@misc{RegnathBiersackSchroederetal., author = {Regnath, Franziska and Biersack, Katharina and Schr{\"o}der, Lena and Stainer, Marie-Christin and von Werder, Dina and P{\"u}rner, Dominik and Haslinger, Bernhard and Lehnen, Nadine}, title = {Experimental evidence for a robust, transdiagnostic marker in functional disorders: Erroneous sensorimotor processing in functional dizziness and functional movement disorder}, series = {Journal of Psychosomatic Research}, volume = {183}, journal = {Journal of Psychosomatic Research}, editor = {Glasauer, Stefan}, publisher = {Elsevier BV}, issn = {0022-3999}, doi = {10.1016/j.jpsychores.2024.111694}, pages = {10}, language = {en} } @misc{RegnathBiersackJaegeretal., author = {Regnath, Franziska and Biersack, Katharina and J{\"a}ger, Nina and Glasauer, Stefan and Lehnen, Nadine}, title = {Not a general, symptom-unspecific, transdiagnostic marker for functional symptoms: sensorimotor processing of head control is intact in chronic pain}, series = {Frontiers in Neurology}, volume = {14}, journal = {Frontiers in Neurology}, issn = {1664-2295}, doi = {10.3389/fneur.2023.1294702}, abstract = {Introduction: Functional disorders are prevalent in all medical fields and pose a tremendous public health problem, with pain being one of the most common functional symptoms. Understanding the underlying, potentially unifying mechanism in functional (pain) disorders is instrumental in facilitating timely diagnosis, stigma reduction, and adequate treatment options. Neuroscientific models of perception suggest that functional symptoms arise due to dysregulated sensorimotor processing in the central nervous system, with brain-based predictions dominating the eventual percept. Experimental evidence for this transdiagnostic mechanism has been established in various functional symptoms. The goal of the current study was to investigate whether erroneous sensorimotor processing is an underlying transdiagnostic mechanism in chronic (functional) pain. Method: A total of 13 patients with chronic (functional) pain [three patients with chronic (functional) pain disorder, F45.40, ICD-10; 10 patients with chronic pain disorder with somatic and psychological factors, F45.41, ICD-10]; and 15 healthy controls performed large combined eye-head gaze shifts toward visual targets, naturally and with increased head moment of inertia. We simultaneously measured participants' eye and head movements to assess head oscillations at the end of the gaze shift, which are an established indicator of (transdiagnostic) sensorimotor processing deficits of head control. Results: Using a Bayesian analysis protocol, we found that patients with chronic (functional) pain and control participants stabilized their heads equally well (Bayes Factor 01 = 3.7, Bayes Factor exclusion = 5.23; corresponding to substantial evidence) during all sessions of the experiment. Conclusion: Our results suggest that patients with chronic (functional) pain do not show measurable symptom-unspecific sensorimotor processing deficits.}, language = {en} } @misc{AubeleGrillEggertetal., author = {Aubele, Maria and Grill, Eva and Eggert, Thomas and Schneider, Erich and Strobl, Ralf and Jahn, Klaus and M{\"u}ller, Martin and Holle, Rolf and Linkohr, Birgit and Heier, Margit and Ladwig, Karl-Heinz and Lehnen, Nadine}, title = {Symptoms in unilatral vestibular hypofunction are associated with number of catch-up saccades and retinal errors: results from the population-based KORA FF4study}, series = {Frontiers in Neurology}, volume = {2023}, journal = {Frontiers in Neurology}, number = {14}, issn = {1664-2295}, pages = {8}, abstract = {Objective: The presence and intensity of symptoms vary in patients with unilateral vestibular hypofunction. We aimed to determine which saccadic and vestibulo-ocular reflex parameters best predict the presence of symptoms in unilateral vestibular hypofunction in order to better understand vestibular compensation and its implications for rehabilitation therapy. Methods: Video head impulse test data were analyzed from a subpopulation of 23 symptomatic and 10 currently symptom-free participants with unilateral vestibular hypofunction, embedded in the KORA (Cooperative Health Research in the Region of Augsburg) FF4 study, the second follow-up of the KORA S4 population-based health survey (2,279 participants). Results: A higher number of catch-up saccades, a higher percentage of covert saccades, and a larger retinal error at 200 ms after the onset of the head impulse were associated with relevant symptoms in participants with unilateral vestibular hypofunction (p = 0.028, p = 0.046, and p = 0.038, respectively). After stepwise selection, the number of catch-up saccades and retinal error at 200 ms remained in the final logistic regression model, which was significantly better than a null model (p = 0.014). Age, gender, saccade amplitude, saccade latency, and VOR gain were not predictive of the presence of symptoms. Conclusion: The accuracy of saccadic compensation seems to be crucial for the presence of symptoms in unilateral vestibular hypofunction, highlighting the role of specific gaze stabilization exercises in rehabilitation. Early saccades, mainly triggered by the vestibular system, do not seem to compensate accurately enough, resulting in a relevant retinal error and the need for more as well as more accurate catch-up saccades, probably triggered by the visual system.}, language = {en} } @misc{vonWerderAubeleRegnathetal., author = {von Werder, Dina and Aubele, Maria and Regnath, Franziska and Tebbe, Elisabeth and Mladenov, Dejan and von Rheinbaben, Victoria and Hahn, Elisabeth and Sch{\"a}fer, Daniel and Biersack, Katharina and Adorjan, Kristina and Stubbe, Hans C. and Bogaerts, Katleen and J{\"o}rres, Rudolf A. and Nowak, Dennis and Van den Bergh, Omer and Glasauer, Stefan and Lehnen, Nadine}, title = {Increased breathlessness in post-COVID syndrome despite normal breathing patterns in a rebreathing challenge}, series = {Scientific reports}, volume = {15}, journal = {Scientific reports}, number = {1}, publisher = {Springer Nature}, address = {[London]}, issn = {2045-2322}, doi = {10.1038/s41598-025-11728-x}, pages = {1 -- 15}, abstract = {Severe symptoms in the absence of measurable body pathology are a frequent hallmark of post-COVID syndrome. From a Bayesian Brain perspective, such symptoms can be explained by incorrect internal models that the brain uses to interpret sensory signals. In this pre-registered study, we investigate whether induced breathlessness perception during a controlled CO2rebreathing challenge is reflected by altered respiratory measures (physiology and breathing patterns), and propose different computational mechanisms that could explain our findings in a Bayesian Brain framework. We analysed data from 40 patients with post-COVID syndrome and 40 healthy participants. Results from lung function, neurological and neurocognitive examination of all participants were within normal limits on the day of the experiment. Using a Bayesian repeated-measures ANOVA, we found that patients' breathlessness was strongly increased (BF10,baseline =8.029, BF10,rebreathing =11636, BF10,recovery =43662) compared to controls. When excluding patients who hyperventilated (N = 8, 20\%) during the experiment from the analysis, differences in breathlessness remained (BF10,baseline =1.283, BF10,rebreathing =126.812, BF10,recovery =751.282). For physiology and breathing patterns, all evidence pointed towards no difference between the two groups (0.307  BF10 \< 0.704). In summary, we found intact breathing patterns and physiology but increased symptom perception in patients with post-COVID syndrome.}, language = {en} }