@inproceedings{GeorgeNoackVaneketal., author = {George, Sandra and Noack, Monika and Vanek, Monika and Rentzsch, Juliane and R{\"o}ber, Nadja and Conrad, Karsten and Roggenbuck, Dirk and K{\"u}pper, Jan-Heiner}, title = {Expression of nicotinic acetylcholine receptor subunits in HEp-2 cells for immunodetection of autoantibody specificities in sera from Myasthenia gravis patients}, series = {From autoantibody research to standardized diagnostic assays in the management of human diseases, report on the 12th Dresden Symposium on Autoantibodies, September 23-26, 2015}, booktitle = {From autoantibody research to standardized diagnostic assays in the management of human diseases, report on the 12th Dresden Symposium on Autoantibodies, September 23-26, 2015}, publisher = {Pabst Science Publishers}, address = {Lengerich}, isbn = {978-3-95853-104-8}, pages = {195 -- 196}, language = {en} } @techreport{WillHeiner, author = {Will, J{\"u}rgen and Heiner, Monika}, title = {Petri nets in biology, chemistry, and medicine : bibliography}, publisher = {BTU, Inst. of Computer Science}, address = {Cottbus}, pages = {I, 36 S.}, language = {en} } @inproceedings{HeinerHeiselHateburetal., author = {Heiner, Monika and Heisel, Maritta and Hatebur, Denis and Rottke, Thomas}, title = {A Problem-Oriented Approach to common Criteria Certification}, series = {Computer safety, reliability and security, 21st international conference, SAFECOMP 2002, Catania, Italy, September 10 - 13, 2002}, booktitle = {Computer safety, reliability and security, 21st international conference, SAFECOMP 2002, Catania, Italy, September 10 - 13, 2002}, editor = {Anderson, Stuart}, publisher = {Springer}, address = {Berlin [u.a.]}, isbn = {3-540-44157-3}, pages = {334 -- 346}, abstract = {Abstract. There is an increasing demand to certify the security of systems according to the Common Criteria (CC). The CC distinguish several evaluation assurance levels (EALs), level EAL7 being the highest and requiring the application of formal techniques. We present a method for requirements engineering an (semi-formal and formal) modeling of systems to be certified according to the higher evaluation assurance levels of the CC. The method is problem oriented, i.e. it is driven by the environment in which the system will operate and by a mission statement. We illustrate our approach by an industrial case study, namely an electronic purse card (EPC) to be implemented on a Java Smart Card. As a novelty, we treat the mutual asymmetric authentication of the card an the terminal into which the card is inserted.}, language = {en} } @article{HeinerKochVoss, author = {Heiner, Monika and Koch, Ina and Voss, Klaus}, title = {Analysis and Simulation of Steady States in Metabolic Pathways with Petri Nets, Proc.}, language = {en} } @misc{HeinerMertkeDeussen, author = {Heiner, Monika and Mertke, Thomas and Deussen, Peter H.}, title = {A Safety-Oriented Technical Language for the Requirement Specification in Control Engineering (Eine Sicherheitsfachsprache zur Formulierung steuerungstechnischer Anforderungen); in German}, language = {en} } @incollection{Heiner, author = {Heiner, Monika}, title = {Understanding Network Behavior by Structured Representations of Transition Invariants}, language = {en} } @misc{GilbertBreitlingHeineretal., author = {Gilbert, David and Breitling, Rainer and Heiner, Monika and Donaldson, Robin}, title = {An Introduction to BioModel Engineering, Illustrated for Signal Transduction Pathways}, language = {en} } @inproceedings{HeinerSchwarickTovchigrechko, author = {Heiner, Monika and Schwarick, Martin and Tovchigrechko, Alexey A.}, title = {DSSZ-MC - A Tool for Symbolic Analysis of Extended Petri Nets}, language = {en} } @inproceedings{HeinerSchwarick, author = {Heiner, Monika and Schwarick, Martin}, title = {CSL model checking of biochemical networks with Interval Decision Diagrams}, language = {en} } @inproceedings{HeinerBreitlingGilbertetal., author = {Heiner, Monika and Breitling, Rainer and Gilbert, David and Priami, C.}, title = {Formal Methods in Molecular Biology}, language = {en} } @inproceedings{LehrackGilbertHeiner, author = {Lehrack, Sebastian and Gilbert, David and Heiner, Monika}, title = {A Unifying Framework for Modelling and Analysing Biochemical Pathways Using Petri Nets}, language = {en} } @incollection{HeinerDonaldsonGilbert, author = {Heiner, Monika and Donaldson, Robin and Gilbert, David}, title = {Petri Nets for Systems Biology}, series = {Symbolic systems biology}, booktitle = {Symbolic systems biology}, editor = {Iyengar, M. Sriram}, publisher = {Jones and Bartlett Learning}, address = {Sudbury, Mass. [u.a.]}, isbn = {978-0-7637-5370-2}, language = {en} } @incollection{HeinerGilbertBreitlingetal., author = {Heiner, Monika and Gilbert, David and Breitling, Rainer and Orton, Richard}, title = {Computation modelling of kinase signalling cascades}, language = {en} } @incollection{HeinerGilbert, author = {Heiner, Monika and Gilbert, David}, title = {How Might Petri Nets Enhance Your Systems Biology Toolkit}, language = {en} } @incollection{HeinerMarwanRohr, author = {Heiner, Monika and Marwan, Wolfgang and Rohr, Christian}, title = {Petri nets in Snoopy: A unifying framework for the graphical display, computational modelling, and simulation of bacterial regulatory networks}, language = {en} } @incollection{HeinerGilbertDonaldson, author = {Heiner, Monika and Gilbert, David and Donaldson, Robin}, title = {Petri Nets for Systems and Synthetic Biology}, language = {en} } @incollection{Heiner, author = {Heiner, Monika}, title = {Understanding Network Behaviour by Structured Representations of Transition Invariants - A Petri Net Perspective on Systems and Synthetic Biology}, language = {en} } @incollection{HeinerKoch, author = {Heiner, Monika and Koch, Ina}, title = {Petri Nets}, language = {en} } @misc{HeinerYangLiu, author = {Heiner, Monika and Yang, Ming and Liu, Fei}, title = {Modeling and analyzing biological systems using colored hierarchical Petri nets illustrated by C. elegans vulval development}, series = {Journal of Biological Systems}, volume = {22}, journal = {Journal of Biological Systems}, number = {3}, issn = {1793-6470}, doi = {10.1142/S0218339014500181}, pages = {463 -- 493}, language = {en} } @misc{HerajyHeiner, author = {Herajy, Mostafa and Heiner, Monika}, title = {Petri Net-Based Collaborative Simulation and Steering of Biochemical Reaction Networks}, series = {Fundamenta Informaticae}, volume = {129}, journal = {Fundamenta Informaticae}, number = {1-2}, issn = {0169-2968}, pages = {49 -- 67}, language = {en} } @misc{BlaetkeDittrichRohretal., author = {Bl{\"a}tke, Mary-Ann and Dittrich, Anna and Rohr, Christian and Heiner, Monika and Schaper, Fred and Marwan, Wolfgang}, title = {JAK/STAT signalling - an executable model assembled from molecule-centred modules demonstrating a module-oriented database concept for systems and synthetic biology}, series = {Molecular BioSystems}, volume = {9}, journal = {Molecular BioSystems}, number = {6}, issn = {1742-2051}, doi = {10.1039/C3MB25593J}, pages = {1290 -- 1307}, language = {en} } @incollection{HeinerLehrackGilbertetal., author = {Heiner, Monika and Lehrack, Sebastian and Gilbert, David and Marwan, Wolfgang}, title = {Extended Stochastic Petri Nets for Model-based Design of Wetlab Experiments}, series = {Transactions on Computational Systems Biology XI}, booktitle = {Transactions on Computational Systems Biology XI}, publisher = {Springer}, address = {Berlin [u.a.]}, isbn = {978-3-642-04185-3}, pages = {138 -- 163}, language = {en} } @misc{GrafahrendBelauSchreiberHeineretal., author = {Grafahrend-Belau, Eva and Schreiber, Falk and Heiner, Monika and Sackmann, Andrea and Junker, Bj{\"o}rn H. and Grunwald, Stefanie and Speer, Astrid and Winder, Katja and Koch, Ina}, title = {Modularization of biochemical networks based on classification of Petri net T-invariants}, series = {BMC Bioinformatics}, volume = {Vol. 9}, journal = {BMC Bioinformatics}, issn = {1471-2105}, doi = {10.1186/1471-2105-9-90}, language = {en} } @misc{BreitlingGilbertHeineretal., author = {Breitling, Rainer and Gilbert, David and Heiner, Monika and Orton, Richard}, title = {A structured approach for the engineering of biochemical network models, illustrated for signalling pathways}, series = {Briefings in Bioinformatics}, volume = {9}, journal = {Briefings in Bioinformatics}, number = {5}, issn = {1477-4054}, doi = {10.1093/bib/bbn026}, pages = {404 -- 421}, language = {en} } @misc{SackmannHeinerKoch, author = {Sackmann, Andrea and Heiner, Monika and Koch, Ina}, title = {Application of Petri net based analysis techniques to signal transduction pathways}, series = {BMC Bioinformatics}, volume = {Vol. 7}, journal = {BMC Bioinformatics}, issn = {1471-2105}, doi = {10.1186/1471-2105-7-482}, language = {en} } @misc{PopovaZeugmannHeinerKoch, author = {Popova-Zeugmann, Louchka and Heiner, Monika and Koch, Ina}, title = {Time Petri Nets for Modelling and Analysis of Biochemical Networks}, series = {Fundamenta Informaticae}, volume = {67}, journal = {Fundamenta Informaticae}, number = {1-3}, issn = {1875-8681}, pages = {149 -- 162}, language = {en} } @misc{KochJunkerHeiner, author = {Koch, Ina and Junker, Bj{\"o}rn H. and Heiner, Monika}, title = {Application of Petri Net Theory for Modelling and Validation of the Sucrose Breakdown Pathway in the Potato Tuber}, series = {Bioinformatics}, volume = {21}, journal = {Bioinformatics}, number = {7}, issn = {1460-2059}, pages = {1219 -- 1226}, language = {en} } @misc{KochSchuelerHeiner, author = {Koch, Ina and Sch{\"u}ler, Markus and Heiner, Monika}, title = {STEPP - Search Tool for Exploration of Petri net Paths: A new tool for Petri net-based path analysis in biochemical networks}, series = {In silico biology}, volume = {Vol. 5}, journal = {In silico biology}, issn = {1434-3207}, language = {en} } @misc{HeinerKochWill, author = {Heiner, Monika and Koch, Ina and Will, J{\"u}rgen}, title = {Model Validation of Biological Pathways Using Petri Nets - Demonstrated for Apoptosis}, series = {BioSystems}, volume = {75}, journal = {BioSystems}, number = {1-3}, doi = {10.1016/j.biosystems.2004.03.003}, pages = {15 -- 28}, language = {en} } @misc{VossHeinerKoch, author = {Voss, Klaus and Heiner, Monika and Koch, Ina}, title = {Steady State Analysis of Metabolic Pathways Using Petri Nets}, series = {In silico biology}, volume = {Vol. 3}, journal = {In silico biology}, issn = {1434-3207}, language = {en} } @misc{HeinerGilbert, author = {Heiner, Monika and Gilbert, David}, title = {BioModel Engineering for Multiscale Systems Biology}, series = {Progress in Biophysics and Molecular Biology}, volume = {111}, journal = {Progress in Biophysics and Molecular Biology}, number = {2-3}, issn = {1873-1732}, doi = {10.1016/j.pbiomolbio.2012.10.001}, pages = {119 -- 128}, language = {en} } @misc{LiuHeiner, author = {Liu, Fei and Heiner, Monika}, title = {Modeling membrane systems using colored stochastic Petri nets}, series = {Natural Computing}, volume = {12}, journal = {Natural Computing}, number = {4}, issn = {1572-9796}, doi = {10.1007/s11047-013-9367-8}, pages = {617 -- 629}, language = {en} } @incollection{HerajySchwarickHeiner, author = {Herajy, Mostafa and Schwarick, Martin and Heiner, Monika}, title = {Hybrid Petri Nets for Modelling the Eukaryotic Cell Cycle}, series = {Transactions on petri nets and other models of concurrency VIII}, booktitle = {Transactions on petri nets and other models of concurrency VIII}, publisher = {Springer}, address = {Berlin [u.a.]}, isbn = {978-3-642-40464-1}, doi = {10.1007/978-3-642-40465-8_7}, pages = {123 -- 141}, language = {en} } @misc{LiuHeiner, author = {Liu, Fei and Heiner, Monika}, title = {Multiscale modelling of coupled Ca2+ channels using coloured stochastic Petri nets}, series = {IET Systems Biology}, volume = {7}, journal = {IET Systems Biology}, number = {4}, issn = {1751-8849}, pages = {106 -- 113}, language = {en} } @misc{HerajyHeiner, author = {Herajy, Mostafa and Heiner, Monika}, title = {Hybrid Representation and Simulation of Stiff Biochemical Networks}, series = {Nonlinear Analysis: Hybrid Systems}, volume = {6}, journal = {Nonlinear Analysis: Hybrid Systems}, number = {4}, issn = {1751-570X}, pages = {942 -- 959}, language = {en} } @incollection{HeinerBreitlingDonaldsonetal., author = {Heiner, Monika and Breitling, Rainer and Donaldson, Robin and Gilbert, David}, title = {Biomodel Engineering - From Structure to Behavior}, series = {Transactions on Computational Systems Biology XII : Special Issue on Modeling Methodologies}, booktitle = {Transactions on Computational Systems Biology XII : Special Issue on Modeling Methodologies}, publisher = {Springer}, address = {Berlin [u.a.]}, isbn = {978-3-642-11711-4}, doi = {10.1007/978-3-642-11712-1}, pages = {1 -- 12}, language = {en} } @misc{HeinerSriram, author = {Heiner, Monika and Sriram, K.}, title = {Structural Analysis to Determine the Core of Hypoxia Response Network}, series = {PLoS ONE}, volume = {5}, journal = {PLoS ONE}, number = {1}, issn = {1932-6203}, doi = {10.1371/journal.pone.0008600}, language = {en} } @misc{RohrMarwanHeiner, author = {Rohr, Christian and Marwan, Wolfgang and Heiner, Monika}, title = {Snoopy - a unifying Petri net framework to investigate biomolecular networks}, series = {Bioinformatics}, volume = {26}, journal = {Bioinformatics}, number = {7}, issn = {1460-2059}, pages = {974 -- 975}, language = {en} } @misc{HeinerSoliman, author = {Heiner, Monika and Soliman, Sylvain}, title = {A Unique Transformation from Ordinary Differential Equations to Reaction Networks}, series = {PLoS one}, volume = {5}, journal = {PLoS one}, number = {12}, issn = {1932-6203}, doi = {10.1371/journal.pone.0014284}, language = {en} } @misc{HeinerVentreWikarski, author = {Heiner, Monika and Ventre, Giorgio and Wikarski, Dietmar}, title = {A Petri Net Based Methodology to Integrate Qaulitative and Quantitative Analysis}, series = {Information and Software Technology}, volume = {36}, journal = {Information and Software Technology}, number = {7}, issn = {0950-5849}, doi = {10.1016/0950-5849(94)90066-3}, pages = {435 -- 441}, language = {en} } @inproceedings{BarbotHaddadHeineretal., author = {Barbot, Benoit and Haddad, Serge and Heiner, Monika and Picaronny, Claudine}, title = {Rare Event Handling in Signalling Cascades}, series = {Proceedings, SIMUL 2014, Sixth International Conference on Advances in System Simulation}, booktitle = {Proceedings, SIMUL 2014, Sixth International Conference on Advances in System Simulation}, publisher = {IARIA}, isbn = {978-1-61208-371-1}, pages = {126 -- 131}, language = {en} } @inproceedings{HerajyHeiner, author = {Herajy, Mostafa and Heiner, Monika}, title = {A Steering Server for Collaborative Simulation of Quantitative Petri Nets}, series = {Application and Theory of Petri Nets and Concurrency, 35th International Conference, PETRI NETS 2014, Tunis, Tunisia, June 23-27, 2014, Proceedings}, booktitle = {Application and Theory of Petri Nets and Concurrency, 35th International Conference, PETRI NETS 2014, Tunis, Tunisia, June 23-27, 2014, Proceedings}, editor = {Ciardo, Gianfranco and Kindler, Ekkart}, publisher = {Springer}, address = {Cham [u.a.]}, isbn = {978-3-319-07733-8}, pages = {374 -- 384}, language = {en} } @inproceedings{HeinerRohrSchwarick, author = {Heiner, Monika and Rohr, Christian and Schwarick, Martin}, title = {MARCIE - Model checking and Reachability analysis done effieciently}, series = {Application and theory of petri nets and concurrency, 34th international conference, proceedings, PETRI NETS 2013, Milan, Italy, June 24 - 28, 2013}, booktitle = {Application and theory of petri nets and concurrency, 34th international conference, proceedings, PETRI NETS 2013, Milan, Italy, June 24 - 28, 2013}, editor = {Colom, Jos{\´e}-Manuel and Desel, J{\"o}rg}, publisher = {Springer}, address = {Heidelberg [u.a.]}, isbn = {978-3-642-38696-1}, pages = {389 -- 399}, language = {en} } @inproceedings{LiuHeiner, author = {Liu, Fei and Heiner, Monika}, title = {Coloured Petri Nets to Model and simulate Biological Systems}, series = {Proceedings of the Workshops of the 31st International Conference on Application and Theory of Petri Nets and Other Models of Concurrency (PETRI NETS 2010)}, booktitle = {Proceedings of the Workshops of the 31st International Conference on Application and Theory of Petri Nets and Other Models of Concurrency (PETRI NETS 2010)}, pages = {70 -- 84}, language = {en} } @inproceedings{HeinerRohrSchwaricketal., author = {Heiner, Monika and Rohr, Christian and Schwarick, Martin and Streif, Stefan}, title = {A Comparative Study of Stochastic Analysis Techniques}, series = {CMSB '10, 8th Conference on Computational Methods in Systems Biology, Trento, Italy — September 29 - October 01, 2010}, booktitle = {CMSB '10, 8th Conference on Computational Methods in Systems Biology, Trento, Italy — September 29 - October 01, 2010}, editor = {Quaglia, Paola}, publisher = {ACM}, address = {New York, NY}, isbn = {978-1-4503-0068-1}, doi = {10.1145/1839764.1839776}, pages = {96 -- 106}, language = {en} } @incollection{BlaetkeHeinerMarwan, author = {Bl{\"a}tke, Mary-Ann and Heiner, Monika and Marwan, Wolfgang}, title = {BioModel Engineering with Petri Nets}, series = {Algebraic and Discrete Mathematical Methods for Modern Biology}, booktitle = {Algebraic and Discrete Mathematical Methods for Modern Biology}, editor = {Robeva, Raina S.}, publisher = {Elsevier}, address = {Amsterdam [u.a.]}, isbn = {978-0-12-801213-0}, pages = {141 -- 193}, language = {en} } @incollection{BlaetkeRohrHeineretal., author = {Bl{\"a}tke, Mary-Ann and Rohr, Christian and Heiner, Monika and Marwan, Wolfgang}, title = {A Petri Net based Framework for Biomodel Engineering}, series = {Large-Scale Networks in Engineering and Life Sciences}, booktitle = {Large-Scale Networks in Engineering and Life Sciences}, editor = {Benner, Peter}, publisher = {Springer}, address = {Heidelberg}, isbn = {978-3-319-08436-7}, doi = {10.1007/978-3-319-08437-4_6}, pages = {317 -- 366}, language = {en} } @incollection{LiuHeiner, author = {Liu, Fei and Heiner, Monika}, title = {Petri Nets for Modeling and Analyzing Biochemical Reaction Networks}, series = {Approaches in Integrative Bioinformatics}, booktitle = {Approaches in Integrative Bioinformatics}, editor = {Chen, Ming and Hofest{\"a}dt, Ralf}, publisher = {Springer}, address = {Heidelberg}, isbn = {978-3-642-41280-6}, doi = {10.1007/978-3-642-41281-3_9}, pages = {245 -- 272}, language = {en} } @misc{LiuHeinerYang, author = {Liu, Fei and Heiner, Monika and Yang, Ming}, title = {Representing Network Reconstruction Solutions with Colored Petri Nets}, series = {Neurocomputing}, volume = {174}, journal = {Neurocomputing}, number = {A}, issn = {0925-2312}, doi = {10.1016/j.neucom.2015.04.112}, pages = {483 -- 493}, language = {en} } @misc{SomekhPelegEranetal., author = {Somekh, Judith and Peleg, Mor and Eran, Alal and Koren, Itay and Feiglin, Ariel and Demishtein, Alik and Shiloh, Ruth and Heiner, Monika and Kong, Sek Won and Elazar, Zvulun and Kohane, Isaac}, title = {A Model-driven methodology for exploring complex disease comorbidities applied to autism spectrum disorder and inflammatory bowel disease}, series = {Biomedical Informatics}, volume = {63}, journal = {Biomedical Informatics}, issn = {1532-0464}, doi = {10.1016/j.jbi.2016.08.008}, pages = {366 -- 378}, language = {en} }