@misc{HomfeldtReseBrenneretal., author = {Homfeldt, Felix and Rese, Alexandra and Brenner, Hanno and Baier, Daniel and Sch{\"a}fer, Fabio}, title = {Identification and Generation of Innovative Ideas in the Procurement of the Automotive Industry: The Case of AUDI AG}, series = {International Journal of Innovation Management}, volume = {21}, journal = {International Journal of Innovation Management}, number = {7}, issn = {1363-9196}, doi = {10.1142/S1363919617500530}, pages = {31}, language = {en} } @book{ZundelBlaettelMinkBrohmannetal., author = {Zundel, Stefan and Bl{\"a}ttel-Mink, Birgit and Brohmann, Bettina and Defila, Rico and Di Giulio, Antonietta and Fischer, Daniel and Fuchs, Doris and G{\"o}lz, Sebastian and G{\"o}tz, Konrad and Homburg, Andreas and Kaufmann-Hayoz, Ruth and Matthies, Ellen and Michelsen, Gerd and Sch{\"a}fer, Martina and Tews, Kerstin and Wassermann, Sandra}, title = {Konsum-Botschaften : was Forschende f{\"u}r die gesellschaftliche Gestaltung nachhaltigen Konsums empfehlen}, edition = {1. Auflage}, publisher = {Hirzel Verlag}, address = {Stuttgart}, isbn = {978-3-7776-2371-9}, pages = {198}, language = {de} } @misc{WerderRegnathSchaeferetal., author = {Werder, Dina von and Regnath, Franziska and Sch{\"a}fer, Daniel and J{\"o}rres, Rudolf and Lehnen, Nadine and Glasauer, Stefan}, title = {Post-COVID breathlessness: a mathematical model of respiratory processing in the brain}, series = {European Archives of Psychiatry and Clinical Neuroscience}, journal = {European Archives of Psychiatry and Clinical Neuroscience}, issn = {0940-1334}, doi = {10.1007/s00406-023-01739-y}, abstract = {Breathlessness is among the most common post-COVID symptoms. In a considerable number of patients, severe breathlessness cannot be explained by peripheral organ impairment. Recent concepts have described how such persistent breathlessness could arise from dysfunctional processing of respiratory information in the brain. In this paper, we present a first quantitative and testable mathematical model of how processing of respiratory-related signals could lead to breathlessness perception. The model is based on recent theories that the brain holds an adaptive and dynamic internal representation of a respiratory state that is based on previous experiences and comprises gas exchange between environment, lung and tissue cells. Perceived breathlessness reflects the brain's estimate of this respiratory state signaling a potentially hazardous disequilibrium in gas exchange. The internal respiratory state evolves from the respiratory state of the last breath, is updated by a sensory measurement of CO2 concentration, and is dependent on the current activity context. To evaluate our model and thus test the assumed mechanism, we used data from an ongoing rebreathing experiment investigating breathlessness in patients with post-COVID without peripheral organ dysfunction (Nā€‰=ā€‰5) and healthy control participants without complaints after COVID-19 (Nā€‰=ā€‰5). Although the observed breathlessness patterns varied extensively between individual participants in the rebreathing experiment, our model shows good performance in replicating these individual, heterogeneous time courses. The model assumes the same underlying processes in the central nervous system in all individuals, i.e., also between patients and healthy control participants, and we hypothesize that differences in breathlessness are explained by different weighting and thus influence of these processes on the final percept. Our model could thus be applied in future studies to provide insight into where in the processing cascade of respiratory signals a deficit is located that leads to (post-COVID) breathlessness. A potential clinical application could be, e.g., the monitoring of effects of pulmonary rehabilitation on respiratory processing in the brain to improve the therapeutic strategies.}, language = {en} }