@misc{EckartShresthaGirietal., author = {Eckart, Sven and Shrestha, Krishna P and Giri, Binod R and Fang, Qilong and Chen, Chen and Li, Wei and Krause, Hartmut and Mauss, Fabian and Liu, Dong and Li, Yuyang}, title = {Chemical insights into ethyl acetate flames from experiment and kinetic modeling: Laminar burning velocity, speciation and NOx emission}, series = {Proceedings of the Combustion Institute}, volume = {40 (2024)}, journal = {Proceedings of the Combustion Institute}, publisher = {Elsevier}, doi = {10.1016/j.proci.2024.105487}, pages = {1 -- 7}, abstract = {Oxygenated fuels, such as alcohols, ethers, and esters, are promising alternatives to conventional fuels. These fuels can help reduce detrimental emissions like carbon monoxide and unburned hydrocarbons and enhance octane ratings. Among these oxygenates, ethyl acetate (EA), a small alkyl ester sourced from biomass, emerges as a clean, promising energy carrier. It serves as a surrogate fuel to facilitate investigations into the combustion behaviours of biodiesel. Despite its importance, the literature knowledge of EA combustion characteristics is limited. Therefore, this study aims to broaden the knowledge of the combustion behaviour of this type of oxygenated fuel compound. In this study, we measured the laminar burning velocities of EA by employing a heat flux burner and a closed combustion vessel over the equivalence ratios of 0.7 - 1.7, pressures of 1 - 10 bar and temperatures ranging from 353 - 423 K. Further, we also measured the NOx emissions in exhaust gas of the premixed flames fueled by EA/air for the first time over the equivalence ratio of 0.8 - 1.2. Additionally, we employed a non-premixed counterflow flame setup for extensive characterisation of species and their concentration under diverse conditions encompassing various strain rates and oxygen concentrations. Finally, we utilized these newly measured data to construct and validate a detailed kinetic model developed as part of this work. The newly developed model will help characterize the combustion properties of EA.}, language = {en} } @misc{LyuFuWilczoketal., author = {Lyu, Yu-Xuan and Fu, Qiang and Wilczok, Dominika and Ying, Kejun and King, Aaron and Antebi, Adam and Vojta, Aleksandar and Stolzing, Alexandra and Moskalev, Alexey and Georgievskaya, Anastasia and Maier, Andrea B. and Olsen, Andrea and Groth, Anja and Simon, Anna Katharina and Brunet, Anne and Jamil, Aisyah and Kulaga, Anton and Bhatti, Asif and Yaden, Benjamin and Pedersen, Bente Klarlund and Schumacher, Bj{\"o}rn and Djordjevic, Boris and Kennedy, Brian and Chen, Chieh and Huang, Christine Yuan and Correll, Christoph U. and Murphy, Coleen T. and Ewald, Collin Y. and Chen, Danica and Valenzano, Dario Riccardo and Sołdacki, Dariusz and Erritzoe, David and Meyer, David and Sinclair, David A. and Chini, Eduardo Nunes and Teeling, Emma C. and Morgen, Eric and Verdin, Eric and Vernet, Erik and Pinilla, Estefano and Fang, Evandro F. and Bischof, Evelyne and Mercken, Evi M. and Finger, Fabian and Kuipers, Folkert and Pun, Frank W. and Gy{\"u}lveszi, Gabor and Civiletto, Gabriele and Zmudze, Garri and Blander, Gil and Pincus, Harold A. and McClure, Joshua and Kirkland, James L. and Peyer, James and Justice, Jamie N. and Vijg, Jan and Gruhn, Jennifer R. and McLaughlin, Jerry and Mannick, Joan and Passos, Jo{\~a}o and Baur, Joseph A. and Betts-LaCroix, Joe and Sedivy, John M. and Speakman, John R. and Shlain, Jordan and Maltzahn, Julia von and Andreasson, Katrin I. and Moody, Kelsey and Palikaras, Konstantinos and Fortney, Kristen and Niedernhofer, Laura J. and Rasmussen, Lene Juel and Veenhoff, Liesbeth M. and Melton, Lisa and Ferrucci, Luigi and Quarta, Marco and Koval, Maria and Marinova, Maria and Hamalainen, Mark and Unfried, Maximilian and Ringel, Michael S. and Filipovic, Milos and Topors, Mourad and Mitin, Natalia and Roy, Nawal and Pintar, Nika and Barzilai, Nir and Binetti, Paolo and Singh, Parminder and Kohlhaas, Paul and Robbins, Paul D. and Rubin, Paul and Fedichev, Peter O. and Kamya, Petrina and Mu{\~n}oz-Canoves, Pura and de Cabo, Rafael and Faragher, Richard G. A. and Konrad, Rob and Ripa, Roberto and Mansukhani, Robin and B{\"u}ttner, Sabrina and Wickstr{\"o}m, Sara A. and Brunemeier, Sebastian and Jakimov, Sergey and Luo, Shan and Rosenzweig-Lipson, Sharon and Tsai, Shih-Yin and Dimmeler, Stefanie and Rando, Thomas A. and Peterson, Tim R. and Woods, Tina and Wyss-Coray, Tony and Finkel, Toren and Strauss, Tzipora and Gladyshev, Vadim N. and Longo, Valter D. and Dwaraka, Varun B. and Gorbunova, Vera and Acosta-Rodr{\´i}guez, Victoria A. and Sorrentino, Vincenzo and Sebastiano, Vittorio and Li, Wenbin and Suh, Yousin and Zhavoronkov, Alex and Scheibye-Knudsen, Morten and Bakula, Daniela}, title = {Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity}, series = {Aging}, volume = {16}, journal = {Aging}, number = {20}, publisher = {Impact Journals, LLC}, issn = {1945-4589}, doi = {10.18632/aging.206135}, pages = {12955 -- 12976}, language = {en} } @article{ChenLiuBerg, author = {Chen, X.-M. and Liu, Fushui and Berg, Heinz Peter}, title = {Untersuchung der Zylinderinnenstr{\"o}mung an einen BDE - Motor mittels Laser - PIV}, language = {de} } @article{ChenBergKeil, author = {Chen, X. and Berg, Heinz Peter and Keil, M.}, title = {Flexible dynamische Messdatenerfassung an einem Motorpr{\"u}fstand}, language = {de} } @inproceedings{BergAntoshkivChenetal., author = {Berg, Heinz Peter and Antoshkiv, Oleksiy and Chen, X.-M. and Liu, F.}, title = {Einsatz von neuartigen Entwicklungswerkzeugen bei der Brennraumgestaltung von Flugmotoren}, series = {Motto: Luft- und Raumfahrt - Schmelztiegel der Disziplinen, Deutscher Luft- und Raumfahrtkongress 2002, Stuttgart, 23. bis 26. September 2002, Bd. 2}, booktitle = {Motto: Luft- und Raumfahrt - Schmelztiegel der Disziplinen, Deutscher Luft- und Raumfahrtkongress 2002, Stuttgart, 23. bis 26. September 2002, Bd. 2}, publisher = {DGLR}, address = {Bonn}, pages = {1499 -- 1506}, language = {de} } @inproceedings{HentschelBrilChenetal., author = {Hentschel, Christian and Bril, Reinder J. and Chen, Yingwei and Braspenning, Ralph and Lan, Tse-Hua}, title = {Video Quality-of-Service f{\"u}r Consumer Terminals - A Novel System f{\"u}r Programmable Components}, language = {en} } @inproceedings{HentschelBrilChen, author = {Hentschel, Christian and Bril, Reinder J. and Chen, Yingwei}, title = {Video Quality of Service for Multimedia Consumer Terminals - An Open and Flexible System Approach}, language = {en} } @misc{HentschelBrilChenetal., author = {Hentschel, Christian and Bril, Reinder J. and Chen, Yingwei and Braspenning, Ralph and Lan, Tse-Hua}, title = {Video Quality-of-Service for Consumer Terminals - A Novel System for Programmable Components}, language = {en} } @inproceedings{HentschelBrilChen, author = {Hentschel, Christian and Bril, Reinder J. and Chen, Yingwei}, title = {Systemkonzept f{\"u}r Multimedia Consumer Terminals mit dynamischen skalierbaren Algorithmen}, language = {de} } @inproceedings{HentschelBrilChenetal., author = {Hentschel, Christian and Bril, Reinder J. and Chen, Yingwei and Braspenning, Ralph and Lan, Tse-Hua}, title = {Video Quality of Service for Conusmer Terminals - A Novel System for Programmable Components}, language = {en} } @article{ChenSuZheng, author = {Chen, Q. and Su, K. and Zheng, Xizhong}, title = {Primitive Recursive Real Numbers}, language = {en} } @article{ChenRettingerSuetal., author = {Chen, Q. and Rettinger, Robert and Su, K. and Sattar, A. and Yue, W. and Lu, G. and Zheng, Xizhong}, title = {Verification of Authentication Protocols for Epistemic Goals via SAT Compilation}, language = {en} } @article{ChenSuYueetal., author = {Chen, Q. and Su, K. and Yue, W. and Zheng, Xizhong}, title = {Instantiation Space: A New Model for Security Protocol Logic}, language = {en} } @misc{ChenSuZheng, author = {Chen, Qingliang and Su, Kaile and Zheng, Xizhong}, title = {Primitive Recursiveness of Real Numbers under Different Representations}, series = {Electronic Notes in Theoretical Computer Science}, volume = {167}, journal = {Electronic Notes in Theoretical Computer Science}, issn = {1571-0661}, pages = {303 -- 324}, language = {en} } @inproceedings{SuChenZhengetal., author = {Su, Kaile and Chen, Qingliang and Zheng, Xizhong and Yue, Weiya}, title = {Reasoning about Knowledge by SAT Solving}, series = {International Conference on Computational Intelligence and Security, CIS 2006, 3 - 6 Nov. 2006, Guangzhou, China}, booktitle = {International Conference on Computational Intelligence and Security, CIS 2006, 3 - 6 Nov. 2006, Guangzhou, China}, publisher = {IEEE Press}, address = {Piscataway, NJ}, isbn = {1-4244-0604-8}, pages = {536 -- 539}, language = {en} } @misc{ZhuChenViehweger, author = {Zhu, Lin and Chen, Xin and Viehweger, Bernd}, title = {Preliminary Study on Deep-Hole Drilling Gamma Titanium Aluminide}, series = {Advanced Materials Research}, journal = {Advanced Materials Research}, number = {139-141}, issn = {1022-6680}, doi = {10.4028/www.scientific.net/AMR.139-141.831}, pages = {831 -- 834}, language = {en} } @article{ChenKeilBerg, author = {Chen, X. and Keil, M. and Berg, Heinz Peter}, title = {Flexible dynamische Messdatenerfassung in der Verbrennungs-motoren- und Kleingasturbinenerprobung}, language = {de} } @article{LopezHellerBitzeretal., author = {Lopez, A. and Heller, Thomas and Bitzer, Thomas and Chen, Q. and Richardson, Neville V.}, title = {The influence of sodium on the adsorption of water on SrTiO3(100)-1x1 surfaces}, language = {en} } @misc{JozefikKersteinSchmidtetal., author = {Jozefik, Zoltan and Kerstein, Alan R. and Schmidt, Heiko and Lyra, Sgouria and Kolla, Hemanth and Chen, Jackie H.}, title = {One-dimensional turbulence modeling of a turbulent counterflow flame with comparison to DNS}, series = {Combustion and Flame}, volume = {162}, journal = {Combustion and Flame}, number = {8}, issn = {1556-2921}, pages = {2999 -- 3015}, language = {en} } @misc{SteffensBeckerAmkreutzetal., author = {Steffens, S. and Becker, C. and Amkreutz, Daniel and Klossek, Andr{\´e} and Kittler, Martin and Chen, Y.-Y. and Schnegg, Alexander and Klingsporn, Max and Abou-Ras, Daniel and Lips, Klaus and Rech, Bernd}, title = {Impact of Dislocations and Dangling Bond Defects on The Electrical Performance of Crystalline Silicon Thin Films}, series = {Applied Physics Letters}, volume = {105}, journal = {Applied Physics Letters}, number = {2}, issn = {1077-3118}, doi = {10.1063/1.4890625}, pages = {022108}, language = {en} } @misc{JozefikKersteinSchmidtetal., author = {Jozefik, Zoltan and Kerstein, Alan R. and Schmidt, Heiko and Lyra, Sgouria and Kolla, Hemanth and Chen, Jackie H.}, title = {One-dimensional turbulence modeling of a turbulent counterflow flame with comparison to DNS}, series = {Combustion and Flame}, volume = {162}, journal = {Combustion and Flame}, number = {8}, issn = {0010-2180}, doi = {10.1016/j.combustflame.2015.05.010}, pages = {2999 -- 3015}, abstract = {The one-dimensional turbulence (ODT) model is applied to a reactant-to-product counterflow configuration and results are compared with DNS data. The model employed herein solves conservation equations for momentum, energy, and species on a one dimensional (1D) domain corresponding to the line spanning the domain between nozzle orifice centers. The effects of turbulent mixing are modeled via a stochastic process, while the Kolmogorov and reactive length and time scales are explicitly resolved and a detailed chemical kinetic mechanism is used. Comparisons between model and DNS results for spatial mean and root-mean-square (RMS) velocity, temperature, and major and minor species profiles are shown. The ODT approach shows qualitatively and quantitatively reasonable agreement with the DNS data. Scatter plots and statistics conditioned on temperature are also compared for heat release rate and all species. ODT is able to capture the range of results depicted by DNS. However, conditional statistics show signs of underignition.}, language = {en} } @misc{LiuChenHeineretal., author = {Liu, Fei and Chen, Siyuan and Heiner, Monika and Song, Hengjie}, title = {Modeling Biological Systems with Uncertain Kinetic Data Using Fuzzy Continuous Petri Nets}, series = {BMC Systems Biology}, volume = {12}, journal = {BMC Systems Biology}, number = {Supplement 4}, issn = {1752-0509}, doi = {10.1186/s12918-018-0568-8}, pages = {64 -- 74}, language = {en} } @inproceedings{ChaoBestleKruegeretal., author = {Chao, Chen-Xiang and Bestle, Dieter and Kr{\"u}ger, D. and Meissner, Bernd}, title = {Increasing the tooth root capacity of symmetric and asymmetric gears by optimizing the tooth root fillet shape}, series = {International Gear Conference 2018, Lyon, 27.-29.08.2018, vol. 1}, booktitle = {International Gear Conference 2018, Lyon, 27.-29.08.2018, vol. 1}, publisher = {Chartridge Books Oxford}, address = {Oxford}, isbn = {978-1-911033-42-4}, pages = {531 -- 541}, abstract = {The international standard ISO 6336-3 defines a calculation method for the tooth root capacity of standard gears with basic rack profile according to ISO 53. However, the results of this method may become too optimistic for non-standard gears with custom root fillets, large pressure angles or asymmetric teeth, since the effect of general mean stresses on the local tooth root strength are neglected. Therefore, a more generic calculation method is suggested, which considers the mean stress influence by utilizing the Haigh diagram. Both approaches are then used as basis of root fillet shape optimizations. A comparison of results demonstrates significant differences in the safety assessment and the resulting root geometry.}, language = {en} } @misc{ChenGlasauerMuelleretal., author = {Chen, Siyi and Glasauer, Stefan and M{\"u}ller, Hermann J. and Conci, Markus}, title = {Surface filling-in and contour interpolation contribute independently to Kanizsa figure formation}, series = {Journal of Experimental Psychology}, volume = {44}, journal = {Journal of Experimental Psychology}, number = {9}, issn = {1939-1277}, doi = {10.1037/xhp0000540}, pages = {1399 -- 1413}, language = {en} } @inproceedings{XueSunBestleetal., author = {Xue, Rui and Sun, Lu and Bestle, Dieter and Wang, Guoping and Chen, Dongyang and Rui, Xiaoting}, title = {Vortex-induced Vibration Analysis of a composite Riser System Based on the Transfer Matrix Method}, series = {14th International Conference on Multibody Systems, Nonlinear Dynamics, and Control - Quebec City, Quebec, Canada, August 26-29, 2018}, booktitle = {14th International Conference on Multibody Systems, Nonlinear Dynamics, and Control - Quebec City, Quebec, Canada, August 26-29, 2018}, publisher = {ASME}, address = {New York}, isbn = {978-0-7918-5183-8}, pages = {10}, language = {en} } @misc{ZhaoChenChangetal., author = {Zhao, Dapeng and Chen, Yu-kai and Chang, Keke and Ebel, Thomas and Luthringer, B{\´e}reng{\`e}re and Willumeit-R{\"o}mer, Regine and Pyczak, Florian}, title = {Surface topography and cytocompatibility of metal injection molded Ti-22Nb alloy as biomaterial}, series = {Transactions of Nonferrous Metals Society of China}, volume = {28}, journal = {Transactions of Nonferrous Metals Society of China}, number = {7}, issn = {1003-6326}, doi = {10.1016/S1003-6326(18)64772-7}, pages = {1342 -- 1350}, language = {en} } @misc{ChenKlinkelDornisch, author = {Chen, Lin and Klinkel, Sven and Dornisch, Wolfgang}, title = {Hybrid collocation-Galerkin approach for the analysis of surface represented 3D-solids employing SB-FEM}, series = {Computer Methods in Applied Mechanics and Engineering}, volume = {295}, journal = {Computer Methods in Applied Mechanics and Engineering}, issn = {0045-7825}, doi = {10.1016/j.cma.2015.07.004}, pages = {268 -- 289}, abstract = {This paper presents a numerical method to solve the three-dimensional elasticity problem of surface represented solids. A surface oriented formulation is derived, in which the three-dimensional solid is described by its boundary surfaces and a radial scaling center. Scaling the boundary surfaces with respect to the scaling center yields a parameterization of the complete solid. The definition of the boundary surfaces is sufficient for the description of the solid. Thus, the formulation conforms ideally to the boundary representation modeling technique used in CAD. In the present approach, no tensor-product structure of three-dimensional objects is exploited to parameterize the physical domain. The weak form of the equation of motion and the weak form of the Neumann boundary conditions are enforced only at the boundary surfaces. It leads to a transformation of the governing partial differential equations of elasticity to an ordinary differential equation (ODE) of Euler type. Solving the ODE leads to the displacement in the radial scaling direction. In the present approach, the isogeometric Galerkin finite element method is employed to describe the geometry of the boundary surfaces and also to approximate the displacement response of the boundary surfaces. It exploits two-dimensional NURBS objects to parameterize the boundary surfaces. The final Euler type ODE is solved by the NURBS based collocation method. The displacement response in the radial scaling direction is approximated by the NURBS basis functions. Hence, the method can be extended to nonlinear problems. The accuracy of the method is validated against analytical solutions. In general, the proposed formulation is able to model solids bounded by an arbitrary number of surfaces.}, language = {en} } @misc{KlinkelChenDornisch, author = {Klinkel, Sven and Chen, Lin and Dornisch, Wolfgang}, title = {A NURBS based hybrid collocation-Galerkin method for the analysis of boundary represented solids}, series = {Computer Methods in Applied Mechanics and Engineering}, volume = {284}, journal = {Computer Methods in Applied Mechanics and Engineering}, issn = {0045-7825}, doi = {10.1016/j.cma.2014.10.029}, pages = {689 -- 711}, abstract = {The paper is concerned with a new numerical method, NURBS based hybrid collocation-Galerkin method (NURBS-HCGM), to solve the in-plane motion problem of elastic solids. It combines the merits of the so-called scaled boundary finite-element method (SB-FEM) and the isogeometric collocation method. For the analysis, the boundary scaling technique of SB-FEM is adopted. It leads to a formulation, where only the boundary of a structure is discretized. Here, the NURBS basis functions are employed for the description of the geometry of the boundary as well as for the approximation of the displacements at the boundary. This is in accordance with the boundary representation modeling technique, which is commonly employed in computer aided design software. The inner domain is described by a radial scaling parameter. Applying the weak form only in circumferential direction the governing partial differential equations of elasticity are transformed to an ordinary differential equation (ODE) of Euler type, where the unknown displacements are a function of the radial scaling parameter. In the present work a NURBS based collocation scheme is introduced to solve this equation. NURBS basis functions are suggested for the approximation of the displacements in scaling direction. The higher continuity provided by NURBS allows to use collocation to solve the ODE directly instead of using the weak form in scaling direction. The proposed approach is validated by comparison with the eigenvalue solution of the ODE. It is remarked that the eigenvalue solution is restricted to linear problems, whereas the proposed method could be extended to nonlinear problems. In general, the presented formulation will allow to model patches bounded by an arbitrary number of contour boundaries. The accuracy of the proposed approach is analyzed and estimated with respect to analytical solutions. The computational cost is investigated with the help of numerical examples and is compared to isogeometric Galerkin approach.}, language = {en} } @misc{HofmanSorfVagiannisetal., author = {Hofman, Jakub and Sorf, Ales and Vagiannis, Dimitrios and Sucha, Simona and Kammerer, Sarah and K{\"u}pper, Jan-Heiner and Chen, Si and Guo, Lei and Ceckova, Martina and Staud, Frantisek}, title = {Brivanib Exhibits Potential for Pharmacokinetic Drug-Drug Interactions and the Modulation of Multidrug Resistance through the Inhibition of Human ABCG2 Drug Efflux Transporter and CYP450 Biotransformation Enzymes}, series = {Molecular Pharmaceutics}, volume = {16}, journal = {Molecular Pharmaceutics}, number = {11}, doi = {10.1021/acs.molpharmaceut.9b00361}, pages = {4436 -- 4450}, language = {en} } @misc{SegabinazziFerreiraGeorgeChenetal., author = {Segabinazzi Ferreira, Raphael and George, Nevin and Chen, Junchao and H{\"u}bner, Michael and Krstic, Milos and Nolte, J{\"o}rg and Vierhaus, Heinrich Theodor}, title = {Configurable Fault Tolerant Circuits and System Level Integration for Self-Awareness}, series = {Proceedings of the Work in Progress Session held in connection with SEAA 2019, the 45th EUROMICRO Conference on Software Engineering and Advanced Applications and DSD 2019, the 22nd EUROMICRO Conference on Digital System Design}, journal = {Proceedings of the Work in Progress Session held in connection with SEAA 2019, the 45th EUROMICRO Conference on Software Engineering and Advanced Applications and DSD 2019, the 22nd EUROMICRO Conference on Digital System Design}, publisher = {SEA-Publications}, address = {Kallithea, Chalkidiki (Greece)}, isbn = {978-3-902457-54-7}, doi = {10.26127/BTUOpen-5050}, pages = {2}, abstract = {Scaling minimum features of ICs down to the 10nm- area and below has allowed high integration rates in electronics. Scaling at supply voltages of 1V and below also implies a rising level of stress which drives aging effects that reduce switching speed and the expected life time. Additionally, vulnerability from particle radiation is increased. Hence, fault detection and on- line correction become a must for many applications. However, not only fault tolerance but self-awareness becomes also an advantage. Provided that by being aware of its own healthy state allow optimized configurations regarding system operation modes and configurable hardware mechanism. This paper shows a preliminary work in a configurable circuit and explores its configuration possibilities when integrated into a complete system.}, language = {en} } @misc{HarlanderLeGalBorciaetal., author = {Harlander, Uwe and Le Gal, Patrice and Borcia, Ion-Dan and Le Diz{\`e}s, St{\´e}phane and Chen, Jun and Favier, Benjamin}, title = {The linear instability of the stratified plane Poiseuille flow}, series = {17th European Turbulence Conference, ETC 2019, September 3 - 6, 2019, Torino, Italy}, journal = {17th European Turbulence Conference, ETC 2019, September 3 - 6, 2019, Torino, Italy}, address = {Turin}, pages = {1}, language = {en} } @misc{ChaoBestleKrueger, author = {Chao, Chen-Xiang and Bestle, Dieter and Kr{\"u}ger, David}, title = {Tooth Root Shape Optimization of Thin-Rimmed Planet Gears}, series = {Proceedings of ASME 2019 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, Volume 10: 2019 International Power Transmission and Gearing Conference}, journal = {Proceedings of ASME 2019 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, Volume 10: 2019 International Power Transmission and Gearing Conference}, isbn = {978-0-7918-5930-8}, doi = {10.1115/DETC2019-97345}, pages = {10}, abstract = {Planetary gearboxes in highly sophisticated applications such as turbofan engines are required to have a high power-to-weight ratio and excellent reliability. Hence, thin-rimmed gear units need to be designed as compact as possible which, however, is usually limited by the tooth root load capacity. In order to come up with the best design, a tooth root shape optimization process is developed for thin-rimmed planet gears.}, language = {en} } @misc{ChaoBestleKrueger, author = {Chao, Chen-Xiang and Bestle, Dieter and Kr{\"u}ger, David}, title = {Isight Process for Optimizing Tooth Roots in a High-Performance Gearbox}, series = {3DExperience Conference Germany 2019At: Darmstadt, Germany}, journal = {3DExperience Conference Germany 2019At: Darmstadt, Germany}, address = {Darmstadt}, language = {en} } @misc{ChaoBestleKruegeretal., author = {Chao, Chen-Xiang and Bestle, Dieter and Kr{\"u}ger, David and Meissner, Bernd}, title = {Zahnfußtragf{\"a}higkeitsoptimierung von Stirnr{\"a}dern f{\"u}r den Einsatz in Hochleistungsgetrieben mithilfe von Isight}, series = {Tagungsband Simulia Anwenderkonferenz, DASSAULT SYST{\`E}MES User Conference, Hanau, 4.-6. Dezember 2018}, journal = {Tagungsband Simulia Anwenderkonferenz, DASSAULT SYST{\`E}MES User Conference, Hanau, 4.-6. Dezember 2018}, address = {Hanau}, pages = {12}, language = {de} } @misc{AndjelkovicVeleskiChenetal., author = {Andjelkovic, Marko and Veleski, Mitko and Chen, Junchao and Simevski, Aleksandar and Krstic, Milos}, title = {A Particle Detector Based on Pulse Stretching Inverter Chain}, series = {26th IEEE International Conference on Electronics, Circuits and Systems (ICECS 2019), Genova}, journal = {26th IEEE International Conference on Electronics, Circuits and Systems (ICECS 2019), Genova}, isbn = {978-1-7281-0996-1}, doi = {10.1109/ICECS46596.2019.8964644}, pages = {4}, language = {en} } @misc{ChenOevermann, author = {Chen, Boxiong and Oevermann, Michael}, title = {An Eulerian stochastic field cavitation model coupled to a pressure based solver}, series = {Computer and Fluids}, volume = {162}, journal = {Computer and Fluids}, issn = {0045-7930}, doi = {10.1016/j.compfluid.2017.12.002}, pages = {1 -- 10}, abstract = {Probability density functions (PDF) and the relevant methods have been widely used to describe non-linear phenomena in the realm of turbulence modelling and CFD. In order to solve PDF transport equations, the main trend of previous studies rely on Monte Carlo method with Lagrangian particle tracking. However, as with any Lagrangian based approach, the scalability of the parallelized simulations of such method is less than satisfactory. An Eulerian stochastic field model has been presented recently by Dumond et al. [1] to simulate cavitating flows. Their model uses a fully compressible density based solver. Here we present an adapted version using an iso-thermal cavitation model adopting the homogeneous mixture assumption in a pressure based flow solver which is more relevant to engine simulations. A PDF method is used to represent a distribution of vapour volume fractions, based on which the Eulerian stochastic field (ESF) method is applied to perform a three-dimensional large eddy simulation (LES) of the cavitation phenomena inside an academic fuel injector configuration. The numerical model is based on a volume of fluids approach and coupled with a pressure based solver for the flow field, and is implemented in the framework of the open source C++ toolbox OpenFOAM. The result of the ESF simulation is compared against that from a typical single volume fraction solver for validation. Vortex structures and its correspondence to cavitation are shown, and the behaviour of the PDF at different probe locations at different times are acquired to demonstrate the potential of the ESF model in capturing both transient and stochastically steady cavitation.}, language = {en} } @misc{AndjelkovicChenSimevskietal., author = {Andjelkovic, Marko and Chen, Junchao and Simevski, Aleksandar and Stamenkovic, Zoran and Krstic, Milos and Kraemer, Rolf}, title = {A Review of Particle Detectors for Space-Borne Self-Adaptive Fault Tolerant Systems}, series = {18th IEEE East-West Design and Test Symposium (EWDTS 2020), Varna, Bulgaria, 04 - 07 September 2020}, journal = {18th IEEE East-West Design and Test Symposium (EWDTS 2020), Varna, Bulgaria, 04 - 07 September 2020}, publisher = {IEEE}, isbn = {978-1-7281-9899-6}, issn = {2472-761X}, doi = {10.1109/EWDTS50664.2020.9225138}, language = {en} } @misc{VagiannisNovotnaSkarkaetal., author = {Vagiannis, Dimitrios and Novotna, Eva and Skarka, Adam and Kammerer, Sarah and K{\"u}pper, Jan-Heiner and Chen, Si and Guo, Lei and Staud, Frantisek and Hofman, Jakub}, title = {Ensartinib (X-396) Effectively Modulates Pharmacokinetic Resistance Mediated by ABCB1 and ABCG2 Drug Efflux Transporters and CYP3A4 Biotransformation Enzyme}, series = {Cancers}, volume = {12}, journal = {Cancers}, number = {4}, issn = {2072-6694}, doi = {10.3390/cancers12040813}, pages = {27}, abstract = {Ensartinib (X-396) is a promising tyrosine kinase inhibitor currently undergoing advanced clinical evaluation for the treatment of non-small cell lung cancer. In this work, we investigate possible interactions of this promising drug candidate with ATP-binding cassette (ABC) drug efflux transporters and cytochrome P450 biotransformation enzymes (CYPs), which play major roles in multidrug resistance (MDR) and pharmacokinetic drug-drug interactions (DDIs). Accumulation studies showed that ensartinib is a potent inhibitor of ABCB1 and ABCG2 transporters. Additionally, incubation experiments with recombinant CYPs showed that ensartinib significantly inhibits CYP3A4 and CYP2C9. Subsequent molecular docking studies confirmed these findings. Drug combination experiments demonstrated that ensartinib synergistically potentiates the antiproliferative effects of daunorubicin, mitoxantrone, and docetaxel in ABCB1, ABCG2, and CYP3A4-overexpressing cellular models, respectively. Advantageously, ensartinib's antitumor efficiency was not compromised by the presence of MDR-associated ABC transporters, although it acted as a substrate of ABCB1 in Madin-Darby Canine Kidney II (MDCKII) monolayer transport assays. Finally, we demonstrated that ensartinib had no significant effect on the mRNA-level expression of examined transporters and enzymes in physiological and lung tumor cellular models. In conclusion, ensartinib may perpetrate clinically relevant pharmacokinetic DDIs and modulate ABCB1-, ABCG2-, and CYP3A4-mediated MDR. The in vitro findings presented here will provide a valuable foundation for future in vivo investigations.}, language = {en} } @misc{LeGalHarlanderBorciaetal., author = {Le Gal, Patrice and Harlander, Uwe and Borcia, Ion-Dan and Le Diz{\`e}s, St{\´e}phane and Chen, J. and Favier, Benjamin}, title = {Instability of vertically stratified horizontal plane Poiseuille flow}, series = {Journal of Fluid Mechanics}, volume = {907}, journal = {Journal of Fluid Mechanics}, number = {R1}, issn = {1469-7645}, doi = {10.1017/jfm.2020.917}, pages = {1 -- 14}, language = {en} } @misc{LiuAssafChenetal., author = {Liu, Fei and Assaf, George and Chen, Ming and Heiner, Monika}, title = {A Petri nets-based framework for whole-cell modeling}, series = {Biosystems}, volume = {210}, journal = {Biosystems}, issn = {0303-2647}, doi = {10.1016/j.biosystems.2021.104533}, abstract = {Whole-cell modeling aims to incorporate all main genes and processes, and their interactions of a cell in one model. Whole-cell modeling has been regarded as the central aim of systems biology but also as a grand challenge, which plays essential roles in current and future systems biology. In this paper, we analyze whole-cell modeling challenges and requirements and classify them into three aspects (or dimensions): heterogeneous biochemical networks, uncertainties in components, and representation of cell structure. We then explore how to use different Petri net classes to address different aspects of whole-cell modeling requirements. Based on these analyses, we present a Petri nets-based framework for whole-cell modeling, which not only addresses many whole-cell modeling requirements, but also offers a graphical, modular, and hierarchical modeling tool. We think this framework can offer a feasible modeling approach for whole-cell model construction.}, language = {en} } @phdthesis{Chao, author = {Chao, Chen-Xiang}, title = {Strategies for Optimizing the Tooth Root Load Capacity of High-Performance Gears}, publisher = {Shaker}, address = {D{\"u}ren}, isbn = {978-3-8440-8453-5}, pages = {xvi, 160}, abstract = {Abstract Strategies for Optimizing the Tooth Root Load Capacity of High-Performance Gears Keywords: planet gears, high-performance gearbox, tooth root load capacity, tooth root optimization, multi-objective optimization In order to achieve greater efficiency, many modern applications such as geared turbofans require high-performance gearboxes with excellent reliability and low weight. The tooth root load capacity often is a limiting design criterion driving minimum face widths and hence the weight of gears. Consequently, strategies for optimizing the tooth root load capacity of gears are explored in this thesis. Two methods for tooth root load capacity analysis - a maximum tensile stress method derived from ISO 6336 and a local fatigue approach taking into account mean stress infl - are introduced and ompared to each other with respect to their applicability to optimization problems. A study with 2D fi element models of unidirectionally loaded sun gears reveals that the local fatigue analysis method should be preferred over the common approach of minimizing the maximum tooth root stress, since applying both methods as optimization targets results in diff nt tooth root shapes and a vast overestimation of safety gains when only tensile stresses are considered. Due to alternating loading, planet gears usually have a lower tooth root load capacity than other gears. Additionally, they are often designed with thin rims making the gear body lighter but also more elastic. Therefore, the tooth root shape of a thin-rimmed planet gear is optimized to explore possible interactions. The results show that overly thin rims negatively affect the maximization of tooth root safety. Hence, it is necessary to conduct multi-objectiveoptimizations of planet gears, which maximize tooth root safety and minimize mass simultaneously by optimizing tooth root shape, rim geometry and face width. The efficacy of this approach is demonstrated for 3D gear simulation models of spur as well as double helical planet gears. Pareto-optimal designs show significant improvements compared to the baseline design. Moreover, investigations demonstrate the opportunity to vastly decrease the computational cost of multi-objective optimizations by scalarizing them and using the result to approximate parts of the Pareto front.}, language = {en} } @misc{ChaoKruegerFlassigetal., author = {Chao, Chen-Xiang and Kr{\"u}ger, David and Flassig, Peter Michael and Meissner, Bernd}, title = {Verfahren zur Herstellung einer Verzahnung und Verzahnung}, language = {de} } @misc{ChaoKruegerFlassigetal., author = {Chao, Chen-Xiang and Kr{\"u}ger, David and Flassig, Peter Michael and Meissner, Bernd}, title = {Method for manufacturing a toothing and toothing}, language = {en} } @misc{ChaoKrueger, author = {Chao, Chen-Xiang and Kr{\"u}ger, David}, title = {Stegzahnrad}, language = {de} } @misc{ChaoKrueger, author = {Chao, Chen-Xiang and Kr{\"u}ger, David}, title = {Gear wheel}, language = {en} } @misc{DorneanuZhangRuanetal., author = {Dorneanu, Bogdan and Zhang, Sushen and Ruan, Hang and Heshmat, Mohamed and Chen, Ruijuan and Vassiliadis, Vassilios S. and Arellano-Garc{\´i}a, Harvey}, title = {Big data and machine learning: A roadmap towards smart plants}, series = {Frontiers of Engineering Management}, volume = {9}, journal = {Frontiers of Engineering Management}, doi = {10.1007/s42524-022-0218-0}, pages = {623 -- 639}, abstract = {Industry 4.0 aims to transform chemical and biochemical processes into intelligent systems via the integration of digital components with the actual physical units involved. This process can be thought of as the addition of a central nervous system with a sensing and control monitoring of components and regulating the performance of the individual physical assets (processes, units, etc.) involved. Established technologies central to the digital integrating components are smart sensing, mobile communication, Internet of Things, modelling and simulation, advanced data processing, storage and analysis, advanced process control, artificial intelligence and machine learning, cloud computing, and virtual and augmented reality. An essential element to this transformation is the exploitation of large amounts of historical process data and large volumes of data generated in real-time by smart sensors widely used in industry. Exploitation of the information contained in these data requires the use of advanced machine learning and artificial intelligence technologies integrated with more traditional modelling techniques. The purpose of this paper is twofold: a) to present the state-of-the-art of the aforementioned technologies, and b) to present a strategic plan for their integration toward the goal of an autonomous smart plant capable of self-adaption and self-regulation for short- and long-term production management.}, language = {en} } @techreport{DeSantisMuellmannPanetal., author = {De Santis, Karina Karolina and M{\"u}llmann, Saskia and Pan, Chen-Chia and Spallek, Jacob and Hoffmann, Stephanie and Haug, Ulrike and Zeeb, Hajo}, title = {Digitalisierung und Gesundheit: Ergebnisse einer zweiten bundesweiten Befragung in Deutschland}, pages = {21}, abstract = {Diese Studie untersuchte Einstellungen zu und Nutzung von digitalen Technologien im Gesundheitskontext anhand einer zweiten bundesweiten Befragung von Internetnutzenden in Deutschland. Unser Ziel war es zu ermitteln, ob und wie sich Einstellungen zu und Nutzung von digitalen Technologien im Gesundheitskontext zwei Jahre nach der ersten Befragung ver{\"a}ndert haben.}, language = {de} } @misc{GaoLuoPanetal., author = {Gao, Yunlong and Luo, Si-Zhe and Pan, Jin-Yan and Chen, Bai-Hua and Zhang, Yi-Song}, title = {Robust PCA Using Adaptive Probability Weighting}, series = {Acta Automatica Sinica}, volume = {47}, journal = {Acta Automatica Sinica}, number = {4}, issn = {0254-4156}, doi = {10.16383/j.aas.c180743}, pages = {825 -- 838}, abstract = {Principal component analysis (PCA) is an important method for processing high-dimensional data. In recent years, PCA models based on various norms have been extensively studied to improve the robustness. However, on the one hand, these algorithms do not consider the relationship between reconstruction error and covariance; on the other hand, they lack the uncertainty of considering the principal component to the data description. Aiming at these problems, this paper proposes a new robust PCA algorithm. Firstly, the L2,p-norm is used to measure the reconstruction error and the description variance of the projection data. Based on the reconstruction error and the description variance, the adaptive probability error minimization model is established to calculate the uncertainty of the principal component's description of the data. Based on the uncertainty, the adaptive probability weighting PCA is established. The corresponding optimization method is designed. The experimental results of artificial data sets, UCI data sets and face databases show that RPCA-PW is superior than other PCA algorithms.}, language = {en} } @article{FongChenWongetal., author = {Fong, Mun-Oon and Chen, Xiangping and Wong, Jie-Wei and Lok, Tow-Jie and Li, Siyang and Low, Jia Tee and Nordin, Nur Syahirra and Miao, Zhikun and Hu, Qiannan and Neffe, Axel T. and Wong, Tuck-Whye and Li, Tiefeng and Yang, Wei}, title = {Multifunctional Roles of Iron Oxide Nanoparticles in a Reversible Shape-Memory Composite}, series = {Advanced Functional Materials}, journal = {Advanced Functional Materials}, publisher = {Wiley}, issn = {1616-301X}, doi = {10.1002/adfm.202418409}, pages = {13}, abstract = {The utilization of functional fillers in the development of composite materials has come a long way since its advent to improve physical, chemical, or mechanical properties of the base material. However, the heterogenous roles contributed by a single type of filler remain uncommon in this field. Here the endowment of various modifications to a 1,8-octanediol/1,12-dodecanedioic acid/citric acid (OD/DDA/CA) matrix through the incorporation of iron oxide nanoparticles (IONPs) is reported. Owing to the relaxation and hysteresis loss behaviors of IONPs when exposed to an alternating magnetic field (AMF), the composites demonstrate a magnetothermal response. Similarly, the excitation and relaxation of electrons in IONPs under near-infrared light (NIR) enable photothermic-responsiveness. In combination, two findings nurtured an observed shape-memory effect when the samples are under actuation by these indirect stimuli, where a shape recovery ratio (≥98\%) and reversible strain (≤7\%) are recorded. Moreover, the catalytic role of IONPs aided transesterification in the covalent network, demonstrated by successful repeated cycles of shape reconfiguration of the samples. This work highlights the prospectives of multifunctional composite fillers in the exploration of bio-derived composite smart materials.}, language = {en} } @misc{DeSantisMuellmannPanetal., author = {De Santis, Karina Karolina and Muellmann, Saskia and Pan, Chen-Chia and Hoffmann, Stephanie and Spallek, Jacob and Haug, Ulrike and Zeeb, Hajo}, title = {Digitisation and health: Second nationwide survey of internet users in Germany}, series = {Digital Health}, volume = {Volume 10}, journal = {Digital Health}, doi = {10.1177/20552076241301457}, pages = {16}, abstract = {Objective: Rapid digitisation of health occurred during the COVID-19 pandemic worldwide. In October 2020, we conducted a survey on digital health technology use in Germany. This study aimed to conduct a second survey to investigate in more detail the internet use in health context and digital technology use for health promotion and disease prevention in Germany. Methods: A cross-sectional, nationwide telephone survey was conducted in November 2022. Anonymous data on internet and digital technology use, digital health literacy, and sociodemographic characteristics were analysed using descriptive statistics and binary logistic regressions. Results: The 1020 participants were aged 18-92 years, 53\% were male, 62\% completed primary or secondary education, 71\% resided in large cities, and 45\% reported a country-average net household income. Overall, 61\% reported internet use in health context via 1-4 devices. Among those, more than 50\% used the internet and apps to obtain general health information and less than 50\% used digital technologies for physical activity promotion or cancer prevention. Overall, 34\% were confident in using the internet for health decisions and 71\% preferred to receive health information non-digitally (e.g. on paper). Internet, app, and digital technology use were associated with higher digital health literacy and income, and residence in larger cities. Digital technologies were used for physical activity promotion by younger and for cancer prevention by older participants. Conclusion: The internet and digital technologies were predominantly used to obtain health information, but less often for health promotion and disease prevention in 2022 in Germany. While health app and digital technology use for physical activity promotion increased, the confidence in using online information for health decisions decreased in 2022 relative to 2020. Factors that promote confidence in online health information and digital technology use for health promotion and disease prevention need to be investigated in future studies.}, language = {en} } @misc{FlorianSchrickerZenzetal., author = {Florian, Tobias and Schricker, Klaus and Zenz, Constantin and Otto, Andreas and Schmidt, Leander and Diegel, Christian and Friedmann, Hannes and Seibold, Marc and Hellwig, Peter and Fr{\"o}hlich, Fabian and Nagel, Falk and Kallage, Peter and Buttazzoni, Michele and Rack, Alexander and Requardt, Herwig and Chen, Yunhui and Bergmann, Jean Pierre}, title = {Combining in situ synchrotron X-ray imaging and multiphysics simulation to reveal pore formation dynamics in laser welding of copper}, series = {International Journal of Machine Tools and Manufacture}, volume = {204}, journal = {International Journal of Machine Tools and Manufacture}, publisher = {Elsevier BV}, issn = {0890-6955}, doi = {10.1016/j.ijmachtools.2024.104224}, pages = {1 -- 22}, abstract = {Laser beam welding has emerged as a powerful tool for manufacturing copper components in electrical vehicles, electronic devices or energy storage, owing to its rapid processing capabilities. Nonetheless, the material's high thermal conductivity and low absorption of infrared light can introduce process instabilities, resulting in defects such as pores. This study employs a hybrid approach that combines in situ synchrotron X-ray imaging with compressible multiphysics process simulation to elucidate pore-forming mechanisms during laser beam welding of copper. High-speed synchrotron X-ray imaging with an acquisition rate of 20,000 images/second facilitates the identification of relevant process regimes concerning pore formation during laser beam welding of copper with a wavelength of 1070 nm. Furthermore, in situ observations with high temporal and spatial resolution present a unique database for extensive validation of a multi-physics process simulation based on welding processes using different concentric intensity distributions. These validated simulation results enable thorough comprehension of process-related pore formation based on the interaction between keyhole, melt pool and resulting flow field. The findings show that pore formation is driven by four different mechanisms: bulging, spiking, upwelling waves at the keyhole rear wall and melt pool ejections. The synergy of high- speed synchrotron X-ray imaging and multi-physics modeling provides a fundamental understanding of the chronological sequence of events leading to process-related pore formation during laser beam welding of copper.}, language = {en} } @misc{DeSantisMuellmannPanetal., author = {De Santis, Karina Karolina and M{\"u}llmann, Saskia and Pan, Chen-Chia and Hoffmann, Stephanie and Spallek, Jacob and Haug, Ulrike and Zeeb, Hajo}, title = {Increased use of digital health technologies but reduced digital health literacy: a comparison in results of two nationwide surveys in 2020 and 2022 in Germany}, series = {German Medical Science}, journal = {German Medical Science}, doi = {10.3205/24gmds631}, url = {http://nbn-resolving.de/urn:nbn:de:0183-24gmds6319}, abstract = {Objective: Digital technologies with internet access, including computers or mobile devices, can contribute to health promotion and disease prevention. This study aimed to compare the results of two nationwide surveys of internet users in Germany that investigated the use pattern, the attitudes towards, and the factors associated with digital technology use in health context. Methods: This study adheres to the ethical guidelines according to the Declaration of Helsinki. Two cross-sectional surveys of internet users living in Germany were performed in 2020 (survey 1) and 2022 (survey 2). Participants were recruited from two different consumer panel samples owned by a market research institute (Cerner Enviza GmbH). Participants provided verbal informed consent for participation in the study according to the Cerner Enviza data privacy policy. Computer-assisted telephone interviews were conducted by Cerner Enviza using questionnaires with 28-30 items developed by study authors. Anonymous data were purchased and analysed by study authors using descriptive statistics. Associations between digital technology use and participant characteristics were tested using binary logistic regression analyses. Results: The participants were adult internet users (survey 1: n=991; survey 2: n=1020). Participant characteristics were similar in both surveys (47-52\% female, 50-55\% aged 40-65 years, 62-66\% with less than tertiary education, 42-45\% with less than country-average household income, 81-82\% residents in former West Germany, and 67-71\% residents in large cities). A similar number of participants in both surveys reported digital technology use in any health context (57-61\%) and rated digital technologies for physical activity promotion as easy to use (87-92\%). Digital technology use increased in 2022 relative to 2020. Specifically, more participants reported health app (63\% vs. 36\%) and digital technology use for physical activity promotion (any use: 44\% vs. 31\%; weekly-daily use: 91\% vs. 64\%) in 2022 vs. 2020. In contrast, digital health literacy decreased in 2022 relative to 2020. Specifically, less participants had high digital health literacy (57\% vs. 69\%) and were confident in using online information for health decisions (34\% vs. 43\%) in 2022 vs. 2020. Digital technology use was associated with higher digital health literacy and younger age (in both surveys), higher income (in survey 1) and residence in larger cities (in survey 2). Conclusion: Digital technologies targeting some health domains, such as physical activity promotion are frequently used and accepted by the users. However, digital health literacy and especially the confidence in using online information for health decisions appear to have decreased in 2022 relative to 2020. Factors that promote digital technology use for health promotion and disease prevention need to be investigated in future studies. Considering that digital health literacy is associated with digital technology use, further research on user needs and preferences is required to understand the reasons for reduction in such literacy in this study.}, language = {en} }