@inproceedings{BergDueckershoffLehmannetal., author = {Berg, Heinz Peter and D{\"u}ckershoff, Roland and Lehmann, Mario and Prechavut, Nontavut}, title = {Micro Turbo-Fuel-Cell-Technology : Hybrid compact turbo machinery technology and thermodynamic aspects regarding design parameters of a high efficient MGT-SOFC-system}, series = {12th European Conference on Turbomachinery Fluid dynamics \& Thermodynamics}, booktitle = {12th European Conference on Turbomachinery Fluid dynamics \& Thermodynamics}, doi = {10.29008/ETC2017-266}, pages = {1 -- 12}, abstract = {The improvement of decentralised energy supply systems has received an important role in the recent years. One option is the combination of SOFC with recuperated MGT. Here, a new strategy for selecting the system parameters, such as the operating temperature of the SOFC, turbine inlet temperature and the pressure ratio of the hybrid system, is presented. By introducing the heat ratio between the heat required to increase the process gas to the SOFC operating temperature and the heat required to raise the SOCF exhaust gas to the TIT, it was found that high efficiency (approx. 68\%) is realisable in a compact hybrid system today. Analysis also shows that the HEX-technology is needed to improve the system effectiveness. Also, high recirculation rates with lower TIT can be considered as the future development direction. In addition, a sample configuration of an oil-free MGT rotor unit with high speed foil bearings is presented.}, language = {en} } @misc{FroemmelLehmannRoedigeretal., author = {Fr{\"o}mmel, Ulrike and Lehmann, Werner and R{\"o}diger, Stefan and B{\"o}hm, Alexander and Nitschke, J{\"o}rg and Weinreich, J{\"o}rg and Groß, Julia and Roggenbuck, Dirk and Zinke, Olaf and Ansorge, Hermann and Vogel, Steffen and Klemm, Per and Wex, Thomas and Schr{\"o}der, Christian and Wieler, Lothar H. and Schierack, Peter}, title = {Adhesion of human and animal Escherichia coli strains in association with their virulence-associated genes and phylogenetic origins}, series = {Applied and environmental microbiology}, volume = {79}, journal = {Applied and environmental microbiology}, number = {19}, issn = {1098-5336}, doi = {10.1128/AEM.01384-13}, pages = {5814 -- 5829}, abstract = {Intestinal colonization is influenced by the ability of the bacterium to inhabit a niche, which is based on the expression of colonization factors. Escherichia coli carries a broad range of virulence-associated genes (VAGs) which contribute to intestinal (inVAGs) and extraintestinal (exVAGs) infection. Moreover, initial evidence indicates that inVAGs and exVAGs support intestinal colonization. We developed new screening tools to genotypically and phenotypically characterize E. coli isolates originating in humans, domestic pigs, and 17 wild mammal and avian species. We analyzed 317 isolates for the occurrence of 44 VAGs using a novel multiplex PCR microbead assay (MPMA) and for adhesion to four epithelial cell lines using a new adhesion assay. We correlated data for the definition of new adhesion genes. inVAGs were identified only sporadically, particularly in roe deer (Capreolus capreolus) and the European hedgehog ( Erinaceus europaeus). The prevalence of exVAGs depended on isolation from a specific host. Human uropathogenic E. coli isolates carried exVAGs with the highest prevalence, followed by badger (Meles meles) and roe deer isolates. Adhesion was found to be very diverse. Adhesion was specific to cells, host, and tissue, though it was also unspecific. Occurrence of the following VAGs was associated with a higher rate of adhesion to one or more cell lines: afa-dra, daaD, tsh, vat, ibeA, fyuA, mat, sfa-foc, malX, pic, irp2, and papC. In summary, we established new screening methods which enabled us to characterize large numbers of E. coli isolates. We defined reservoirs for potential pathogenic E. coli. We also identified a very broad range of colonization strategies and defined potential new adhesion genes.}, language = {en} } @incollection{RoedigerSchierackBoehmetal., author = {R{\"o}diger, Stefan and Schierack, Peter and B{\"o}hm, Alexander and Nitschke, J{\"o}rg and Berger, Ingo and Fr{\"o}mmel, Ulrike and Schmidt, Carsten and Ruhland, Mirko and Schimke, Ingolf and Roggenbuck, Dirk and Lehmann, Werner and Schr{\"o}der, Christian}, title = {A highly versatile microscope imaging technology platform for the multiplex real-time detection of biomolecules and autoimmune antibodies}, series = {Molecular diagnostics}, booktitle = {Molecular diagnostics}, editor = {Seitz, Harald and Berger, Ingo}, publisher = {Springer}, address = {Berlin [u.a.]}, isbn = {978-3-642-37690-0}, pages = {35 -- 74}, language = {en} } @misc{RoedigerLiebschSchmidtetal., author = {R{\"o}diger, Stefan and Liebsch, Claudia and Schmidt, Carsten and Lehmann, Werner and Resch-Genger, U. and Schedler, Uwe and Schierack, Peter}, title = {Nucleic acid detection based on the use of microbeads: a review}, series = {Microchimica Acta}, volume = {181}, journal = {Microchimica Acta}, number = {11-12}, issn = {0026-3672}, doi = {10.1007/s00604-014-1243-4}, pages = {1151 -- 1168}, language = {en} } @misc{RoedigerLehmannFroemmeletal., author = {R{\"o}diger, Stefan and Lehmann, Werner and Fr{\"o}mmel, Ulrike and B{\"o}hm, Alexander and Nitschke, J{\"o}rg and Burdukiewicz, Michał and Schr{\"o}der, Christian and Dangla, R{\´e}mi and Droniou, Magali and Schierack, Peter}, title = {The Modi Operandi of the VideoScan Platform for the Detection and Analysis of Nucleic Acids. Life Science Day 2013 \& 17. Leibniz Conference of Advanced Science, Freie Universit{\"a}t Berlin, 24.10.2013}, pages = {1}, language = {en} } @inproceedings{RoedigerHanschmannSteidleetal., author = {R{\"o}diger, Stefan and Hanschmann, Henning and Steidle, Michael and Schr{\"o}der, Christian and Schierack, Peter and Lehmann, Werner}, title = {Detection of Borrelia, Bordetella and HPV with the LoopTag Real-Time PCR Probe System}, series = {International journal of medical microbiology}, volume = {303}, booktitle = {International journal of medical microbiology}, number = {Supplement 1}, issn = {1618-0607}, pages = {12 -- 13}, language = {en} } @misc{LiebschRoedigerBoehmetal., author = {Liebsch, Claudia and R{\"o}diger, Stefan and B{\"o}hm, Alexander and Nitschke, J{\"o}rg and Weinreich, J{\"o}rg and Fruth, Angelika and Roggenbuck, Dirk and Lehmann, Werner and Schedler, Uwe and Juretzek, Thomas and Schierack, Peter}, title = {Solid-phase microbead array for multiplex O-serotyping of Escherichia coli}, series = {Microchimica Acta}, volume = {184}, journal = {Microchimica Acta}, number = {5}, issn = {0026-3672}, doi = {10.1007/s00604-017-2088-4}, pages = {1405 -- 1415}, language = {en} } @misc{BurdukiewiczSpiessBlagodatskikhetal., author = {Burdukiewicz, Michał and Spiess, Andrej-Nikolai and Blagodatskikh, Konstantin A. and Lehmann, Werner and Schierack, Peter and R{\"o}diger, Stefan}, title = {Algorithms for automated detection of hook effect-bearing amplification curves}, series = {Biomolecular Detection and Quantification}, volume = {16}, journal = {Biomolecular Detection and Quantification}, issn = {2214-7535}, doi = {10.1016/j.bdq.2018.08.001}, pages = {1 -- 4}, language = {en} } @misc{KruegerGengeJungKuepperetal., author = {Kr{\"u}ger-Genge, Anne and Jung, Friedrich and K{\"u}pper, Jan-Heiner and Lehmann, Christian and Franke, Ralf-Peter}, title = {Actin type and distribution in erythrocytes}, series = {Journal of Cellular Biotechnology}, volume = {3}, journal = {Journal of Cellular Biotechnology}, number = {2}, issn = {2352-3697}, doi = {10.3233/JCB-179014}, pages = {81 -- 83}, abstract = {Erythrocytes transport oxygen from the lungs to the tissues. The excess surface area together with the elasticity of the erythrocyte cell membrane provides the flexibility needed to pass through the microvasculature where the oxygen exchange occurs. Although the architecture of the red cell and its membrane-associated cytoskeletal network is known in general, the factors that control the characteristic shape change during echinocyte formation are poorly understood. In this short report we show that in echinocytes a completely reorganized membrane cytoskeleton with a box-like structure of actin filaments prevailed indicating the importance of the actin cytoskeleton during echinocyte formation.}, language = {en} } @misc{DinterBurdukiewiczSchieracketal., author = {Dinter, Franziska and Burdukiewicz, Michał and Schierack, Peter and Lehmann, Werner and Nestler, J{\"o}rg and Dame, Gregory and R{\"o}diger, Stefan}, title = {Simultaneous detection and quantification of DNA and protein biomarkers in spectrum of cardiovascular diseases in a microfluidic microbead chip}, series = {Analytical and Bioanalytical Chemistry}, volume = {411}, journal = {Analytical and Bioanalytical Chemistry}, number = {29}, issn = {1618-2650}, doi = {10.1007/s00216-019-02199-x}, pages = {7725 -- 7735}, language = {en} } @misc{BergKleisslHimmelbergetal., author = {Berg, Heinz Peter and Kleissl, Marko and Himmelberg, Axel and Lehmann, Mario and Prechavut, Nontavut and Vorpahl, Michael}, title = {Heat balancing of direct reforming fuel cells in MGT-SOFC hybrid systems}, series = {9th Thai Society of Mechanical Engineers, International Conference on Mechanical Engineering (TSME-ICoME 2018) 11-14 December 2018, Phuket, Thailand}, journal = {9th Thai Society of Mechanical Engineers, International Conference on Mechanical Engineering (TSME-ICoME 2018) 11-14 December 2018, Phuket, Thailand}, editor = {Prukvilailert, Monchai}, edition = {1. Auflage}, publisher = {IOP Publishing/IOP Science}, address = {Bristol}, issn = {1757-899X}, doi = {10.1088/1757-899X/501/1/012007}, pages = {50 -- 60}, abstract = {Solid oxide fuel cells convert chemical energy in electrical energy and are highly suitable for the conversion of hydrocarbon based fuels and products from PowerToGas conversions. Embedded in a micro gas turbine-cycle instead of the combustion chamber the heat energy of the injected fuel, released in the SOFC-Stack, can additionally converted into work and by a turbine-generator into electricity. In a compact system, SOFC stacks are designed to realize a direct steam-reforming process inside. In such direct-reforming fuel cell systems the SOFC operating temperature due to the heat demand for reforming, can be reduced to a value in the range of the outlet temperature of the downstream flow (650°C). If the cycle uses a recuperating system, the operating conditions of the SOFC can be realized without additional high-temperature heat exchanger systems. The system with an uncooled turbine, described in [1], just can reach the operating temperature with an additional high-temperature heat exchange. The system described in this publication does not require an additional high-temperature heat exchanger, because the X-value, as the ratio between the exchanged heat quantity and the required amount of heat to complete the MGT-cycle [2] due to the referring process, is nearly zero and can be realized via the inner container wall (of the MLC). The cycle is completed (between the SOFC and the turbine entry) by the heat input of an afterburner. Here the unreacted fuel of the SOFC fuel-stream is used to provide the necessary heat energy for the downstream turbo-generator-system.}, language = {en} } @misc{LehnenRadziejWeigeletal., author = {Lehnen, Nadine and Radziej, Katharina and Weigel, Angelika and K{\"a}nel, Roland von and Glasauer, Stefan and Pietron, Victor and Van den Bergh, Omer and L{\"o}we, Bernd and Lehmann, Marco and Henningsen, Peter}, title = {Complementing conceptual models of persistent somatic symptoms with mathematical formalization}, series = {Psychosomatic Medicine}, volume = {82}, journal = {Psychosomatic Medicine}, number = {5}, issn = {1534-7796}, doi = {10.1097/PSY.0000000000000801}, pages = {527 -- 528}, language = {en} } @misc{SchmidtSchierackGerberetal., author = {Schmidt, Carsten and Schierack, Peter and Gerber, Ulrike and Schr{\"o}der, Christian and Choi, Youngeun and Bald, Ilko and Lehmann, Werner and R{\"o}diger, Stefan}, title = {Streptavidin Homologues for Applications on Solid Surfaces at High Temperatures}, series = {Langmuir}, volume = {36}, journal = {Langmuir}, number = {2}, issn = {1520-5827}, doi = {10.1021/acs.langmuir.9b02339}, pages = {628 -- 636}, language = {en} } @misc{DueckershoffBergHimmelbergetal., author = {D{\"u}ckershoff, Roland and Berg, Heinz Peter and Himmelberg, Axel and Lehmann, Mario and Kleissl, Marko}, title = {Influence on the Electrical Efficiency of a Hybrid MGT-SOFC-System by μ-fogging in a-Two-Staged Compressor System}, series = {IOP Conference Series: Materials Science and Engineering}, journal = {IOP Conference Series: Materials Science and Engineering}, editor = {Ashton, Anete}, edition = {1. Auflage}, publisher = {IOP Science}, address = {Bristol}, issn = {1757-899X}, doi = {10.1088/1757-899X/886/1/012041}, pages = {1 -- 8}, abstract = {Hybrid combinations of solid oxide fuel cell and recuperated micro gas turbines can convert the chemical energy of hydrocarbon-based fuels in electrical energy with high electrical efficiency. With an integrated and improved cycle management, more than 70\% of the energy content of the fuel could be converted. Therefore, the systems are highly suitable for the Power-To-Gas conversion. In particular, a pressure charging of the SOFC fuel cell leads to an increase in stack performance. By a downstream turbo set, after residual fuels are intentionally oxidized with an afterburner, additional electrical energy can be gained from the expansion of the hot exhaust gas stream and the overall efficiency can be increased. In order to increase the electrical efficiency of the system, it is proposed, to ensure the required compression of the process air in particular by a-two-staged turbo compressor with an intermediate cooling system. By thus achievable reduction of the dissipation of the compressor and by targeted condensation of finest drops in front of the second compressor stage affected by intermediate cooling, an increase in efficiency of the system is possible. This is achieved by targeted cooling of the process air behind a low pressure compression, so that it is saturated over 100\% relative air humidity. As a result, a slightly supersaturated airflow is available for the second compressor stage, which enters the compressor after heat removal via an intermediate cooling having a small number of microdroplets. Therefore, the condensed water evaporates again by the heat of compression in the second stage and the compressed flow ultimately enters the recuperation at a lower temperature than during normal compression. Thus, more heat can be recovered within the recuperation system. Therefore, the electrical energy of the system can be produced having higher efficiency, because the heat dissipation of the overall system decreases. In this article it is presented, how such a process is thermodynamically modelled and how a technical realization can be built after optimization by simulations. Finally, in this study, the process-influencing factors are analyzed to show the highest possible electrical yield of such a system.}, language = {en} } @misc{HanschmannRoedigerKrameretal., author = {Hanschmann, Henning and R{\"o}diger, Stefan and Kramer, Toni and Hanschmann, Katrin and Steidle, Michael and Fingerle, Volker and Schmidt, Carsten and Lehmann, Werner and Schierack, Peter}, title = {LoopTag FRET Probe System for Multiplex qPCR Detection of Borrelia Species}, series = {Life}, volume = {11}, journal = {Life}, number = {11}, issn = {2075-1729}, doi = {10.3390/life11111163}, language = {en} } @misc{SchmidtKammelTanneretal., author = {Schmidt, Carsten and Kammel, Anne and Tanner, Julian A. and Kinghorn, Andrew B. and Khan, Muhammad Moman and Lehmann, Werner and Menger, Marcus and Schedler, Uwe and Schierack, Peter and R{\"o}diger, Stefan}, title = {A Multiparametic Fluorescence Assay for Screening Aptamer-Protein Interactions Based on Microbeads}, series = {Scientific Reports}, volume = {12}, journal = {Scientific Reports}, issn = {2045-2322}, doi = {10.1038/s41598-022-06817-0}, pages = {10}, language = {en} } @misc{GeitheZengSchmidtetal., author = {Geithe, Christiane and Zeng, Bo and Schmidt, Carsten and Dinter, Franziska and Roggenbuck, Dirk and Lehmann, Werner and Dame, Gregory and Schierack, Peter and Hanack, Katja and R{\"o}diger, Stefan}, title = {A multiplex microchamber diffusion assay for the antibody-based detection of microRNAs on randomly ordered microbeads}, series = {Biosensors and Bioelectronics: X}, volume = {18 (2024)}, journal = {Biosensors and Bioelectronics: X}, publisher = {Elsevier BV}, issn = {2590-1370}, doi = {10.1016/j.biosx.2024.100484}, pages = {1 -- 7}, language = {en} } @misc{HoferLehmannSchneideretal., author = {Hofer, Markus and Lehmann, Peter and Schneider, Anna and Maurer, Thomas and St{\"a}hli, Manfred and Krafczyk, Manfred}, title = {Modelling the emergence of surface erosion rills in an artificial catchment}, series = {Structures and processes of the initial ecosystem development, 1st International Conference assoc. with 4th Meeting of Young Researchers in Earth Sciences (MYRES), 20-24 Sept. 2010, Cottbus, Germany}, journal = {Structures and processes of the initial ecosystem development, 1st International Conference assoc. with 4th Meeting of Young Researchers in Earth Sciences (MYRES), 20-24 Sept. 2010, Cottbus, Germany}, publisher = {BTU}, address = {Cottbus}, pages = {S. 53}, language = {en} } @inproceedings{HoferLehmannSchneideretal., author = {Hofer, Markus and Lehmann, Peter and Schneider, Anna and Maurer, Thomas and St{\"a}hli, Manfred and Krafczyk, Manfred}, title = {Modelling the emergence of surface erosion rills in an artificial catchment}, series = {EGU General Assembly 2010, held in Vienna, Austria, 02 - 07 May 2010}, booktitle = {EGU General Assembly 2010, held in Vienna, Austria, 02 - 07 May 2010}, publisher = {European Geophysical Society}, address = {Katlenburg-Lindau}, language = {en} }