TY - GEN A1 - Krüger-Genge, Anne A1 - Jung, Friedrich A1 - Hufert, Frank A1 - Jung, Ernst Michael A1 - Küpper, Jan-Heiner A1 - Storsberg, J. T1 - Effects of gut microbial metabolite trimethylamine N-oxide (TMAO) on platelets and endothelial cells T2 - Clinical Hemorheology and Microcirculation N2 - Thrombotic events result from different pathologies and are the underlying causes of severe diseases like stroke or myocardial infarction. Recent basic research now revealed a link between food uptake, food conversion and gut metabolism. Gut microbial production of trimethylamine N-oxide (TMAO) from dietary nutrients like choline, lecithin and L-carnitine was associated with the development of cardiovascular diseases. Within this review we give a systematic overview about the influence of TMAO on blood components like platelets and endothelial cells which both are involved as key players in thrombotic processes. In summary, a mechanistic correlation between the gut microbiome, TMAO and cardiovascular diseases becomes obvious and emphasizes to the significance of the intestinal microbiome. KW - Microbiome KW - trimethylamin-N-oxide KW - platelets KW - endothelial cells KW - atherosclerosis Y1 - 2020 UR - https://opus4.kobv.de/opus4-UBICO/frontdoor/index/index/docId/26316 UR - https://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch209206 SN - 1875-8622 SN - 1386-0291 VL - 76 IS - 2 SP - 309 EP - 316 ER -