@misc{JenihhinHamdiouiSonzaReordaetal., author = {Jenihhin, Maksim and Hamdioui, Said and Sonza-Reorda, Matteo and Krstic, Milos and Langend{\"o}rfer, Peter and Sauer, Christian and Klotz, Anton and H{\"u}bner, Michael and Nolte, J{\"o}rg and Vierhaus, Heinrich Theodor and Selimis, Georgions and Alexandrescu, Dan and Taouil, Mottaqiallah and Schrijen, Geert-Jan and Sterpone, Luca and Squillero, Giovanni and Dyka, Zoya and Raik, Jaan}, title = {RESCUE: Interdependent Challenges of Reliability, Security and Quality in Nanoelectronic Systems}, series = {ArXiv.org}, journal = {ArXiv.org}, pages = {7}, language = {en} } @misc{SchurigUmehHenzeetal., author = {Schurig, Mona and Umeh, Obinna and Henze, Henriette and Jung, Marie Juliane and Gresing, Lennart and Blanchard, Veronique and Maltzahn, Julia von and H{\"u}bner, Christian and Franzka, Patricia}, title = {Consequences of GMPPB deficiency for neuromuscular development and maintenance}, series = {Frontiers in Molecular Neuroscience}, volume = {17}, journal = {Frontiers in Molecular Neuroscience}, issn = {1662-5099}, doi = {10.3389/fnmol.2024.1356326}, abstract = {Guanosine diphosphate-mannose pyrophosphorylase B (GMPPB) catalyzes the conversion of mannose-1-phosphate and GTP to GDP-mannose, which is required as a mannose donor for the biosynthesis of glycan structures necessary for proper cellular functions. Mutations in GMPPB have been associated with variable neuromuscular disorders such as muscular dystrophy and myasthenic syndromes. Here, we report that GMPPB protein abundance increases during brain and skeletal muscle development, which is accompanied by an increase in overall protein mannosylation. To model the human disorder in mice, we generated heterozygous GMPPB KO mice using CRISPR/Cas9. While we were able to obtain homozygous KO mice from heterozygous matings at the blastocyst stage, homozygous KO embryos were absent beyond embryonic day E8.5, suggesting that the homozygous loss of GMPPB results in early embryonic lethality. Since patients with GMPPB loss-of-function manifest with neuromuscular disorders, we investigated the role of GMPPB in vitro. Thereby, we found that the siRNA-mediated knockdown of Gmppb in either primary myoblasts or the myoblast cell line C2C12 impaired myoblast differentiation and resulted in myotube degeneration. siRNA-mediated knockdown of Gmppb also impaired the neuron-like differentiation of N2A cells. Taken together, our data highlight the essential role of GMPPB during development and differentiation, especially in myogenic and neuronal cell types.}, language = {en} } @misc{MahmoodScharobaSchorlemeretal., author = {Mahmood, Safdar and Scharoba, Stefan and Schorlemer, Jonas and Schulz, Christian and H{\"u}bner, Michael and Reichenbach, Marc}, title = {Detecting Improvised Land-mines using Deep Neural Networks on GPR Image Dataset targeting FPGAs }, series = {IEEE Nordic Circuits and Systems Conference (NORCAS), 25-26 October 2022, Oslo, Norway}, journal = {IEEE Nordic Circuits and Systems Conference (NORCAS), 25-26 October 2022, Oslo, Norway}, publisher = {IEEE}, address = {Piscataway, NJ}, isbn = {979-8-3503-4550-6}, doi = {10.1109/norcas57515.2022.9934735}, pages = {1 -- 7}, language = {en} } @incollection{TsonkovaBoehmHuebneretal., author = {Tsonkova, Penka and B{\"o}hm, Christian and H{\"u}bner, Rico and Ehritt, Julia}, title = {Managing hedgerows to optimise ecosystem services in agroforestry systems}, series = {Agroforestry for sustainable agriculture}, booktitle = {Agroforestry for sustainable agriculture}, editor = {Mosquera-Losada, Mar{\´i}a Rosa and Prabhu, Ravi}, publisher = {Burleigh Dodds Science Publishing}, address = {Cambridge}, isbn = {978-1-78676-220-7}, doi = {10.19103/AS.2018.0041.03}, pages = {39 -- 88}, language = {en} } @inproceedings{TsonkovaBoehmHuebner, author = {Tsonkova, Penka and B{\"o}hm, Christian and H{\"u}bner, Rico}, title = {The biomass potential of existing linear woody-features in the agricultural landscape}, series = {Proceedings of the 4th European Agroforestry Conference Agroforestry as Sustainable Land Use 28-30 May 2018, Nijmegen, The Netherlands}, booktitle = {Proceedings of the 4th European Agroforestry Conference Agroforestry as Sustainable Land Use 28-30 May 2018, Nijmegen, The Netherlands}, editor = {Ferreiro-Dom{\´i}nguez, Nuria and Mosquera-Losada, Mar{\´i}a Rosa}, address = {Santiago de Compostela}, isbn = {978-84-09-02384-4}, pages = {527 -- 531}, abstract = {Linear woody-features, such as hedgerows, windbreaks, and riparian buffer strips, composed of trees and/or shrubs are anthropogenic features, established in the past for different purposes, such as provision of field boundaries, protection from wind and supply of fuelwood. Today, they are primarily valued for their ecological benefit, while their production function has received rather little attention. This study assessed the biomass potential of existing linear woodyfeatures in a study area in southern Brandenburg, Germany. The merchantable tree volume of the measured woody-features ranged between 240 m3 ha-1 and 710 m3 ha-1, depending on the relative proportion of trees and shrubs. The results suggest that the biomass potential of linear woody-features with predominant tree proportion per hectare can be higher than this of forests. A strategy for utilising the production function of these woody-features should take into account the provision of benefits such as wind protection, habitat provision and landscape aesthetics.}, language = {en} } @misc{TsonkovaBoehmEhrittetal., author = {Tsonkova, Penka and B{\"o}hm, Christian and Ehritt, Julia and H{\"u}bner, Rico}, title = {Assessing multiple ecosystem functions of linear woody-features in the agricultural landscape}, series = {Book of Abstracts, 4th World Congress on Agroforestry. Agroforestry: strengthening links between science, society and policy}, journal = {Book of Abstracts, 4th World Congress on Agroforestry. Agroforestry: strengthening links between science, society and policy}, editor = {Dupraz, Christian and Gosme, Marie and Lawson, Gerry}, publisher = {CIRAD, INRA, World Agroforestry}, address = {Montpellier}, pages = {544}, language = {en} } @misc{ShahinHuebnerHerglotz, author = {Shahin, Keyvan and H{\"u}bner, Michael and Herglotz, Christian}, title = {A width-configurable hardware approach for accelerating fixed-point simulation}, series = {IEEE Computer Society Annual Symposium on VLSI (ISVLSI)}, journal = {IEEE Computer Society Annual Symposium on VLSI (ISVLSI)}, publisher = {IEEE}, address = {Piscataway, NJ}, isbn = {979-8-3315-3477-6}, issn = {2159-3477}, doi = {10.1109/ISVLSI65124.2025.11130205}, pages = {6}, abstract = {Fixed-point simulation is a critical step in the design flow of Digital Signal Processing (DSP) systems and consumes a significant portion of the overall development time. This work proposes a novel hardware-based approach to improve the performance of fixed-point simulation through a widthconfigurable architecture implemented on Field-Programmable Gate Arrays (FPGAs). To our knowledge, this is the first reported hardware-based solution for fixed-point simulation reported in the literature, which provides substantial speedup compared to traditional software-based approaches. The presented approach utilizes High-Level Synthesis (HLS) tools to create modular, reusable components that enhance the design reusability. This approach accelerates fixed-point simulation for various applications, requiring only minor modifications to the application code to utilize it. By incorporating simulation capabilities within reusable functions, this work improves the efficiency and adaptability of the fixed-point simulation process. Implementation results for two FIR filter applications show that the proposed methodology is superior to traditional software-based approaches in reducing simulation time by two orders of magnitude and thus has the potential to improve the productivity of the DSP system design flow.}, language = {en} } @misc{MunozHernandezAliShahinetal., author = {Mu{\~n}oz-Hernandez, Hector Gerardo and Ali, Muhammad and Shahin, Keyvan and Siyavashi, Alireza and G{\"o}hringer, Diana and Reichenbach, Marc and Herglotz, Christian and H{\"u}bner, Michael}, title = {Towards complete open-source environments : FPGA-based GPU overlay controlled by RISC-V}, series = {Architecture of computing systems : 38th International Conference, ARCS 2025 Kiel, Germany, April 22-24, 2025, proceedings}, journal = {Architecture of computing systems : 38th International Conference, ARCS 2025 Kiel, Germany, April 22-24, 2025, proceedings}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-032-03280-5}, issn = {0302-9743}, doi = {https://doi.org/10.1007/978-3-032-03281-2_7}, pages = {94 -- 108}, abstract = {Image and signal processing applications have been widely implemented in Field Programmable Gate Arrays (FPGAs) and Graphical Processing Units (GPUs) due to their energy efficiency and performance, respectively. GPUs provide high data processing parallelism and are usually chosen to accelerate applications where low energy consumption is not a high priority. On the other hand, FPGAs are more tailored to hardware solutions due to their reconfigurability, but they struggle to outperform GPUs in data throughput. Soft IP cores implemented on reconfigurable hardware, are an alternative offering advantages from both worlds. Some of these soft-core solutions offer an entire environment that includes scripts to automate their implementation, custom compilers, and other diverse tools. Unfortunately, some of these soft-cores are dependent on proprietary Intellectual Property (IP) or require hardware expertise to use properly. In this work, we propose an extended version of a popular open-source soft GPU, which can now run alongside a soft RISC-V core, and with High-Bandwidth memory (HBM2) compatibility. Previously, this soft GPU was only ready to be deployed in boards with a hard ARM core, but now it can be easily used in FPGAs without this requirement. We also provide an evaluation of how the soft GPU performs with respect to the pure RISC-V core, and a hard ARM core achieving geometric mean speed-ups of 114.60x and 19.72x respectively when performing some image and signal processing applications. Finally, we demonstrate how our soft GPU benefits from the HBM integration.}, language = {en} }