@misc{ChenGlasauerMuelleretal., author = {Chen, Siyi and Glasauer, Stefan and M{\"u}ller, Hermann J. and Conci, Markus}, title = {Surface filling-in and contour interpolation contribute independently to Kanizsa figure formation}, series = {Journal of Experimental Psychology}, volume = {44}, journal = {Journal of Experimental Psychology}, number = {9}, issn = {1939-1277}, doi = {10.1037/xhp0000540}, pages = {1399 -- 1413}, language = {en} } @inproceedings{XueSunBestleetal., author = {Xue, Rui and Sun, Lu and Bestle, Dieter and Wang, Guoping and Chen, Dongyang and Rui, Xiaoting}, title = {Vortex-induced Vibration Analysis of a composite Riser System Based on the Transfer Matrix Method}, series = {14th International Conference on Multibody Systems, Nonlinear Dynamics, and Control - Quebec City, Quebec, Canada, August 26-29, 2018}, booktitle = {14th International Conference on Multibody Systems, Nonlinear Dynamics, and Control - Quebec City, Quebec, Canada, August 26-29, 2018}, publisher = {ASME}, address = {New York}, isbn = {978-0-7918-5183-8}, pages = {10}, language = {en} } @misc{ZhaoChenChangetal., author = {Zhao, Dapeng and Chen, Yu-kai and Chang, Keke and Ebel, Thomas and Luthringer, B{\´e}reng{\`e}re and Willumeit-R{\"o}mer, Regine and Pyczak, Florian}, title = {Surface topography and cytocompatibility of metal injection molded Ti-22Nb alloy as biomaterial}, series = {Transactions of Nonferrous Metals Society of China}, volume = {28}, journal = {Transactions of Nonferrous Metals Society of China}, number = {7}, issn = {1003-6326}, doi = {10.1016/S1003-6326(18)64772-7}, pages = {1342 -- 1350}, language = {en} } @misc{ChenKlinkelDornisch, author = {Chen, Lin and Klinkel, Sven and Dornisch, Wolfgang}, title = {Hybrid collocation-Galerkin approach for the analysis of surface represented 3D-solids employing SB-FEM}, series = {Computer Methods in Applied Mechanics and Engineering}, volume = {295}, journal = {Computer Methods in Applied Mechanics and Engineering}, issn = {0045-7825}, doi = {10.1016/j.cma.2015.07.004}, pages = {268 -- 289}, abstract = {This paper presents a numerical method to solve the three-dimensional elasticity problem of surface represented solids. A surface oriented formulation is derived, in which the three-dimensional solid is described by its boundary surfaces and a radial scaling center. Scaling the boundary surfaces with respect to the scaling center yields a parameterization of the complete solid. The definition of the boundary surfaces is sufficient for the description of the solid. Thus, the formulation conforms ideally to the boundary representation modeling technique used in CAD. In the present approach, no tensor-product structure of three-dimensional objects is exploited to parameterize the physical domain. The weak form of the equation of motion and the weak form of the Neumann boundary conditions are enforced only at the boundary surfaces. It leads to a transformation of the governing partial differential equations of elasticity to an ordinary differential equation (ODE) of Euler type. Solving the ODE leads to the displacement in the radial scaling direction. In the present approach, the isogeometric Galerkin finite element method is employed to describe the geometry of the boundary surfaces and also to approximate the displacement response of the boundary surfaces. It exploits two-dimensional NURBS objects to parameterize the boundary surfaces. The final Euler type ODE is solved by the NURBS based collocation method. The displacement response in the radial scaling direction is approximated by the NURBS basis functions. Hence, the method can be extended to nonlinear problems. The accuracy of the method is validated against analytical solutions. In general, the proposed formulation is able to model solids bounded by an arbitrary number of surfaces.}, language = {en} } @misc{KlinkelChenDornisch, author = {Klinkel, Sven and Chen, Lin and Dornisch, Wolfgang}, title = {A NURBS based hybrid collocation-Galerkin method for the analysis of boundary represented solids}, series = {Computer Methods in Applied Mechanics and Engineering}, volume = {284}, journal = {Computer Methods in Applied Mechanics and Engineering}, issn = {0045-7825}, doi = {10.1016/j.cma.2014.10.029}, pages = {689 -- 711}, abstract = {The paper is concerned with a new numerical method, NURBS based hybrid collocation-Galerkin method (NURBS-HCGM), to solve the in-plane motion problem of elastic solids. It combines the merits of the so-called scaled boundary finite-element method (SB-FEM) and the isogeometric collocation method. For the analysis, the boundary scaling technique of SB-FEM is adopted. It leads to a formulation, where only the boundary of a structure is discretized. Here, the NURBS basis functions are employed for the description of the geometry of the boundary as well as for the approximation of the displacements at the boundary. This is in accordance with the boundary representation modeling technique, which is commonly employed in computer aided design software. The inner domain is described by a radial scaling parameter. Applying the weak form only in circumferential direction the governing partial differential equations of elasticity are transformed to an ordinary differential equation (ODE) of Euler type, where the unknown displacements are a function of the radial scaling parameter. In the present work a NURBS based collocation scheme is introduced to solve this equation. NURBS basis functions are suggested for the approximation of the displacements in scaling direction. The higher continuity provided by NURBS allows to use collocation to solve the ODE directly instead of using the weak form in scaling direction. The proposed approach is validated by comparison with the eigenvalue solution of the ODE. It is remarked that the eigenvalue solution is restricted to linear problems, whereas the proposed method could be extended to nonlinear problems. In general, the presented formulation will allow to model patches bounded by an arbitrary number of contour boundaries. The accuracy of the proposed approach is analyzed and estimated with respect to analytical solutions. The computational cost is investigated with the help of numerical examples and is compared to isogeometric Galerkin approach.}, language = {en} } @misc{HofmanSorfVagiannisetal., author = {Hofman, Jakub and Sorf, Ales and Vagiannis, Dimitrios and Sucha, Simona and Kammerer, Sarah and K{\"u}pper, Jan-Heiner and Chen, Si and Guo, Lei and Ceckova, Martina and Staud, Frantisek}, title = {Brivanib Exhibits Potential for Pharmacokinetic Drug-Drug Interactions and the Modulation of Multidrug Resistance through the Inhibition of Human ABCG2 Drug Efflux Transporter and CYP450 Biotransformation Enzymes}, series = {Molecular Pharmaceutics}, volume = {16}, journal = {Molecular Pharmaceutics}, number = {11}, doi = {10.1021/acs.molpharmaceut.9b00361}, pages = {4436 -- 4450}, language = {en} } @misc{SegabinazziFerreiraGeorgeChenetal., author = {Segabinazzi Ferreira, Raphael and George, Nevin and Chen, Junchao and H{\"u}bner, Michael and Krstic, Milos and Nolte, J{\"o}rg and Vierhaus, Heinrich Theodor}, title = {Configurable Fault Tolerant Circuits and System Level Integration for Self-Awareness}, series = {Proceedings of the Work in Progress Session held in connection with SEAA 2019, the 45th EUROMICRO Conference on Software Engineering and Advanced Applications and DSD 2019, the 22nd EUROMICRO Conference on Digital System Design}, journal = {Proceedings of the Work in Progress Session held in connection with SEAA 2019, the 45th EUROMICRO Conference on Software Engineering and Advanced Applications and DSD 2019, the 22nd EUROMICRO Conference on Digital System Design}, publisher = {SEA-Publications}, address = {Kallithea, Chalkidiki (Greece)}, isbn = {978-3-902457-54-7}, doi = {10.26127/BTUOpen-5050}, pages = {2}, abstract = {Scaling minimum features of ICs down to the 10nm- area and below has allowed high integration rates in electronics. Scaling at supply voltages of 1V and below also implies a rising level of stress which drives aging effects that reduce switching speed and the expected life time. Additionally, vulnerability from particle radiation is increased. Hence, fault detection and on- line correction become a must for many applications. However, not only fault tolerance but self-awareness becomes also an advantage. Provided that by being aware of its own healthy state allow optimized configurations regarding system operation modes and configurable hardware mechanism. This paper shows a preliminary work in a configurable circuit and explores its configuration possibilities when integrated into a complete system.}, language = {en} } @misc{HarlanderLeGalBorciaetal., author = {Harlander, Uwe and Le Gal, Patrice and Borcia, Ion-Dan and Le Diz{\`e}s, St{\´e}phane and Chen, Jun and Favier, Benjamin}, title = {The linear instability of the stratified plane Poiseuille flow}, series = {17th European Turbulence Conference, ETC 2019, September 3 - 6, 2019, Torino, Italy}, journal = {17th European Turbulence Conference, ETC 2019, September 3 - 6, 2019, Torino, Italy}, address = {Turin}, pages = {1}, language = {en} } @misc{ChaoBestleKrueger, author = {Chao, Chen-Xiang and Bestle, Dieter and Kr{\"u}ger, David}, title = {Tooth Root Shape Optimization of Thin-Rimmed Planet Gears}, series = {Proceedings of ASME 2019 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, Volume 10: 2019 International Power Transmission and Gearing Conference}, journal = {Proceedings of ASME 2019 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, Volume 10: 2019 International Power Transmission and Gearing Conference}, isbn = {978-0-7918-5930-8}, doi = {10.1115/DETC2019-97345}, pages = {10}, abstract = {Planetary gearboxes in highly sophisticated applications such as turbofan engines are required to have a high power-to-weight ratio and excellent reliability. Hence, thin-rimmed gear units need to be designed as compact as possible which, however, is usually limited by the tooth root load capacity. In order to come up with the best design, a tooth root shape optimization process is developed for thin-rimmed planet gears.}, language = {en} } @misc{ChaoBestleKrueger, author = {Chao, Chen-Xiang and Bestle, Dieter and Kr{\"u}ger, David}, title = {Isight Process for Optimizing Tooth Roots in a High-Performance Gearbox}, series = {3DExperience Conference Germany 2019At: Darmstadt, Germany}, journal = {3DExperience Conference Germany 2019At: Darmstadt, Germany}, address = {Darmstadt}, language = {en} } @misc{ChaoBestleKruegeretal., author = {Chao, Chen-Xiang and Bestle, Dieter and Kr{\"u}ger, David and Meissner, Bernd}, title = {Zahnfußtragf{\"a}higkeitsoptimierung von Stirnr{\"a}dern f{\"u}r den Einsatz in Hochleistungsgetrieben mithilfe von Isight}, series = {Tagungsband Simulia Anwenderkonferenz, DASSAULT SYST{\`E}MES User Conference, Hanau, 4.-6. Dezember 2018}, journal = {Tagungsband Simulia Anwenderkonferenz, DASSAULT SYST{\`E}MES User Conference, Hanau, 4.-6. Dezember 2018}, address = {Hanau}, pages = {12}, language = {de} } @misc{AndjelkovicVeleskiChenetal., author = {Andjelkovic, Marko and Veleski, Mitko and Chen, Junchao and Simevski, Aleksandar and Krstic, Milos}, title = {A Particle Detector Based on Pulse Stretching Inverter Chain}, series = {26th IEEE International Conference on Electronics, Circuits and Systems (ICECS 2019), Genova}, journal = {26th IEEE International Conference on Electronics, Circuits and Systems (ICECS 2019), Genova}, isbn = {978-1-7281-0996-1}, doi = {10.1109/ICECS46596.2019.8964644}, pages = {4}, language = {en} } @misc{ChenOevermann, author = {Chen, Boxiong and Oevermann, Michael}, title = {An Eulerian stochastic field cavitation model coupled to a pressure based solver}, series = {Computer and Fluids}, volume = {162}, journal = {Computer and Fluids}, issn = {0045-7930}, doi = {10.1016/j.compfluid.2017.12.002}, pages = {1 -- 10}, abstract = {Probability density functions (PDF) and the relevant methods have been widely used to describe non-linear phenomena in the realm of turbulence modelling and CFD. In order to solve PDF transport equations, the main trend of previous studies rely on Monte Carlo method with Lagrangian particle tracking. However, as with any Lagrangian based approach, the scalability of the parallelized simulations of such method is less than satisfactory. An Eulerian stochastic field model has been presented recently by Dumond et al. [1] to simulate cavitating flows. Their model uses a fully compressible density based solver. Here we present an adapted version using an iso-thermal cavitation model adopting the homogeneous mixture assumption in a pressure based flow solver which is more relevant to engine simulations. A PDF method is used to represent a distribution of vapour volume fractions, based on which the Eulerian stochastic field (ESF) method is applied to perform a three-dimensional large eddy simulation (LES) of the cavitation phenomena inside an academic fuel injector configuration. The numerical model is based on a volume of fluids approach and coupled with a pressure based solver for the flow field, and is implemented in the framework of the open source C++ toolbox OpenFOAM. The result of the ESF simulation is compared against that from a typical single volume fraction solver for validation. Vortex structures and its correspondence to cavitation are shown, and the behaviour of the PDF at different probe locations at different times are acquired to demonstrate the potential of the ESF model in capturing both transient and stochastically steady cavitation.}, language = {en} } @misc{AndjelkovicChenSimevskietal., author = {Andjelkovic, Marko and Chen, Junchao and Simevski, Aleksandar and Stamenkovic, Zoran and Krstic, Milos and Kraemer, Rolf}, title = {A Review of Particle Detectors for Space-Borne Self-Adaptive Fault Tolerant Systems}, series = {18th IEEE East-West Design and Test Symposium (EWDTS 2020), Varna, Bulgaria, 04 - 07 September 2020}, journal = {18th IEEE East-West Design and Test Symposium (EWDTS 2020), Varna, Bulgaria, 04 - 07 September 2020}, publisher = {IEEE}, isbn = {978-1-7281-9899-6}, issn = {2472-761X}, doi = {10.1109/EWDTS50664.2020.9225138}, language = {en} } @misc{VagiannisNovotnaSkarkaetal., author = {Vagiannis, Dimitrios and Novotna, Eva and Skarka, Adam and Kammerer, Sarah and K{\"u}pper, Jan-Heiner and Chen, Si and Guo, Lei and Staud, Frantisek and Hofman, Jakub}, title = {Ensartinib (X-396) Effectively Modulates Pharmacokinetic Resistance Mediated by ABCB1 and ABCG2 Drug Efflux Transporters and CYP3A4 Biotransformation Enzyme}, series = {Cancers}, volume = {12}, journal = {Cancers}, number = {4}, issn = {2072-6694}, doi = {10.3390/cancers12040813}, pages = {27}, abstract = {Ensartinib (X-396) is a promising tyrosine kinase inhibitor currently undergoing advanced clinical evaluation for the treatment of non-small cell lung cancer. In this work, we investigate possible interactions of this promising drug candidate with ATP-binding cassette (ABC) drug efflux transporters and cytochrome P450 biotransformation enzymes (CYPs), which play major roles in multidrug resistance (MDR) and pharmacokinetic drug-drug interactions (DDIs). Accumulation studies showed that ensartinib is a potent inhibitor of ABCB1 and ABCG2 transporters. Additionally, incubation experiments with recombinant CYPs showed that ensartinib significantly inhibits CYP3A4 and CYP2C9. Subsequent molecular docking studies confirmed these findings. Drug combination experiments demonstrated that ensartinib synergistically potentiates the antiproliferative effects of daunorubicin, mitoxantrone, and docetaxel in ABCB1, ABCG2, and CYP3A4-overexpressing cellular models, respectively. Advantageously, ensartinib's antitumor efficiency was not compromised by the presence of MDR-associated ABC transporters, although it acted as a substrate of ABCB1 in Madin-Darby Canine Kidney II (MDCKII) monolayer transport assays. Finally, we demonstrated that ensartinib had no significant effect on the mRNA-level expression of examined transporters and enzymes in physiological and lung tumor cellular models. In conclusion, ensartinib may perpetrate clinically relevant pharmacokinetic DDIs and modulate ABCB1-, ABCG2-, and CYP3A4-mediated MDR. The in vitro findings presented here will provide a valuable foundation for future in vivo investigations.}, language = {en} } @misc{LeGalHarlanderBorciaetal., author = {Le Gal, Patrice and Harlander, Uwe and Borcia, Ion-Dan and Le Diz{\`e}s, St{\´e}phane and Chen, J. and Favier, Benjamin}, title = {Instability of vertically stratified horizontal plane Poiseuille flow}, series = {Journal of Fluid Mechanics}, volume = {907}, journal = {Journal of Fluid Mechanics}, number = {R1}, issn = {1469-7645}, doi = {10.1017/jfm.2020.917}, pages = {1 -- 14}, language = {en} } @misc{LiuAssafChenetal., author = {Liu, Fei and Assaf, George and Chen, Ming and Heiner, Monika}, title = {A Petri nets-based framework for whole-cell modeling}, series = {Biosystems}, volume = {210}, journal = {Biosystems}, issn = {0303-2647}, doi = {10.1016/j.biosystems.2021.104533}, abstract = {Whole-cell modeling aims to incorporate all main genes and processes, and their interactions of a cell in one model. Whole-cell modeling has been regarded as the central aim of systems biology but also as a grand challenge, which plays essential roles in current and future systems biology. In this paper, we analyze whole-cell modeling challenges and requirements and classify them into three aspects (or dimensions): heterogeneous biochemical networks, uncertainties in components, and representation of cell structure. We then explore how to use different Petri net classes to address different aspects of whole-cell modeling requirements. Based on these analyses, we present a Petri nets-based framework for whole-cell modeling, which not only addresses many whole-cell modeling requirements, but also offers a graphical, modular, and hierarchical modeling tool. We think this framework can offer a feasible modeling approach for whole-cell model construction.}, language = {en} } @phdthesis{Chao, author = {Chao, Chen-Xiang}, title = {Strategies for Optimizing the Tooth Root Load Capacity of High-Performance Gears}, publisher = {Shaker}, address = {D{\"u}ren}, isbn = {978-3-8440-8453-5}, pages = {xvi, 160}, abstract = {Abstract Strategies for Optimizing the Tooth Root Load Capacity of High-Performance Gears Keywords: planet gears, high-performance gearbox, tooth root load capacity, tooth root optimization, multi-objective optimization In order to achieve greater efficiency, many modern applications such as geared turbofans require high-performance gearboxes with excellent reliability and low weight. The tooth root load capacity often is a limiting design criterion driving minimum face widths and hence the weight of gears. Consequently, strategies for optimizing the tooth root load capacity of gears are explored in this thesis. Two methods for tooth root load capacity analysis - a maximum tensile stress method derived from ISO 6336 and a local fatigue approach taking into account mean stress infl - are introduced and ompared to each other with respect to their applicability to optimization problems. A study with 2D fi element models of unidirectionally loaded sun gears reveals that the local fatigue analysis method should be preferred over the common approach of minimizing the maximum tooth root stress, since applying both methods as optimization targets results in diff nt tooth root shapes and a vast overestimation of safety gains when only tensile stresses are considered. Due to alternating loading, planet gears usually have a lower tooth root load capacity than other gears. Additionally, they are often designed with thin rims making the gear body lighter but also more elastic. Therefore, the tooth root shape of a thin-rimmed planet gear is optimized to explore possible interactions. The results show that overly thin rims negatively affect the maximization of tooth root safety. Hence, it is necessary to conduct multi-objectiveoptimizations of planet gears, which maximize tooth root safety and minimize mass simultaneously by optimizing tooth root shape, rim geometry and face width. The efficacy of this approach is demonstrated for 3D gear simulation models of spur as well as double helical planet gears. Pareto-optimal designs show significant improvements compared to the baseline design. Moreover, investigations demonstrate the opportunity to vastly decrease the computational cost of multi-objective optimizations by scalarizing them and using the result to approximate parts of the Pareto front.}, language = {en} } @misc{ChaoKruegerFlassigetal., author = {Chao, Chen-Xiang and Kr{\"u}ger, David and Flassig, Peter Michael and Meissner, Bernd}, title = {Verfahren zur Herstellung einer Verzahnung und Verzahnung}, language = {de} } @misc{ChaoKruegerFlassigetal., author = {Chao, Chen-Xiang and Kr{\"u}ger, David and Flassig, Peter Michael and Meissner, Bernd}, title = {Method for manufacturing a toothing and toothing}, language = {en} }