@incollection{ScholaskeSpallekEntringer, author = {Scholaske, Laura and Spallek, Jacob and Entringer, Sonja}, title = {Intergenerationale {\"U}bertragung von Migrationserfahrungen und fetale Programmierung von Krankheit und Gesundheit}, series = {Handbuch Migration und Gesundheit : Grundlagen, Perspektiven und Strategien}, booktitle = {Handbuch Migration und Gesundheit : Grundlagen, Perspektiven und Strategien}, editor = {Spallek, Jacob and Zeeb, Hajo}, edition = {1}, publisher = {Hogrefe AG}, address = {Bern}, isbn = {978-3-456-85995-8}, pages = {351 -- 368}, abstract = {Gesundheitsdisparit{\"a}ten manifestieren sich in der Nachkommengeneration von Migrant*innen teilweise schon in fr{\"u}hen Lebensjahren. Viele dieser Gesundheits-disparit{\"a}ten werden durch sozio{\"o}konomische Benachteiligung und Akkulturation vermittelt. Anhand des Konzeptes der fetalen Pro-grammierung kann erkl{\"a}rt werden, dass das m{\"u}tterliche Stresserleben - vermittelt {\"u}ber endokrine und immunologische Prozesse - die sp{\"a}tere Gesundheit und Krank-heitsvulnerabilit{\"a}t der Nachkommen bereits in der Schwangerschaft beeinflusst. Es gibt aus der internationalen Forschung zahlreiche Belege daf{\"u}r, dass endokrine und immunologische Prozesse den Zusam-menhang zwischen m{\"u}tterlichen migrationsbezogenen Stressoren und Schwangerschafts-, Geburts- und sp{\"a}teren Gesundheitsoutcomes des Kindes vermitteln. Bei Migrant*innen in Deutschland sind diese Zusammenh{\"a}nge weitestgehend unterforscht.}, language = {de} } @misc{ScholaskeSpallekEntringer, author = {Scholaske, Laura and Spallek, Jacob and Entringer, Sonja}, title = {Fetale Programmierung von Gesundheitsdisparit{\"a}ten bei Kindern mit Migrationshintergrund}, series = {Public Health Forum}, volume = {29}, journal = {Public Health Forum}, number = {2}, issn = {1876-4851}, doi = {10.1515/pubhef-2021-0015}, pages = {131 -- 134}, abstract = {Kinder von Migrant*innen zeigen bereits in fr{\"u}hen Lebensjahren h{\"a}ufig Gesundheitsdisparit{\"a}ten, die mit m{\"u}tterlicher Gesundheit und migrationsbezogenen Faktoren eng zusammenh{\"a}ngen. Zur Erkl{\"a}rung dieses Ph{\"a}nomens der intergenerationalen Transmission von Gesundheitsdisparit{\"a}ten schlagen wir ein Modell vor, das eine Lebensverlaufsperspektive mit dem Konzept der fetalen Programmierung von Gesundheit und Krankheitsvulnerabilit{\"a}t zusammenbringt.}, language = {de} } @misc{SpallekScholaskeDumanetal., author = {Spallek, Jacob and Scholaske, Laura and Duman, Elif Aysimi and Razum, Oliver and Entringer, Sonja}, title = {Association of maternal migrant background with inflammation during pregnancy - results of a birth cohort study in Germany}, series = {Brain, Behavior, and Immunity}, volume = {Vol. 96}, journal = {Brain, Behavior, and Immunity}, issn = {1090-2139}, doi = {10.1016/j.bbi.2021.06.010}, pages = {271 -- 278}, abstract = {Background Health disparities in children of immigrants are prevalent from birth and are hypothesized to - in part - emerge as a biological consequence of migration's unfavorable social and psychological sequelae. The aim of this study was to examine whether maternal migrant background is associated with inflammation during pregnancy - a key pathway by which maternal states and conditions during pregnancy may influence fetal development and subsequent pregnancy, birth, and child developmental and health outcomes. Material and Methods Data was available from 126 pregnant women who participated in a population based multi-site prospective birth cohort study in Bielefeld and Berlin, Germany. The study included two study visits in mid- and late pregnancy. At each visit, a composite maternal pro-inflammatory score was derived from circulating levels of plasma inflammatory markers (IL-6, CRP). Migrant background was defined by country of origin of participants and their parents' (Turkey or other) and generation status (1st or 2nd generation). We applied hierarchical linear models (HLM) in order to quantify the relationship between different migrant background variables and inflammation during pregnancy after adjustment for potential confounders (including socioeconomic status). Results Migrant background was significantly associated with inflammation during pregnancy. When compared to women without migrant background, levels of inflammation were increased in 1) pregnant women with migrant background in general (B = 0.35, SE = 0.12, p < .01); 2) 1st (B = 0.28, SE = 0.15, p < .10) and 2nd generation (B = 0.40, SE = 0.15, p < .01); 3) women with a Turkish migrant background (B = 0.28, SE = 0.14, p < .10) and women with another migrant background (B = 0.42, SE = 0.15, p <.01); and 4) 2nd generation Turkish origin women (B = 0.38, SE = 0.20, p <.10), 1st generation women with other migrant background (B = 0.44, SE = 0.26, p <.10), and 2nd generation women with other migrant background (B=0.43, SE = 0.17, p <.05). Discussion Our findings support a role for maternal inflammation as a pathway of intergenerational transmission of migration-related health inequalities, suggest that the effect seems to persist in 2nd generation immigrants, and highlight the need for future research and targeted interventions in this context.}, language = {en} }