@misc{KammererSokolowskiHackletal., author = {Kammerer, Sarah and Sokolowski, Armin Andreas and Hackl, Hubert and Platzer, Dieter and Jahn, Stephan Wenzel and El-Heliebi, Amin and Schwarzenbacher, Daniela and Stiegelbauer, Verena and Pichler, Martin and Rezania, Simin and Fiegl, Heidelinde and Peintinger, Florentia and Regitnig, Peter and H{\"o}fler, Gerald and Schreibmayer, Wolfgang and Bauernhofer, Thomas}, title = {KCNJ3 is a new independent prognostic marker for estrogen receptor positive breast cancer patients}, series = {OncoTarget : open access impact journal}, volume = {7}, journal = {OncoTarget : open access impact journal}, number = {51}, doi = {10.18632/oncotarget.13224}, pages = {84705 -- 84717}, abstract = {Numerous studies showed abnormal expression of ion channels in different cancer types. Amongst these, the potassium channel gene KCNJ3 (encoding for GIRK1 proteins) has been reported to be upregulated in tumors of patients with breast cancer and to correlate with positive lymph node status. We aimed to study KCNJ3 levels in different breast cancer subtypes using gene expression data from the TCGA, to validate our findings using RNA in situ hybridization in a validation cohort (GEO ID GSE17705), and to study the prognostic value of KCNJ3using survival analysis. In a total of > 1000 breast cancer patients of two independent data sets we showed a) that KCNJ3 expression is upregulated in tumor tissue compared to corresponding normal tissue (p < 0.001), b) that KCNJ3 expression is associated with estrogen receptor (ER) positive tumors (p < 0.001), but that KCNJ3 expression is variable within this group, and c) that ER positive patients with high KCNJ3 levels have worse overall (p < 0.05) and disease free survival probabilities (p < 0.01), whereby KCNJ3 is an independent prognostic factor (p <0.05). In conclusion, our data suggest that patients with ER positive breast cancer might be stratified into high risk and low risk groups based on the KCNJ3 levels in the tumor.}, language = {en} } @inproceedings{HendlerBestleFlassig, author = {Hendler, Marco and Bestle, Dieter and Flassig, Peter Michael}, title = {Cloning Strategy for Aerodynamic Compressor Design based on Throughflow Analysis}, series = {Proceedings of Montreal 2018, Global Power and Propulsion Forum, 7-9.05.2018}, booktitle = {Proceedings of Montreal 2018, Global Power and Propulsion Forum, 7-9.05.2018}, pages = {8}, abstract = {Due to their high complexity, aero engine development is a time-consuming and cost-intensive process. Therefore, pre-developed proven aerodynamic and geometric compressor information is often used as starting point and transferred to new compressor designs. In the present paper, a new approach for aerodynamic cloning of an already existing compressor flow to a new compressor geometry by use of a streamline curvature based Throughflow solver is presented. Parameterized compressor quantities are automatically modified with the help of optimization strategies, and the resulting compressor aerodynamics are compared to a reference design in each iteration step. The target is to minimize the discrepancy between reference design and new design regarding essential flow parameters like de Haller number, Mach number etc., and thereby to reproduce the aerodynamic image of the reference design. Thus, already collected experience from existing compressor flow fields can be used to reduce costs for developing as well as testing of new compressor configurations. Conducted investigations show a notable acceleration of the design process in comparison to former strategies starting from scratch while achieving an acceptable compliance of aerodynamic parameters.}, language = {en} } @inproceedings{ExtraLockanBestleetal., author = {Extra, Simon and Lockan, Michael and Bestle, Dieter and Flassig, Peter Michael}, title = {A Comparison of Strategies for Efficient Core Engine Optimization with Coupled Subsystems}, series = {Proceedings of Montreal 2018, Global Power and Propulsion Forum, 7-9.05.2018}, booktitle = {Proceedings of Montreal 2018, Global Power and Propulsion Forum, 7-9.05.2018}, pages = {8}, abstract = {The present paper compares four different optimization strategies for decoupled optimization in the context of preliminary core engine design for aero engines. An optimization with the AAO (All-At-Once) approach is performed as a baseline and compared against the performance and results of three cascaded optimization strategies: CO (Collaborative Optimization), BLISS 2000 (Bi-Level Integrated System Synthesis) and ISOC (Interface Segmentation Optimization Concept). The optimization problem is based on a thermodynamic core engine model representing an industrial application example. The results are assessed with respect to typical requirements for multidisciplinary core engine design. The impact of the used optimization strategy on the performance of the optimization concept is investigated and discussed.}, language = {en} } @inproceedings{ExtraLockanBestleetal., author = {Extra, Simon and Lockan, Michael and Bestle, Dieter and Flassig, Peter Michael}, title = {Coupled Subsystem Optimization for Preliminary Core Engine Design}, series = {Evolutionary and deterministic methods for design optimization and control with applications to industrial and societal problems, Sep. 13-15, 2017 in Madrid, Spain, EUROGEN 2017, Book of abstracts}, booktitle = {Evolutionary and deterministic methods for design optimization and control with applications to industrial and societal problems, Sep. 13-15, 2017 in Madrid, Spain, EUROGEN 2017, Book of abstracts}, publisher = {Technical University}, address = {Madrid}, isbn = {978-84-697-5112-1}, language = {en} } @misc{HendlerBestleFlassig, author = {Hendler, Marco and Bestle, Dieter and Flassig, Peter Michael}, title = {Component-specific Engine Design Taking into Account Holistic Design Aspects}, series = {International Journal of Turbomachinery, Propulsion and Power}, volume = {3}, journal = {International Journal of Turbomachinery, Propulsion and Power}, number = {2}, issn = {2504-186X}, doi = {10.3390/ijtpp3020012}, pages = {1 -- 16}, language = {en} } @inproceedings{ExtraLockanBestleetal., author = {Extra, Simon and Lockan, Michael and Bestle, Dieter and Flassig, Peter Michael}, title = {Coupled Subsystem Optimiziation for Preliminary Core Engine Design}, series = {Evolutionary and Deterministic Methods for Design Optimization and Control With Applications to Industrial and Societal Problems}, booktitle = {Evolutionary and Deterministic Methods for Design Optimization and Control With Applications to Industrial and Societal Problems}, editor = {Andr{\`e}s-P{\`e}rez, Esther and Gonz{\´a}lez, Leo M. and Periaux, Jacques and Gauger, Nicolas R. and Quagliarella, Domenico and Giannakoglou, Kyriakos C.}, publisher = {Springer International Publishing}, address = {Cham}, isbn = {978-3-319-89889-6}, doi = {10.1007/978-3-319-89890-2_33}, pages = {513 -- 527}, language = {en} } @misc{KotKegelmannDasetal., author = {Kot, Małgorzata and Kegelmann, Lukas and Das, Chittaranjan and Kus, Peter and Tsud, Nataliya and Matol{\´i}nov{\´a}, Iva and Albrecht, Steve and Matolin, Vladimir and Schmeißer, Dieter}, title = {Room temperature atomic layer deposited Al₂O₃ improves perovskite solar cells efficiency over time}, series = {ChemSusChem}, volume = {11}, journal = {ChemSusChem}, number = {20}, issn = {1864-5631}, doi = {10.1002/cssc.201801434}, pages = {3640 -- 3648}, abstract = {Electrical characterisation of perovskite solar cells consisting of room-temperature atomic-layer-deposited aluminium oxide (RT-ALD-Al₂O₃) film on top of a methyl ammonium lead triiodide (CH₃NH₃PbI₃) absorber showed excellent stability of the power conversion efficiency (PCE) over along time. Under the same environmental conditions (for 355 d), the average PCE of solar cells without the ALD layer decreased from 13.6 to 9.6 \%, whereas that of solar cells containing 9 ALD cycles of depositing RT-ALD-Al₂O₃on top of CH₃NH₃PbI₃ increased from 9.4 to 10.8 \%. Spectromicroscopic investigations of the ALD/perovskite interface revealed that the maximum PCE with the ALD layer is obtained when the so-called perovskite cleaning process induced by ALD precursors is complete. The PCE enhancement over time is probably related to a self-healing process induced by the RT-ALD-Al₂O₃ film. This work may provide a new direction for further improving the long-term stability and performance of perovskite solar cells.}, language = {en} } @misc{ExtraHendlerBestleetal., author = {Extra, Simon and Hendler, Marco and Bestle, Dieter and Flassig, Peter Michael}, title = {Verbesserte Vorauslegung des Kerntriebwerks mithilfe eines kaskadierten Optimierungsprozesses}, series = {Luft- und Raumfahrt - Digitalisierung und Vernetzung, Deutscher Luft- und Raumfahrtkongress 2018, 04.-06. September 2018, Friedrichshafen, Graf-Zeppelin-Haus}, journal = {Luft- und Raumfahrt - Digitalisierung und Vernetzung, Deutscher Luft- und Raumfahrtkongress 2018, 04.-06. September 2018, Friedrichshafen, Graf-Zeppelin-Haus}, publisher = {Deutsche Gesellschaft f{\"u}r Luft- und Raumfahrt - Lilienthal-Oberth e.V.}, address = {Bonn}, doi = {10.25967/480163}, url = {http://nbn-resolving.de/urn:nbn:de:101:1-2020011711475557798029}, pages = {10}, language = {de} } @misc{KotHenkelNaumannetal., author = {Kot, Małgorzata and Henkel, Karsten and Naumann, Franziska and Gargouri, Hassan and Tarnawska, Lidia Lupina and Wilker, Viola and Kus, Peter and Pożarowska, Emilia and Garain, Samiran and Rouissi, Zied and Schmeißer, Dieter}, title = {Comparison of plasma-enhanced atomic layer deposition AlN films prepared with different plasma sources}, series = {Journal of Vacuum Science and Technology A}, volume = {37}, journal = {Journal of Vacuum Science and Technology A}, number = {2}, issn = {0734-2101}, doi = {10.1116/1.5079628}, pages = {11}, abstract = {A comparative study of thin aluminum nitride (AlN) films deposited by plasma-enhanced atomic layer deposition in the SENTECH SI ALD LL system applying either a direct inductively coupled plasma (ICP) or an indirect capacitively coupled plasma (CCP) source is presented. The films prepared with the ICP source (based on a planar triple spiral antenna) exhibit improved properties concerning the growth rate per cycle, total cycle duration, homogeneity, refractive index, fixed and mobile electrical charges, and residual oxygen content compared to the CCP source, where the comparison is based on the applied plasma power of 200 W. The increase of the plasma power to 600 W in the ICP process significantly reduces the residual oxygen content and enhances the electrical breakdown field. The AlN layers grown under these conditions, with a growth rate per cycle of 1.54 {\AA}/cycle, contain residual oxygen and carbon concentrations of about 10\% and 4\%, respectively, and possess a refractive index of 2.07 (at 632.8 nm).}, language = {en} } @misc{KotHenkelMuelleretal., author = {Kot, Małgorzata and Henkel, Karsten and M{\"u}ller, Klaus and Kegelmann, Lukas and Albrecht, Steve and Tsud, Nataliya and K{\´u}s, Peter and Matolinov{\´a}, Iva and Schmeißer, Dieter}, title = {Al2O3-Atomic Layer Deposited Films on CH3NH3PbI3 : Intrinsic Defects and Passivation Mechanisms}, series = {Energy Technology , The Journal of Physical Chemistry C}, volume = {7}, journal = {Energy Technology , The Journal of Physical Chemistry C}, number = {11}, issn = {2194-4288}, doi = {10.1002/ente.201900975}, pages = {10}, abstract = {The initial interaction of atomic layer deposited films of Al2O3 at room temperature on CH3NH3PbI3 (MAPI) films is studied. Synchrotron radiation-based photoelectron spectroscopy is applied to analyze the initial changes in the Al-derived features by comparing samples with different Al2O3 film thicknesses. It is found that polarons and excitons, both intrinsic defects of Al2O3, play a key role in the interface formation. The polaronic states uptake a charge from the MAPI substrate. This charge is transferred to and stabilized in the excitonic state of Al2O3 which is assigned to predominately tetrahedral coordinated Al sites. This charge transfer is initiated by vacancies present in the MAPI substrate and stabilizes a covalent bonding at the Al2O3-MAPI interface but also causes a roughening of the interface which may lead to the formation of grain boundaries. On top of the rough interface, 2D Al2O3 clusters with an increasing number of octahedrally coordinated Al—O bonds grow, and with increasing Al2O3 coverage, they introduce self-healing of the structural defects.}, language = {en} } @misc{UrbanoBestleGerstbergeretal., author = {Urbano, Jos{\`e} and Bestle, Dieter and Gerstberger, Ulf and Flassig, Peter Michael}, title = {Low-Order Representation of Manufacturing Variations Based on B-Spline Morphing}, series = {ASME 2019 International Mechanical Engineering Congress and Exposition, November 11-14, 2019 Salt Lake City, Utah, USA}, journal = {ASME 2019 International Mechanical Engineering Congress and Exposition, November 11-14, 2019 Salt Lake City, Utah, USA}, publisher = {American Society of Mechanical Engineers}, isbn = {978-0-7918-5938-4}, doi = {10.1115/IMECE2019-10294}, language = {en} } @techreport{MuellerDieterBauhusetal., author = {M{\"u}ller, J{\"o}rg and Dieter, M. and Bauhus, J. and Spellmann, H. and M{\"o}hring, B. and Wagner, S. and Wolf, Heino and Niekisch, M. and Weiger, H. and Feindt, Peter H. and Hamm, Ulrich and W{\"a}tzold, Frank and Wolters, Volkmar and Engels, Eve-Marie and Schraml, U. and Lang, F. and Pr{\"o}bstl-Haider, U. and Richter, K.}, title = {Wege zu einem effizienten Waldnaturschutz in Deutschland. Stellungnahme}, publisher = {Wissenschaftlicher Beirat Waldpolitik und Wissenschaftlicher Beirat Biodiversit{\"a}t und Genetische Ressourcen beim BMEL}, pages = {62}, language = {de} } @misc{KotKegelmannKoebleretal., author = {Kot, Małgorzata and Kegelmann, Lukas and K{\"o}bler, Hans and Vorokhta, Mykhailo and Escudero, Carlos and K{\´u}š, Peter and Šm{\´i}d, Břetislav and Tallarida, Massimo and Albrecht, Steve and Abate, Antonio and Matol{\´i}nov{\´a}, Iva and Schmeißer, Dieter and Flege, Jan Ingo}, title = {In situ Near-Ambient Pressure X-ray Photoelectron Spectroscopy Reveals the Influence of Photon Flux and Water on the Stability of Halide Perovskite}, series = {ChemSusChem}, volume = {13}, journal = {ChemSusChem}, number = {21}, issn = {1864-5631}, doi = {10.1002/cssc.202001527}, pages = {5722 -- 5730}, abstract = {For several years, scientists have been trying to understand the mechanisms that reduce the long-term stability of perovskite solar cells. In this work, we examined the effect of water and photon flux on the stability of CH3NH3PbI3 perovskite films and solar cells using in situ near-ambient pressure X-ray photoelectron spectroscopy (NAP-XPS), field emission scanning electron microscopy (FESEM), and current density-voltage (J-V) characterization. The used amount of water vapor (up to 1 mbar) had a negligible impact on the perovskite film. The higher the photon flux, the more prominent were the changes in the NAP-XPS and FESEM data; also, a faster decline in power conversion efficiency (PCE) and a more substantial hysteresis in the J-V characteristics were observed. Based on our results, it can be concluded that the PCE decrease originates from the creation of Frenkel pair defects in the perovskite film under illumination. The stronger the illumination, the higher the number of Frenkel defects, leading to a faster PCE decline and more substantial hysteresis in the J-V sweeps.}, language = {en} }