@misc{BreckenkampRazumSpalleketal., author = {Breckenkamp, J{\"u}rgen and Razum, Oliver and Spallek, Jacob and Berger, Klaus and Chaix, Basile and Sauzet, Odile}, title = {A method to define the relevant ego-centred spatial scale for the assessment of neighbourhood effects: the example of cardiovascular risk factors}, series = {BMC Public Health}, volume = {21}, journal = {BMC Public Health}, issn = {1471-2458}, doi = {10.1186/s12889-021-11356-w}, pages = {7}, abstract = {Introduction: The neighbourhood in which one lives affects health through complex pathways not yet fully understood. A way to move forward in assessing these pathways direction is to explore the spatial structure of health phenomena to generate hypotheses and examine whether the neighbourhood characteristics are able to explain this spatial structure. We compare the spatial structure of two cardiovascular disease risk factors in three European urban areas, thus assessing if a non-measured neighbourhood effect or spatial processes is present by either modelling the correlation structure at individual level or by estimating the intra-class correlation within administrative units. Methods: Data from three independent studies (RECORD, DHS and BaBi), covering each a European urban area, are used. The characteristics of the spatial correlation structure of cardiovascular risk factors (BMI and systolic blood pressure) adjusted for age, sex, educational attainment and income are estimated by fitting an exponential model to the semi-variogram based on the geo-coordinates of places of residence. For comparison purposes, a random effect model is also fitted to estimate the intra-class correlation within administrative units. We then discuss the benefits of modelling the correlation structure to evaluate the presence of unmeasured spatial effects on health. Results: BMI and blood pressure are consistently found to be spatially structured across the studies, the spatial correlation structures being stronger for BMI. Eight to 22\% of the variability in BMI were spatially structured with radii ranging from 100 to 240 m (range). Only a small part of the correlation of residuals was explained by adjusting for the correlation within administrative units (from 0 to 4 percentage points). Discussion: The individual spatial correlation approach provides much stronger evidence of spatial effects than the multilevel approach even for small administrative units. Spatial correlation structure offers new possibilities to assess the relevant spatial scale for health. Stronger correlation structure seen for BMI may be due to neighbourhood socioeconomic conditions and processes like social norms at work in the immediate neighbourhood.}, language = {en} } @misc{MianiLudwigDoyleetal., author = {Miani, C{\´e}line and Ludwig, Angelique and Doyle, Ina-Merle and Breckenkamp, J{\"u}rgen and H{\"o}ller-Holtrichter, Chantal and Spallek, Jacob and Razum, Oliver}, title = {The role of education and migration background in explaining differences in folic acid supplementation intake in pregnancy: Results from a German birth cohort study}, series = {Public Health Nutrition}, journal = {Public Health Nutrition}, issn = {1475-2727}, doi = {10.1017/S1368980021003621}, pages = {1 -- 24}, abstract = {Objective: Official German recommendations advise women to start taking folic acid supplementation (FAS) before conception and continue during the first pregnancy trimester to lower the risk of birth defects. Women from lower socioeconomic background and ethnic minorities tend to be less likely to take FAS in other European countries. As little is known about the determinants of FAS in Germany, we aimed to investigate the association between FAS and formal education and migration background, adjusting for demographic factors. Design: We used data (2013-2016) on nutrition and socioeconomic and migration background from the baseline questionnaire of the BaBi cohort study. We performed multivariate regressions and mediation analyses. Setting: Bielefeld, Germany. Participants: 947 women (pregnant or who had given birth in the past two months). Results: 16.7\% of the participants (158/947) didn't use FAS. Migration-related variables (e.g. language, length of stay) were not associated with FAS in the adjusted models. FAS was lower in women with lower level of formal education and in unplanned pregnancies. Reasons given by women for not taking FAS were unplanned pregnancy and lack of knowledge of FAS. Conclusions: Health practitioners may be inclined to see migrant women as an inherently at-risk group for failed intake of FAS. However, it is primarily women who did not plan their pregnancy, and women of lower formal education level, who are at risk. Different public health strategies to counter low supplementation rates should be supported, those addressing the social determinants of health (i.e. education) and those more focussed on family planning.}, language = {en} } @misc{WandschneiderBatramZantvoortAlazeetal., author = {Wandschneider, Lisa and Batram-Zantvoort, Stephanie and Alaze, Anita and Niehues, Vera and Spallek, Jacob and Razum, Oliver and Miani, C{\´e}line}, title = {Self-reported mental well-being of mothers with young children during the first wave of the COVID-19 pandemic in Germany: A mixed-methods study}, series = {Women's Health}, volume = {18}, journal = {Women's Health}, issn = {1617-8041}, doi = {10.1177/17455057221114274}, pages = {1 -- 17}, abstract = {Objectives: Mothers of young children have been identified as a particularly vulnerable group during the COVID-19 pandemic. We aimed to explore how occupational, psychosocial and partnership-related factors were associated with their self-reported mental well-being during the first COVID-19 wave. Methods: Five hundred fifty participants of the BaBi cohort study (est. 2013, Bielefeld, North-Rhine Westphalia, Germany) were invited to complete an online survey and to take part in email interviews (April-May 2020). With survey data, we assessed self-reported mental well-being through validated instruments (eight-item Patient Health Questionnaire; short version of the Symptom Checklist) and ran linear regression models for occupational, psychosocial and partnership-related factors. We performed content analysis on the interviews' data to further understand the determinants of the women's mental well-being. Results: One hundred twenty-four women participated in the survey; of which 17 also participated in the interviews. A perceived lack of support in childcare was associated with higher levels of depressive symptoms, while having a higher internal locus of control was associated with lower levels. Psychological distress was higher in those reporting lack of emotional or childcare support. Interviews confirmed the interplay of potential stressors and highlighted the difficulties to reconcile different expectations of motherhood. Discussion: Occupational, psychosocial and partner-related factors can act (to varying degree) both as resources and stressors to the self-reported mental well-being of mothers of young children. These impacts took different forms and created opportunities or challenges, depending on specific life circumstances, such as work or family situations, relationships and own psychosocial resources. Although not representative, our study contributes to building the COVID-19 evidence base, delineating the mental health toll of the pandemic on mothers of young children and the factors that contribute to it.}, language = {en} } @misc{EntringerScholaskeKurtetal., author = {Entringer, Sonja and Scholaske, Laura and Kurt, Medlin and Duman, Elif Aysimi and Adam, Emma K. and Razum, Oliver and Spallek, Jacob}, title = {Diurnal cortisol variation during pregnancy in Turkish origin and non-migrant women in a German birth cohort study}, series = {Journal of Psychosomatic Research}, volume = {162}, journal = {Journal of Psychosomatic Research}, issn = {0022-3999}, doi = {10.1016/j.jpsychores.2022.111020}, pages = {1 -- 10}, abstract = {Background Immigrants from Turkey experience health disadvantages relative to non-immigrant populations in Germany that are manifest from the earliest stages of the lifespan onwards and are perpetuated across generations. Chronic stress and perturbations of stress-responsive physiological systems, including the hypothalamus-pituitary-adrenal (HPA)-axis, are believed to in part mediate this relationship. Cortisol plays an important role in the association between maternal stress during pregnancy and many pregnancy-, birth- and offspring-related outcomes. We therefore examined whether maternal migrant background is associated with diurnal cortisol variation during pregnancy. Methods 109 pregnant women (incl. n = 32 Turkish origin women) that participated in a multi-site prospective cohort study in Germany collected saliva samples across the day on two consecutive days around 24 and 32 weeks gestation. Hierarchical linear models were applied to quantify associations between migrant background and diurnal cortisol variation across pregnancy. Results Women of Turkish origin exhibited a significantly lower cortisol awakening response (CAR) and a flatter diurnal cortisol slope (DCS) compared to non-migrant women after adjusting for household income. These relationships between migrant status and diurnal cortisol variation were mainly driven by 2nd generation migrants. Discussion A potential HPA axis dysregulation of Turkish-origin pregnant women may contribute to the intergenerational transmission of health disadvantages in this group.}, language = {en} } @misc{ScholaskeEntringerRazumetal., author = {Scholaske, Laura and Entringer, Sonja and Razum, Oliver and Spallek, Jacob}, title = {Elevated stress during pregnancy in women of Turkish origin: Results from a prospective cohort study}, series = {European Journal of Public Health}, volume = {32}, journal = {European Journal of Public Health}, number = {Supplement_3}, issn = {1101-1262}, doi = {10.1093/eurpub/ckac129.608}, pages = {2}, abstract = {Background Ethnic health disparities exist in the context of pregnancy and childbirth, suggesting that women of Turkish origin (i.e., they or their parents born in Turkey) in Germany have higher risks for some adverse maternal health and child developmental outcomes. Stress is believed to be a relevant pathway by which migration may be associated with these risks. In this study, we tested associations of Turkish origin with stress biology and psychological stress experiences during pregnancy. Methods 140 pregnant women (33 of Turkish/26 of other origin) participated in a prospective cohort study that was carried out in Bielefeld and Berlin (Spallek et al., 2020). Inflammatory markers CRP and IL-6 from venous blood samples and diurnal cortisol profiles from salivary cortisol samples were derived and participants completed the Perceived Stress Scale (PSS) and Center for Epidemiologic Studies Depression Scale (CESD) at two study visits during pregnancy (T1: 20-25 weeks of gestation, T2: 30-35 weeks of gestation). Multilevel models were conducted to account for the nested data structure due to repeated measurements. Results Compared to non-migrant women, women of Turkish origin had significantly higher inflammatory levels (b = 0.28, SE = 0.14, p=.052) (Spallek et al., 2021), a blunted cortisol awakening response (b=-0.21, CI=-0.38-0.03, p<.05), a flatter diurnal cortisol slope (b = 0.02, CI = 0.00-0.04, p<.05), and higher PSS (b = 0.46, SE = 0.13, p< .001) and CESD scores (b = 0.29, SE = 0.08, p<.001) during pregnancy after adjusting for socioeconomic factors. Conclusions The results of our study suggest higher stress at the biological and psychological level in pregnant women of Turkish origin. Stress is a risk factor for pregnancy complications and poor birth and child developmental outcomes. To reduce such unequally distributed risks, interventions for stress reduction are needed that are tailored to women of Turkish origin.}, language = {en} } @misc{ScholaskeSpallekDumanetal., author = {Scholaske, Laura and Spallek, Jacob and Duman, Elif Aysimi and Adam, Emma K. and Razum, Oliver and Entringer, Sonja}, title = {Increased Levels of Psychological Stress and Alterations in Stress Biology during Pregnancy among Women of Turkish-Origin in Germany}, series = {Psychoneuroendocrinology}, volume = {153}, journal = {Psychoneuroendocrinology}, publisher = {ScienceDirect}, issn = {0306-4530}, doi = {10.1016/j.psyneuen.2023.106269}, pages = {1}, abstract = {Background People of Turkish origin constitute one of the biggest migrant groups in Germany. They have an increased risk to develop stress-related health disadvantages, and this risk is also prevalent in the offspring generation from early ages on. We have conducted a multi-site prospective cohort study to examine the role of stress and stress biology in this intergenerational perpetuation of health disparities. Methods 140 pregnant women (33 of Turkish origin) participated in a prospective cohort study with two study visits during pregnancy and one after birth (T1: 20-25 weeks of gestation, T2: 30-35 weeks of gestation, T3: four weeks after birth). At T1 and T2, women completed the Perceived Stress Scale and Center for Epidemiologic Studies Depression Scale and collected saliva samples after awakening, 30 minutes after awakening, and in the evening, and venous blood samples were collected for analysis of CRP and IL-6 concentrations. Results Multilevel models showed that Turkish-origin women exhibited higher levels of perceived stress and depressive symptoms, had increased inflammatory levels (Spallek et al., 2021), a blunted cortisol awakening response and flatter diurnal cortisol slope during pregnancy compared to non-migrant women after adjustment for socioeconomic factors.Some of the effects were mainly driven by 2nd generation migrants. Conclusions Increased levels of psychosocial stress and stress-related biological alterations among Turkish-origin pregnant women may contribute to the intergenerational transmission of health disadvantages in this group.}, language = {de} } @incollection{NowakTallarekHoffmannetal., author = {Nowak, Anna Christina and Tallarek, Marie and Hoffmann, Stephanie and H{\"o}vener, Claudia and Razum, Oliver and Spallek, Jacob}, title = {Nachhaltigkeit in der Gesundheit(sversorgung) von zugewanderten Menschen}, series = {Gesundheit und Nachhaltigkeit}, booktitle = {Gesundheit und Nachhaltigkeit}, editor = {Hartung, Susanne and Wihofszky, Petra}, publisher = {Springer}, address = {Berlin, Heidelberg}, isbn = {978-3-662-64954-1}, doi = {10.1007/978-3-662-64954-1_22-1}, pages = {11}, abstract = {In diesem Beitrag wird facettenartig eine Br{\"u}cke zwischen Zuwanderung und Gesundheit(-sversorgung) unter besonderer Ber{\"u}cksichtigung der globalen Ziele zur nachhaltigen Entwicklung geschlagen. Um Migrationserfahrungen als (potenziellen) Einflussfaktor auf gesundheitliche Chancengleichheit zu verstehen, wird die politisch-rechtliche Situation von Menschen mit Einwanderungsgeschichte im Zugang zur Gesundheitsversorgung und zu Pr{\"a}ventions- und Gesundheitsf{\"o}rderungsmaßnahmen beschrieben. Dabei zeigt sich, dass sich die gesundheitliche Versorgungssituation durch soziale, politische, institutionelle und strukturelle Ungleichheiten und Benachteiligungen auszeichnet, die weder in den globalen Zielen zur nachhaltigen Entwicklung noch in der deutschen Nachhaltigkeitsstrategie angemessene Ber{\"u}cksichtigung finden.}, language = {de} } @misc{SpallekZeebRazum, author = {Spallek, Jacob and Zeeb, Hajo and Razum, Oliver}, title = {Lebenslauforientierte Epidemiologie in der Migrationsforschung}, series = {Bundesgesundheitsblatt}, volume = {66}, journal = {Bundesgesundheitsblatt}, number = {10}, issn = {1437-1588}, doi = {10.1007/s00103-023-03761-w}, pages = {1092 -- 1098}, abstract = {Es gibt viele Gr{\"u}nde f{\"u}r Migration, von freier Entscheidung bis zu erzwungener Flucht. Entsprechend vielf{\"a}ltig sind auch die Vorgeschichten und Lebensumst{\"a}nde der migrierenden Menschen. Die damit einhergehenden unterschiedlichen Expositionen beeinflussen die Gesundheit der Migrant*innen und ihrer Kinder. Um ein solch komplexes Ph{\"a}nomen zu erfassen, ist ein Ansatz erforderlich, der die besonderen Umst{\"a}nde im Lebenslauf der Migrant*innen einbezieht. Ein etablierter methodischer Ansatz, der dies leisten kann, ist die Lebenslaufepidemiologie. Bei der Anwendung dieses Konzepts auf migrierende Bev{\"o}lkerungen werden Expositionen vor, w{\"a}hrend und nach der Migration untersucht. In der epidemiologischen Forschung zur Gesundheit von eingewanderten Menschen ist es w{\"u}nschenswert, alle diese 3 Phasen zu ber{\"u}cksichtigen. Eine Herausforderung hierbei ist, dass verl{\"a}ssliche Daten {\"u}ber den gesamten Lebenslauf nicht immer verf{\"u}gbar sind. Eine valide, zeitnahe Erhebung und datenschutzgerechte Verkn{\"u}pfung longitudinaler Daten aus verschiedenen Quellen k{\"o}nnen die lebenslaufbezogene Forschung zur Gesundheit von Migrant*innen in Deutschland verbessern. Perspektivisch sollten entsprechende Daten auch aus den Herkunftsl{\"a}ndern von Migrant*innen einbezogen werden.}, language = {de} } @incollection{SpallekRazum, author = {Spallek, Jacob and Razum, Oliver}, title = {Migration und Gesundheit}, series = {Soziologie von Gesundheit und Krankheit}, booktitle = {Soziologie von Gesundheit und Krankheit}, editor = {Richter, Matthias and Hurrelmann, Klaus}, edition = {2. Auflage}, publisher = {Springer VS}, address = {Wiesbaden}, isbn = {978-3-658-42102-1}, doi = {10.1007/978-3-658-42103-8_11}, pages = {187 -- 202}, language = {de} } @incollection{RazumButlerSpallek, author = {Razum, Oliver and Butler, Jeffrey and Spallek, Jacob}, title = {Gesundheitliche Chancen und Risiken von Migrant*innen: Handlungsm{\"o}glichkeiten einer kommunalen Gesundheitspolitik.}, series = {Handbuch Lokale Integrationspolitik.}, booktitle = {Handbuch Lokale Integrationspolitik.}, editor = {Gesemann, Frank and Filsinger, Dieter and M{\"u}nch, Sybille}, edition = {2. Auflage}, publisher = {Springer VS}, address = {Wiesbaden}, isbn = {978-3-658-43195-2}, doi = {10.1007/978-3-658-43195-2_34-1}, pages = {1 -- 23}, abstract = {Migrant*innen haben gesundheitliche Vor- und Nachteile gegen{\"u}ber der nicht-migrierten Bev{\"o}lkerung. Der Zusammenhang zwischen Migration und Gesundheit ist mehrdimensional, weitere - insbesondere soziale - Faktoren m{\"u}ssen bei der Interpretation beachtet werden. Erkl{\"a}rungsmodelle bilden die Komplexit{\"a}t des Zusammenhangs ab. Die zentralen Modelle haben eine Perspektive auf den gesamten Lebenslauf von migrierten Menschen (vor, w{\"a}hrend und nach der Migration). Sie helfen der kommunalen Gesundheitspolitik, geeignete Daten zu erheben und wirksame Interventionen zu entwickeln.}, language = {de} }