@inproceedings{MaussAhmediFrankeetal., author = {Mauß, Fabian and Ahmedi, Abdelhadi and Franke, A. and Soyhan, Hakan Serhad and Sund{\´e}n, Bengt}, title = {"Prediction Tool for the Ion Current in SI-Combustion"}, language = {en} } @misc{FrostWeissHerteletal., author = {Frost, Fabian and Weiss, Stefan and Hertel, Johannes and R{\"u}hlemann, Malte and Bang, Corinna and Franke, Andre and Nauck, Matthias and D{\"o}rr, Marcus and V{\"o}lzke, Henry and Roggenbuck, Dirk and Schierack, Peter and V{\"o}lker, Uwe and Homuth, Georg and Aghdassi, Ali A. and Sendler, Matthias and Lerch, Markus M. and Weiss, Frank U.}, title = {Fecal glycoprotein 2 is a marker of gut microbiota dysbiosis and systemic inflammation}, series = {Gut Pathogens}, volume = {16}, journal = {Gut Pathogens}, number = {1}, publisher = {Springer Science and Business Media LLC}, issn = {1757-4749}, doi = {10.1186/s13099-024-00657-1}, pages = {1 -- 11}, abstract = {Background autoantigenic glycoprotein 2 (GP2) is an important component of the innate immune system which originates from the exocrine pancreas as well as from the small intestines. The relationship of GP2 with the intestinal microbiome as well as the systemic implications of increased fecal GP2 levels are, however, still unclear. Therefore, fecal samples from 2,812 individuals of the Study of Health in Pomerania (SHIP) were collected to determine GP2 levels (enzyme-linked immunosorbent assay) and gut microbiota profiles (16 S rRNA gene sequencing). These data were correlated and associated with highly standardised and comprehensive phenotypic data of the study participants. Results Fecal GP2 levels were increased in individuals with higher body mass index and smokers, whereas lower levels were found in case of preserved exocrine pancreatic function, female sex or a healthier diet. Moreover, higher GP2 levels were associated with increased serum levels of high-sensitivity C-reactive protein, loss of gut microbial diversity and an increase of potentially detrimental bacteria (Streptococcus, Haemophilus, Clostridium XIVa, or Collinsella). At the same time, predicted microbial pathways for the biosynthesis of beneficial short-chain fatty acids or lactic acid were depleted in individuals with high fecal GP2. Of note, GP2 exhibited a stronger association to overall microbiome variation than calprotectin. Conclusion Fecal GP2 is a biomarker of gut microbiota dysbiosis and associated with increased systemic inflammation. The intestines may be more important as origin for GP2 than pancreatic acinar cells. Future studies need to investigate the potential clinical value in disease specific patient cohorts.}, language = {en} } @misc{StoellnerAaliBoenkeetal., author = {St{\"o}llner, Thomas and Aali, Abolfazl and Boenke, Nicole and Davoudi, Hossein and Draganits, Erich and Fathi, Homa and Franke, Kristina A. and Herd, Rainer and Kosczinski, Katja and Mashkour, Marjan and Mostafapour, Iman and Nezafati, Nima and {\"O}hrstr{\"o}m, Lena and R{\"u}hli, Frank and Saeidi, Sahand and Schapals, Fabian and Schimerl, Nicolas and Sikorski, Beate and Zifar, Hamed}, title = {Salt Mining and Salt Miners at Talkherud-Douzlākh, Northwestern Iran: From Landscape to Resource-Scape}, series = {Journal of World Prehistory}, volume = {2024}, journal = {Journal of World Prehistory}, number = {Volume 37}, doi = {10.1007/s10963-024-09183-z}, pages = {61 -- 140}, abstract = {The Douzlākh salt deposit (region: Māhneshān, Zanjān Province, Iran) is unique for its pure and crystal rock salt and was an important supplier of culinary ('table') salt in Achaemenid, Sassanid and Middle Islamic times. At the same time, the site was of central importance to the economic life of the rural populations in the Talkherud Basin. This article focuses on the question of which strategies were decisive for the exploitation of the salt mountain and how a potential supra-regional interest in the culinary salt was perhaps reciprocally connected with a rural hinterland. This hinterland was recently investigated in greater detail by our ongoing research. Did a resource-scape based on salt develop with specific economic and social strategies and practices around the Douzlākh? And was this development triggered by state or imperial control and demand? These questions are being pursued from a perspective utilising a variety of subjects and methods in archaeology, archaeobiology, archaeometry and geoarchaeology. In addition to a detailed on-site artefact study, several on- and off-site datasets have been collected and analysed within a multidisciplinary framework. This article synthesises the results of a major 12-year project to identify the organisational principles and daily practices within this specific salt-scape. The sensational finds of the Douzlākh salt mummies, along with the generally outstanding preservation of organic ecofacts and artefacts, allow insights into antique lifeworlds that are otherwise hard to come by. The multidisciplinary study of on- and off-site data allows far-reaching insights into interdisciplinary topics, such as the social system, supply and logistics, or the presence of non-local or non-indigenous populations.}, language = {en} }