@misc{BrinkmannOberrathAwakowiczetal., author = {Brinkmann, Ralf Peter and Oberrath, Jens and Awakowicz, Peter and Lapke, Martin and Musch, Thomas and Mussenbrock, Thomas and Rolfes, Ilona and Schulz, Christian and Storch, Robert and Styrnoll, Tim and Zietz, Christian}, title = {Device and Use of the Device for Measuring the Density and/or the Electron Temperature and/or the Collision Frequency of a Plasma}, language = {en} } @misc{SchulzSchneiderKohlbecheretal., author = {Schulz, Christian M. and Schneider, Erich and Kohlbecher, Stefan and Hapfelmeier, Alexander and Heuser, Fabian}, title = {The influence of anaesthetists' experience on workload, performance and visual attention during simulated critical incidents}, series = {Journal of Clinical Monitoring and Computing}, volume = {28}, journal = {Journal of Clinical Monitoring and Computing}, number = {5}, issn = {1387-1307}, doi = {10.1007/s10877-013-9443-8}, pages = {475 -- 480}, language = {en} } @misc{LehnenHeuserSağlametal., author = {Lehnen, Nadine and Heuser, Fabian and Sağlam, Murat and Schulz, Christian M. and Wagner, Klaus J. and Taki, Masakatsu and Kochs, Eberhard F. and Jahn, Klaus and Schneider, Erich}, title = {Opioid-induced nausea involves a vestibular problem preventable by head-rest}, series = {PLoS one}, volume = {10}, journal = {PLoS one}, number = {8}, issn = {1932-6203}, doi = {10.1371/journal.pone.0135263}, pages = {e0135263}, language = {en} } @misc{SchulzSkrzypczakSchneideretal., author = {Schulz, Christian M. and Skrzypczak, M. and Schneider, Erich and Hapfelmeier, Alexander and Martin, J. and Kochs, Eberhard F. and Schneider, G.}, title = {Assessment of subjective workload in an anaesthesia simulator environment: reliability and validity}, series = {European Journal of Anaesthesiology}, volume = {28}, journal = {European Journal of Anaesthesiology}, number = {7}, issn = {0265-0215}, pages = {502 -- 505}, language = {en} } @misc{HeuserSchulzSağlametal., author = {Heuser, Fabian and Schulz, Christian and Sağlam, Murat and Ramaioli, Cecilia and Heuberger, Maria and Wagner, Klaus J. and Jahn, Klaus and Schneider, Erich and Brandt, Thomas and Glasauer, Stefan and Lehnen, Nadine}, title = {Preventing opioid-induced nausea and vomiting: Rest your head and close your eyes?}, series = {PloS one}, volume = {12}, journal = {PloS one}, number = {3}, issn = {1932-6203}, doi = {10.1371/journal.pone.0173925}, pages = {e0173925}, language = {en} } @incollection{SchmidtSchulz, author = {Schmidt, Sindy and Schulz, Christian}, title = {Entwicklung eines Steuerungs- und Regelungsprogrammes f{\"u}r einen Pr{\"u}fstand zur Pr{\"u}fung von Feuerwehrpumpen}, series = {Virtuelle Instrumente in der Praxis 2015 : Begleitband zum 20. VIP-Kongress}, booktitle = {Virtuelle Instrumente in der Praxis 2015 : Begleitband zum 20. VIP-Kongress}, publisher = {VDE Verlag GmbH}, address = {Berlin}, isbn = {978-3-8007-3669-0}, pages = {79 -- 81}, abstract = {Kurzdokumentation {\"u}ber die Programmierung einer Software, f{\"u}r die Anwendung automatischer Pr{\"u}froutinen, zur Pr{\"u}fung von Feuerwehrpumpen, Armaturen und Saugschl{\"a}uchen, unter Verwendung von LabVIEW als grafische Programmieroberfl{\"a}che.}, language = {de} } @misc{PrillSinghSeeberetal., author = {Prill, Robert and Singh, Jasvinder A. and Seeber, Gesine H. and Mai Nielsen, Sabrina and Goodman, Susan and Michel, Sven and Kopkow, Christian and Schulz, Robert and Choong, Peter and Hommel, Hagen}, title = {Patient, physiotherapist and surgeon endorsement of the core domain set for total hip and total knee replacement in Germany: a study protocol for an OMERACT initiative}, series = {BMJ open}, volume = {10}, journal = {BMJ open}, number = {6}, issn = {2044-6055}, doi = {10.1136/bmjopen-2019-035207}, pages = {8}, language = {en} } @misc{SchulzKruegerGengeLendleinetal., author = {Schulz, Christian and Kr{\"u}ger-Genge, Anne and Lendlein, Andreas and K{\"u}pper, Jan-Heiner and Jung, Friedrich}, title = {Potential Effects of Nonadherent on Adherent Human Umbilical Venous Endothelial Cells in Cell Culture}, series = {International Journal of Molecular Science}, volume = {22}, journal = {International Journal of Molecular Science}, number = {3}, doi = {10.3390/ijms22031493}, pages = {15}, abstract = {The adherence and shear-resistance of human umbilical venous endothelial cells (HUVEC) on polymers is determined in vitro in order to qualify cardiovascular implant materials. In these tests, variable fractions of HUVEC do not adhere to the material but remain suspended in the culture medium. Nonadherent HUVEC usually stop growing, rapidly lose their viability and can release mediators able to influence the growth and function of the adherent HUVEC. The aim of this study was the investigation of the time dependent behaviour of HUVEC under controlled nonadherent conditions, in order to gain insights into potential influences of these cells on their surrounding environment in particular adherent HUVEC in the context of in vitro biofunctionality assessment of cardiovascular implant materials. Data from adherent or nonadherent HUVEC growing on polystyrene-based cell adhesive tissue culture plates (TCP) or nonadhesive low attachment plates (LAP) allow to calculate the number of mediators released into the culture medium either from adherent or nonadherent cells. Thus, the source of the inflammatory mediators can be identified. For nonadherent HUVEC, a time-dependent aggregation without further proliferation was observed. The rate of apoptotic/dead HUVEC progressively increased over 90\% within two days. Concomitant with distinct blebbing and loss of membrane integrity over time, augmented releases of prostacyclin (PGI2, up to 2.91 ± 0.62 fg/cell) and platelet-derived growth factor BB (PDGF-BB, up to 1.46 ± 0.42 fg/cell) were detected. The study revealed that nonadherent, dying HUVEC released mediators, which can influence the surrounding microenvironment and thereby the results of in vitro biofunctionality assessment of cardiovascular implant materials. Neglecting nonadherent HUVEC bears the risk for under- or overestimation of the materials endothelialization potential, which could lead to the loss of relevant candidates or to uncertainty with regard to their suitability for cardiac applications. One approach to minimize the influence from nonadherent endothelial cells could be their removal shortly after observing initial cell adhesion. However, this would require an individual adaptation of the study design, depending on the properties of the biomaterial used.}, language = {en} } @misc{PrillSinghSeeberetal., author = {Prill, Robert and Singh, Jasvinder A. and Seeber, Gesine H. and Mai Nielsen, Sabrina and Goodman, Susan and Michel, Sven and Kopkow, Christian and Schulz, Robert and Choong, Peter and Hommel, Hagen}, title = {Endorsement des OMERACT Core Domain Sets f{\"u}r H{\"u}ft- und Kniegelenkersatz: ein Survey unter Patienten, Physiotherapeuten und Orthop{\"a}den in Deutschland - ein Studienprotokoll}, series = {4. Forschungssymposium Physiotherapie, FSPT2019 Abstractband}, journal = {4. Forschungssymposium Physiotherapie, FSPT2019 Abstractband}, pages = {45 -- 46}, language = {de} } @misc{SchulzJungKuepper, author = {Schulz, Christian and Jung, Friedrich and K{\"u}pper, Jan-Heiner}, title = {Inhibition of phase-1 biotransformation and cytostatic effects of diphenyleneiodonium on hepatoblastoma cell line HepG2 and a CYP3A4-overexpressing HepG2 cell clone}, series = {Clinical Hemorheology and Microcirculation}, volume = {79}, journal = {Clinical Hemorheology and Microcirculation}, number = {1}, issn = {1875-8622}, doi = {10.3233/CH-219117}, pages = {231 -- 243}, abstract = {Cell-based in vitro liver models are an important tool in the development and evaluation of new drugs in pharmacological and toxicological drug assessment. Hepatic microsomal enzyme complexes, consisting of cytochrome P450 oxidoreductase (CPR) and cytochrome P450 monooxygenases (CYPs), play a decisive role in catalysing phase-1 biotransformation of pharmaceuticals and xenobiotics. For a comprehensive understanding of the phase-1 biotransformation of drugs, the availability of well-characterized substances for the targeted modulation of in vitro liver models is essential. In this study, we investigated diphenyleneiodonium (DPI) for its ability to inhibit phase-1 enzyme activity and further its toxicological profile in an in vitro HepG2 cell model with and without recombinant expression of the most important drug metabolization enzyme CYP3A4. Aim of the study was to identify effective DPI concentrations for CPR/CYP activity modulation and potentially associated dose and time dependent hepatotoxic effects. The cells were treated with DPI doses up to 5,000nM (versus vehicle control) for a maximum of 48 h and subsequently examined for CYP3A4 activity as well as various toxicological relevant parameters such as cell morphology, integrity and viability, intracellular ATP level, and proliferation. Concluding, the experiments revealed a time- and concentration-dependent DPI mediated partial and complete inhibition of CYP3A4 activity in CYP3A4 overexpressing HepG2-cells (HepG2-CYP3A4). Other cell functions, including ATP synthesis and consequently the proliferation were negatively affected in both in vitro cell models. Since neither cell integrity nor cell viability were reduced, the effect of DPI in HepG2 can be assessed as cytostatic rather than cytotoxic.}, language = {en} }