@misc{AvitabileSalchertWerneretal., author = {Avitabile, Daniele and Salchert, Katrin and Werner, Carsten and Capogrossi, Maurizio C. and Pesce, Maurizio}, title = {Growth induction and low-oxygen apoptosis inhibition of human CD34+ progenitors in collagen gels}, series = {BioMed Research International}, journal = {BioMed Research International}, issn = {2314-6133}, doi = {10.1155/2013/542810}, pages = {542810}, abstract = {Various reports have indicated low survival of injected progenitors into unfavorable environments such as the ischemic myocardium or lower limb tissues. This represents a major bottleneck in stem-cell-based cardiovascular regenerative medicine. Strategies to enhance survival of these cells in recipient tissues have been therefore sought to improve stem cell survival and ensure long-term engraftment. In the present contribution, we show that embedding human cord blood-derived CD34(+) cells into a collagen I-based hydrogel containing cytokines is a suitable strategy to promote stem cell proliferation and protect these cells from anoxia-induced apoptosis.}, language = {en} }