@misc{SpiegelKallaClaassenetal., author = {Spiegel, Rainer and Kalla, Roger and Claassen, Jens and Bardins, Stanislav and Anci{\~a}es da Silva, F{\´a}bio and Farahmand, Parvis and Hahn, Ales and Schneider, Erich}, title = {Aminopyridine treatment in a patient with bilateral vestibular failure and cryptogenic downbeat nystagmus}, series = {Journal of Neuro-Ophthalmology}, volume = {32}, journal = {Journal of Neuro-Ophthalmology}, number = {2}, issn = {1536-5166}, pages = {190}, language = {en} } @misc{ClaassenSpiegelKallaetal., author = {Claassen, Jens and Spiegel, Rainer and Kalla, Roger and Faldon, Mary and Kennard, Christopher and Schneider, Erich}, title = {A randomised double-blind, cross-over trial of 4-aminopyridine for downbeat nystagmus-effects on slowphase eye velocity, postural stability, locomotion and symptoms}, series = {Journal of neurology, neurosurgery, and psychiatry}, volume = {84}, journal = {Journal of neurology, neurosurgery, and psychiatry}, number = {12}, issn = {0022-3050}, doi = {10.1136/jnnp-2012-304736}, pages = {1392 -- 1399}, language = {en} } @misc{ClaassenFeilBardinsetal., author = {Claassen, Jens and Feil, Katharina and Bardins, Stanislav and Teufel, Julian and Spiegel, Rainer and Kalla, Roger and Schneider, Erich}, title = {Dalfampridine in patients with downbeat nystagmus-an observational study}, series = {Journal of Neurology}, volume = {260}, journal = {Journal of Neurology}, number = {8}, issn = {0340-5354}, doi = {10.1007/s00415-013-6911-5}, pages = {1992 -- 1996}, language = {en} } @misc{SpiegelClaassenTeufeletal., author = {Spiegel, Rainer and Claassen, Jens and Teufel, Julian and Bardins, Stanislav and Schneider, Erich and Lehrer, Nicole and Jahn, Klaus and Anciaes da Silva, F{\´a}bio and Hahn, Ales and Farahmand, Parvis and Brandt, Thomas and Strupp, Michael and Kalla, Roger}, title = {Resting in darkness improves downbeat nystagmus: evidence from an observational study}, series = {Annals of the New York Academy of Sciences}, volume = {1375}, journal = {Annals of the New York Academy of Sciences}, number = {1}, issn = {1749-6632}, doi = {10.1111/nyas.13172}, pages = {66 -- 73}, abstract = {Resting in an upright position during daytime decreases downbeat nystagmus (DBN). When measured in brightness only, that is, without intermitting exposure to darkness, it does not make a significant difference whether patients have previously rested in brightness or in darkness. In real-world scenarios, people are often exposed to brightness and darkness intermittently. The aim of this study was to analyze whether resting in brightness or resting in darkness was associated with a lower post-resting DBN after intermitting exposures to brightness and darkness. Eight patients were recorded with three-dimensional video-oculography in brightness and darkness conditions, each following two 2-h resting intervals under either brightness or darkness resting conditions. The dependent variable was DBN intensity, measured in mean slow phase velocity. A repeated measures ANOVA with the factors measurement condition (brightness vs. darkness), resting condition (brightness vs. darkness), and time (after first vs. second resting interval) showed a significant effect for the factor resting condition, where previous resting in darkness was associated with a significantly lower DBN relative to previous resting in brightness (P < 0.01). The clinical relevance is to advise patients with DBN to rest in darkness.}, language = {en} } @misc{FriedrichSchneiderBuerkleinetal., author = {Friedrich, Maximilian U. and Schneider, Erich and Buerklein, Miriam and Taeger, Johannes and Hartig, Johannes and Volkmann, Jens and Peach, Robert and Zeller, Daniel}, title = {Smartphone video nystagmography using convolutional neural networks: ConVNG}, series = {Journal of Neurology}, volume = {270}, journal = {Journal of Neurology}, issn = {1432-1459}, doi = {10.1007/s00415-022-11493-1}, pages = {2518 -- 2530}, abstract = {Eye movement abnormalities are commonplace in neurological disorders. However, unaided eye movement assessments lack granularity. Although videooculography (VOG) improves diagnostic accuracy, resource intensiveness precludes its broad use. To bridge this care gap, we here validate a framework for smartphone video-based nystagmography capitalizing on recent computer vision advances. Methods A convolutional neural network was fine-tuned for pupil tracking using > 550 annotated frames: ConVNG. In a cross-sectional approach, slow-phase velocity of optokinetic nystagmus was calculated in 10 subjects using ConVNG and VOG. Equivalence of accuracy and precision was assessed using the "two one-sample t-test" (TOST) and Bayesian interval-null approaches. ConVNG was systematically compared to OpenFace and MediaPipe as computer vision (CV) benchmarks for gaze estimation. Results ConVNG tracking accuracy reached 9-15\% of an average pupil diameter. In a fully independent clinical video dataset, ConVNG robustly detected pupil keypoints (median prediction confidence 0.85). SPV measurement accuracy was equivalent to VOG (TOST p < 0.017; Bayes factors (BF) > 24). ConVNG, but not MediaPipe, achieved equivalence to VOG in all SPV calculations. Median precision was 0.30°/s for ConVNG, 0.7°/s for MediaPipe and 0.12°/s for VOG. ConVNG precision was significantly higher than MediaPipe in vertical planes, but both algorithms' precision was inferior to VOG. Conclusions ConVNG enables offline smartphone video nystagmography with an accuracy comparable to VOG and significantly higher precision than MediaPipe, a benchmark computer vision application for gaze estimation. This serves as a blueprint for highly accessible tools with potential to accelerate progress toward precise and personalized Medicine.}, language = {en} } @misc{FeilClaassenBrandinsetal., author = {Feil, Katharina and Claassen, Jens and Brandins, Stanislavs and Teufel, Julian and Krafczyk, Siegbert and Schneider, Erich}, title = {Effect of chlorzoxazone in patients with downbeat nystagmus: a pilot trial}, series = {Neurology}, volume = {81}, journal = {Neurology}, number = {13}, issn = {0028-3878}, doi = {10.1212/WNL.0b013e3182a55f6d}, pages = {1152 -- 1158}, language = {en} } @misc{KallaSpiegelClaassenetal., author = {Kalla, Roger and Spiegel, Rainer and Claassen, Jens and Bardins, Stanislav and Hahn, Ales and Schneider, Erich and Lehrer, Nicole and Glasauer, Stefan and Brandt, Thomas and Strupp, Michael}, title = {Comparison of 10-mg doses of 4-aminopyridine and 3,4-diaminopyridine for the treatment of downbeat nystagmus}, series = {Journal of neuro-ophthalmology}, volume = {32}, journal = {Journal of neuro-ophthalmology}, number = {2}, issn = {1536-5166}, doi = {10.1097/WNO.0b013e3182258086}, pages = {320 -- 325}, language = {en} } @misc{QuinkensteinBoehmFreeseetal., author = {Quinkenstein, Ansgar and B{\"o}hm, Christian and Freese, Dirk and W{\"o}llecke, Jens and Gr{\"u}newald, Holger and Schneider, Bernd Uwe and H{\"u}ttl, Reinhard F.}, title = {Alley-Cropping - Ein klima-adaptierbares Landnutzungssystem zur nachhaltigen Biomasseproduktion}, series = {Forum der Forschung}, volume = {12}, journal = {Forum der Forschung}, number = {21}, issn = {0947-6989}, pages = {131 -- 138}, language = {de} } @misc{SchneiderWeissRuheetal., author = {Schneider, Jens and Weiss, Romano and Ruhe, Madeleine and Jung, Tobias and Roggenbuck, Dirk and Stohwasser, Ralf and Schierack, Peter and R{\"o}diger, Stefan}, title = {Open source bioimage informatic tools for the analysis of DNA damage and associated biomarkers}, series = {Journal of Laboratory and Precision Medicine}, volume = {4}, journal = {Journal of Laboratory and Precision Medicine}, issn = {2519-9005}, doi = {10.21037/jlpm.2019.04.05}, language = {en} } @misc{RoedigerSchneiderSaueretal., author = {R{\"o}diger, Stefan and Schneider, Jens and Sauer, Lysann and Reddig, Annika and Schierack, Peter and Roggenbuck, Dirk and Schr{\"o}der, Christian}, title = {A Multiparameter Platform for The Analysis of DNA Double-strand Breaks and Associated Biomarkers after genome Editing Austrian Biomarker Symposium (ASBD) 2016, 10.-11.03.2016, Wien, {\"O}sterreich}, language = {en} } @misc{SauerRoedigerSchneideretal., author = {Sauer, Lysann and R{\"o}diger, Stefan and Schneider, Jens and Schierack, Peter and Roggenbuck, Dirk and Schr{\"o}der, Christian}, title = {Functional Multiparameter Analy sis of Double-Strand Breaks and Associate Biomarkers during Genome Editing, Genome Editing and Gene Modulation Congress 2016, 6.-8.04.2016, Oxford, United Kingdom}, language = {en} } @misc{QuinkensteinWoelleckeBoehmetal., author = {Quinkenstein, Ansgar and W{\"o}llecke, Jens and B{\"o}hm, Christian and Gr{\"u}newald, Holger and Freese, Dirk and Schneider, Bernd Uwe and H{\"u}ttl, Reinhard F.}, title = {Ecological benefits of the alley cropping agroforestry system in sensitive regions of Europe}, series = {Environmental Science \& Policy}, volume = {12}, journal = {Environmental Science \& Policy}, number = {8}, issn = {1462-9011}, doi = {10.1016/j.envsci.2009.08.008}, pages = {1112 -- 1121}, language = {en} } @incollection{BoehmEttererKempaetal., author = {B{\"o}hm, Christian and Etterer, Florian and Kempa, Daniela and K{\"o}nig, Bettina and Matthes, Gesa and Schaffrin, Andr{\´e} and Schindele, Stephan and Schneider, Jens and Streit, Anne von}, title = {Land nachhaltig nutzen}, series = {Nachhaltige Landnutzung managen : Akteure beteiligen - Ideen entwickeln - Konflikte l{\"o}sen}, booktitle = {Nachhaltige Landnutzung managen : Akteure beteiligen - Ideen entwickeln - Konflikte l{\"o}sen}, editor = {Sch{\"o}n, Susanne and Eismann, Christian and Wendt-Schwarzburg, Helke and Ansmann, Till}, publisher = {wbv Media GmbH \& Co KG}, address = {Bielefeld}, isbn = {978-3-7639-6027-9}, pages = {12 -- 24}, language = {de} } @incollection{QuinkensteinSchultzeGruenewaldetal., author = {Quinkenstein, Ansgar and Schultze, Bernd and Gr{\"u}newald, Holger and W{\"o}llecke, Jens and Schneider, Bernd Uwe and Jochheim, Hubert and H{\"u}ttl, Reinhard F.}, title = {Landschafts{\"o}kologische Aspekte der Dendromasseproduktion - Analyse und Bewertung von Risiken und Vorteilswirkungen}, series = {DENROM - Zukunftsrohstoff Dendromasse : systemische Analyse, Leitbilder und Szenarien f{\"u}r die nachhaltige energetische und stoffliche Verwertung von Dendromasse aus Wald- und Agrarholz}, booktitle = {DENROM - Zukunftsrohstoff Dendromasse : systemische Analyse, Leitbilder und Szenarien f{\"u}r die nachhaltige energetische und stoffliche Verwertung von Dendromasse aus Wald- und Agrarholz}, editor = {Murach, Dieter and Knur, Lisa and Schultze, Mareike}, publisher = {Verlag Kessel}, address = {Remagen-Oberwinter}, isbn = {978-3-941300-05-7}, pages = {193 -- 204}, language = {de} } @incollection{WoelleckeBoellmannSchneideretal., author = {W{\"o}llecke, Jens and B{\"o}llmann, J{\"o}rg and Schneider, Bernd Uwe and H{\"u}ttl, Reinhard F.}, title = {Vergleichende Untersuchungen zur Durchwurzelbarkeit und Mykorrhizierung auf forstlich rekultivierten Kippsubstraten}, series = {Neue Ans{\"a}tze in der land- und forstwirtschaftlichen Rekultivierung}, booktitle = {Neue Ans{\"a}tze in der land- und forstwirtschaftlichen Rekultivierung}, editor = {H{\"u}ttl, Reinhard F. and Schneider, Bernd Uwe}, publisher = {BTU}, address = {Cottbus}, isbn = {978-3-937728-06-3}, pages = {207 -- 224}, language = {de} } @inproceedings{WoelleckeGruenewaldSchneideretal., author = {W{\"o}llecke, Jens and Gr{\"u}newald, Holger and Schneider, Bernd Uwe and H{\"u}ttl, Reinhard F.}, title = {Alley-Cropping - Eine M{\"o}glichkeit der Etablierung von Biotopverbundstrukturen in der Agrarlandschaft?}, series = {Naturschutz und {\"O}kologie, ausgew{\"a}hlte Beitr{\"a}ge zur Gf{\"O}-Jahrestagung 2007 in Marburg}, booktitle = {Naturschutz und {\"O}kologie, ausgew{\"a}hlte Beitr{\"a}ge zur Gf{\"O}-Jahrestagung 2007 in Marburg}, publisher = {Bundesamt f{\"u}r Naturschutz}, address = {Bonn-Bad Godesberg}, isbn = {978-3-7843-3960-3}, pages = {73 -- 78}, language = {de} }