@misc{LehnenHeuserSağlametal., author = {Lehnen, Nadine and Heuser, Fabian and Sağlam, Murat and Schulz, Christian M. and Wagner, Klaus J. and Taki, Masakatsu and Kochs, Eberhard F. and Jahn, Klaus and Schneider, Erich}, title = {Opioid-induced nausea involves a vestibular problem preventable by head-rest}, series = {PLoS one}, volume = {10}, journal = {PLoS one}, number = {8}, issn = {1932-6203}, doi = {10.1371/journal.pone.0135263}, pages = {e0135263}, language = {en} } @misc{HeuserSchulzSağlametal., author = {Heuser, Fabian and Schulz, Christian and Sağlam, Murat and Ramaioli, Cecilia and Heuberger, Maria and Wagner, Klaus J. and Jahn, Klaus and Schneider, Erich and Brandt, Thomas and Glasauer, Stefan and Lehnen, Nadine}, title = {Preventing opioid-induced nausea and vomiting: Rest your head and close your eyes?}, series = {PloS one}, volume = {12}, journal = {PloS one}, number = {3}, issn = {1932-6203}, doi = {10.1371/journal.pone.0173925}, pages = {e0173925}, language = {en} } @misc{LehnenRamaioliToddetal., author = {Lehnen, Nadine and Ramaioli, Cecilia and Todd, Nicholas Sean and Bartl, Klaus and Kohlbecher, Stefan and Jahn, Klaus and Schneider, Erich}, title = {Clinical and video head impulses: a simple bedside test in children}, series = {Journal of Neurology}, volume = {264}, journal = {Journal of Neurology}, number = {5}, issn = {1432-1459}, doi = {10.1007/s00415-017-8450-y}, pages = {1002 -- 1004}, language = {en} } @misc{HeubergerSağlamToddetal., author = {Heuberger, Maria and Sağlam, Murat and Todd, Nicholas Sean and Jahn, Klaus and Schneider, Erich and Lehnen, Nadine}, title = {Covert anti-compensatory quick eye movements during head impulses}, series = {PLoS One}, volume = {9}, journal = {PLoS One}, number = {4}, issn = {1932-6203}, doi = {10.1371/journal.pone.0093086}, pages = {e93086}, language = {en} } @misc{HelmchenMachnerLehnenetal., author = {Helmchen, Christoph and Machner, Bj{\"o}rn and Lehnen, Nadine and Jahn, Klaus and Schneider, Erich}, title = {Current state of diagnostic management of acute vertigo: a survey of neurologists in Germany}, series = {Journal of Neurology}, volume = {261}, journal = {Journal of Neurology}, number = {8}, issn = {0340-5354}, doi = {10.1007/s00415-014-7405-9}, pages = {1638 -- 1640}, language = {en} } @misc{JahnSchneider, author = {Jahn, Klaus and Schneider, Erich}, title = {Untersuchung der vestibul{\"a}ren Funktion bei Schwindelpatienten}, series = {Nervenheilkunde}, volume = {31}, journal = {Nervenheilkunde}, number = {5}, issn = {0722-1541}, pages = {370 -- 377}, language = {de} } @misc{SchneiderJahnDieterichetal., author = {Schneider, Erich and Jahn, Klaus and Dieterich, Marianne and Brandt, Thomas and Strupp, Michael}, title = {Gait deviations induced by visual stimulation in roll}, series = {Experimental Brain Research}, volume = {185}, journal = {Experimental Brain Research}, number = {1}, issn = {0014-4819}, doi = {10.1007/s00221-007-1134-6}, pages = {21 -- 26}, language = {en} } @misc{LehnenSchneiderJahn, author = {Lehnen, Nadine and Schneider, Erich and Jahn, Klaus}, title = {Klinische Untersuchungen bei Schwindel: Kopfimpulstest und dynamische Sehsch{\"a}rfe}, series = {Neurotransmitter}, volume = {24}, journal = {Neurotransmitter}, number = {4}, issn = {2196-6397}, pages = {39 -- 43}, language = {de} } @misc{LehnenSchneiderJahn, author = {Lehnen, Nadine and Schneider, Erich and Jahn, Klaus}, title = {Do neurologists need the head impulse test?}, series = {Nervenarzt}, volume = {84}, journal = {Nervenarzt}, number = {8}, issn = {0028-2804}, doi = {10.1007/s00115-013-3822-8}, pages = {973 -- 974}, language = {de} } @misc{JahnNaesslSchneideretal., author = {Jahn, Klaus and Naeßl, Andrea and Schneider, Erich and Strupp, Michael and Brandt, Thomas and Dieterich, Marianne}, title = {Inverse u-shaped curve for age dependency of torsional eye movement responses to galvanic vestibular stimulation}, series = {Brain}, volume = {126}, journal = {Brain}, number = {7}, issn = {1460-2156}, doi = {10.1093/brain/awg163}, pages = {1579 -- 1589}, language = {en} } @misc{JahnNaesslStruppetal., author = {Jahn, Klaus and Naeßl, Andrea and Strupp, Michael and Schneider, Erich and Brandt, Thomas and Dieterich, Marianne}, title = {Torsional eye movement responses to monaural and binaural galvanic vestibular stimulation: side-to-side asymmetries.}, series = {Annals of the New York Academy of Sciences}, volume = {1004}, journal = {Annals of the New York Academy of Sciences}, issn = {0077-8923}, doi = {10.1111/j.1749-6632.2003.tb00265.x}, pages = {485 -- 489}, language = {en} } @misc{JahnStruppSchneideretal., author = {Jahn, Klaus and Strupp, Michael and Schneider, Erich and Dieterich, Marianne and Brandt, Thomas}, title = {Visually induced gait deviations during different locomotion speeds}, series = {Experimental Brain Research}, volume = {141}, journal = {Experimental Brain Research}, number = {3}, issn = {0014-4819}, doi = {10.1007/s002210100884}, pages = {370 -- 374}, language = {en} } @misc{JahnStruppSchneideretal., author = {Jahn, Klaus and Strupp, Michael and Schneider, Erich and Dieterich, Marianne and Brandt, Thomas}, title = {Differential effects of vestibular stimulation on walking and running}, series = {Neuroreport}, volume = {11}, journal = {Neuroreport}, number = {8}, issn = {1473-558X}, pages = {1745 -- 1748}, language = {en} } @misc{GlasauerSchneiderJahnetal., author = {Glasauer, Stefan and Schneider, Erich and Jahn, Klaus and Strupp, Michael}, title = {How the eyes move the body}, series = {Neurology}, volume = {65}, journal = {Neurology}, number = {8}, issn = {0028-3878}, doi = {10.1212/01.wnl.0000175132.01370.fc}, pages = {1291 -- 1293}, language = {en} } @misc{StruppGlasauerJahnetal., author = {Strupp, Michael and Glasauer, Stefan and Jahn, Klaus and Schneider, Erich and Krafczyk, Siegbert and Brandt, Thomas}, title = {Eye movements and balance}, series = {Annals of the New York Academy of Sciences}, volume = {1004}, journal = {Annals of the New York Academy of Sciences}, issn = {1749-6632}, pages = {352 -- 358}, language = {en} } @misc{LiRezaniaKammereretal., author = {Li, Chouyang and Rezania, Simin and Kammerer, Sarah and Sokolowski, Armin Andreas and Devaney, Trevor Thomas Joseph and Gorischek, Astrid and Jahn, Stephan Wenzel and Hackl, Hubert and Groschner, Klaus and Windpassinger, Christian and Malle, Ernst and Bauernhofer, Thomas and Schreibmayer, Wolfgang}, title = {Piezo1 forms mechanosensitive ion channels in the human MCF-7 breast cancer cell line}, series = {Scientific Reports}, volume = {5}, journal = {Scientific Reports}, issn = {2045-2322}, doi = {10.1038/srep08364}, pages = {9}, abstract = {Mechanical interaction between cells - specifically distortion of tensional homeostasis-emerged as an important aspect of breast cancer genesis and progression. We investigated the biophysical characteristics of mechanosensitive ion channels (MSCs) in the malignant MCF-7 breast cancer cell line. MSCs turned out to be the most abundant ion channel species and could be activated by negative pressure at the outer side of the cell membrane in a saturable manner. Assessing single channel conductance (GΛ) for different monovalent cations revealed an increase in the succession: Li⁺ < Na⁺ < K⁺ ≈Rb⁺ ≈ Cs⁺. Divalent cations permeated also with the order: Ca²⁺ < Ba²⁺. Comparison of biophysical properties enabled us to identify MSCs in MCF-7 as ion channels formed by the Piezo1 protein. Using patch clamp technique no functional MSCs were observed in the benign MCF-10A mammary epithelial cell line. Blocking of MSCs by GsMTx-4 resulted in decreased motility of MCF-7, but not of MCF-10A cells, underscoring a possible role of Piezo1 in invasion and metastatic propagation. The role of Piezo1 in biology and progression of breast cancer is further substantiated by markedly reduced overall survival in patients with increased Piezo1 mRNA levels in the primary tumor.}, language = {en} } @misc{LehnenKellererKnorretal., author = {Lehnen, Nadine and Kellerer, Silvy and Knorr, Alexander G. and Schlick, Cornelia and Jahn, Klaus and Schneider, Erich and Heuberger, Maria and Ramaioli, Cecilia}, title = {Head-Movement-Emphasized Rehabilitation in Bilateral Vestibulopathy}, series = {Frontiers in Neurology}, volume = {9}, journal = {Frontiers in Neurology}, issn = {1664-2295}, doi = {10.3389/fneur.2018.00562}, pages = {6}, language = {en} } @misc{SchoeberlPradhanIrvingetal., author = {Sch{\"o}berl, Florian and Pradhan, Cauchy and Irving, Stephanie and Buerger, Katharina and Xiong, Guoming and Kugler, G{\"u}nter and Kohlbecher, Stefan and Engmann, Julia and Werner, Philipp and Brendel, Matthias and Schneider, Erich and Perneczky, Robert and Jahn, Klaus and Foug{\`e}re, Christian la and Bartenstein, Peter and Brandt, Thomas and Dietrich, Marianne and Zwergal, Andreas}, title = {Real-space navigation testing differentiates between amyloid-positive and -negative aMCI}, series = {Neurology : official journal of the American Academy of Neurology}, volume = {94}, journal = {Neurology : official journal of the American Academy of Neurology}, number = {8}, issn = {1526-632X}, doi = {10.1212/WNL.0000000000008758}, pages = {e861 -- e873}, language = {en} } @misc{GrillHeubergerStrobletal., author = {Grill, Eva and Heuberger, Maria and Strobl, Ralf and Saglam, Murat and Holle, Rolf and Linkohr, Birgit and Ladwig, Karl-Heinz and Peters, Annette and Schneider, Erich and Jahn, Klaus and Lehnen, Nadine}, title = {Prevalence, determinants, and consequences of vestibular hypofunction. results from the kora-ff4 survey}, series = {Frontiers in Neurology}, volume = {9}, journal = {Frontiers in Neurology}, issn = {1664-2295}, doi = {10.3389/fneur.2018.01076}, pages = {8}, abstract = {Objective: Uni- or bilateral vestibular hypofunction (VH) impairs balance and mobility, and may specifically lead to injury from falls and to disability. The extent of this problem in the general population is still unknown and most likely to be underestimated. Objective of this study was to determine the prevalence, determinants, and consequences of VH in the general population. Methods: Data originates from the cross-sectional second follow-up (FF4) in 2013/14 of the KORA (Cooperative Health Research in the Region of Augsburg)-S4 study (1999-2001) from Southern Germany. This was a random sample of the target population consisting of all residents of the region aged 25-74 years in 1999. We included all participants who reported moderate or severe vertigo or dizziness during the last 12 months and a random sub-sample of participants representative for the general population without vertigo or dizziness during the last 12 months were tested. VH was assessed with the Video-Head Impulse Test (vHIT). Trained examiners applied high-acceleration, small-amplitude passive head rotations ("head impulses") to the left and right in the plane of the horizontal semicircular canals while participants fixated a target straight ahead. During head impulses, head movements were measured with inertial sensors, eye movements with video-oculography (EyeSeeCam vHIT). Results: A total of 2,279 participants were included (mean age 60.8 years, 51.6\% female), 570 (25.0\%) with moderate or severe vertigo or dizziness during the last 12 months. Of these, 450 were assessed with vHIT where 26 (5.8\%) had unilateral VH, and 16 (3.6\%) had bilateral VH. Likewise, 190 asymptomatic participants were tested. Of these 5 (2.6\%) had unilateral VH, and 2 (1.1\%) had bilateral VH. Prevalence of uni- or bilateral VH among tested symptomatic participants was 2.4\% in those < 48 years, and 32.1\% in individuals aged 79 and over. Age-adjusted prevalence was 6.7\% (95\% CI 4.8\%; 8.6\%). VH was associated with worse health, falls, hearing loss, hearing impairment, and ear pressure. Conclusion: VH may affect between 53 and 95 million adults in Europe and the US. While not all affected persons will experience the full spectrum of symptoms and consequences, adequate diagnostic and therapeutic measures should become standard of care to decrease the burden of disease.}, language = {en} } @misc{SpiegelClaassenTeufeletal., author = {Spiegel, Rainer and Claassen, Jens and Teufel, Julian and Bardins, Stanislav and Schneider, Erich and Lehrer, Nicole and Jahn, Klaus and Anciaes da Silva, F{\´a}bio and Hahn, Ales and Farahmand, Parvis and Brandt, Thomas and Strupp, Michael and Kalla, Roger}, title = {Resting in darkness improves downbeat nystagmus: evidence from an observational study}, series = {Annals of the New York Academy of Sciences}, volume = {1375}, journal = {Annals of the New York Academy of Sciences}, number = {1}, issn = {1749-6632}, doi = {10.1111/nyas.13172}, pages = {66 -- 73}, abstract = {Resting in an upright position during daytime decreases downbeat nystagmus (DBN). When measured in brightness only, that is, without intermitting exposure to darkness, it does not make a significant difference whether patients have previously rested in brightness or in darkness. In real-world scenarios, people are often exposed to brightness and darkness intermittently. The aim of this study was to analyze whether resting in brightness or resting in darkness was associated with a lower post-resting DBN after intermitting exposures to brightness and darkness. Eight patients were recorded with three-dimensional video-oculography in brightness and darkness conditions, each following two 2-h resting intervals under either brightness or darkness resting conditions. The dependent variable was DBN intensity, measured in mean slow phase velocity. A repeated measures ANOVA with the factors measurement condition (brightness vs. darkness), resting condition (brightness vs. darkness), and time (after first vs. second resting interval) showed a significant effect for the factor resting condition, where previous resting in darkness was associated with a significantly lower DBN relative to previous resting in brightness (P < 0.01). The clinical relevance is to advise patients with DBN to rest in darkness.}, language = {en} } @misc{AubeleGrillEggertetal., author = {Aubele, Maria and Grill, Eva and Eggert, Thomas and Schneider, Erich and Strobl, Ralf and Jahn, Klaus and M{\"u}ller, Martin and Holle, Rolf and Linkohr, Birgit and Heier, Margit and Ladwig, Karl-Heinz and Lehnen, Nadine}, title = {Symptoms in unilatral vestibular hypofunction are associated with number of catch-up saccades and retinal errors: results from the population-based KORA FF4study}, series = {Frontiers in Neurology}, volume = {2023}, journal = {Frontiers in Neurology}, number = {14}, issn = {1664-2295}, pages = {8}, abstract = {Objective: The presence and intensity of symptoms vary in patients with unilateral vestibular hypofunction. We aimed to determine which saccadic and vestibulo-ocular reflex parameters best predict the presence of symptoms in unilateral vestibular hypofunction in order to better understand vestibular compensation and its implications for rehabilitation therapy. Methods: Video head impulse test data were analyzed from a subpopulation of 23 symptomatic and 10 currently symptom-free participants with unilateral vestibular hypofunction, embedded in the KORA (Cooperative Health Research in the Region of Augsburg) FF4 study, the second follow-up of the KORA S4 population-based health survey (2,279 participants). Results: A higher number of catch-up saccades, a higher percentage of covert saccades, and a larger retinal error at 200 ms after the onset of the head impulse were associated with relevant symptoms in participants with unilateral vestibular hypofunction (p = 0.028, p = 0.046, and p = 0.038, respectively). After stepwise selection, the number of catch-up saccades and retinal error at 200 ms remained in the final logistic regression model, which was significantly better than a null model (p = 0.014). Age, gender, saccade amplitude, saccade latency, and VOR gain were not predictive of the presence of symptoms. Conclusion: The accuracy of saccadic compensation seems to be crucial for the presence of symptoms in unilateral vestibular hypofunction, highlighting the role of specific gaze stabilization exercises in rehabilitation. Early saccades, mainly triggered by the vestibular system, do not seem to compensate accurately enough, resulting in a relevant retinal error and the need for more as well as more accurate catch-up saccades, probably triggered by the visual system.}, language = {en} }