@misc{RiedelKrahlBuderetal., author = {Riedel, Ramona and Krahl, Kathrin and Buder, Kai and B{\"o}llmann, J{\"o}rg and Braun, Burga and Martienssen, Marion}, title = {Novel standard biodegradation test for synthetic phosphonates}, series = {Journal of Microbiological Methods}, volume = {Vol. 212}, journal = {Journal of Microbiological Methods}, issn = {1872-8359}, doi = {10.1016/j.mimet.2023.106793}, pages = {1 -- 13}, abstract = {Determination of biodegradation of synthetic phosphonates such as aminotris(methylenephosphonic acid) (ATMP), ethylenediamine tetra(methylenephosphonic acid) (EDTMP), or diethylenetriamine penta(methylenephosphonic acid) (DTPMP) is a great challenge. Commonly, ready biodegradability of organic substances is assessed by OECD 301 standard tests. However, due to the chemical imbalance of carbon to phosphorus synthetic phosphonates do not promote microbial growth and, thus, limiting its biodegradation. Therefore, standard OECD test methods are not always reliable to predict the real biodegradability of phosphonates. In the presented study, we report the development of a standardized batch system suitable to synthetic phosphonates such as ATMP, EDTMP, DTPMP and others. The novel standard batch test is applicable with pure strains, activated sludge from different wastewater treatment plants (i.e., municipal and industrial), and with tap water as inoculum. We optimized the required calcium and magnesium exposure levels as well as the amount of the start inoculum biomass. We demonstrated that our test also allows to determine several parameters including ortho-phosphate (o-PO43􀀀 ), total phosphorus (TP), ammonium (NH4+) and total organic carbon (TOC). In addition, also LC/MS analyses of cell-free medium is applicable for determining the mother compounds and metabolites. We applied our optimized standardized batch with selected phosphonates and evidenced that the chemical structure has a major influence of the microbial growth rates. Thus, our novel batch test overcomes drawbacks of the OECD 301 test series for determination of easy biodegradability for stoichiometric imbalanced organic compounds such as phosphonates.}, language = {en} } @misc{BerensRiedelRederetal., author = {Berens, Eva-Maria and Riedel, J{\"o}rg and Reder, Maren and Razum, Oliver and Kolip, Petra and Spallek, Jacob}, title = {Postalische Befragung von Frauen mit t{\"u}rkischem Migrationshintergrund - Identifizierung, Stichprobenbereinigung und Response im Rahmen der InEMa-Studie}, series = {Das Gesundheitswesen}, volume = {79}, journal = {Das Gesundheitswesen}, number = {12}, issn = {0941-3790}, doi = {10.1055/s-0035-1564076}, pages = {1000 -- 1003}, language = {de} } @misc{CharisseErusPomponioetal., author = {Chariss{\´e}, Daniel and Erus, Guray and Pomponio, Raymond and Gorges, Martin and Schmidt, Nele and Schneider, Christine and Liepelt-Scarfone, Inga and Riedel, Oliver and Reetz, Kathrin and Schulz, J{\"o}rg B. and Berg, Daniela and Storch, Alexander and Witt, Karsten and Dodel, Richard and Kalbe, Elke and Kassubek, Jan and Hilker-Roggendorf, R{\"u}diger and Baudrexel, Simon}, title = {Brain age and Alzheimer's-like atrophy are domain-specific predictors of cognitive impairment in Parkinson's disease}, series = {Neurobiology of Aging}, volume = {109}, journal = {Neurobiology of Aging}, issn = {0197-4580}, doi = {10.1016/j.neurobiolaging.2021.08.020}, pages = {31 -- 42}, abstract = {Recently, it was shown that patients with Parkinson's disease (PD) who exhibit an "Alzheimer's disease (AD)-like" pattern of brain atrophy are at greater risk for future cognitive decline. This study aimed to investigate whether this association is domain-specific and whether atrophy associated with brain aging also relates to cognitive impairment in PD. SPARE-AD, an MRI index capturing AD-like atrophy, and atrophy-based estimates of brain age were computed from longitudinal structural imaging data of 178 PD patients and 84 healthy subjects from the LANDSCAPE cohort. All patients underwent an extensive neuropsychological test battery. Patients diagnosed with mild cognitive impairment or dementia were found to have higher SPARE-AD scores as compared to patients with normal cognition and healthy controls. All patient groups showed increased brain age. SPARE-AD predicted impairment in memory, language and executive functions, whereas advanced brain age was associated with deficits in attention and working memory. Data suggest that SPARE-AD and brain age are differentially related to domain-specific cognitive decline in PD. The underlying pathomechanisms remain to be determined.}, language = {en} }