application could be, e.g., the monitoring of effects of pulmonary rehabilitation on respiratory processing in the brain to improve the therapeutic strategies.}, language = {en} }