TY - CHAP A1 - Scherbahn, Vitali A1 - Nizamov, Shavkat A1 - Mirsky, Vladimir M. A2 - Schöning, Michael J. A2 - Poghossian, Arshak T1 - Toward ultrasensitive surface plasmon resonance sensors T2 - Label-free biosensing : advanced materials, devices and applications N2 - Despite the history of application of surface plasmon resonance (SPR) for chemo- and biosensing being over 30 years long, the development of this technique is still in progress. This review is focused on the technological aspects of further improvement of analytical performance of SPR transducers based on Kretschmann configuration. We describe basic measurement configurations, their improvements and optimizations, and their drawbacks and limitations. An importance of referencing in SPR sensors is highlighted. The referencing approaches are classified into the following domains: (1) macroscopic spatially separated referencing, (2) self-referencing based on micro-patterning, (3) in-place referencing, (4) spatiotemporal referencing, and (5) electrochemically assisted referencing. The underlying principles of these approaches, examples of their implementation, and resulting improvements of sensor performance are described. Finally, an analysis of SPR data and an extraction of affinity properties are discussed. KW - Self-referencing KW - Surface plasmon resonance KW - Surface plasmon resonance microscopy Y1 - 2018 UR - https://opus4.kobv.de/opus4-UBICO/frontdoor/index/index/docId/22845 SN - 978-3-319-75220-4 SN - 978-3-319-75219-8 SP - 409 EP - 448 PB - Springer CY - Cham ER -