@misc{KordiSaydiAzimietal., author = {Kordi, N and Saydi, A and Azimi, M and Mazdarani, F and Gadruni, K and Jung, F and Karami, S}, title = {Cuproptosis and physical training}, series = {Clinical Hemorheology and Microcirculation}, volume = {88 (2024)}, journal = {Clinical Hemorheology and Microcirculation}, number = {3}, doi = {10.3233/CH-242329}, pages = {337 -- 350}, abstract = {Copper is an essential element in the human body, involved in many physiological and metabolic functions, including coagulation, oxidative metabolism, and hormone production. The maintenance of copper homeostasis within cells is a complex procedure that is intrinsically controlled by a multitude of intricate mechanisms. Disorders of copper homeostasis encompass a wide range of pathological conditions, including degenerative neurological diseases, metabolic disorders, cardio-cerebrovascular diseases, and tumors. Cuproptosis, a recently identified non-apoptotic mode of cell death mode, is characterized by copper dependence and the regulation of mitochondrial respiration. Cuproptosis represents a novel form of cell death distinct from the previously described modes, including apoptosis, necrosis, pyroptosis, and ferroptosis. Excess copper has been shown to induce cuproptosis by stimulating protein toxic stress responses via copper-dependent abnormal oligomerization of lipoylation proteins within the tricarboxyli}, language = {en} }