@misc{MantskavaChkhitauriShekiladzeetal., author = {Mantskava, M and Chkhitauri, L and Shekiladze, E and Tskhvediani, N and Kalmakhelidze, S and Momtselidze, N and Prantl, L and Jung, F and Machalinski, B and Wojciech, P and Sanikidze, T}, title = {Impact of different severity hyperglycemia on erythrocyte rheological properties}, series = {Clinical Hemorheology and Microcirculation}, volume = {87 (2024)}, journal = {Clinical Hemorheology and Microcirculation}, number = {2}, doi = {10.3233/CH-239104}, pages = {271 -- 281}, abstract = {BACKGROUND: The triad "insulin resistance, prediabetes, diabetes" is three independent neologies with characteristic features and development. In addition, each are characterized by progression and the possibility of transition from one form to other. Due to the fact that diabetes is one of the common diseases associated with high rates of disability, it is necessary to improve diagnostic methods and educational regimens for successful prevention and treatment of the disease. OBJECTIVE: We investigated Band 3 protein (B3p) level, osmotic resistance of erythrocytes, the total antioxidant activity (TAA) of blood serum, level of HbA1 in group patients with insulin resistance (IR), prediabetes, and Type 2 Diabetes Mellitus (T2DM) and comparative with health control group. METHODS: We used original, accurate research methods that measure the essence of the studied quantities. RESULTS: Disruptions of glucose and insulin homeostasis ay lead to the initiation of oxidative stress (in our study demonstrated by a decrea}, language = {en} }