@incollection{UlrichSchlegelMertensetal., author = {Ulrich, Rainer G. and Schlegel, Matthias and Mertens, Marc and Groschup, Martin H. and Schmidt-Chanasit, Jonas and Plenge-B{\"o}nig, Anita and Jacob, Jens and Pelz, Hans-Joachim and Freise, Jona and Wenk, Matthias and Thiel, J{\"o}rg and Triebenbacher, Cornelia and Schmolz, Eric and Kurth, Andreas and Kr{\"u}ger, Frank and R{\"u}he, Ferdinand and Kiffner, Christian and Ansorge, Hermann and Gerwin, Werner and Wegener, Wolfgang and M{\"u}ller, J{\"o}rg and Bemmann, Margit and Wolf, Ronny and Otto, Lutz-Florian and Oehme, Rainer and Pfeffer, Martin and Heckel, Gerald and Schex, Susanne and Essbauer, Sandra S.}, title = {Netzwerk Nagetier-{\"u}bertragene Pathogene: Monitoring von Hantavirus-Infektionen in Deutschland}, series = {Wildhygiene, Wildtierkrankheiten, Parasiten, Epidemiologie}, booktitle = {Wildhygiene, Wildtierkrankheiten, Parasiten, Epidemiologie}, publisher = {Ges. f{\"u}r Wildtier- und Jagdforschung}, address = {Halle/Saale}, isbn = {978-378-88131-2-3}, issn = {1436-3895}, pages = {229 -- 250}, language = {de} } @misc{LangeSchneiderMutzetal., author = {Lange, Carsten and Schneider, Matthias and Mutz, Michael and Haustein, Martin and Halle, Martin and Seidel, Michael}, title = {Model-based design for restoration of a small urban river}, series = {Journal of Hydro-environment Research}, volume = {9}, journal = {Journal of Hydro-environment Research}, number = {2}, issn = {1570-6443}, doi = {10.1016/j.jher.2015.04.003}, pages = {226 -- 236}, language = {en} } @misc{WernerZidekKammereretal., author = {Werner, Jens Martin and Zidek, Martin and Kammerer, Sylvia and Platz Batista da Silva, Natascha and Jung, Friedrich and Schlitt, Hans J{\"u}rgen and Hornung, Matthias and Jung, Ernst Michael}, title = {Intraoperative contrast-enhanced ultrasound can have a crucial role in surgical decision-making during hepato-pancreatico-biliary surgery -Analysis of impact and input}, series = {Clinical Hemorheology and Microcirculation}, volume = {78}, journal = {Clinical Hemorheology and Microcirculation}, number = {1}, doi = {10.3233/CH-201031}, pages = {1 -- 14}, abstract = {OBJECTIVE: To assess the impact and procedural input of intraoperative ultrasound (IOUS) with contrast-enhanced ultrasound (CEUS) and ultrasound elastography on surgical decision making during the procedure and consequently the out-come after hepato-pancreatico-biliary (HPB) surgery. MATERIALS AND METHODS: Data of 50 consecutive patients, who underwent HPB surgery from 04/2018 to 07/2018 were prospectively collected for this study. During surgery, IOUS with a high-resolution ultrasound device using CEUS after bolus injection of 2.4-5 ml Sulphur hexafluoride microbubbles using a 6-9 MHz probe and a share wave and strain elastography was performed by an experienced examiner. Process and time analysis were carried out using mobile phone timer. RESULTS: The IOUS with CEUS and elastography correctly identified 42 malignant tumors and 4 benign lesions. In 3 cases, the examination provided false positive result (identifying 3 benign lesions as malignant) and in 1 case a malignant lesion was incorrectly assessed as benign (sensitivity 97,7\%, specificity 57,1\%, PPV 93,3\% and NPV 80\%). The specific question by the surgeon could be answered successfully in 98\% of the cases. In 76\% of the cases, there was a modification (42\%) or a fundamental change (34\%) of the planned surgical approach due to the information provided by the IOUS. Within the last group, the IOUS had a major impact on therapy outcome. In 7 patients an additional tumor resection was required, in 5 patients the tumor was assessed as inoperable, and in total in 5 patients an intraoperative RFA (4/5) or postoperative RITA (1/5) was required. Regarding procedural input, there was only a slight, but significant difference between the transport and set-up times before the intraoperative use (mean: 14 min 22 s) and the return transport (mean 13 min 6 s), (p = 0,038). The average examination time was 14 minutes, which makes only one third of the overall time demand. CONCLUSION: Combination of IOUS with CEUS and elastography in oncological HPB surgery provides valuable information that affects surgical decision-making. The procedural input of about 45 minutes seems to be a good investment considering the improvement of the surgical procedure and a significant modification of the therapy approach in the majority of the cases.}, language = {en} } @misc{FoersterSchenkZollneretal., author = {F{\"o}rster, Stefan and Schenk, Sebastian and Zollner, Eva Maria and Krahn, Oliver and Chiang, Cheng-Tien and Schumann, Florian O. and Bayat, Alireza and Schindler, Karl-Michael and Trautmann, Martin and Hammer, Ren{\´e} and Meinel, Klaus and Adeagbo, Waheed A. and Hergert, Wolfram and Flege, Jan Ingo and Falta, Jens and Ellguth, Martin and Tusche, Christian and DeBoissieu, Marc and Muntwiler, Matthias and Gerber, Thomas and Widdra, Wolf}, title = {Quasicrystals and their Approximants in 2D Ternary Oxides}, series = {Physia Status Solidi B}, volume = {257}, journal = {Physia Status Solidi B}, number = {7}, issn = {0370-1972}, doi = {10.1002/pssb.201900624}, pages = {11}, abstract = {2D oxide quasicrystals (OQCs) are recently discovered aperiodic, but well-ordered oxide interfaces. In this topical review, an introduction to these new thin-film systems is given. The concept of quasicrystals and their approximants is explained for BaTiO3 and SrTiO3 derived OQCs and related periodic structures in these 2D oxides. In situ microscopy unravels the high-temperature formation process of OQCs on Pt(111). The dodecagonal structure is discussed regarding tiling statistics and tiling decoration based on the results of atomically resolved scanning tunneling microscopy and various diffraction techniques. In addition, angle-resolved ultraviolet photoemission spectroscopy and X-ray photoelectron spectroscopy results prove a metallic character of the 2D oxide.}, language = {en} } @misc{BoetzlSponslerAlbrechtetal., author = {Boetzl, Fabian and Sponsler, Douglas and Albrecht, Matthias and Bat{\´a}ry, P{\´e}ter and Birkhofer, Klaus and Knapp, Michal and Krauss, Jochen and Maas, Bea and Martin, Emily A. and Sirami, Cl{\´e}lia and Sutter, Louis and Bertrand, Colette and Baillod, Aliette and Bota, Gerard and Bretagnolle, Vincent and Brotons, Llu{\´i}s and Frank, Thomas and Fusser, Moritz and Giralt, David and Gonz{\´a}lez, Ezequiel and Hof, Anouschka and Luka, Henryk and Marrec, Ronan and Nash, Michael and Ng, Katherina and Plantegenest, Manuel and Poulin, Brigitte and Siriwardena, Gavin and Zubair-Anjum, Muhammad and Entling, Martin and Steffan-Dewenter, Ingolf and Schirmel, Jens}, title = {Distance functions of carabids in crop fields depend on functional traits, crop type and adjacent habitat: a synthesis}, series = {Proceedings Royal Society. Series B, Biological sciences}, volume = {Vol. 291}, journal = {Proceedings Royal Society. Series B, Biological sciences}, issn = {1471-2954}, doi = {10.1098/rspb.2023.2383}, pages = {1 -- 10}, language = {en} } @inproceedings{WarneckeKrautzKlattetal., author = {Warnecke, Martin and Krautz, Hans Joachim and Klatt, Matthias and Aha, Ulrich}, title = {Instandhaltungsoptimierung mit genetischen Algorithmen}, language = {de} } @misc{KoziolAleckeGorniketal., author = {Koziol, Matthias and Alecke, Bj{\"o}rn and Gornik, Martin and Joedicke, Wolfgang and Unstied, Gerhard and Walther, J{\"o}rg}, title = {St{\"a}dtebaulicher Investitions- und F{\"o}rderbedarf 2007 bis 2013 in Deutschland}, series = {Raumforschung und Raumordnung}, volume = {66}, journal = {Raumforschung und Raumordnung}, number = {3}, issn = {0034-011}, language = {de} } @misc{KinnePorajKobielskaUllrichetal., author = {Kinne, Matthias and Poraj-Kobielska, Marzena and Ullrich, Ren{\´e} and Nousiainen, Paula and Sipil{\"a}, Jussi and Scheibner, Katrin and Hammel, Kenneth E. and Hofrichter, Martin}, title = {Oxidative cleavage of non-phenolic b-O-4 lignin model dimers by an extracellular aromatic peroxygenase}, series = {Holzforschung}, volume = {65}, journal = {Holzforschung}, number = {5}, issn = {1437-434X}, doi = {10.1515/HF.2011.057}, pages = {673 -- 679}, abstract = {The extracellular aromatic peroxygenase of the agaric fungus Agrocybe aegerita catalyzed the H2O2-dependent cleavage of non-phenolic arylglycerol-b-aryl ethers (b-O-4 ethers). For instance 1-(3,4-dimethoxyphenyl)-2-(2-methoxy-phenoxy)pro- pane-1,3-diol, a recalcitrant dimeric lignin model compound that represents the major non-phenolic substructure in lignin, was selectively O-demethylated at the para-methoxy group to give formaldehyde and 1-(4-hydroxy-3-methoxyphenyl)- 2-(2-methoxyphenoxy)propane-1,3-diol. The phenol moiety of the latter compound was then enzymatically oxidized into phenoxy radicals and a quinoid cation, which initiated the autocatalytic cleavage of the dimer and the formation of monomers such as 2-methoxy-1,4-benzoquinone and phenoxyl-substituted propionic acid. The introduction of 18O from H218O2 and H218O at different positions into the products provided information about the routes of ether cleavage. Studies with a 14C-labeled lignin model dimer showed that more than 70\% of the intermediates formed were further coupled to form polymers with molecular masses above 10 kDa. The results indicate that fungal aromatic peroxyge- nases may be involved in the bioconversion of methoxylated plant ingredients originating from lignin or other sources.}, language = {en} } @misc{PorajKobielskaKinneUllrichetal., author = {Poraj-Kobielska, Marzena and Kinne, Matthias and Ullrich, Ren{\´e} and Scheibner, Katrin and Kayser, Gernot and Hammel, Kenneth E. and Hofrichter, Martin}, title = {Preparation of human drug metabolites using fungal peroxygenases}, series = {Biochemical Pharmacology}, volume = {82}, journal = {Biochemical Pharmacology}, number = {7}, issn = {1873-2968}, doi = {10.1016/j.bcp.2011.06.020}, pages = {789 -- 796}, abstract = {The synthesis of hydroxylated and O- or N-dealkylated human drug metabolites (HDMs) via selective monooxygenation remains a challenging task for synthetic organic chemists. Here we report that aromatic peroxygenases (APOs; EC 1.11.2.1) secreted by the agaric fungi Agrocybe aegerita and Coprinellus radians catalyzed the H₂O₂-dependent selective monooxygenation of diverse drugs, including acetanilide, dextrorphan, ibuprofen, naproxen, phenacetin, sildenafil and tolbutamide. Reactions included the hydroxylation of aromatic rings and aliphatic side chains, as well as O- and N-dealkylations and exhibited different regioselectivities depending on the particular APO used. At best, desired HDMs were obtained in yields greater than 80\% and with isomeric purities up to 99\%. Oxidations of tolbutamide, acetanilide and carbamazepine in the presence of H₂¹⁸O₂ resulted in almost complete incorporation of ¹⁸O into the corresponding products, thus establishing that these reactions are peroxygenations. The deethylation of phenacetin-d₁ showed an observed intramolecular deuterium isotope effect [(k(H)/k(D))(obs)] of 3.1±0.2, which is consistent with the existence of a cytochrome P450-like intermediate in the reaction cycle of APOs. Our results indicate that fungal peroxygenases may be useful biocatalytic tools to prepare pharmacologically relevant drug metabolites.}, language = {en} } @misc{PengWollenbergerKinneetal., author = {Peng, Lei and Wollenberger, Ulla and Kinne, Matthias and Hofrichter, Martin and Ullrich, Ren{\´e} and Scheibner, Katrin and Fischer, Anna and Scheller, Frieder W.}, title = {Peroxygenase based sensor for aromatic compounds}, series = {Biosensors and Bioelectronics}, volume = {26}, journal = {Biosensors and Bioelectronics}, number = {4}, issn = {1873-4235}, doi = {10.1016/j.bios.2010.07.075}, url = {http://nbn-resolving.de/http://www.sciencedirect.com/science/article/pii/S0956566310004501}, pages = {1432 -- 1436}, abstract = {We report on the redox behaviour of the peroxygenase from Agrocybe aegerita (AaeAPO) which has been electrostatically immobilized in a matrix of chitosan-embedded gold nanoparticles on the surface of a glassy carbon electrode. AaeAPO contains a covalently bound heme-thiolate as the redox active group that exchanges directly electrons with the electrode via the gold nanoparticles. The formal potential E ° ′ of AaeAPO in the gold nanoparticles-chitosan film was estimated to be -(286 ± 9) mV at pH 7.0. The heterogeneous electron transfer rate constant (ks) increases from 3.7 in the scan rate range from 0.2 to 3.0 V s-1 and level off at 63.7 s-1. Furthermore, the peroxide-dependent hydroxylation of aromatic compounds was applied to develop a sensor for naphthalene and nitrophenol. The amperometric measurements of naphthalene are based on the indication of H2O2 consumption. For the chitosan-embedded gold nanoparticle system, the linear range extends from 4 to 40 μM naphthalene with a detection limit of 4.0 μM (S/N = 3) and repeatability of 5.7\% for 40 μM naphthalene.}, language = {en} }