@misc{KordiSaydiAzimietal., author = {Kordi, N and Saydi, A and Azimi, M and Mazdarani, F and Gadruni, K and Jung, F and Karami, S}, title = {Cuproptosis and physical training}, series = {Clinical Hemorheology and Microcirculation}, volume = {88 (2024)}, journal = {Clinical Hemorheology and Microcirculation}, number = {3}, doi = {10.3233/CH-242329}, pages = {337 -- 350}, abstract = {Copper is an essential element in the human body, involved in many physiological and metabolic functions, including coagulation, oxidative metabolism, and hormone production. The maintenance of copper homeostasis within cells is a complex procedure that is intrinsically controlled by a multitude of intricate mechanisms. Disorders of copper homeostasis encompass a wide range of pathological conditions, including degenerative neurological diseases, metabolic disorders, cardio-cerebrovascular diseases, and tumors. Cuproptosis, a recently identified non-apoptotic mode of cell death mode, is characterized by copper dependence and the regulation of mitochondrial respiration. Cuproptosis represents a novel form of cell death distinct from the previously described modes, including apoptosis, necrosis, pyroptosis, and ferroptosis. Excess copper has been shown to induce cuproptosis by stimulating protein toxic stress responses via copper-dependent abnormal oligomerization of lipoylation proteins within the tricarboxyli}, language = {en} } @misc{SaydiBehpoorKhamisAbadietal., author = {Saydi, A and Behpoor, N and Khamis Abadi, F and Jung, F and Kordi, N}, title = {Modulation of pulmonary oxidative status in methamphetamine-withdrawn rats, comparing the effects of continuous training and NBS superfood supplementation}, series = {Clinical Hemorheology and Microcirculation}, volume = {88 (2024)}, journal = {Clinical Hemorheology and Microcirculation}, number = {3}, doi = {10.3233/CH-242306}, pages = {373 -- 384}, abstract = {OBJECTIVE: This study aimed to investigate the effects of six weeks of continuous training and Nutrition Bio-shield (NBS) Superfood Supplementation on the state of oxidative stress by the expression of Nrf2, NOX4, superoxide dismutase, and malondialdehyde genes in the lungs of rats after methamphetamine withdrawal. METHODS: Forty male Wistar rats were randomly divided into five groups (n = 8, per group), undergoing methamphetamine administration (six weeks, 5 mg/kg ip, and once per day) followed by a 21-day withdrawal period. The rats were supplemented NBS superfood at a dosage of 25 g/kg per day for six weeks. The training protocol was 30 minutes of daily continuous training (treadmill running), five days a week for six weeks. The regimen escalated from a pace of 3 m/min for the initial 5 minutes, to 5 m/min for the following 5 minutes, culminating at 8 m/min for the remainder of the session, all at a 0° incline. A one-way analysis of variance was performed to analyze the gene expression of Nrf2, NOX4, MDA, and SOD in the lungs tissue of rats. RESULTS: The results indicated that, in the experimental groups which underwent continuous training and NBS Superfood supplementation, the expression of the Nrf2 gene exhibited a significant elevation compared to the control group (P < 0.05), while the NOX4, MDA, and SOD genes expression exhibited a significant decline in comparison to the control group (P < 0.05). CONCLUSION: In general, both exercise interventions and NBS superfood supplementation, when employed separately or in combination after methamphetamine withdrawal, can enhance the state of oxidative stress in the lung.}, language = {en} } @misc{KordiSanaeiAkraminiaetal., author = {Kordi, N and Sanaei, M and Akraminia, P and Yavari, S and Saydi, A and Abadi, FK and Heydari, N and Jung, F and Karami, S}, title = {PANoptosis and cardiovascular disease: The preventive role of exercise training}, series = {Clinical Hemorheology and Microcirculation}, volume = {88 (2024)}, journal = {Clinical Hemorheology and Microcirculation}, number = {4}, doi = {10.3233/CH-242396}, pages = {499 -- 512}, abstract = {Regulated cell death, including pyroptosis, apoptosis, and necroptosis, is vital for the body's defense system. Recent research suggests that these three types of cell death are interconnected, giving rise to a new concept called PANoptosis. PANoptosis has been linked to various diseases, making it crucial to comprehend its mechanism for effective treatments. PANoptosis is controlled by upstream receptors and molecular signals, which form polymeric complexes known as PANoptosomes. Cell death combines necroptosis, apoptosis, and pyroptosis and cannot be fully explained by any of these processes alone. Understanding pyroptosis, apoptosis, and necroptosis is essential for understanding PANoptosis. Physical exercise has been shown to suppress pyroptotic, apoptotic, and necroptotic signaling pathways by reducing inflammatory factors, proapoptotic factors, and necroptotic factors such as caspases and TNF-alpha. This ultimately leads to a decrease in cardiac structural remodeling. The beneficial effects of exercise on cardiovascular health may be attributed to its ability to inhibit these cell death pathways.}, language = {en} }