@misc{LehnenHeuserSağlametal., author = {Lehnen, Nadine and Heuser, Fabian and Sağlam, Murat and Schulz, Christian M. and Wagner, Klaus J. and Taki, Masakatsu and Kochs, Eberhard F. and Jahn, Klaus and Schneider, Erich}, title = {Opioid-induced nausea involves a vestibular problem preventable by head-rest}, series = {PLoS one}, volume = {10}, journal = {PLoS one}, number = {8}, issn = {1932-6203}, doi = {10.1371/journal.pone.0135263}, pages = {e0135263}, language = {en} } @misc{HeubergerSağlamToddetal., author = {Heuberger, Maria and Sağlam, Murat and Todd, Nicholas Sean and Jahn, Klaus and Schneider, Erich and Lehnen, Nadine}, title = {Covert anti-compensatory quick eye movements during head impulses}, series = {PLoS One}, volume = {9}, journal = {PLoS One}, number = {4}, issn = {1932-6203}, doi = {10.1371/journal.pone.0093086}, pages = {e93086}, language = {en} } @misc{HelmchenMachnerLehnenetal., author = {Helmchen, Christoph and Machner, Bj{\"o}rn and Lehnen, Nadine and Jahn, Klaus and Schneider, Erich}, title = {Current state of diagnostic management of acute vertigo: a survey of neurologists in Germany}, series = {Journal of Neurology}, volume = {261}, journal = {Journal of Neurology}, number = {8}, issn = {0340-5354}, doi = {10.1007/s00415-014-7405-9}, pages = {1638 -- 1640}, language = {en} } @misc{LehnenSchneiderJahn, author = {Lehnen, Nadine and Schneider, Erich and Jahn, Klaus}, title = {Klinische Untersuchungen bei Schwindel: Kopfimpulstest und dynamische Sehsch{\"a}rfe}, series = {Neurotransmitter}, volume = {24}, journal = {Neurotransmitter}, number = {4}, issn = {2196-6397}, pages = {39 -- 43}, language = {de} } @misc{LehnenSchneiderJahn, author = {Lehnen, Nadine and Schneider, Erich and Jahn, Klaus}, title = {Do neurologists need the head impulse test?}, series = {Nervenarzt}, volume = {84}, journal = {Nervenarzt}, number = {8}, issn = {0028-2804}, doi = {10.1007/s00115-013-3822-8}, pages = {973 -- 974}, language = {de} } @misc{HeuserSchulzSağlametal., author = {Heuser, Fabian and Schulz, Christian and Sağlam, Murat and Ramaioli, Cecilia and Heuberger, Maria and Wagner, Klaus J. and Jahn, Klaus and Schneider, Erich and Brandt, Thomas and Glasauer, Stefan and Lehnen, Nadine}, title = {Preventing opioid-induced nausea and vomiting: Rest your head and close your eyes?}, series = {PloS one}, volume = {12}, journal = {PloS one}, number = {3}, issn = {1932-6203}, doi = {10.1371/journal.pone.0173925}, pages = {e0173925}, language = {en} } @misc{LehnenKellererKnorretal., author = {Lehnen, Nadine and Kellerer, Silvy and Knorr, Alexander G. and Schlick, Cornelia and Jahn, Klaus and Schneider, Erich and Heuberger, Maria and Ramaioli, Cecilia}, title = {Head-Movement-Emphasized Rehabilitation in Bilateral Vestibulopathy}, series = {Frontiers in Neurology}, volume = {9}, journal = {Frontiers in Neurology}, issn = {1664-2295}, doi = {10.3389/fneur.2018.00562}, pages = {6}, language = {en} } @misc{LehnenRamaioliToddetal., author = {Lehnen, Nadine and Ramaioli, Cecilia and Todd, Nicholas Sean and Bartl, Klaus and Kohlbecher, Stefan and Jahn, Klaus and Schneider, Erich}, title = {Clinical and video head impulses: a simple bedside test in children}, series = {Journal of Neurology}, volume = {264}, journal = {Journal of Neurology}, number = {5}, issn = {1432-1459}, doi = {10.1007/s00415-017-8450-y}, pages = {1002 -- 1004}, language = {en} } @misc{GrillHeubergerStrobletal., author = {Grill, Eva and Heuberger, Maria and Strobl, Ralf and Saglam, Murat and Holle, Rolf and Linkohr, Birgit and Ladwig, Karl-Heinz and Peters, Annette and Schneider, Erich and Jahn, Klaus and Lehnen, Nadine}, title = {Prevalence, determinants, and consequences of vestibular hypofunction. results from the kora-ff4 survey}, series = {Frontiers in Neurology}, volume = {9}, journal = {Frontiers in Neurology}, issn = {1664-2295}, doi = {10.3389/fneur.2018.01076}, pages = {8}, abstract = {Objective: Uni- or bilateral vestibular hypofunction (VH) impairs balance and mobility, and may specifically lead to injury from falls and to disability. The extent of this problem in the general population is still unknown and most likely to be underestimated. Objective of this study was to determine the prevalence, determinants, and consequences of VH in the general population. Methods: Data originates from the cross-sectional second follow-up (FF4) in 2013/14 of the KORA (Cooperative Health Research in the Region of Augsburg)-S4 study (1999-2001) from Southern Germany. This was a random sample of the target population consisting of all residents of the region aged 25-74 years in 1999. We included all participants who reported moderate or severe vertigo or dizziness during the last 12 months and a random sub-sample of participants representative for the general population without vertigo or dizziness during the last 12 months were tested. VH was assessed with the Video-Head Impulse Test (vHIT). Trained examiners applied high-acceleration, small-amplitude passive head rotations ("head impulses") to the left and right in the plane of the horizontal semicircular canals while participants fixated a target straight ahead. During head impulses, head movements were measured with inertial sensors, eye movements with video-oculography (EyeSeeCam vHIT). Results: A total of 2,279 participants were included (mean age 60.8 years, 51.6\% female), 570 (25.0\%) with moderate or severe vertigo or dizziness during the last 12 months. Of these, 450 were assessed with vHIT where 26 (5.8\%) had unilateral VH, and 16 (3.6\%) had bilateral VH. Likewise, 190 asymptomatic participants were tested. Of these 5 (2.6\%) had unilateral VH, and 2 (1.1\%) had bilateral VH. Prevalence of uni- or bilateral VH among tested symptomatic participants was 2.4\% in those < 48 years, and 32.1\% in individuals aged 79 and over. Age-adjusted prevalence was 6.7\% (95\% CI 4.8\%; 8.6\%). VH was associated with worse health, falls, hearing loss, hearing impairment, and ear pressure. Conclusion: VH may affect between 53 and 95 million adults in Europe and the US. While not all affected persons will experience the full spectrum of symptoms and consequences, adequate diagnostic and therapeutic measures should become standard of care to decrease the burden of disease.}, language = {en} } @misc{AubeleGrillEggertetal., author = {Aubele, Maria and Grill, Eva and Eggert, Thomas and Schneider, Erich and Strobl, Ralf and Jahn, Klaus and M{\"u}ller, Martin and Holle, Rolf and Linkohr, Birgit and Heier, Margit and Ladwig, Karl-Heinz and Lehnen, Nadine}, title = {Symptoms in unilatral vestibular hypofunction are associated with number of catch-up saccades and retinal errors: results from the population-based KORA FF4study}, series = {Frontiers in Neurology}, volume = {2023}, journal = {Frontiers in Neurology}, number = {14}, issn = {1664-2295}, pages = {8}, abstract = {Objective: The presence and intensity of symptoms vary in patients with unilateral vestibular hypofunction. We aimed to determine which saccadic and vestibulo-ocular reflex parameters best predict the presence of symptoms in unilateral vestibular hypofunction in order to better understand vestibular compensation and its implications for rehabilitation therapy. Methods: Video head impulse test data were analyzed from a subpopulation of 23 symptomatic and 10 currently symptom-free participants with unilateral vestibular hypofunction, embedded in the KORA (Cooperative Health Research in the Region of Augsburg) FF4 study, the second follow-up of the KORA S4 population-based health survey (2,279 participants). Results: A higher number of catch-up saccades, a higher percentage of covert saccades, and a larger retinal error at 200 ms after the onset of the head impulse were associated with relevant symptoms in participants with unilateral vestibular hypofunction (p = 0.028, p = 0.046, and p = 0.038, respectively). After stepwise selection, the number of catch-up saccades and retinal error at 200 ms remained in the final logistic regression model, which was significantly better than a null model (p = 0.014). Age, gender, saccade amplitude, saccade latency, and VOR gain were not predictive of the presence of symptoms. Conclusion: The accuracy of saccadic compensation seems to be crucial for the presence of symptoms in unilateral vestibular hypofunction, highlighting the role of specific gaze stabilization exercises in rehabilitation. Early saccades, mainly triggered by the vestibular system, do not seem to compensate accurately enough, resulting in a relevant retinal error and the need for more as well as more accurate catch-up saccades, probably triggered by the visual system.}, language = {en} }