@misc{SpiegelKallaClaassenetal., author = {Spiegel, Rainer and Kalla, Roger and Claassen, Jens and Bardins, Stanislav and Anci{\~a}es da Silva, F{\´a}bio and Farahmand, Parvis and Hahn, Ales and Schneider, Erich}, title = {Aminopyridine treatment in a patient with bilateral vestibular failure and cryptogenic downbeat nystagmus}, series = {Journal of Neuro-Ophthalmology}, volume = {32}, journal = {Journal of Neuro-Ophthalmology}, number = {2}, issn = {1536-5166}, pages = {190}, language = {en} } @misc{ClaassenSpiegelKallaetal., author = {Claassen, Jens and Spiegel, Rainer and Kalla, Roger and Faldon, Mary and Kennard, Christopher and Schneider, Erich}, title = {A randomised double-blind, cross-over trial of 4-aminopyridine for downbeat nystagmus-effects on slowphase eye velocity, postural stability, locomotion and symptoms}, series = {Journal of neurology, neurosurgery, and psychiatry}, volume = {84}, journal = {Journal of neurology, neurosurgery, and psychiatry}, number = {12}, issn = {0022-3050}, doi = {10.1136/jnnp-2012-304736}, pages = {1392 -- 1399}, language = {en} } @misc{ClaassenFeilBardinsetal., author = {Claassen, Jens and Feil, Katharina and Bardins, Stanislav and Teufel, Julian and Spiegel, Rainer and Kalla, Roger and Schneider, Erich}, title = {Dalfampridine in patients with downbeat nystagmus-an observational study}, series = {Journal of Neurology}, volume = {260}, journal = {Journal of Neurology}, number = {8}, issn = {0340-5354}, doi = {10.1007/s00415-013-6911-5}, pages = {1992 -- 1996}, language = {en} } @misc{SpiegelClaassenTeufeletal., author = {Spiegel, Rainer and Claassen, Jens and Teufel, Julian and Bardins, Stanislav and Schneider, Erich and Lehrer, Nicole and Jahn, Klaus and Anciaes da Silva, F{\´a}bio and Hahn, Ales and Farahmand, Parvis and Brandt, Thomas and Strupp, Michael and Kalla, Roger}, title = {Resting in darkness improves downbeat nystagmus: evidence from an observational study}, series = {Annals of the New York Academy of Sciences}, volume = {1375}, journal = {Annals of the New York Academy of Sciences}, number = {1}, issn = {1749-6632}, doi = {10.1111/nyas.13172}, pages = {66 -- 73}, abstract = {Resting in an upright position during daytime decreases downbeat nystagmus (DBN). When measured in brightness only, that is, without intermitting exposure to darkness, it does not make a significant difference whether patients have previously rested in brightness or in darkness. In real-world scenarios, people are often exposed to brightness and darkness intermittently. The aim of this study was to analyze whether resting in brightness or resting in darkness was associated with a lower post-resting DBN after intermitting exposures to brightness and darkness. Eight patients were recorded with three-dimensional video-oculography in brightness and darkness conditions, each following two 2-h resting intervals under either brightness or darkness resting conditions. The dependent variable was DBN intensity, measured in mean slow phase velocity. A repeated measures ANOVA with the factors measurement condition (brightness vs. darkness), resting condition (brightness vs. darkness), and time (after first vs. second resting interval) showed a significant effect for the factor resting condition, where previous resting in darkness was associated with a significantly lower DBN relative to previous resting in brightness (P < 0.01). The clinical relevance is to advise patients with DBN to rest in darkness.}, language = {en} } @misc{KallaSpiegelClaassenetal., author = {Kalla, Roger and Spiegel, Rainer and Claassen, Jens and Bardins, Stanislav and Hahn, Ales and Schneider, Erich and Lehrer, Nicole and Glasauer, Stefan and Brandt, Thomas and Strupp, Michael}, title = {Comparison of 10-mg doses of 4-aminopyridine and 3,4-diaminopyridine for the treatment of downbeat nystagmus}, series = {Journal of neuro-ophthalmology}, volume = {32}, journal = {Journal of neuro-ophthalmology}, number = {2}, issn = {1536-5166}, doi = {10.1097/WNO.0b013e3182258086}, pages = {320 -- 325}, language = {en} } @misc{TeufelBardinsSpiegeletal., author = {Teufel, Julian and Bardins, Stanislav and Spiegel, Rainer and Kremmyda, O. and Schneider, Erich and Strupp, Michael and Kalla, R.}, title = {Real time computerbased visual feedback improves visual acuity in downbeat nystagmus, a pilot study}, series = {Journal of NeuroEngineering and Rehabilitation}, volume = {13}, journal = {Journal of NeuroEngineering and Rehabilitation}, number = {1}, issn = {1743-0003}, language = {de} } @misc{SpiegelKallaRettingeretal., author = {Spiegel, Rainer and Kalla, R. and Rettinger, N. and Schneider, Erich and Straumann, D. and Marti, S. and Glasauer, Stefan}, title = {Head position during resting modifies spontaneous daytime decrease of downbeat nystagmus}, series = {Neurology}, volume = {75}, journal = {Neurology}, number = {21}, issn = {0028-3878}, doi = {10.1212/WNL.0b013e3181feb22f}, pages = {1928 -- 1932}, language = {en} }