@misc{SchulzSkrzypczakSchneideretal., author = {Schulz, Christian M. and Skrzypczak, M. and Schneider, Erich and Hapfelmeier, Alexander and Martin, J. and Kochs, Eberhard F. and Schneider, G.}, title = {Assessment of subjective workload in an anaesthesia simulator environment: reliability and validity}, series = {European Journal of Anaesthesiology}, volume = {28}, journal = {European Journal of Anaesthesiology}, number = {7}, issn = {0265-0215}, pages = {502 -- 505}, language = {en} } @incollection{KohlbecherBartlSchneideretal., author = {Kohlbecher, Stefan and Bartl, Klaus and Schneider, Erich and Blume, J{\"u}rgen and Bannat, Alexander and Sosnowski, Stefan and K{\"u}hnlenz, Kolja and Rigoll, Gerhard and Wallhoff, Frank}, title = {Test environment for studying the human-likeness of robotic eye movements}, series = {Biologically Inspired Robotics}, booktitle = {Biologically Inspired Robotics}, editor = {Liu, Yunhui and Sun, Dong}, publisher = {CRC Press}, address = {Boca Raton, Fl}, isbn = {1-4398-5488-2}, pages = {309}, language = {en} } @misc{SchulzSchneiderKohlbecheretal., author = {Schulz, Christian M. and Schneider, Erich and Kohlbecher, Stefan and Hapfelmeier, Alexander and Heuser, Fabian}, title = {The influence of anaesthetists' experience on workload, performance and visual attention during simulated critical incidents}, series = {Journal of Clinical Monitoring and Computing}, volume = {28}, journal = {Journal of Clinical Monitoring and Computing}, number = {5}, issn = {1387-1307}, doi = {10.1007/s10877-013-9443-8}, pages = {475 -- 480}, language = {en} } @misc{RamaioliColagiorgioSağlametal., author = {Ramaioli, Cecilia and Colagiorgio, Paolo and Sağlam, Murat and Heuser, Fabian and Schneider, Erich}, title = {The effect of vestibulo-ocular reflex deficits and covert saccades on dynamic vision in opioid-induced vestibular}, series = {PLoS One}, volume = {9}, journal = {PLoS One}, number = {10}, issn = {1932-6203}, doi = {10.1371/journal.pone.0110322}, pages = {e110322}, language = {en} } @misc{LehnenHeuserSağlametal., author = {Lehnen, Nadine and Heuser, Fabian and Sağlam, Murat and Schulz, Christian M. and Wagner, Klaus J. and Taki, Masakatsu and Kochs, Eberhard F. and Jahn, Klaus and Schneider, Erich}, title = {Opioid-induced nausea involves a vestibular problem preventable by head-rest}, series = {PLoS one}, volume = {10}, journal = {PLoS one}, number = {8}, issn = {1932-6203}, doi = {10.1371/journal.pone.0135263}, pages = {e0135263}, language = {en} } @misc{KuglerHartKohlbecheretal., author = {Kugler, G{\"u}nter and Hart, Bernhard Marius 't and Kohlbecher, Stefan and Einh{\"a}user, Wolfgang and Schneider, Erich}, title = {Gaze in visual search is guided more efficiently by positive cues than by negative cues}, series = {PLoS one}, volume = {10}, journal = {PLoS one}, number = {12}, issn = {1932-6203}, doi = {10.1371/journal.pone.0145910}, pages = {e0145910}, language = {en} } @misc{KuglerHartKohlbecheretal., author = {Kugler, G{\"u}nter and Hart, Bernhard Marius 't and Kohlbecher, Stefan and Bartl, Klaus and Schumann, Frank and Einh{\"a}user, Wolfgang and Schneider, Erich}, title = {Visual search in the real world: Color vision deficiency affects peripheral guidance, but leaves foveal verification largely unaffected}, series = {Frontiers in human neuroscience}, volume = {9}, journal = {Frontiers in human neuroscience}, issn = {1662-5161}, doi = {10.3389/fnhum.2015.00680}, pages = {680}, language = {en} } @misc{LuisZhuCostaetal., author = {Luis, Leonel and Zhu, Hong and Costa, Jo{\~a}o and Valls-Sol{\´e}, Josep and Brandt, Thomas and Zhou, Wu and Schneider, Erich}, title = {Reply to the commentary on luis et al. "spontaneous plugging of the horizontal semicircular canal with reversible canal dysfunction and recovery of vestibular evoked myogenic potentials}, series = {Otology \& Neurotology}, volume = {35}, journal = {Otology \& Neurotology}, number = {2}, issn = {1531-7129}, pages = {379 -- 383}, language = {en} } @misc{KuglerHuppertSchneideretal., author = {Kugler, G{\"u}nter and Huppert, Doreen and Schneider, Erich and Brandt, Thomas}, title = {Fear of heights freezes gaze to the horizon}, series = {Journal of Vestibular Research}, volume = {24}, journal = {Journal of Vestibular Research}, number = {5-6}, issn = {0957-4271}, doi = {10.3233/VES-140529}, pages = {433 -- 441}, language = {en} } @misc{KuglerHuppertEckletal., author = {Kugler, G{\"u}nter and Huppert, Doreen and Eckl, Maria and Schneider, Erich and Brandt, Thomas}, title = {Visual exploration during locomotion limited by fear of heights}, series = {PLoS One}, volume = {9}, journal = {PLoS One}, number = {8}, issn = {1932-6203}, doi = {10.1371/journal.pone.0105906}, pages = {e105906}, language = {en} } @misc{JerinBartlSchneideretal., author = {Jerin, Claudia and Bartl, Klaus and Schneider, Erich and G{\"u}rkov, Robert}, title = {Enhancing the reproducibility of ocular vestibular evoked myogenic potentials by use of a visual target originating from a head-mounted laser}, series = {European Archives of Oto-Rhino-Laryngology}, volume = {272}, journal = {European Archives of Oto-Rhino-Laryngology}, number = {10}, issn = {0937-4477}, doi = {10.1007/s00405-014-3271-4}, pages = {2737 -- 2740}, language = {en} } @misc{HeubergerSağlamToddetal., author = {Heuberger, Maria and Sağlam, Murat and Todd, Nicholas Sean and Jahn, Klaus and Schneider, Erich and Lehnen, Nadine}, title = {Covert anti-compensatory quick eye movements during head impulses}, series = {PLoS One}, volume = {9}, journal = {PLoS One}, number = {4}, issn = {1932-6203}, doi = {10.1371/journal.pone.0093086}, pages = {e93086}, language = {en} } @misc{HelmchenMachnerLehnenetal., author = {Helmchen, Christoph and Machner, Bj{\"o}rn and Lehnen, Nadine and Jahn, Klaus and Schneider, Erich}, title = {Current state of diagnostic management of acute vertigo: a survey of neurologists in Germany}, series = {Journal of Neurology}, volume = {261}, journal = {Journal of Neurology}, number = {8}, issn = {0340-5354}, doi = {10.1007/s00415-014-7405-9}, pages = {1638 -- 1640}, language = {en} } @misc{AgrawalSchubertMigliaccioetal., author = {Agrawal, Yuri and Schubert, Michael C. and Migliaccio, Americo A. and Zee, David S. and Schneider, Erich and Lehnen, Nadine}, title = {Evaluation of quantitative head impulse testing using search coils versus video-oculography in older individuals}, series = {Otology \& neurotology}, volume = {35}, journal = {Otology \& neurotology}, number = {2}, issn = {1537-4505}, doi = {10.1097/MAO.0b013e318287f343}, pages = {283 -- 288}, language = {en} } @misc{SrulijesMackKlenketal., author = {Srulijes, Karin and Mack, David J. and Klenk, Jochen and Ihlen, Espen A. F. and Schwenk, Michael and Lindemann, Ulrich and Schneider, Erich}, title = {Association between vestibulo-ocular reflex suppression, balance, gait, and fall risk in ageing and neurodegenerative disease: protocol of a one-year prospective follow-up study.}, series = {BMC Neurol}, volume = {15}, journal = {BMC Neurol}, issn = {1471-2377}, doi = {10.1186/s12883-015-0447-5}, pages = {192}, language = {en} } @misc{SchneiderVillgrattnerVockerothetal., author = {Schneider, Erich and Villgrattner, Thomas and Vockeroth, Johannes and Bartl, Klaus and Kohlbecher, Stefan and Bardins, Stanislav and Ulbrich, Heinz and Brandt, Thomas}, title = {Eyeseecam: an eye movement-driven head camera for the examination of natural visual exploration}, series = {Annals of the New York Academy of Sciences}, volume = {1164}, journal = {Annals of the New York Academy of Sciences}, issn = {1749-6632}, doi = {10.1111/j.1749-6632.2009.03858.x}, pages = {461 -- 467}, language = {en} } @misc{SchneiderBartlGlasauer, author = {Schneider, Erich and Bartl, Klaus and Glasauer, Stefan}, title = {Galvanic vestibular stimulation combines with earth-horizontal rotation in roll to induce the illusion of translation.}, series = {Annals of the New York Academy of Sciences}, volume = {1164}, journal = {Annals of the New York Academy of Sciences}, issn = {1749-6632}, doi = {10.1111/j.1749-6632.2008.03732.x}, pages = {116 -- 118}, language = {en} } @misc{HartVockerothSchumannetal., author = {Hart, Bernhard Marius 't and Vockeroth, Johannes and Schumann, Frank and Bartl, Klaus and Schneider, Erich and K{\"o}nig, Peter and Einh{\"a}user, Wolfgang}, title = {Gaze allocation in natural stimuli: Comparing free exploration to head-fixed viewing conditions.}, series = {Visual Cognition}, volume = {17}, journal = {Visual Cognition}, number = {6-7}, issn = {1350-6285}, doi = {10.1080/13506280902812304}, pages = {1132 -- 1158}, language = {en} } @misc{SpiegelKallaClaassenetal., author = {Spiegel, Rainer and Kalla, Roger and Claassen, Jens and Bardins, Stanislav and Anci{\~a}es da Silva, F{\´a}bio and Farahmand, Parvis and Hahn, Ales and Schneider, Erich}, title = {Aminopyridine treatment in a patient with bilateral vestibular failure and cryptogenic downbeat nystagmus}, series = {Journal of Neuro-Ophthalmology}, volume = {32}, journal = {Journal of Neuro-Ophthalmology}, number = {2}, issn = {1536-5166}, pages = {190}, language = {en} } @misc{VillgrattnerSchneiderAnderschetal., author = {Villgrattner, Thomas and Schneider, Erich and Andersch, Philipp and Ulbrich, Heinz}, title = {Compact high dynamic 3 DoF camera orientation system: Development and control}, series = {Journal of System Design and Dynamics}, volume = {5}, journal = {Journal of System Design and Dynamics}, number = {5}, issn = {1881-3046}, doi = {10.1299/jsdd.5.819}, pages = {819 -- 828}, language = {en} } @misc{KohlbecherSchneider, author = {Kohlbecher, Stefan and Schneider, Erich}, title = {On-line classification and prediction of eye movements by multiplemodel kalman filtering}, series = {Annals of the New York Academy of Sciences}, volume = {1164}, journal = {Annals of the New York Academy of Sciences}, issn = {1749-6632}, doi = {10.1111/j.1749-6632.2009.03776.x}, pages = {400 -- 402}, language = {en} } @misc{EinhaeuserMoellerSchumannetal., author = {Einh{\"a}user, Wolfgang and Moeller, Gudrun U. and Schumann, Frank and Conradt, J{\"o}rg and Vockeroth, Johannes and Bartl, Klaus and Schneider, Erich and K{\"o}nig, Peter}, title = {Eye-head coordination during free exploration in human and cat.}, series = {Annals of the New York Academy of Sciences}, volume = {1164}, journal = {Annals of the New York Academy of Sciences}, issn = {1749-6632}, doi = {10.1111/j.1749-6632.2008.03709.x}, pages = {353 -- 366}, language = {en} } @misc{BartlLehnenKohlbecheretal., author = {Bartl, Klaus and Lehnen, Nadine and Kohlbecher, Stefan and Schneider, Erich}, title = {Head impulse testing using video-oculography}, series = {Annals of the New York Academy of Sciences}, volume = {1164}, journal = {Annals of the New York Academy of Sciences}, issn = {1749-6632}, doi = {10.1111/j.1749-6632.2009.03850.x}, pages = {331 -- 333}, language = {en} } @misc{SchneiderJahnDieterichetal., author = {Schneider, Erich and Jahn, Klaus and Dieterich, Marianne and Brandt, Thomas and Strupp, Michael}, title = {Gait deviations induced by visual stimulation in roll}, series = {Experimental Brain Research}, volume = {185}, journal = {Experimental Brain Research}, number = {1}, issn = {0014-4819}, doi = {10.1007/s00221-007-1134-6}, pages = {21 -- 26}, language = {en} } @misc{SchumannEinhaeuserVockerothetal., author = {Schumann, Frank and Einh{\"a}user, Wolfgang and Vockeroth, Johannes and Bartl, Klaus and Schneider, Erich and K{\"o}nig, Peter}, title = {Salient features in gaze-aligned recordings of human visual input during free exploration of natural environments}, series = {Journal of Vision}, volume = {8}, journal = {Journal of Vision}, number = {14}, issn = {1534-7362}, doi = {10.1167/8.14.12}, pages = {1210 -- 1217}, language = {en} } @misc{LuisCostaVazGarciaetal., author = {Luis, Leonel and Costa, Jo{\~a}o and Vaz Garcia, Fernando and Valls-Sol{\´e}, Josep and Brandt, Thomas and Schneider, Erich}, title = {Spontaneous plugging of the horizontal semicircular canal with reversible canal dysfunction and recovery of vestibular evoked myogenic potentials}, series = {Otology \& neurotology}, volume = {34}, journal = {Otology \& neurotology}, number = {4}, issn = {1537-4505}, pages = {743 -- 747}, language = {en} } @misc{ClaassenSpiegelKallaetal., author = {Claassen, Jens and Spiegel, Rainer and Kalla, Roger and Faldon, Mary and Kennard, Christopher and Schneider, Erich}, title = {A randomised double-blind, cross-over trial of 4-aminopyridine for downbeat nystagmus-effects on slowphase eye velocity, postural stability, locomotion and symptoms}, series = {Journal of neurology, neurosurgery, and psychiatry}, volume = {84}, journal = {Journal of neurology, neurosurgery, and psychiatry}, number = {12}, issn = {0022-3050}, doi = {10.1136/jnnp-2012-304736}, pages = {1392 -- 1399}, language = {en} } @misc{ClaassenFeilBardinsetal., author = {Claassen, Jens and Feil, Katharina and Bardins, Stanislav and Teufel, Julian and Spiegel, Rainer and Kalla, Roger and Schneider, Erich}, title = {Dalfampridine in patients with downbeat nystagmus-an observational study}, series = {Journal of Neurology}, volume = {260}, journal = {Journal of Neurology}, number = {8}, issn = {0340-5354}, doi = {10.1007/s00415-013-6911-5}, pages = {1992 -- 1996}, language = {en} } @misc{BrandtGlasauerSchneider, author = {Brandt, Thomas and Glasauer, Stefan and Schneider, Erich}, title = {A third eye for the surgeon}, series = {Journal of neurology, neurosurgery, and psychiatry}, volume = {77}, journal = {Journal of neurology, neurosurgery, and psychiatry}, number = {2}, issn = {0022-3050}, doi = {10.1136/jnnp.2005.073734}, pages = {278}, language = {en} } @misc{JahnNaesslSchneideretal., author = {Jahn, Klaus and Naeßl, Andrea and Schneider, Erich and Strupp, Michael and Brandt, Thomas and Dieterich, Marianne}, title = {Inverse u-shaped curve for age dependency of torsional eye movement responses to galvanic vestibular stimulation}, series = {Brain}, volume = {126}, journal = {Brain}, number = {7}, issn = {1460-2156}, doi = {10.1093/brain/awg163}, pages = {1579 -- 1589}, language = {en} } @misc{JahnNaesslStruppetal., author = {Jahn, Klaus and Naeßl, Andrea and Strupp, Michael and Schneider, Erich and Brandt, Thomas and Dieterich, Marianne}, title = {Torsional eye movement responses to monaural and binaural galvanic vestibular stimulation: side-to-side asymmetries.}, series = {Annals of the New York Academy of Sciences}, volume = {1004}, journal = {Annals of the New York Academy of Sciences}, issn = {0077-8923}, doi = {10.1111/j.1749-6632.2003.tb00265.x}, pages = {485 -- 489}, language = {en} } @misc{JahnStruppSchneideretal., author = {Jahn, Klaus and Strupp, Michael and Schneider, Erich and Dieterich, Marianne and Brandt, Thomas}, title = {Visually induced gait deviations during different locomotion speeds}, series = {Experimental Brain Research}, volume = {141}, journal = {Experimental Brain Research}, number = {3}, issn = {0014-4819}, doi = {10.1007/s002210100884}, pages = {370 -- 374}, language = {en} } @misc{SchneiderGlasauerDieterich, author = {Schneider, Erich and Glasauer, Stefan and Dieterich, Marianne}, title = {Central processing of human ocular torsion analyzed by galvanic vestibular stimulation}, series = {Neuroreport}, volume = {11}, journal = {Neuroreport}, number = {7}, issn = {0959-4965}, pages = {1559 -- 1563}, language = {en} } @misc{JahnStruppSchneideretal., author = {Jahn, Klaus and Strupp, Michael and Schneider, Erich and Dieterich, Marianne and Brandt, Thomas}, title = {Differential effects of vestibular stimulation on walking and running}, series = {Neuroreport}, volume = {11}, journal = {Neuroreport}, number = {8}, issn = {1473-558X}, pages = {1745 -- 1748}, language = {en} } @misc{StephanDeutschlaenderNolteetal., author = {Stephan, Thomas and Deutschl{\"a}nder, Angela and Nolte, Annina and Schneider, Erich and Wiesmann, Martin and Brandt, Thomas and Dieterich, Marianne}, title = {Functional mri of galvanic vestibular stimulation with alternating currents at different frequencies}, series = {Neuroimage}, volume = {26}, journal = {Neuroimage}, number = {3}, issn = {1053-8119}, doi = {10.1016/j.neuroimage.2005.02.049}, pages = {721 -- 732}, language = {en} } @misc{GlasauerSchneiderJahnetal., author = {Glasauer, Stefan and Schneider, Erich and Jahn, Klaus and Strupp, Michael}, title = {How the eyes move the body}, series = {Neurology}, volume = {65}, journal = {Neurology}, number = {8}, issn = {0028-3878}, doi = {10.1212/01.wnl.0000175132.01370.fc}, pages = {1291 -- 1293}, language = {en} } @misc{BartlSchneiderGlasauer, author = {Bartl, Klaus and Schneider, Erich and Glasauer, Stefan}, title = {Dependence of the torsional vestibulo-ocular reflex on the direction of gravity}, series = {Annals of the New York Academy of Sciences}, volume = {1039}, journal = {Annals of the New York Academy of Sciences}, issn = {1749-6632}, doi = {10.1196/annals.1325.043}, pages = {455 -- 458}, language = {en} } @inproceedings{StollKohlbecherMarxetal., author = {Stoll, Josef and Kohlbecher, Stefan and Marx, Svenja and Schneider, Erich and Einh{\"a}user, Wolfgang}, title = {Mobile three dimensional gaze tracking}, series = {Medicine meets virtual reality 18}, booktitle = {Medicine meets virtual reality 18}, editor = {Westwood, James D.}, publisher = {IOS Press}, address = {Amsterdam}, isbn = {978-1-60750-705-5}, pages = {616 -- 622}, language = {en} } @inproceedings{KohlbecherBartlBardinsetal., author = {Kohlbecher, Stefan and Bartl, Klaus and Bardins, Stanislav and Schneider, Erich}, title = {Low-latency combined eye and head tracking system for teleoperating a robotic head in real-time}, series = {Proceedings of the 2010 Symposium on EyeTracking Research \& Applications}, booktitle = {Proceedings of the 2010 Symposium on EyeTracking Research \& Applications}, publisher = {ACM Press}, address = {New York}, isbn = {978-1-60558-994-7}, doi = {10.1145/1743666.1743695}, pages = {117 -- 120}, language = {en} } @inproceedings{VockerothBartlPfanzeltetal., author = {Vockeroth, Johannes and Bartl, Klaus and Pfanzelt, Sandra and Schneider, Erich}, title = {Medical documentation using a gaze-driven camera}, series = {Medicine meets virtual reality 17}, booktitle = {Medicine meets virtual reality 17}, editor = {Westwood, James D.}, publisher = {IOS Press}, address = {Amsterdam}, isbn = {978-160-750-402-3}, pages = {413 -- 416}, language = {en} } @inproceedings{SchneiderKohlbecherBartletal., author = {Schneider, Erich and Kohlbecher, Stefan and Bartl, Klaus and Wallhoff, Frank and Brandt, Thomas}, title = {Experimental platform for wizard-of-oz evaluations of biomimetic active vision in robots}, series = {IEEE International Conference on Robotics and Biomimetics (ROBIO), 2009, 19 - 23 Dec. 2009, Guilin, China}, booktitle = {IEEE International Conference on Robotics and Biomimetics (ROBIO), 2009, 19 - 23 Dec. 2009, Guilin, China}, publisher = {IEEE}, address = {Piscataway, NJ}, isbn = {978-1-4244-4774-9}, pages = {1484 -- 1489}, language = {en} } @misc{SchneiderGlasauerBrandtetal., author = {Schneider, Erich and Glasauer, Stefan and Brandt, Thomas and Dieterich, Marianne}, title = {Nonlinear nystagmus processing causes torsional vor nonlinearity}, series = {Annals of the New York Academy of Sciences}, volume = {1004}, journal = {Annals of the New York Academy of Sciences}, issn = {1749-6632}, pages = {500 -- 505}, language = {en} } @misc{StruppGlasauerJahnetal., author = {Strupp, Michael and Glasauer, Stefan and Jahn, Klaus and Schneider, Erich and Krafczyk, Siegbert and Brandt, Thomas}, title = {Eye movements and balance}, series = {Annals of the New York Academy of Sciences}, volume = {1004}, journal = {Annals of the New York Academy of Sciences}, issn = {1749-6632}, pages = {352 -- 358}, language = {en} } @misc{StruppGlasauerSchneideretal., author = {Strupp, Michael and Glasauer, Stefan and Schneider, Erich and Eggert, Thomas and Glaser, Miriam}, title = {Anterior canal failure: ocular torsion without perceptual tilt due to preserved otolith function}, series = {Journal of Neurology Neurosurgery \& Psychiatry}, volume = {74}, journal = {Journal of Neurology Neurosurgery \& Psychiatry}, number = {9}, issn = {1468-330X}, doi = {10.1136/jnnp.74.9.1336}, pages = {1336 -- 1338}, language = {en} } @misc{HeuserSchulzSağlametal., author = {Heuser, Fabian and Schulz, Christian and Sağlam, Murat and Ramaioli, Cecilia and Heuberger, Maria and Wagner, Klaus J. and Jahn, Klaus and Schneider, Erich and Brandt, Thomas and Glasauer, Stefan and Lehnen, Nadine}, title = {Preventing opioid-induced nausea and vomiting: Rest your head and close your eyes?}, series = {PloS one}, volume = {12}, journal = {PloS one}, number = {3}, issn = {1932-6203}, doi = {10.1371/journal.pone.0173925}, pages = {e0173925}, language = {en} } @misc{LehnenKellererKnorretal., author = {Lehnen, Nadine and Kellerer, Silvy and Knorr, Alexander G. and Schlick, Cornelia and Jahn, Klaus and Schneider, Erich and Heuberger, Maria and Ramaioli, Cecilia}, title = {Head-Movement-Emphasized Rehabilitation in Bilateral Vestibulopathy}, series = {Frontiers in Neurology}, volume = {9}, journal = {Frontiers in Neurology}, issn = {1664-2295}, doi = {10.3389/fneur.2018.00562}, pages = {6}, language = {en} } @misc{HeubergerGrillSaglametal., author = {Heuberger, Maria and Grill, Eva and Saglam, Murat and Ramaioli, Cecilia and M{\"u}ller, Martin and Strobl, Ralf and Holle, Rolf and Peters, Annette and Schneider, Erich and Lehnen, Nadine}, title = {Usability of the Video Head Impulse Test: Lessons from the Population-Based Prospective KORA Study}, series = {Frontiers in Neurology}, volume = {9}, journal = {Frontiers in Neurology}, issn = {1664-2295}, doi = {10.3389/fneur.2018.00659}, pages = {7}, language = {en} } @misc{SchoeberlIrvingPradhanetal., author = {Sch{\"o}berl, Florian and Irving, Stephanie and Pradhan, Cauchy and Bardins, Stanislav and Trapp, Christoph and Schneider, Erich and Kugler, G{\"u}nter and Bartenstein, Peter and Dietrich, Marianne and Brandt, Thomas and Zwergal, Andreas}, title = {Prolonged allocentric navigation deficits indicate hippocampal damage in TGA}, series = {Neurology : official journal of the American Academy of Neurology}, volume = {92}, journal = {Neurology : official journal of the American Academy of Neurology}, number = {3}, issn = {0028-3878}, doi = {10.1212/WNL.0000000000006779}, pages = {e234 -- e243}, abstract = {Objective To investigate long-term recovery of allocentric and egocentric spatial orientation as a sensitive marker for hippocampal and extrahippocampal network function in transient global amnesia (TGA). Methods A group of 18 patients with TGA performed an established real-space navigation paradigm, requiring allo- and egocentric spatial orientation abilities, 3 days (postacute stage) and 3 months (follow-up) after symptom onset. Visual exploration behavior and navigation strategy were documented by a gaze-controlled, head-fixed camera. Allo- and egocentric spatial orientation performance was compared to that of 12 age-matched healthy controls. Navigation-induced brain activations were measured using [18F]-fluorodeoxyglucose-PET in a subgroup of 8 patients in the postacute stage and compared to those of the controls. Results In the postacute stage, the patients navigated worse and had higher error rates than controls in allocentric (p = 0.002), but not in egocentric, route planning (p = 0.30), despite complete recovery of verbal (p = 0.58) and figural memory (p = 0.11). Until follow-up, allocentric navigation deficits improved, but higher error rates and reduced use of shortcuts persisted (p < 0.0001). Patients still exhibited relatively more fixations of unique landmarks during follow-up (p = 0.05). PET measurements during the postacute stage showed increased navigation-induced brain activations in the right hippocampus, bilateral retrosplenial, parietal, and mesiofrontal cortices, and cerebellar dentate nucleus in patients compared to controls (p < 0.005). Conclusions Patients with TGA show selective and prolonged deficits of allocentric spatial orientation. Activations in right hippocampal and extrahippocampal hubs of the cerebral navigation network functionally substitute for the deficit in creating and updating the internal cognitive map in TGA.}, language = {en} } @misc{GrillHeubergerStrobletal., author = {Grill, Eva and Heuberger, Maria and Strobl, Ralf and Saglam, Murat and Holle, Rolf and Linkohr, Birgit and Ladwig, Karl-Heinz and Peters, Annette and Schneider, Erich and Jahn, Klaus and Lehnen, Nadine}, title = {Prevalence, determinants, and consequences of vestibular hypofunction. results from the kora-ff4 survey}, series = {Frontiers in Neurology}, volume = {9}, journal = {Frontiers in Neurology}, issn = {1664-2295}, doi = {10.3389/fneur.2018.01076}, pages = {8}, abstract = {Objective: Uni- or bilateral vestibular hypofunction (VH) impairs balance and mobility, and may specifically lead to injury from falls and to disability. The extent of this problem in the general population is still unknown and most likely to be underestimated. Objective of this study was to determine the prevalence, determinants, and consequences of VH in the general population. Methods: Data originates from the cross-sectional second follow-up (FF4) in 2013/14 of the KORA (Cooperative Health Research in the Region of Augsburg)-S4 study (1999-2001) from Southern Germany. This was a random sample of the target population consisting of all residents of the region aged 25-74 years in 1999. We included all participants who reported moderate or severe vertigo or dizziness during the last 12 months and a random sub-sample of participants representative for the general population without vertigo or dizziness during the last 12 months were tested. VH was assessed with the Video-Head Impulse Test (vHIT). Trained examiners applied high-acceleration, small-amplitude passive head rotations ("head impulses") to the left and right in the plane of the horizontal semicircular canals while participants fixated a target straight ahead. During head impulses, head movements were measured with inertial sensors, eye movements with video-oculography (EyeSeeCam vHIT). Results: A total of 2,279 participants were included (mean age 60.8 years, 51.6\% female), 570 (25.0\%) with moderate or severe vertigo or dizziness during the last 12 months. Of these, 450 were assessed with vHIT where 26 (5.8\%) had unilateral VH, and 16 (3.6\%) had bilateral VH. Likewise, 190 asymptomatic participants were tested. Of these 5 (2.6\%) had unilateral VH, and 2 (1.1\%) had bilateral VH. Prevalence of uni- or bilateral VH among tested symptomatic participants was 2.4\% in those < 48 years, and 32.1\% in individuals aged 79 and over. Age-adjusted prevalence was 6.7\% (95\% CI 4.8\%; 8.6\%). VH was associated with worse health, falls, hearing loss, hearing impairment, and ear pressure. Conclusion: VH may affect between 53 and 95 million adults in Europe and the US. While not all affected persons will experience the full spectrum of symptoms and consequences, adequate diagnostic and therapeutic measures should become standard of care to decrease the burden of disease.}, language = {en} } @misc{DonaldTanChakrapanietal., author = {Donald, Aimee and Tan, Chong Y. and Chakrapani, Anupam and Hughes, Derralyn A. and Sharma, Reena and Cole, Duncan and Bardins, Stanislav and Gorges, Martin and Jones, Simon A. and Schneider, Erich}, title = {Eye movement biomarkers allow for the definition of phenotypes in Gaucher Disease}, series = {Orphanet journal of rare diseases : OJRD}, volume = {15}, journal = {Orphanet journal of rare diseases : OJRD}, issn = {1750-1172}, doi = {10.1186/s13023-020-01637-9}, pages = {12}, abstract = {Background: Neurological forms of Gaucher disease, the inherited disorder of β-Glucosylceramidase caused by bi-allelic variants in GBA1, is a progressive disorder which lacks a disease-modifying therapy. Systemic manifestations of disease are effectively treated with enzyme replacement therapy, however, molecules which cross the blood-brain barrier are still under investigation. Clinical trials of such therapeutics require robust, reproducible clinical endpoints to demonstrate efficacy and clear phenotypic definitions to identify suitable patients for inclusion in trials. The single consistent clinical feature in all patients with neuronopathic disease is the presence of a supranuclear saccadic gaze palsy, in the presence of Gaucher disease this finding serves as diagnostic of 'type 3' Gaucher disease.}, language = {en} }