@misc{NeubertHielscherWalteretal., author = {Neubert, Tilmann J. and Hielscher, Maximilian M. and Walter, Keven and Schr{\"o}ter, Carolin M. and Stage, Marion and Rosencrantz, Ruben R. and Panis, Felix and Rompel, Annette and Balasubramanian, Kannan and Waldvogel, Siegfried R. and B{\"o}rner, Hans G.}, title = {Electrosynthesis of mussel-inspired adhesive polymers as a novel class of transient enzyme stabilizers}, series = {Angewandte Chemie : a journal of the Gesellschaft Deutscher Chemiker. International edition}, volume = {64}, journal = {Angewandte Chemie : a journal of the Gesellschaft Deutscher Chemiker. International edition}, number = {6}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1433-7851}, doi = {10.1002/anie.202419684}, pages = {1 -- 8}, abstract = {Multifunctional ortho-quinones are required for the formation of thiol-catechol-connectivities (TCC) but can be delicate to handle. We present the electrochemical oxidation of the dipeptide DiDOPA, achieving up to 92 \% conversion efficiency of the catechols to ortho-quinones. Graphite and stainless steel could be employed as cost-efficient electrodes. The electrochemical activation yields quinone-solutions, which are free of undesired reactive compounds and eliminates the challenging step of isolating the reactive quinones. The DiDOPA quinones were employed in polyaddition reactions with multi-thiols, forming oligomers that functioned as transient enzyme stabilizers (TES). These TCC-TES-additives improved the thermal stability and the activity of tyrosinase in heat stress assays.}, language = {en} }